Doxorubicin Loaded(加载多柔比星)研究综述
Doxorubicin Loaded 加载多柔比星 - Doxorubicin loaded in folated IPSAM exhibited a significant in vitro anti-cancer activity against KB cells. [1] The presented results of the test with BSA (bovine serum albumin) and doxorubicin loaded into nanoparticles showed a similar release profile for both substances. [2] This release system was based on photocleavage-bridged polysilsesquioxane nanoparticles which acted as nanocarriers of doxorubicin loaded on the surface via electrostatic interaction. [3] Finally, quantum chemical study at B3lyp/6–311++g** level of theory was performed to reveal the pH-triggered release of doxorubicin loaded on these nanoparticles which the obtained results were in agreement with experimental evidences. [4] Doxorubicin loaded in poloxamer 188‐coated PLGA nanoparticles (Dox‐NP + P188) was shown to produce a high antitumor effect against the experimental orthotopic 101. [5] Cytotoxicity and flow cytometry data showed that doxorubicin loaded in cetuximab–DNA conjugates was more potent in terms of cell cytotoxicity than free doxorubicin in EGFR‐overexpressed cell lines, thus suggesting that the conjugates were more selectively and easily taken up into cells, followed by rapid release of doxorubicin from the system into the cytoplasm from endosomes. [6] Employing a mouse melanoma model, topical application of doxorubicin-loaded FNAs accommodates ≥2-fold improvement in drug accumulation and tumor inhibition relative to topically-applied free doxorubicin, or doxorubicin loaded in liposomes and polymeric nanoparticles. [7] Furthermore, the nanoprobe realizes the dual-responsive release of doxorubicin loaded in the mesoporous channels in systems containing cathepsin B and glutathione, and can effectively kill tumor cells and inhibit the growth of tumor. [8]负载在叶状 IPSAM 中的多柔比星对 KB 细胞表现出显着的体外抗癌活性。 [1] 将 BSA（牛血清白蛋白）和多柔比星加载到纳米颗粒中的测试结果显示两种物质的释放曲线相似。 [2] 该释放系统基于光裂解桥接的聚倍半硅氧烷纳米颗粒，该纳米颗粒充当通过静电相互作用加载在表面上的多柔比星的纳米载体。 [3] 最后，进行了 B3lyp/6–311++g** 理论水平的量子化学研究，以揭示负载在这些纳米颗粒上的阿霉素的 pH 触发释放，所得结果与实验证据一致。 [4] 负载在泊洛沙姆 188 涂层的 PLGA 纳米颗粒（Dox-NP + P188）中的多柔比星对实验性原位 101 产生了高抗肿瘤作用。 [5] 细胞毒性和流式细胞术数据显示，在 EGFR 过表达的细胞系中，负载在西妥昔单抗-DNA 偶联物中的多柔比星在细胞毒性方面比游离多柔比星更有效，因此表明偶联物更具选择性和更容易被细胞吸收，随后快速多柔比星从系统释放到内体的细胞质中。 [6] 采用小鼠黑色素瘤模型，与局部应用游离阿霉素或负载在脂质体和聚合物纳米颗粒中的阿霉素相比，局部应用负载阿霉素的 FNA 可将药物积累和肿瘤抑制改善≥2 倍。 [7] 此外，该纳米探针在含有组织蛋白酶B和谷胱甘肽的系统中实现了载于介孔通道的多柔比星的双重响应释放，可有效杀伤肿瘤细胞，抑制肿瘤生长。 [8]
doxorubicin loaded nanoparticle 负载阿霉素的纳米颗粒
The finally obtained AIE polymer was further employed to construct doxorubicin loaded nanoparticles as a promising theranostics platform for cancer therapy. [1] We report the synthesis of a dual delivery system composed of chemically bound pH-responsive formaldehyde polymer prodrugs and pH-responsive doxorubicin loaded nanoparticles to increase the therapeutic index of doxorubicin by working in synergy with formaldehyde to enable the formation of DOX-DNA adducts and limiting the cardiotoxicity of anthracyclines. [2] The peptide-modified nanoparticles have showed no obvious cytotoxicity and can be internalized into L929 cells; moreover, the doxorubicin loaded nanoparticles incubated with HeLa cells have showed GSH-responsive capability and induced cell apoptosis. [3]最终获得的 AIE 聚合物进一步用于构建负载多柔比星的纳米颗粒，作为用于癌症治疗的有前途的治疗诊断平台。 [1] 我们报告了由化学结合的 pH 响应性甲醛聚合物前药和 pH 响应性多柔比星负载纳米粒子组成的双重递送系统的合成，通过与甲醛协同作用来增加多柔比星的治疗指数，从而能够形成 DOX-DNA 加合物并限制蒽环类药物的心脏毒性。 [2] 肽修饰的纳米粒子无明显细胞毒性，可内化到L929细胞中；此外，与 HeLa 细胞一起孵育的负载阿霉素的纳米颗粒显示出 GSH 响应能力并诱导细胞凋亡。 [3]