Fatty Acid Derived(脂肪酸衍生)研究综述
Fatty Acid Derived 脂肪酸衍生 - In CD, as a result of PPARα down-regulation, liver mitochondrial fatty acid-derived acetyl-CoA would, like glucose-derived acetyl-CoA, be used for lipid anabolism and fuel nuclear acetylation events which might trigger aralar-1 re-activation as seen in non-CD HCC. [1] From an engineering perspective, biosynthesis of fatty acid-derived chemicals (FACs) is an attractive and promising solution to produce chemicals from abundant renewable feedstocks and carbon dioxide in microbial chassis. [2] Histone deacylase 11 and human sirtuins are able to remove fatty acid-derived acyl moieties from the ε-amino group of lysine residues. [3] Malonyl-CoA is an important building block for microbial synthesis of numerous pharmaceutically interesting or fatty acid-derived compounds including polyketides, flavonoids, phenylpropanoids and fatty acids. [4] Males produce fatty acid-derived chiral hydroxylactones as pheromones in their rectal vesicle that attract and arrest virgin females. [5] Application to two independent cohorts of elderly men and women showed the routine detection of 86 metabolites, identified fasting state influences on essential fatty acid-derived oxylipins, N-acylethanolamides and conjugated bile acids, identified rare presence of high and low testosterone levels and the presence of NSAIDs in ∼10% of these populations. [6] , biofuels and fatty acid-derived materials). [7] Volatile terpenes and fatty acid-derived volatiles were the principal aroma volatiles that accumulated during the spreading of green tea, and the trends of their changes were consistent with the expression pattern of related synthesis pathway genes, indicating that they were primarily derived from de novo synthesis rather than glycoside hydrolysis. [8] Their findings indicate that omega-3 fatty acid-derived N-acyl taurines (NATs) greatly accumulate in bile and also in plasma following omega-3 supplementation. [9] Maresins (MaR) are a family of essential fatty acid-derived lipid mediators that play a central role in the regulation of inflammation with several studies demonstrating that these mediators display protective activities in airway inflammation. [10] toruloides has the potential to serve as a platform strain for efficient production of fatty acid-derived molecules. [11] This work reports thermal stability, traction and tribofilm formation properties of three fatty acid-derived ionic liquids (FAILs) and evaluates the influence of the chemical structure of the anion on the properties indicated above. [12] The endocannabinoidome, comprising several fatty acid-derived mediators, plays a central role in the regulation of food intake. [13] Here we identified in bile a class of hypotriglyceridemic omega-3 fatty acid-derived N-acyl taurines (NATs) that, after dietary omega-3 fatty acid supplementation, increased to concentrations similar to those of steroidal bile acids. [14] Polyunsaturated fatty acid-derived lipid mediators (PUFA-LM) can promote inflammation or resolution of inflammation. [15] This contribution describes the current understanding and recent progress made on endogenous natural products that are produced by human cells, including amines, steroids, and fatty acid-derived natural products. [16] Among the proresolving mediators, the essential fatty acid-derived specialized proresolving lipid mediators (SPM) govern immune responses to limit disease severity. [17] Owing to their high energy density and composition, fatty acid-derived chemicals possess a wide range of applications such as biofuels, biomaterials, and other biochemical, and as a consequence, the global annual demand for products has surpassed 2 million tons. [18] Currently, interest in metabolic engineering of yeasts as microbial cell factories for biofuel production, which varies from short-chain ethanol to long-chain fatty acid-derived molecules, is growing. [19] Little is known about such survival mechanisms, although ascarosides (ascarylose with fatty acid-derived side chains) have