Associated Cancers(相关癌症)研究综述
Associated Cancers 相关癌症 - The incidence of LS in the general population is estimated at 1 in 279, with an even higher incidence in those with colorectal cancer and endometrial cancer, the two most common Lynch-associated cancers. [1] Despite the high frequency of HPV infections, in most cases, the virus is cleared by the host immune response and only a small proportion of infected individuals develop persistent infections that can result in malignant transformation, indicating that other elements, including biological, genetic and environmental factors may influence the individual susceptibility to HPV-associated cancers. [2] There is a high burden of human papillomavirus (HPV) associated cancers in low- and middle-income countries (LMICs). [3] While burden of HPV-associated cancers and mortality is higher in low-income countries, there is limited data about knowledge of it among health care students and professionals. [4] Background Hepatocellular carcinoma (HCC) is one of the most prevalent and inflammation-associated cancers. [5] 36% of total female genital tract tumours are Human Papilloma Virus-associated cancers. [6] e17504 Background: Invasive cervical cancer (ICC) is one of the HIV-associated cancers with a high burden in Nigeria. [7] The HPV burden highlights the need for continued monitoring of HPV-associated cancers, cervical cancer screening, and HPV vaccination to track and prevent disease. [8] The incidence of human papillomavirus (HPV)-associated cancers, especially those from the head and neck region, has increased. [9] US population‐based cancer registries can be used for surveillance of human papillomavirus (HPV) types found in HPV‐associated cancers. [10] In digestive organs, inflammation-associated cancers include colitis-associated colorectal cancers, Helicobacter pylori-associated gastric cancer, as well as Barrett’s esophagus and esophageal adenocarcinoma associated with chronic duodenogastric-esophageal reflux. [11] Aberrant activation of IKK2 is the leading cause of most inflammatory diseases and many associated cancers. [12] Although molecular biological mechanisms of high-risk HPV (HR-HPV)-associated carcinogenesis is well studied, it remains unclarified why cervical cancer is the most common among these HPV-associated cancers. [13] The risk of HPV-associated cancers (SIR 4. [14] However, the role of lncRNAs in EBV-associated cancers is rarely reported. [15] The expression of p16 is a good surrogate of human papillomavirus (HPV) infection in HPV-associated cancers. [16] These findings serve as a paradigm for therapeutic targeting of fusion oncoprotein-associated cancers by hyperthermia. [17] The high morbidity and long-term effects of current treatment options make clear the need for easy-to-administer, low-cost therapies, which can specifically treat both early and advanced HPV-associated cancers. [18] This tissue-specificity means that the biology of normal tissues carries important information regarding the pathophysiology of the associated cancers, information that can be leveraged to improve the power and accuracy of cancer genomic analyses. [19] 48) for infection-associated cancers and to an MP-SIR of 1. [20] Current study