31p Mrs(31p 夫人)研究综述
31p Mrs 31p 夫人 - Glycemic control (CGM), cardiac function (echocardiography), vascular stiffness (Sphygmacor and Dynapulse), autonomic function, IS (hyperinsulinemic euglycemic clamp), and mitochondrial function in vivo (31P MRS) and ex vivo (muscle biopsy with high resolution respirometry) were measured after each phase. [1] Characterization of glucose fluxes from biopsy specimen could have been replaced by 13C and 31P MRS, which was able to quantify defects of glucose metabolism in diabetes and other insulin resistant states. [2] However, current applications of 31P MRS are generally restricted to relatively small volumes as small coils are used. [3] Conclusion We developed a setup with a 31P transceiver and 1H Rx endorectal coil in combination with an 8‐channel transceiver external body array coil and demonstrated its safety and feasibility for obtaining multiparametric imaging and 1H and 31P MRSI at 7T in patients with prostate cancer within one MR examination. [4] While intracellular pH can be measured noninvasively via phosphorus spectroscopy (31P MRSI), Amide Proton Transfer‐Chemical Exchange Saturation Transfer (APT‐CEST) MRI has been suggested as an alternative method for pH quantification. [5] After 8 weeks of RSV treatment, tolerance to IR injury was assessed during ex vivo experiments, with simultaneous measurement of energy metabolism by 31P MRS, myocardial function and coronary flow. [6] 31P MRSI may sample intracellular pH changes from brain tumours (acidification upon antiangiogenic treatment, basification at fast proliferation and relapse). [7] They are most commonly used for dynamic phosphorous magnetic resonance spectroscopy (31P MRS), but can also be used for lactate production measurements, perfusion studies using arterial spin labelling or muscle oxygenation measurements by blood oxygen dependent contrast sequences. [8] Then, ex vivo experiments were performed on isolated perfused hearts to evaluate tolerance to ischemia-reperfusion, with simultaneous measurement of energy metabolism by 31P MRS and contractile function. [9] ABSTRACT Purpose We determined if a high-intensity aerobic exercise program would be safe, improve expected fitness and clinical outcomes, and alter exploratory phosphorous magnetic resonance spectroscopy (31P MRS) outcomes in persons with multiple sclerosis (PwMS). [10] MR offers the unique possibility to noninvasively investigate cellular energy metabolism via 31P MRS, while blood perfusion, which provides oxygen and substrates to the tissue, is accessible by arterial spin labeling (ASL) 1H MRI. [11]血糖控制 (CGM)、心脏功能（超声心动图）、血管僵硬（Sphygmacor 和 Dynapulse）、自主神经功能、IS（高胰岛素正常血糖钳夹）和体内线粒体功能（31P MRS）和离体（高分辨率呼吸测量法的肌肉活检）在每个阶段之后测量。 [1] 活检标本中葡萄糖通量的表征可以被 13C 和 31P MRS 取代，这能够量化糖尿病和其他胰岛素抵抗状态中葡萄糖代谢的缺陷。 [2] 然而，由于使用了小线圈，31P MRS 的当前应用通常仅限于相对较小的体积。 [3] 结论 我们开发了一个带有 31P 收发器和 1H Rx 直肠内线圈以及 8 通道收发器外部体阵列线圈的装置，并证明了其在前列腺癌患者中获得 7T 多参数成像和 1H 和 31P MRSI 的安全性和可行性。磁共振检查。 [4] 虽然可以通过磷光谱 (31P MRSI) 无创测量细胞内 pH 值，但已建议使用酰胺质子转移-化学交换饱和转移 (APT-CEST) MRI 作为 pH 量化的替代方法。 [5] RSV 治疗 8 周后，在体外实验期间评估对 IR 损伤的耐受性，同时通过 31P MRS 测量能量代谢、心肌功能和冠状动脉血流。 [6] 31P MRSI 可以对脑肿瘤的细胞内 pH 变化进行采样（抗血管生成治疗时的酸化、快速增殖和复发时的碱化）。 [7] 它们最常用于动态磷磁共振波谱 (31P MRS)，但也可用于乳酸生成测量、使用动脉自旋标记的灌注研究或通过血氧依赖性对比序列进行的肌肉氧合测量。 [8] 然后，在离体灌注的心脏上进行离体实验，以评估对缺血再灌注的耐受性，同时通过 31P MRS 和收缩功能测量能量代谢。 [9] 摘要目的 我们确定高强度有氧运动计划是否安全、改善预期健康和临床结果，并改变多发性硬化症 (PwMS) 患者的探索性磷磁共振波谱 (31P MRS) 结果。 [10] MR 为通过 31P MRS 无创研究细胞能量代谢提供了独特的可能性，而为组织提供氧气和底物的血液灌注可通过动脉自旋标记 (ASL) 1H MRI 获得。 [11]