Conjugated Small(共轭小)研究综述
Conjugated Small 共轭小 - Lipid-conjugated small-interfering RNAs (siRNAs) exhibit accumulation and gene silencing in extrahepatic tissues, providing an opportunity to expand therapeutic siRNA utility beyond the liver. [1] A subcutaneously administered GalNAc-conjugated small-interfering RNA (siRNA) targeting F12 mRNA (ALN-F12) was developed, and potency was evaluated in mice, rats, and cynomolgus monkeys. [2]脂质缀合的小干扰 RNA (siRNA) 在肝外组织中表现出积累和基因沉默，为将治疗性 siRNA 应用扩展到肝脏以外提供了机会。 [1] 开发了一种针对 F12 mRNA (ALN-F12) 的皮下给药 GalNAc 缀合的小干扰 RNA (siRNA)，并在小鼠、大鼠和食蟹猴中评估了效力。 [2]
Organic Conjugated Small
Here, the effect of the organic conjugated small molecule crystal growth process on the evolution of the crystal morphology and consequent charge transport properties are studied. [1] Engineering well-defined supramolecular fluorescent nano-architectures based on organic conjugated small molecules has been an essential scientific challenge. [2] The principal innovation of this approach is based on the supra-molecular interactions between the designed organic conjugated small molecule (OCSM), Zr4+ ion and phosphorylated CREB. [3]在这里，研究了有机共轭小分子晶体生长过程对晶体形态演变和随之而来的电荷传输特性的影响。 [1] 基于有机共轭小分子的工程定义明确的超分子荧光纳米结构一直是一项重要的科学挑战。 [2] 这种方法的主要创新是基于设计的有机共轭小分子 (OCSM)、Zr4+ 离子和磷酸化 CREB 之间的超分子相互作用。 [3]
Type Conjugated Small
A–π–D–π–A type conjugated small molecules play an indispensable role in organic photovoltaics. [1] We designed and synthesized four donor–acceptor-type conjugated small-molecule compounds DPP-CN-DTE-1, DPP-CN-DTE-2, DPP-DTE-CN-1 and DPP-DTE-CN-2. [2] A series of new acceptor-donor-acceptor (A-D-A) type conjugated small-molecule-dyes based on indacenodithieno[3,2-b]thiophene (IDTT) and 2-(2-methyl-4H-chromen-4-ylidene)malononitrile (CMCN), named IDTT-CMCN and IDTT-HT-CMCN, have been synthesized for application in organic solar cells. [3]A-π-D-π-A型共轭小分子在有机光伏发电中发挥着不可或缺的作用。 [1] 我们设计并合成了四种供体-受体型共轭小分子化合物 DPP-CN-DTE-1、DPP-CN-DTE-2、DPP-DTE-CN-1 和 DPP-DTE-CN-2。 [2] 一系列基于茚并二噻吩并[3,2-b]噻吩（IDTT）和2-（2-甲基-4H-色烯-4-亚基）丙二腈的新型受体-供体-受体（A-D-A）型共轭小分子染料(CMCN)，命名为 IDTT-CMCN 和 IDTT-HT-CMCN，已被合成用于有机太阳能电池。 [3]
Fully Conjugated Small 全共轭小
The fully conjugated small molecules give low optical gaps (1. [1] The fully conjugated small molecules give low optical gaps (1. [2]完全共轭的小分子具有低光学间隙 (1. [1] 完全共轭的小分子具有低光学间隙 (1. [2]
conjugated small molecule 共轭小分子
Conjugated small molecules and polymers interact with each other, resulting in complex solution-state aggregates and solid-state microstructures. [1] Low-bandgap π-conjugated small molecules have multiple applications. [2] A–π–D–π–A type conjugated small molecules play an indispensable role in organic photovoltaics. [3] Two conjugated small molecules with different conjugated side chains were synthesized to study their photovoltaic performances. [4] The fully conjugated small molecules give low optical gaps (1. [5] Cyclic and linear conjugated small molecules comprising