Flexible Dose(灵活剂量)研究综述
Flexible Dose 灵活剂量 - AIM: This research aimed to investigate the fasting blood sugar level of a male patient with schizophrenia treated with flexible dose. [1] Patients were randomized to adjunctive brexpiprazole (fixed or flexible doses in the range of 1-3 mg/d; n = 1,032) or placebo (n = 819) for 6 weeks. [2] METHODS Data were analyzed from the primary study, an 8-week, randomized, double-blind, head-to-head study in which participants with well-treated depressive symptoms but experiencing TESD with SSRIs were directly switched to flexible doses (10/20 mg) of vortioxetine or escitalopram. [3] Eligible patients with a mean pain intensity score of 4 or more on an 11-point numeric rating scale were randomly assigned to receive either active treatment with a flexible dose of pregabalin or placebo for 16 weeks. [4] METHODS BMS patients were treated with topical clonazepam and a flexible dose of VO (10 mg, 15 mg, or 20 mg). [5] In addition, the solid formulations are designed for adults and often their dosage is not suitable for children that require a flexible dose based on their weight. [6] Participants were treated with flexible doses of fesoterodine. [7] 5 to 3 mg/d (flexible dose) adjunct to their current antidepressant treatment. [8] After at least 4-week’s treatment with pregabalin (flexible dose, 150 to 600 mg/d), pregabalin-treated patients showed reduced pain −1. [9] Conclusion: FDM 3D printing offers a disruptive technology for the manufacture of solid dosage forms of medicines of flexible doses with excellent dose precision and pharmacopeial properties. [10]目的：本研究旨在调查灵活剂量治疗的男性精神分裂症患者的空腹血糖水平。 [1] 患者被随机分配至辅助性 brexpiprazole（固定或灵活剂量，范围为 1-3 mg/d；n = 1,032）或安慰剂（n = 819），持续 6 周。 [2] 方法 数据分析来自初步研究，这是一项为期 8 周、随机、双盲、头对头的研究，在该研究中，抑郁症状得到良好治疗但使用 SSRIs 经历 TESD 的参与者直接转换为灵活剂量（10/20 mg ) vortioxetine 或依他普仑。 [3] 在 11 点数字评定量表上平均疼痛强度评分为 4 分或更高的合格患者被随机分配接受灵活剂量的普瑞巴林或安慰剂的积极治疗 16 周。 [4] 方法 BMS 患者接受局部氯硝西泮和灵活剂量的 VO（10 mg、15 mg 或 20 mg）治疗。 [5] 此外，固体制剂是为成人设计的，其剂量通常不适合需要根据体重灵活剂量的儿童。 [6] 参与者接受了灵活剂量的非索罗定治疗。 [7] 5 至 3 毫克/天（灵活剂量）辅助他们目前的抗抑郁治疗。 [8] 在使用普瑞巴林（灵活剂量，150 至 600 mg/d）治疗至少 4 周后，接受普瑞巴林治疗的患者的疼痛减轻 -1。 [9] 结论：FDM 3D 打印为制造具有优异剂量精度和药典特性的灵活剂量药物固体剂型提供了一种颠覆性技术。 [10]
flexible dose adjustment 灵活的剂量调整
Flexible dose adjustment of oral sema (3, 7, and 14 mg) once daily (N=253) was tested vs. [1] Conclusion: Adherence to Buprenorphine wasbetter in flexible dose adjustment group. [2] The PIONEER 7 study compared oral semaglutide with flexible dose adjustment to sitagliptin (a dipeptidyl peptidase 4 inhibitor and established T2DM therapeutic). [3] We aimed to compare the efficacy and safety of flexible dose adjustments of oral semaglutide with sitagliptin 100 mg. [4]测试了每日一次口服 sema（3、7 和 14 mg）的灵活剂量调整（N = 253）与 [1] 结论：灵活剂量调整组丁丙诺啡依从性较好。 [2] PIONEER 7 研究将口服 semaglutide 与灵活的剂量调整与西格列汀（一种二肽基肽酶 4 抑制剂和已确立的 T2DM 治疗剂）进行了比较。 [3] 我们旨在比较口服 semaglutide 与 100 mg 西格列汀灵活剂量调整的疗效和安全性。 [4]