Epigenetically Inactivated(表观遗传失活)研究综述
Epigenetically Inactivated 表观遗传失活 - Our findings suggest that SorCS1 is epigenetically inactivated in a substantial fraction of CRC, and its expression may be a promising prognostic factor in CRC patients. [1] ResultsWe are the first to report that ZAR1 is epigenetically inactivated not only in lung cancer but also across cancer types, and ZAR1 methylation occurs across its complete CpG island. [2] The SLC5A8 gene encodes Na monocarboxylate transporter 1, which is epigenetically inactivated in various tumour types. [3]我们的研究结果表明，SorCS1 在大部分 CRC 中表观遗传失活，其表达可能是 CRC 患者有希望的预后因素。 [1] 结果我们是第一个报道ZAR1表观遗传失活不仅在肺癌中而且在各种癌症类型中均发生，并且ZAR1甲基化发生在其完整的CpG岛。 [2] SLC5A8 基因编码单羧酸钠转运蛋白 1，它在各种肿瘤类型中表观遗传失活。 [3]