dithienylethene (DTE) and thiophene groups were synthesized via Suzuki and McMurry couplings. [6] Conjugated small molecules have been extensively applied in the biomedical field owing to their tunable light-harvesting capability. [7] Despite remarkable progress in the development of new materials and relevant applications in organic electronics, some challenges remain, not only on the design and synthesis of novel structural materials (such as π-conjugated small molecule or polymer semiconductors, dielectrics, electrodes, and substrates), but also the development of efficient interface engineering strategies, for the fabrication of high-performance and high-stability devices, and eventually the realization of commercially available products. [8] Metal phthalocyanines (MPcs) are an abundant class of conjugated small molecules comprising and their integration into thin films is critial for the proper function of next generation applications. [9] The charge carrier mobility of conjugated small molecules (CSMs) depends on the intermolecular interactions and morphology. [10] Herein, a new type of π-conjugated small molecule of 4-guanidinobenzoic-acid-hydrochloride (4-GBACl) is demonstrated to effectively cross-link the Pb-X framework of perovskites. [11] Cyanopyridone-based conjugated small molecule (CP) doped poly(methyl 2-methylpropenoate) polymeric films were obtained using solvent-casting approach with various concentrations of CP loading ranging from 1 to 6 wt%. [12] Moreover, this report demonstrates the great potential of conjugated small molecules for photothermal applications, owing to their versatility and flexibility in structural engineering and its diminishing radiative decay properties. [13] Here, the effect of the organic conjugated small molecule crystal growth process on the evolution of the crystal morphology and consequent charge transport properties are studied. [14] Structural design of organic π-conjugated small molecules allows the energy band structure and electronic properties of the molecules to be tuned as needed, which provides a feasible strategy for enhancing the performance of optoelectronic devices. [15] The fully conjugated small molecules give low optical gaps (1. [16] In order to regulate the energy level of SnO2 films, we currently in this study employed a non-conjugated small molecule 2-(Dimethylamino) ethyl methacrylate (DMAEMA) to modify SnO2 films, which are applied as electron transportation layers in inverted non-fullerene organic solar cells (OSCs). [17] The π-conjugated small molecule 2,2',7,7'-tetrakis[N,N-di(4-methoxyphenyl)amino]-9,9-spirobifluorene (spiro-OMeTAD) is the most frequently used semiconductor in the hole-conducting layer1-6, and its electrical properties considerably affect the charge collection efficiencies of the solar cell7. [18] An acceptor-donor-acceptor (A-D-A) conjugated small molecule, DHII-EH-TR, was designed, synthesized, and