Improved Diabetic(改善糖尿病)研究综述
Improved Diabetic 改善糖尿病 - Administration of silibinin to db/db mice improved diabetic condition, as evidenced by the decrease of body weight, HbAc1level and serum insulin level in db/db mice. [1] We hypothesized that the MGO scavenger glyoxalase 1 (GLO1) reverses bone marrow-derived PC (BMPC) dysfunction through augmenting the activity of an important endoplasmic reticulum stress sensor, inositol-requiring enzyme 1α (IRE1α), resulting in improved diabetic wound healing. [2] DIM also improved diabetic nephropathy by inhibiting the expression of PKC-α, the marker of albuminuria, and TGF-β1, an indicator of renal hypertrophy, in diabetic mice. [3] Bariatric procedures result in long-term weight loss, improved diabetic regulation and decreased overall mortality [5]. [4] These results suggested that DG improved diabetic vascular injury possibly by reducing oxidative stress, which provides scientific evidence for the application of DG for diabetic vascular therapy. [5] Conclusion Present findings concluded that Crocin treatment improved diabetic testopathy and impairment of seminiferous tubules induced by high-fat diet and streptozotocin. [6] The histopathological findings showed that ABA improved diabetic cardiomyocyte necrosis and fibrosis. [7] CONCLUSIONS We found that a 100-ng dose of CNP-miR146a improved diabetic wound healing and did not impair the biomechanical properties of the skin post-healing. [8] Aims/Introduction: We previously reported that stem cell transplantation into limb skeletal muscle improved diabetic polyneuropathy (DPN) in diabetic animal models. [9] All the three doses of the root extract significantly improved diabetic dyslipidemia and the body weight of diabetic mice. [10] TMP administration in T2D rats improved diabetic condition, as demonstrated by significant (P < 0. [11] On the other hand, dapagliflozin improved diabetic retinopathy via antioxidant and anti-inflammatory actions also it improved retinal regeneration via increasing the expression of brain derived nerve growth factor. [12] The results revealed that NLE improved diabetic kidney injury by reducing blood glucose, serum creatinine, and blood urea nitrogen levels and enhanced antioxidant enzyme activities in kidney tissue. [13] RESULTS Oral treatment of boschnaloside for 4 weeks improved diabetic symptoms including fasting blood sugar, hemoglobin A1c, glucose intolerance, and Homeostatic Model Assessment of Ins Resistance, accompanied by circulating GLP-1active and adiponectin levels. [14] We concluded that SDF-1/CXCR4 pathway improved diabetic retinopathy possibly by increasing cell viability. [15] In conclusion, LCZ696 improved diabetic cardiomyopathy by reducing cardiac inflammation, oxidative stress, and apoptosis. [16] ResultsResults showed that empagliflozin improved diabetic myocardial structure and function, decreased myocardial oxidative stress and ameliorated myocardial fibrosis. [17]对 db/db 小鼠施用水飞蓟宾可改善糖尿病状况，db/db 小鼠体重、HbAc1 水平和血清胰岛素水平的降低证明了这一点。 [1] 我们假设 MGO 清除剂乙二醛酶 1 (GLO1) 通过增强一种重要的内质网应激传感器——肌醇需要酶 1α (IRE1α) 的活性来逆转骨髓来源的 PC (BMPC) 功能障碍，从而改善糖尿病伤口的愈合。 [2] DIM 还通过抑制糖尿病小鼠中蛋白尿标志物 PKC-α 和肾肥大指标 TGF-β1 的表达来改善糖尿病肾病。 [3] 减肥手术可导致长期体重减轻、改善糖尿病调节并降低总体死亡率 [5]。 [4] 这些结果表明，DG可能通过降低氧化应激来改善糖尿病血管损伤，这为DG在糖尿病血管治疗中的应用提供了科学依据。 [5] 结论 目前的研究结果表明，Crocin 治疗可改善由高脂饮食和链脲佐菌素引起的糖尿病性睾丸病和曲细精管损伤。 [6] 组织病理学结果表明，ABA改善了糖尿病心肌细胞坏死和纤维化。 [7] 结论 我们发现 100 ng 剂量的 CNP-miR146a 可以改善糖尿病伤口的愈合，并且不会损害愈合后皮肤的生物力学特性。 [8] 目标/简介：我们之前报道过干细胞移植到肢体骨骼肌中可以改善糖尿病动物模型中的糖尿病多发性神经病 (DPN)。 [9] 所有三个剂量的根提取物均显着改善了糖尿病性血脂异常和糖尿病小鼠的体重。 [10] T2D 大鼠中的 TMP 给药改善了糖尿病状况，显着（P<0. [11] 另一方面，达格列净通过抗氧化和抗炎作用改善了糖尿病视网膜病变，还通过增加脑源性神经生长因子的表达改善了视网膜再生。 [12] 结果表明，NLE 通过降低血糖、血清肌酐和血尿素氮水平以及增强肾组织中的抗氧化酶活性来改善糖尿病肾损伤。 [13] 结果 boschnaloside 的口服治疗 4 周改善了糖尿病症状，包括空腹血糖、血红蛋白 A1c、葡萄糖耐受不良和 Ins 抵抗的稳态模型评估，并伴有循环 GLP-1 活性和脂联素水平。 [14] 我们得出结论，SDF-1/CXCR4 通路可能通过增加细胞活力来改善糖尿病视网膜病变。 [15] 总之，LCZ696 通过减少心脏炎症、氧化应激和细胞凋亡来改善糖尿病心肌病。 [16] 结果结果显示，恩格列净改善糖尿病心肌结构和功能，降低心肌氧化应激，改善心肌纤维化。 [17]
improved diabetic condition 改善糖尿病状况
Administration of silibinin to db/db mice improved diabetic condition, as evidenced by the decrease of body weight, HbAc1level and serum insulin level in db/db mice. [1] TMP administration in T2D rats improved diabetic condition, as demonstrated by significant (P < 0. [2]对 db/db 小鼠施用水飞蓟宾可改善糖尿病状况，db/db 小鼠体重、HbAc1 水平和血清胰岛素水平的降低证明了这一点。 [1] T2D 大鼠中的 TMP 给药改善了糖尿病状况，显着（P<0. [2]
improved diabetic wound 改善糖尿病伤口
We hypothesized that the MGO scavenger glyoxalase 1 (GLO1) reverses bone marrow-derived PC (BMPC) dysfunction through augmenting the activity of an important endoplasmic reticulum stress sensor, inositol-requiring enzyme 1α (IRE1α), resulting in improved diabetic wound healing. [1] CONCLUSIONS We found that a 100-ng dose of CNP-miR146a improved diabetic wound healing and did not impair the biomechanical properties of the skin post-healing. [2]我们假设 MGO 清除剂乙二醛酶 1 (GLO1) 通过增强一种重要的内质网应激传感器——肌醇需要酶 1α (IRE1α) 的活性来逆转骨髓来源的 PC (BMPC) 功能障碍，从而改善糖尿病伤口的愈合。 [1] 结论 我们发现 100 ng 剂量的 CNP-miR146a 可以改善糖尿病伤口的愈合，并且不会损害愈合后皮肤的生物力学特性。 [2]
improved diabetic retinopathy 改善糖尿病视网膜病变
On the other hand, dapagliflozin improved diabetic retinopathy via antioxidant and anti-inflammatory actions also it improved retinal regeneration via increasing the expression of brain derived nerve growth factor. [1] We concluded that SDF-1/CXCR4 pathway improved diabetic retinopathy possibly by increasing cell viability. [2]另一方面，达格列净通过抗氧化和抗炎作用改善了糖尿病视网膜病变，还通过增加脑源性神经生长因子的表达改善了视网膜再生。 [1] 我们得出结论，SDF-1/CXCR4 通路可能通过增加细胞活力来改善糖尿病视网膜病变。 [2]