identified novel and potent inhibitors of SMAD4 mutant that could be used as a drug candidate for the development of personalized medicine for gall bladder and other associated cancers. [21] However, it is occasionally difficult to distinguish these neoplasms from dysplasia or colitis-associated cancers because of the influence of inflammation. [22] While anti-PD1/PD-L1 antibodies have activity in pts with HPV-associated cancers, the majority do not derive benefit from these agents as monotherapy. [23] Conventional chemotherapy or molecular target therapies have been used to treat virus-associated cancers. [24] These findings are linked with the creation of new biomarkers and therapy for identifying and treating biofilmassociated cancers. [25] This article will focus on the role of highly selective inhibitors targeting the RET and their efficacy and safety in therapy for RET-associated cancers. [26] Vaccination during adolescence can prevent HPV-associated cancers, but vaccine uptake among adolescents is low and influenced by factors serving as barriers and facilitators to HPV vaccination. [27] Namely, gain or loss or NOTCH1 activity promotes the development of human papillomavirus (HPV)-associated cancers. [28] These results establish an important regulatory mechanism of BRCA1 function in the DDR and may have implications in the development or prognosis of BRCA1-associated cancers. [29] India severely suffers from 3 HPV-associated cancers (cervical cancer, oral cancer, and oropharyngeal cancer). [30] These ncRNAs have different functions that contribute to virus persistence in the asymptomatic host and to the development of EBV-associated cancers. [31] Patients with CKD have impaired immune functions that predispose them to an increased risk of infections, as well as virus-associated cancers and a diminished vaccine response. [32] Oncogenic human papillomavirus (HPV) genomes are often integrated into host chromosomes in HPV-associated cancers. [33] FOXA1, a transcription factor essential for the binding of other transcription factors on chromatin, is associated with hormone receptor-associated cancers, such as breast and endometrial cancer. [34] Recent Findings Immunogenic properties of the majority of Lynch syndrome polyps and associated cancers include microsatellite instability leading to a high mutational burden and the development of novel frameshift peptides, i. [35] Regardless of type, all ED-associated cancers had an over three-fold higher mortality, with cumulative death rate of 32. [36] Therapeutic cancer vaccines are part of the current therapeutic options for HPV-associated cancers. [37] These findings suggest that modulation of dietary oil composition and inhibition of E-FABP activity may represent novel strategies to enhance T-cell function in the prevention and treatment of obesity-associated cancers. [38] DNA-based immunotherapy offers great potential for the treatment of persisting HPV infections and associated cancers. [39] A Markov cohort model estimated the 5-year medical costs for 15 diet-associated cancers diagnosed in 2015. [40] Infection-associated cancers are commonly attributed to viral, and to a lesser extent, parasitic and bacterial etiologies. [41] These findings