its solar cell performance studied. [19] Engineering well-defined supramolecular fluorescent nano-architectures based on organic conjugated small molecules has been an essential scientific challenge. [20] The principal innovation of this approach is based on the supra-molecular interactions between the designed organic conjugated small molecule (OCSM), Zr4+ ion and phosphorylated CREB. [21] By combining in situ NMR spectroscopy and theoretical calculations, the conjugated small molecule TT is shown to exhibit distinct temperature-dependent local structural features that are related to macroscopic properties. [22] Progresses in the design and application of conjugated small molecules, oligomers and polymers have empowered rapid development of organic electronic technology as an alternative to conventional devices. [23] Organic solar cells based on π-conjugated small molecules (SM-OSCs) have developed rapidly in the past few years. [24] To research the effects of different kinds of terminals on the solar cell performance, in this paper, carbazole (Cz), 2-octylthiophene (T) and 2-octylhiothiophene (TS) units are picked as end-capping units, with a pyran-bridged indacenodithiophene (IDTP) as central core and two fluorinated benzothiadiazole (DFBT) as acceptors, three π-conjugated small molecules (SMs) with D(A-Ar)2 framework, namely IDTP(DFBT-Cz)2, IDTP(DFBT-T)2 and IDTP(DFBT-TS)2, respectively, were designed and synthesized for application as donor materials in solution-processed small molecular organic solar cells (SM-OSCs). [25] Treatment of 6a with non-conjugated small molecules such as phenyl isocyanates, phenyl isothiocyanate, and benzaldehyde resulted in formation of Sc/γ-C [4 + 2] cycloaddition products 7-9 because of nucleophilic reactivity at the β-diketiminato γ-carbon, with retention of ScP interactions. [26] In general, flexible alkyl chain is used to enhance the solubility of conjugated small molecules by disrupting the attraction between molecules. [27] We report the photoinduced excited-state dynamics of a series of novel Pt(II)-bisacetylide containing conjugated small molecules that possess geometric shapes resembling “roller wheels,” but that differ in lengths of the linear conjugated chromophores, i. [28] Then, a reasonable structure for A-CDs was put forward, which confirmed that unconjugated small molecules could transform into carbon dots with the sp2 core, and was helpful in the discussion of the photoluminescence mechanism. [29] The conjugated small molecule iso-Indigo (i-Indigo) comprises two phenyl rings that are twisted (the dihedral angle is 15°) at the junction. [30] NHPI conjugated small molecules act as an efficient hole mediator to reduce the recombination of electron–hole pairs and enhance the photocatalytic activity of g-C3N4. [31] Carbazole-based conjugated small molecule electrolytes (CSEs) containing different numbers of amine groups were synthesized and applied to bulk-heterojunction (BHJ) organic solar cells for the formation of a spontaneous self-assembled electron transporting layer (ETL). [32] Cross-coupling reactions have played a key role in producing numerous types of π-conjugated small molecules having appealing properties for practical applications in organic electronics, especially in the field of photovoltaics. [33]共轭小分子和聚合物相互作用，形成复杂的溶液状态聚集体和固态微结构。 [1] 低带隙π共轭小分子有多种应用。 [2] A-π-D-π-A型共轭小分子在有机光伏发电中发挥着不可或缺的作用。 [3] 合成了两种具有不同共轭侧链的共轭小分子来研究它们的光伏性能。 [4] 完全共轭的小分子具有低光学间隙 (1. [5] 通过 Suzuki 和 McMurry 偶联合成了包含二噻吩基乙烯 (DTE) 和噻吩基团的环状和线性共轭小分子。 [6] 共轭小分子由于其可调谐的光捕获能力已广泛应用于生物医学领域。 [7] 尽管在新材料的开发和有机电子相关应用方面取得了显着进展，但仍然存在一些挑战，不仅是新型结构材料（如 π 共轭小分子或聚合物半导体、电介质、电极和基板）的设计和合成，而且还开发了高效的界面工程策略，用于制造高性能和高稳定性的设备，并最终实现商用产品。 [8] 金属酞菁 (MPcs) 是一类丰富的共轭小分子，它们包含在薄膜中，对于下一代应用的正常功能至关重要。 [9] 共轭小分子 (CSM) 的电荷载流子迁移率取决于分子间相互作用和形态。 [10] 在此，一种新型的 π 共轭小分子 4-胍基苯甲酸-盐酸盐 (4-GBACl) 被证明可以有效地交联钙钛矿的 Pb-X 骨架。 [11] 使用溶剂浇铸方法获得了基于氰基吡啶酮的共轭小分子 (CP) 掺杂的聚 (2-甲基丙烯酸甲酯) 聚合物薄膜，其中 CP 负载的不同浓度范围为 1 至 6 wt%。 [12] 此外，该报告展示了共轭小分子在光热应用中的巨大潜力，因为它们在结构工程中的多功能性和灵活性以及其减少的辐射衰减特性。 [13] 在这里，研究了有机共轭小分子晶体生长过程对晶体形态演变和随之而来的电荷传输特性的影响。 [14] 有机π共轭小分子的结构设计可以根据需要调整分子的能带结构和电子特性，为提高光电器件的性能提供了可行的策略。 [15] 完全共轭的小分子具有低光学间隙 (1. [16] 为了调节 SnO2 薄膜的能级，我们目前在本研究中采用非共轭小分子 2-(二甲氨基) 甲基丙烯酸乙酯 (DMAEMA) 来修饰 SnO2 薄膜，用作倒置非富勒烯中的电子传输层有机太阳能电池（OSC）。 [17] π共轭小分子2,2',7,7'-四[N,N-二(4-甲氧基苯基)氨基]-9,9-螺二芴(spiro-OMeTAD)是空穴中最常用的半导体- 导电层 1-6，其电性能显着影响太阳能电池的电荷收集效率 7。 [18] 设计、合成了一种受体-供体-受体（A-D-A）共轭小分子DHII-EH-TR，并研究了其太阳能电池性能。 [19] 基于有机共轭小分子的工程定义明确的超分子荧光纳米结构一直是一项重要的科学挑战。 [20] 这种方法的主要创新是基于设计的有机共轭小分子 (OCSM)、Zr4+ 离子和磷酸化 CREB 之间的超分子相互作用。 [21] 通过结合原位核磁共振光谱和理论计算，共轭小分子 TT 显示出与宏观性质相关的明显的温度依赖性局部结构特征。 [22] 共轭小分子、低聚物和聚合物的设计和应用取得的进展推动了有机电子技术作为传统器件的替代品的快速发展。 [23] 基于π共轭小分子（SM-OSCs）的有机太阳能电池在过去几年发展迅速。 [24] 为了研究不同类型的末端对太阳能电池性能的影响，本文选取咔唑（Cz）、2-辛基噻吩（T）和2-辛基噻吩（TS）单元作为封端单元，以吡喃-桥接茚并二噻吩 (IDTP) 作为中心核心，两个氟化苯并噻二唑 (DFBT) 作为受体，三个具有 D(A-Ar)2 骨架的 π-共轭小分子 (SM)，即 IDTP(DFBT-Cz)2、IDTP(DFBT- T)2 和 IDTP(DFBT-TS)2 分别被设计和合成用作溶液处理小分子有机太阳能电池 (SM-OSC) 中的供体材料。 [25] 用非共轭小分子如异氰酸苯酯、异硫氰酸苯酯和苯甲醛处理 6a 导致形成 Sc/γ-C [4 + 2] 环加成产物 7-9，因为 β-二酮亚氨基 γ-碳的亲核反应性，保留 ScP 相互作用。 [26] 通常，柔性烷基链用于通过破坏分子之间的吸引力来增强共轭小分子的溶解度。 [27] 我们报告了一系列新型 Pt(II)-双乙炔化物的光诱导激发态动力学，这些分子含有共轭小分子，其几何形状类似于“滚轮”，但线性共轭生色团的长度不同，即。 [28] 然后，提出了合理的A-CDs结构，证实了非共轭小分子可以转化为具有sp2核的碳点，有助于光致发光机理的探讨。 [29] 共轭小分子异靛蓝 (i-Indigo) 包含两个在连接处扭曲（二面角为 15°）的苯环。 [30] NHPI共轭小分子作为一种有效的空穴介体来减少电子-空穴对的复合并增强g-C3N4的光催化活性。 [31] 合成了含有不同数量胺基的咔唑基共轭小分子电解质 (CSE)，并将其应用于体异质结 (BHJ) 有机太阳能电池中，以形成自发自组装电子传输层 (ETL)。 [32] 交叉偶联反应在产生多种类型的 π 共轭小分子方面发挥了关键作用，这些小分子具有吸引人的特性，适用于有机电子学，特别是光伏领域的实际应用。 [33]
conjugated small interfering 共轭小干扰
