D3 Analogues(D3 类似物)研究综述
D3 Analogues D3 类似物 - Two novel 20-hydroxyvitamin D3 analogues (4a,b) with the A-ring modification have been synthesized by a convergent manner. [1] Two novel 16-oxa-vitamin D3 analogues were synthesized using a tandem Ti(ii)-mediated enyne cyclization/Cu-catalyzed allylation, Ru-catalyzed ring-closing metathesis reaction, and a low-valent titanium (LVT)-mediated stereoselective radical reduction of 8α,14α-epoxide as the key steps for the synthesis of the 16-oxa-C,D ring unit. [2] Two novel 23-fluorinated 25-hydroxyvitamin D3 analogues were synthesized using Inhoffen–Lythgoe diol as a precursor of the CD-ring, efficiently. [3]已通过收敛方式合成了两种具有 A 环修饰的新型 20-羟基维生素 D3 类似物 (4a,b)。 [1] 使用串联 Ti(ii) 介导的烯炔环化/Cu 催化的烯丙基化、Ru 催化的闭环复分解反应和低价钛 (LVT) 介导的立体选择性自由基合成了两种新型 16-oxa-vitamin D3 类似物8α,14α-环氧化物的还原是合成 16-oxa-C,D 环单元的关键步骤。 [2] 使用 Inhoffen-Lythgoe 二醇作为 CD 环的前体，有效地合成了两种新型 23-氟化 25-羟基维生素 D3 类似物。 [3]
Hydroxyvitamin D3 Analogues 羟基维生素 D3 类似物
Two novel 20-hydroxyvitamin D3 analogues (4a,b) with the A-ring modification have been synthesized by a convergent manner. [1] Two novel 23-fluorinated 25-hydroxyvitamin D3 analogues were synthesized using Inhoffen–Lythgoe diol as a precursor of the CD-ring, efficiently. [2]已通过收敛方式合成了两种具有 A 环修饰的新型 20-羟基维生素 D3 类似物 (4a,b)。 [1] 使用 Inhoffen-Lythgoe 二醇作为 CD 环的前体，有效地合成了两种新型 23-氟化 25-羟基维生素 D3 类似物。 [2]