been reported to mediate the formation of dauer larvae in the free-living nematode Caenorhabditis elegans. [20] Besides, we tested their compatibility with established glycerol dialkyl glycerol tetraethers and stable isotope proxies in KM-1 to probe the use of fatty acid-derived proxies for paleoclimate reconstruction. [21] Endophytes are reservoirs of new and effective bioactive compounds that generally belong to the classes such as terpenoids and steroids, fatty acid-derived substances and polyketides, alkaloids, nonribosomal polypeptides, and enzyme cofactors. [22] Fatty acid-derived acyl chains of phospholipids and lipoproteins are central to bacterial membrane fluidity and lipoprotein function. [23] Human sirtuins (SIRT1-7) regulate not only deacetylation but also deacylation of fatty acid-derived acyl moieties (defatty-acylation) at the ε-amino group of lysine residues. [24] We tested the possibility that volicitin, a common fatty acid-derived elicitor in caterpillar regurgitant plays a role in this difference. [25] AMP-activated protein kinase (AMPK) is recognized as a critical regulator of cellular energy metabolism impacted by AMP/ATP and ADP/ATP ratios, or glucose- and fatty acid-derived metabolites. [26]在 CD 中，由于 PPARα 下调，肝脏线粒体脂肪酸衍生的乙酰辅酶 A 将与葡萄糖衍生的乙酰辅酶 A 一样，用于脂质合成代谢和燃料核乙酰化事件，这可能触发 aralar-1 重新激活如在非 CD HCC 中所见。 [1] 从工程的角度来看，脂肪酸衍生化学品 (FAC) 的生物合成是一种有吸引力且有前途的解决方案，可以从丰富的可再生原料和微生物底盘中的二氧化碳生产化学品。 [2] 组蛋白脱酰基酶 11 和人类去乙酰化酶能够从赖氨酸残基的 ε-氨基中去除脂肪酸衍生的酰基部分。 [3] 丙二酰辅酶 A 是微生物合成许多药学上有趣的或脂肪酸衍生化合物的重要组成部分，包括聚酮化合物、类黄酮、苯丙烷和脂肪酸。 [4] 雄性在其直肠囊泡中产生脂肪酸衍生的手性羟基内酯作为信息素，以吸引和逮捕处女。 [5] 对两个独立的老年男性和女性队列的应用表明，常规检测了 86 种代谢物，确定了空腹状态对必需脂肪酸衍生的羟脂、N-酰基乙醇酰胺和共轭胆汁酸的影响，确定了罕见的高和低睾酮水平的存在以及这些人群中约 10% 的非甾体抗炎药。 [6] 、生物燃料和脂肪酸衍生材料）。 [7] 挥发性萜类和脂肪酸衍生挥发物是绿茶传播过程中积累的主要香气挥发物，其变化趋势与相关合成途径基因的表达模式一致，表明它们主要来源于从头合成。而不是糖苷水解。 [8] 他们的研究结果表明，补充 omega-3 后，omega-3 脂肪酸衍生的 N-酰基牛磺酸 (NATs) 在胆汁和血浆中大量积累。 [9] Maresins (MaR) 是一个必需脂肪酸衍生的脂质介质家族，在炎症调节中发挥核心作用，多项研究表明这些介质在气道炎症中表现出保护活性。 [10] toruloides 具有作为高效生产脂肪酸衍生分子的平台菌株的潜力。 [11] 这项工作报告了三种脂肪酸衍生离子液体 (FAIL) 的热稳定性、牵引力和摩擦膜形成特性，并评估了阴离子的化学结构对上述特性的影响。 [12] 内源性大麻素组由几种脂肪酸衍生的介质组成，在调节食物摄入中起核心作用。 [13] 在这里，我们在胆汁中发现了一类低甘油三酯血症 omega-3 脂肪酸衍生的 N-酰基牛磺酸 (NAT)，在膳食补充 omega-3 脂肪酸后，其浓度增加到与甾体胆汁酸相似的浓度。 [14] 多不饱和脂肪酸衍生的脂质介质 (PUFA-LM) 可以促进炎症或炎症消退。 [15] 该贡献描述了目前对人体细胞产生的内源性天然产物的理解和最近取得的进展，包括胺、类固醇和脂肪酸衍生的天然产物。 [16] 在促分解介质中，必需脂肪酸衍生的专门促分解脂质介质 (SPM) 控制免疫反应以限制疾病的严重程度。 [17] 由于其高能量密度和高成分，脂肪酸衍生化学品具有广泛的应用，如生物燃料、生物材料和其他生化产品，因此，全球对产品的年需求量已超过 200 万吨。 [18] 目前，酵母代谢工程作为微生物细胞工厂生产生物燃料（从短链乙醇到长链脂肪酸衍生分子）的兴趣正在增长。 [19] 关于这种生存机制知之甚少，尽管据报道蛔苷（具有脂肪酸衍生侧链的蛔虫糖）介导自由生活线虫秀丽隐杆线虫中 dauer 幼虫的形成。 [20] 此外，我们测试了它们与 KM-1 中已建立的甘油二烷基甘油四醚和稳定同位素代理的相容性，以探索脂肪酸衍生代理在古气候重建中的应用。 [21] 内生菌是新的有效生物活性化合物的储存库，这些化合物通常属于萜类和类固醇、脂肪酸衍生物质和聚酮化合物、生物碱、非核糖体多肽和酶辅助因子等类别。 [22] 脂肪酸衍生的磷脂和脂蛋白酰基链是细菌膜流动性和脂蛋白功能的核心。 [23] 人类去乙酰化酶 (SIRT1-7) 不仅调节赖氨酸残基的 ε-氨基处的脂肪酸衍生酰基部分的脱乙酰化（脱脂酰化），还调节脱乙酰化。 [24] 我们测试了毛虫反流中常见的脂肪酸衍生诱导剂 volicitin 在这种差异中发挥作用的可能性。 [25] AMP 活化蛋白激酶 (AMPK) 被认为是受 AMP/ATP 和 ADP/ATP 比率或葡萄糖和脂肪酸衍生代谢物影响的细胞能量代谢的关键调节剂。 [26]
3 Fatty Acid Derived
Objectives Omega-3 fatty acid derived endocannabinoids are metabolized by cytochrome P450s to form bioactive endocannabinoid epoxides that are anti-inflammatory. [1] Herein, we review the discovery of omega-3 fatty acid derived eCBs that are generated from long chain omega-3 PUFAs - docosahexaenoyl ethanolamide (DHA-EA or synaptamide), docosahexanoyl-glycerol (DHG), eicosapentaenoyl ethanolamide (EPA-EA) and eicosapentanoylglycerol (EPG). [2]目标 Omega-3 脂肪酸衍生的内源性大麻素被细胞色素 P450 代谢，形成具有抗炎作用的生物活性内源性大麻素环氧化物。 [1] 在此，我们回顾了由长链 omega-3 PUFA - 二十二碳六烯酰乙醇酰胺（DHA-EA 或突触酰胺）、二十二碳六烯酰甘油（DHG）、二十碳五烯酰乙醇酰胺（EPA-EA）和二十碳五酰甘油（EPG）。 [2]
Chain Fatty Acid Derived
Butyrate is a short‐chain fatty acid derived from the metabolism of indigestible carbohydrates by the gut microbiota. [1] Acetate is a short chain fatty acid derived from AA oxidation, and acetate levels were significantly higher in urine collected overnight with food provided ad libitum compared with urine collected after 9 h fasting. [2]丁酸盐是一种短链脂肪酸，来源于肠道微生物群对难消化碳水化合物的代谢。 [1] 醋酸盐是一种来源于 AA 氧化的短链脂肪酸，与空腹 9 小时后收集的尿液相比，随意提供食物过夜收集的尿液中的醋酸盐水平显着更高。 [2]