define a novel mechanism responsible for vIRF1-induced oncogenesis and establish the scientific basis for targeting these molecules for treating KSHV-associated cancers. [42] In this chapter, we explore how proteomics has contributed to our current understanding of gammaherpesvirus biology and their oncogenic processes, as well as the clinical applications of proteomics for the detection and treatment of gammaherpesvirus-associated cancers. [43] Serum anti-E6 and anti-E7 antibodies appear to have prognostic significance for HPV-associated cancers. [44] People with HIV have a higher risk of developing HPV infection and HPV-associated cancers due to a lower immune response, and due to viral interactions. [45] This review summarizes the currently available epigenetic profiles of several well-studied EBV-associated cancers and the relevant distinct mechanisms leading to aberrant epigenetic signatures due to EBV. [46] These organs are frequently associated with chronic stress and injury during life, subjecting these tissues to frequent regeneration and to the risk of developing disease-associated cancers. [47] Background Human papillomavirus (HPV) associated cancers are increasingly reported globally, including in sub-Saharan Africa (SSA). [48] pylori) has been classified as a Class I carcinogen by the International Agency of Research on Cancer (IARC) and has been identified as the most common etiologic agent of infection-associated cancers. [49] Finally, we stress the emerging roles of these NFX1 splice variants in high-risk human papillomavirus-associated cancers, and the increased expression of the longer splice variant, NFX1-123, found in these cancers. [50]一般人群中 LS 的发病率估计为每 279 人中有 1 人，在结直肠癌和子宫内膜癌这两种最常见的 Lynch 相关癌症中发病率更高。 [1] 尽管 HPV 感染的频率很高，但在大多数情况下，病毒会被宿主免疫反应清除，只有一小部分感染者会出现持续感染，从而导致恶性转化，这表明其他因素，包括生物、遗传和环境因素可能会影响个体对 HPV 相关癌症的易感性。 [2] 在低收入和中等收入国家 (LMIC)，人乳头瘤病毒 (HPV) 相关癌症的负担很重。 [3] 虽然低收入国家 HPV 相关癌症的负担和死亡率较高，但有关卫生保健学生和专业人士的知识数据有限。 [4] 背景 肝细胞癌 (HCC) 是最普遍和炎症相关的癌症之一。 [5] 36% 的女性生殖道肿瘤是人乳头瘤病毒相关癌症。 [6] e17504 背景：浸润性宫颈癌 (ICC) 是尼日利亚高负担的 HIV 相关癌症之一。 [7] HPV 负担凸显了持续监测 HPV 相关癌症、宫颈癌筛查和 HPV 疫苗接种以追踪和预防疾病的必要性。 [8] 与人乳头瘤病毒 (HPV) 相关的癌症，尤其是头颈部癌症的发病率有所增加。 [9] 美国基于人群的癌症登记可用于监测 HPV 相关癌症中发现的人乳头瘤病毒 (HPV) 类型。 [10] 在消化器官中，与炎症相关的癌症包括与结肠炎相关的结直肠癌、与幽门螺杆菌相关的胃癌，以及与慢性十二指肠-食管反流相关的巴雷特食管和食管腺癌。 [11] IKK2 的异常激活是大多数炎症性疾病和许多相关癌症的主要原因。 [12] 尽管对高危 HPV (HR-HPV) 相关癌变的分子生物学机制进行了深入研究，但仍不清楚为什么宫颈癌是这些 HPV 相关癌症中最常见的。 [13] HPV 相关癌症的风险 (SIR 4. [14] 然而，很少报道 lncRNA 在 EBV 相关癌症中的作用。 [15] p16 的表达是 HPV 相关癌症中人乳头瘤病毒 (HPV) 感染的良好替代物。 [16] 这些发现可作为通过热疗治疗融合癌蛋白相关癌症的范例。 [17] 当前治疗方案的高发病率和长期影响清楚地表明需要易于管理、低成本的疗法，该疗法可以专门治疗早期和晚期 HPV 相关癌症。 [18] 这种组织特异性意味着正常组织的生物学携带有关相关癌症病理生理学的重要信息，这些信息可用于提高癌症基因组分析的能力和准确性。 [19] 48) 用于感染相关癌症和 MP-SIR 为 1。 [20] 目前的研究确定了新型有效的 SMAD4 突变体抑制剂，可用作开发针对胆囊和其他相关癌症的个性化药物的候选药物。 [21] 然而，由于炎症的影响，有时很难将这些肿瘤与不典型增生或结肠炎相关的癌症区分开来。 [22] 虽然抗 PD1/PD-L1 抗体在 HPV 相关癌症患者中具有活性，但大多数人并未从这些药物作为单一疗法中获益。 [23] 常规化学疗法或分子靶向疗法已被用于治疗病毒相关癌症。 [24] 这些发现与用于识别和治疗生物膜相关癌症的新生物标志物和疗法的产生有关。 [25] 本文将重点关注针对 RET 的高选择性抑制剂的作用及其在 RET 相关癌症治疗中的疗效和安全性。 [26] 青春期接种疫苗可以预防 HPV 相关癌症，但青少年的疫苗接种率很低，并且受 HPV 疫苗接种的障碍和促进因素的影响。 [27] 即，获得或损失或NOTCH1活性促进人乳头瘤病毒（HPV）相关癌症的发展。 [28] 这些结果建立了 DDR 中 BRCA1 功能的重要调节机制，并可能对 BRCA1 相关癌症的发展或预后产生影响。 [29] 印度严重患有 3 种 HPV 相关癌症（宫颈癌、口腔癌和口咽癌）。 [30] 这些 ncRNA 具有不同的功能，有助于病毒在无症状宿主中的持久性和 EBV 相关癌症的发展。 [31] CKD 患者的免疫功能受损，这使他们更容易受到感染、病毒相关癌症和疫苗反应减弱的风险。 [32] 致癌人乳头瘤病毒 (HPV) 基因组通常整合到 HPV 相关癌症的宿主染色体中。 [33] FOXA1 是一种转录因子，对染色质上其他转录因子的结合至关重要，它与激素受体相关的癌症有关，例如乳腺癌和子宫内膜癌。 [34] 最新发现 大多数 Lynch 综合征息肉和相关癌症的免疫原性特性包括导致高突变负担的微卫星不稳定性和新型移码肽的发展，即。 [35] 无论哪种类型，所有 ED 相关癌症的死亡率都高出三倍以上，累积死亡率为 32。 [36] 治疗性癌症疫苗是当前 HPV 相关癌症治疗选择的一部分。 [37] 这些发现表明，调节膳食油成分和抑制 E-FABP 活性可能代表了在预防和治疗肥胖相关癌症中增强 T 细胞功能的新策略。 [38] 基于 DNA 的免疫疗法为治疗持续性 HPV 感染和相关癌症提供了巨大的潜力。 [39] 马尔可夫队列模型估计了 2015 年诊断出的 15 种饮食相关癌症的 5 年医疗费用。 [40] 感染相关癌症通常归因于病毒，在较小程度上归因于寄生虫和细菌病因。 [41] 这些发现定义了一种负责 vIRF1 诱导的肿瘤发生的新机制，并为靶向这些分子治疗 KSHV 相关癌症奠定了科学基础。 [42] 在本章中，我们将探讨蛋白质组学如何有助于我们目前对伽马疱疹病毒生物学及其致癌过程的理解，以及蛋白质组学在检测和治疗伽马疱疹病毒相关癌症中的临床应用。 [43] 血清抗 E6 和抗 E7 抗体似乎对 HPV 相关癌症具有预后意义。 [44] 由于免疫反应较低和病毒相互作用，艾滋病毒感染者患 HPV 感染和 HPV 相关癌症的风险较高。 [45] 本综述总结了几种经过充分研究的 EBV 相关癌症的表观遗传谱以及导致 EBV 引起的异常表观遗传特征的相关独特机制。 [46] 这些器官经常与生命中的慢性压力和损伤有关，使这些组织频繁再生并面临发展为疾病相关癌症的风险。 [47] 背景 人类乳头瘤病毒 (HPV) 相关癌症在全球范围内越来越多地被报道，包括在撒哈拉以南非洲 (SSA)。 [48] pylori) 已被国际癌症研究机构 (IARC) 列为 I 类致癌物，并已被确定为感染相关癌症的最常见病原体。 [49] 最后，我们强调这些 NFX1 剪接变体在高危人乳头瘤病毒相关癌症中的新兴作用，以及在这些癌症中发现的较长剪接变体 NFX1-123 的表达增加。 [50]
associated obesity associated
Methods: Alcohol-associated cancers, HPV-associated, obesity-associated, physical inactivity-associated, and tobacco-associated were defined using ICD-O-3 site codes. [1] Alcohol-associated cancers, HPV-associated, obesity-associated, physical inactivity-associated, and tobacco-associated were defined using ICD-O-3 site codes. [2] Alcohol-associated cancers, HPV-associated, obesity-associated, physical inactivity-associated, and tobacco-associated were defined using ICD-O-3 site codes. [3]方法：使用 ICD-O-3 位点代码定义酒精相关癌症、HPV 相关癌症、肥胖相关癌症、身体不活动相关癌症和烟草相关癌症。 [1] 使用 ICD-O-3 位点代码定义与酒精相关的癌症、与 HPV 相关的、与肥胖相关的、与缺乏身体活动相关的和与烟草相关的癌症。 [2] nan [3]
Hpv Associated Cancers
Discussion/Conclusion: Nasopharyngeal cancers lacked associations with lifestyle or HPV associated cancers, suggesting a role for germline genetics, which was also true for the high-risk families of three HNC patients. [1] Taking into consideration the rising number of HPV associated cancers among men in many developed countries and the risk of transmission to women, male HPV infection is a serious concern. [2] One change in the eighth edition, for example, is the introduction of a new staging system for high-risk human papillomavirus (HPV)-associated oropharyngeal cancers, recognizing the fact that these tumors have a biology and prognosis distinct from non-HPV associated cancers in the same anatomic location. [3] These HPV associated cancers possess unique clinicopathological behavior and exhibits better prognosis than their negative counterparts. [4] Many clinical trials are investigating checkpoint inhibitor treatments in HPV associated cancers but response rates are limited; combination with vaccination is being tested. [5]讨论/结论：鼻咽癌与生活方式或 HPV 相关癌症缺乏关联，这表明生殖系遗传学的作用，这对于三名 HNC 患者的高危家庭也是如此。 [1] 考虑到许多发达国家男性中 HPV 相关癌症的数量不断增加以及传播给女性的风险，男性 HPV 感染是一个严重的问题。 [2] nan [3] nan [4] nan [5]
Ebv Associated Cancers
Each year EBV associated cancers account for over 200,000 new cases of cancer and cause 150,000 deaths world-wide. [1] EBV encodes more than 40 miRNAs, most of which have been studied in the context of EBV associated cancers. [2]每年，EBV 相关癌症导致全球超过 200,000 例新的癌症病例，并导致 150,000 人死亡。 [1] nan [2]