To this end, we used a subcutaneously delivered, GalNAc (N-Acetylgalactosamine)-conjugated small interfering RNA (siRNA) to selectively target and suppress liver Angptl3 in rats with puromycin-induced NS, which exhibits clinical features of NS including proteinuria, hypoalbuminemia, hyperlipidemia, and renal histologic abnormalities. [1] N-Acetylgalactosamine (GalNAc) conjugated small interfering RNA (siRNA) are a leading RNA interference (RNAi) platform allowing targeted inhibition of disease-causing genes in hepatocytes. [2] We aim to enhance the immunogenicity of breast tumor by taking advantage of the unique strength of EpCAM-aptamer conjugated small interfering RNAs (AsiCs), which can knock down gene expression selectively in EpCAM+ BC cells, to make aggressive BCs visible to T-cells and improve T-cell tumor recruitment and function. [3] In this study, we describe the development of a subcutaneously administered N-acetylgalactosamine (GalNAc)-conjugated small interfering RNA (siRNA) targeting the C5 component of complement that silences C5 expression in the liver (ALN-CC5). [4]为此，我们使用皮下递送的 GalNAc（N-乙酰半乳糖胺）缀合的小干扰 RNA（siRNA）选择性靶向和抑制嘌呤霉素诱导的 NS 大鼠的肝脏 Angptl3，其表现出 NS 的临床特征，包括蛋白尿、低白蛋白血症、高脂血症和肾脏组织学异常。 [1] N-乙酰半乳糖胺 (GalNAc) 缀合的小干扰 RNA (siRNA) 是领先的 RNA 干扰 (RNAi) 平台，可靶向抑制肝细胞中的致病基因。 [2] 我们的目标是通过利用 EpCAM-适体结合小干扰 RNA (AsiCs) 的独特优势来增强乳腺肿瘤的免疫原性，它可以选择性地敲低 EpCAM+ BC 细胞中的基因表达，使 T 细胞可见侵袭性 BCs 和改善 T 细胞肿瘤募集和功能。 [3] 在这项研究中，我们描述了一种皮下给药的 N-乙酰半乳糖胺 (GalNAc) 缀合的小干扰 RNA (siRNA)，其靶向补体的 C5 成分，使肝脏中的 C5 表达沉默 (ALN-CC5)。 [4]
conjugated small organic 共轭小有机物
Tuning the fluorescence of π-conjugated small organic molecules through the structural modifications and in the presence of external stimuli have found immense applications ranging from sensing, switching, optoelectronics to bioimaging. [1] These π-conjugated small organic molecules exhibit aggregation induced emission (AIE) property, photo/physical stability, good cytocompatibility as well as biodegradability and easy surface modulation ability. [2] To engineer the NiOx/perovskite interface and promote the interfacial hole transfer, two pyridine-terminated conjugated small organic molecules (PTZ-1 and PTZ-2) are synthesized to link the NiOx and perovskite layers for NiOx based perovskite solar cells (PSCs). [3]通过结构修饰和存在外部刺激来调节 π 共轭小有机分子的荧光已发现从传感、开关、光电子学到生物成像的巨大应用。 [1] 这些 π 共轭有机小分子具有聚集诱导发射 (AIE) 特性、光/物理稳定性、良好的细胞相容性以及可生物降解性和易表面调节能力。 [2] 为了设计 NiOx/钙钛矿界面并促进界面空穴转移，合成了两个以吡啶为末端的共轭小有机分子（PTZ-1 和 PTZ-2）以连接 NiOx 基钙钛矿太阳能电池（PSC）的 NiOx 和钙钛矿层。 [3]
conjugated small molecular
Conjugated small molecular electrolytes (CSMEs), based on carbazole, containing different number of N and F atoms, were synthesized and introduced as the electron transport layer (ETL) for the fabrication of the polymer solar cells. [1] In this work, three diketopyrrolopyrrole-based conjugated small molecular semiconductors characterized by the combination of a diketopyrrolopyrrole (DPP) central core, thiazole π-conjugated moiety, and dicyanovinyl end group with different alkyl side chain substituents, 2TzDPPA1-2DCV, 2TzDPPA2-2DCV, and 2TzDPPA3-2DCV were synthesized. [2]合成了基于咔唑的共轭小分子电解质（CSME），含有不同数量的 N 和 F 原子，并将其作为电子传输层（ETL）用于制造聚合物太阳能电池。 [1] 在这项工作中，三种基于二酮吡咯并吡咯的共轭小分子半导体，其特征是二酮吡咯并吡咯 (DPP) 中心核、噻唑 π 共轭部分和具有不同烷基侧链取代基的二氰基乙烯基端基，2TzDPPA1-2DCV，2TzDPPA2-2DCV，合成2TzDPPA3-2DCV。 [2]