Genome Scans(基因组扫描)研究综述
Genome Scans 基因组扫描 - Genome scans of nucleotide diversity suggest positive selection on chromosome 2, 4, 5, 7, and 10 in durra sorghums, with successive adaptation during diffusion along the Sahel. [1] Our results validate previous reference-based strategies and suggest that the chromosome-scale hare draft genome should enable chromosome-wide analyses and genome scans on hares. [2] Several authors have suggested that variation in the intensity of background selection could cause variation in FST across the genome, which could confound signals of local adaptation in genome scans. [3] In these study systems, genome scans to identify candidate genes under selection have been applied. [4] As such, the objectives of the present study were to estimate genetic components of milk yield, fat yield, and protein yield considering heat stress and to perform whole-genome scans and a subsequent gene-set analysis for identifying candidate genes and functional gene-sets implicated in milk production under heat stress conditions. [5] It would be highly appreciated if genome scans and analysis are used in further studies to explore the genome-wide patterns of GMC between plants and pollinators. [6] Through whole-genome scans of differentiation and single-nucleotide polymorphism (SNP) genotyping, we associated winter coat color polymorphism to the genomic region of the pigmentation gene Agouti, previously linked to introgression-driven winter coat color variation in the snowshoe hare (Lepus americanus). [7] The overlapping outlier approach (OOA), where genome scans of multiple independent lineages are used to find outliers that overlap and therefore identify convergently evolving loci, is becoming popular. [8] Despite decreasing sequencing costs, whole‐genome sequencing for population‐based genome scans for selection is still prohibitively expensive for organisms with large genomes. [9] Genome scans and allele‐environment association analyses indicate that the population fragments in the deforested grasslands of the southwest are adaptively different from those in the more forested northeast. [10] Here, I evaluate the effect of neutral inversions and recombination variation on genome scans for selection, including tests for selective sweeps, differentiation outlier tests, and association tests. [11] Genome scans are popular to uncover outlier loci potentially involved in the genetic architecture of local adaptation, however links between outliers and phenotypic variation are rarely addressed. [12] We analysed the fine-scale genetic structure in the mussel Mytilus galloprovincialis using a few ancestry-informative loci previously identified from genome scans. [13] Genome scans in recently separated species can inform on molecular mechanisms and evolutionary processes driving divergence. [14] A primary method for drug target deconvolution in Plasmodium falciparum is in vitro evolution of compound-resistant parasites followed by whole-genome scans. [15] Genome scans are popular to uncover outlier loci potentially involved in the genetic architecture of local adaptation, however links between outliers and phenotypic variation are rarely addressed. [16]核苷酸多样性的基因组扫描表明，在杜拉高粱的 2、4、5、7 和 10 号染色体上进行正选择，并在沿萨赫勒地区的扩散过程中连续适应。 [1] 我们的结果验证了以前基于参考的策略，并表明染色体规模的野兔基因组草图应该能够对野兔进行全染色体分析和基因组扫描。 [2] 几位作者提出，背景选择强度的变化可能导致整个基因组的 FST 发生变化，这可能会混淆基因组扫描中局部适应的信号。 [3] 在这些研究系统中，已应用基因组扫描来识别正在选择的候选基因。 [4] 因此，本研究的目的是在考虑热应激的情况下估计牛奶产量、脂肪产量和蛋白质产量的遗传成分，并进行全基因组扫描和随后的基因集分析，以识别候选基因和功能基因集与热应激条件下的产奶量有关。 [5] 如果在进一步的研究中使用基因组扫描和分析来探索植物和传粉媒介之间 GMC 的全基因组模式，我们将不胜感激。 [6] 通过对分化和单核苷酸多态性 (SNP) 基因分型的全基因组扫描，我们将冬季毛色多态性与色素沉着基因 Agouti 的基因组区域相关联，该区域以前与雪鞋野兔 (Lepus americanus) 中基因渗入驱动的冬季毛色变化有关。 ）。 [7] 重叠异常值方法 (OOA) 正在变得流行，其中使用多个独立谱系的基因组扫描来查找重叠的异常值，从而识别趋同进化的基因座。 [8] 尽管测序成本降低，但基于群体的基因组扫描进行选择的全基因组测序对于具有大基因组的生物体来说仍然过于昂贵。 [9] 基因组扫描和等位基因-环境关联分析表明，西南部森林砍伐草原中的种群碎片与森林茂密的东北部的种群碎片适应性不同。 [10] 在这里，我评估了中性倒位和重组变异对选择基因组扫描的影响，包括选择性扫描测试、分化异常值测试和关联测试。 [11] 基因组扫描通常用于发现可能参与局部适应的遗传结构的异常位点，但是很少解决异常值与表型变异之间的联系。 [12] 我们使用先前从基因组扫描中确定的一些祖先信息位点分析了贻贝中的精细遗传结构。 [13] 对最近分离的物种进行基因组扫描可以了解驱动分歧的分子机制和进化过程。 [14] 恶性疟原虫中药物靶标反卷积的主要方法是在体外进化出抗复合寄生虫，然后进行全基因组扫描。 [15] 基因组扫描通常用于发现可能参与局部适应的遗传结构的异常位点，但是很少解决异常值与表型变异之间的联系。 [16]
Powerful Genome Scans 强大的基因组扫描
We show that conditionally deleterious mutations driving non-local maladaptation may be undetectable by even the most powerful genome scans, as differences in allele frequency between populations are typically small. [1] We show that conditionally deleterious mutations driving nonlocal maladaptation may be undetectable by even the most powerful genome scans, as differences in allele frequency between populations are typically small. [2]我们表明，即使是最强大的基因组扫描也可能无法检测到驱动非局部适应不良的条件有害突变，因为群体之间等位基因频率的差异通常很小。 [1] 我们表明，即使是最强大的基因组扫描也可能无法检测到驱动非局部适应不良的条件有害突变，因为人群之间等位基因频率的差异通常很小。 [2]
genome scans acros 基因组扫描
Genome scans across individuals from recently polluted and nearby unpolluted soils in Belgium revealed no evidence of population structure but detected allelic divergence and gene copy number variation in genes involved in metal exclusion, storage, immobilization, and reactive oxygen species detoxification. [1] Genome scans across 12 bees showed that miRNA copy number is highly conserved and is not associated with variation in social organization. [2] These results have implications for studies seeking to deploy low‐density SNP collections or genome scans across genetically diverse populations/species showing similar genetic characteristics and patterns of LD decay for a wide variety of purposes. [3]对比利时最近受污染和附近未受污染土壤的个体进行基因组扫描，未发现种群结构的证据，但检测到与金属排斥、储存、固定和活性氧解毒有关的基因中的等位基因分歧和基因拷贝数变异。 [1] 对 12 只蜜蜂的基因组扫描显示 miRNA 拷贝数高度保守，与社会组织的变化无关。 [2] 这些结果对于寻求在遗传多样性种群/物种中部署低密度 SNP 集合或基因组扫描的研究具有重要意义，这些种群/物种显示出相似的遗传特征和 LD 衰减模式，用于各种目的。 [3]
genome scans identified 基因组扫描鉴定
RESULTS Genome scans identified three L. [1] Genome scans identified 17 genes that were highly differentiated among Wb populations. [2]结果 基因组扫描确定了三个 L. [1] 基因组扫描确定了 17 个在 Wb 种群中高度分化的基因。 [2]