Developing Associated Cancers
These lesions may serve as a predictive marker to identify patients who carry germline BAP1 mutations and thus are at higher risk of developing associated cancers. [1] 5-fold higher risk of developing associated cancers compared with seronegative dermatomyositis. [2]这些病变可作为预测标志物来识别携带生殖系 BAP1 突变的患者，因此患相关癌症的风险更高。 [1] 与血清阴性皮肌炎相比，发生相关癌症的风险高 5 倍。 [2]
Syndrome Associated Cancers
Further genetic testing was performed on these patients which highlighted 28 patients with BRAF positive genes who went on to screening for Lynch syndrome associated cancers. [1] We aimed to assess medical student knowledge of Lynch syndrome associated cancers and screening and prevention measures to decrease malignancy risk in patients with Lynch syndrome. [2]对这些患者进行了进一步的基因检测，其中突出显示了 28 名 BRAF 阳性基因的患者，这些患者继续筛查林奇综合征相关癌症。 [1] 我们的目的是评估医学生对林奇综合征相关癌症的知识以及降低林奇综合征患者恶性肿瘤风险的筛查和预防措施。 [2]
associated cancers include
In digestive organs, inflammation-associated cancers include colitis-associated colorectal cancers, Helicobacter pylori-associated gastric cancer, as well as Barrett’s esophagus and esophageal adenocarcinoma associated with chronic duodenogastric-esophageal reflux. [1] Recent Findings Immunogenic properties of the majority of Lynch syndrome polyps and associated cancers include microsatellite instability leading to a high mutational burden and the development of novel frameshift peptides, i. [2] Instead, current treatments for HPV-associated cancers include surgery, chemotherapy, and radiation, and affect diseased and healthy tissues alike. [3]在消化器官中，与炎症相关的癌症包括与结肠炎相关的结直肠癌、与幽门螺杆菌相关的胃癌，以及与慢性十二指肠-食管反流相关的巴雷特食管和食管腺癌。 [1] 最新发现 大多数 Lynch 综合征息肉和相关癌症的免疫原性特性包括导致高突变负担的微卫星不稳定性和新型移码肽的发展，即。 [2] nan [3]
associated cancers among
, immunodeficiency, un-protected sex) increase likelihood for developing anal and other HPV-associated cancers among people living with HIV/AIDS (PLWHA). [1] Taking into consideration the rising number of HPV associated cancers among men in many developed countries and the risk of transmission to women, male HPV infection is a serious concern. [2]、免疫缺陷、无保护的性行为）增加了 HIV/AIDS (PLWHA) 患者患肛门癌和其他 HPV 相关癌症的可能性。 [1] 考虑到许多发达国家男性中 HPV 相关癌症的数量不断增加以及传播给女性的风险，男性 HPV 感染是一个严重的问题。 [2]
associated cancers typically
POLE-associated cancers typically display hypermutation, and a unique mutational signature, with a predominance of C > A transversions in the context TCT and C > T transitions in the context TCG. [1] POLE-associated cancers typically display hypermutation, microsatellite stability and a unique mutational signature, with a predominance of C > A transversions in the context TCT. [2]POLE 相关癌症通常表现出超突变和独特的突变特征，在 TCT 上下文中以 C > A 颠换和在 TCG 上下文中 C > T 转换占优势。 [1] POLE 相关癌症通常表现出超突变、微卫星稳定性和独特的突变特征，在 TCT 中 C > A 颠换占优势。 [2]
associated cancers account
OBJECTIVES Human papillomavirus (HPV)-associated cancers account for about 9% of the cancer mortality burden in the United States; however, survival differs among sociodemographic factors. [1] Each year EBV associated cancers account for over 200,000 new cases of cancer and cause 150,000 deaths world-wide. [2]目标 与人乳头瘤病毒 (HPV) 相关的癌症约占美国癌症死亡率负担的 9%；然而，生存率因社会人口因素而异。 [1] 每年，EBV 相关癌症导致全球超过 200,000 例新的癌症病例，并导致 150,000 人死亡。 [2]