Epigenetically Repressed(表观遗传抑制)研究综述
Epigenetically Repressed 表观遗传抑制 - While PDLIM2 is epigenetically repressed in human lung cancer, associating with therapeutic resistance and poor prognosis, its global or lung epithelial-specific deletion in mice causes increased lung cancer development, chemoresistance, and complete resistance to anti-PD-1 and epigenetic drugs. [1] The expression of the metabolic tumor suppressor gene fructose‐1,6‐bisphosphatase (FBP1), epigenetically repressed in HCC, was restored by CM‐272. [2] Furthermore, we discovered that miR-424/503 was epigenetically repressed by hypermethylation in the promoter regions, which directly modulated the expression of KIF23 to improve the oncogenic performance of cancer cells in vitro. [3] Repetitive DNA sequences and some genes are epigenetically repressed by transcriptional gene silencing (TGS). [4]虽然 PDLIM2 在人类肺癌中受到表观遗传抑制,与治疗耐药和预后不良有关,但其在小鼠中的全局或肺上皮特异性缺失会导致肺癌发展增加、化学抗性以及对抗 PD-1 和表观遗传药物的完全抗性。 [1] CM-272 恢复了在 HCC 中表观遗传抑制的代谢性肿瘤抑制基因果糖-1,6-双磷酸酶 (FBP1) 的表达。 [2] 此外,我们发现 miR-424/503 受到启动子区域高甲基化的表观遗传抑制,这直接调节 KIF23 的表达以改善癌细胞的体外致癌性能。 [3] 重复的 DNA 序列和一些基因在表观遗传上受到转录基因沉默 (TGS) 的抑制。 [4]