Introduction to Sensitive Drug

Notably it is important to prevent thermal degradation of heat-sensitive drugs during HME.

SZC acts in the gastrointestinal tract and additionally binds hydrogen ions in acidic environments like the stomach, potentially transiently increasing gastric pH and leading to drug interactions with pH-sensitive drugs.

Echinocandins were the most sensitive drugs.

The sensitivity of CCA to cytotoxic chemotherapy drugs and targeted drugs varies from person to person, and therefore, the screening of sensitive drugs has become an important topic after CCA surgeries.

Successful synthesis of these hollow UCNPs at room temperature in one-pot makes large-scale production possible due to the simplicity and low temperature nature of the synthesis and opens new ways to load sensitizer dyes or other materials for enhanced upconversion emission or multiplexed assays/imaging, or loading of photosensitive drugs for therapeutic applications.

To proceed with experimental and clinical trials, it is necessary to clarify the effective photosensitive drugs that are feasible for photochemical diagnosis and local treatment.

A recently developed viscous liquid aliphatic polycarbonate, poly(trimethylene carbonate-co-5-hydroxy trimethylene carbonate), has advantageous properties for the delivery of acid-sensitive drugs s.

In antifungal susceptibility testing, Itraconazole was the most sensitive drug and Fluconazole was the least sensitive one with only 58.

Therefore, a library of polymerized and cationic photosensitive drugs (polyphotosensitizers, pPSs) with HIF-1α siRNA delivery capability is constructed to realize using "drug" to deliver "gene".

Photodynamic therapy (PDT) is a treatment that uses light-sensitive drugs and a light source to destroy cancer cells.

We hypothesized that the combined abilities of closed-loop trans-skull Magnetic Resonance Imaging guided Focused Ultrasound (MRgFUS) hyperthermia with those of thermosensitive drugs can alleviate challenges in drug delivery and improve survival in gliomas.

The most sensitive drug was itraconazole, and more number of resistances was noted with fluconazole.

Drug resistance was highest for ampicillin (56%), and imipenem (100%) was the most sensitive drug.

Nevertheless, its application to high-melting-point and thermosensitive drugs has been rarely reported.

Photodynamic Therapy (PDT) consists of using a light source and a photosensitive drug at an appropriate wavelength and molecular oxygen to trigger cell death through the production of reactive oxygen species.

These octadecyl chain-bearing, PEGylated dendrimer-based vesicles are therefore promising redox-sensitive drug and gene delivery systems for potential applications in combination cancer therapy.

Acinetobacter baumannii and Klebsiella pneumoniae were the commonest biofilm forming organisms and Amikacin, Gentamicin and Ciprofloxacin were most sensitive drugs.

To address these targets classes, we explored kinetically controlled proteases as structural dynamics–sensitive druggability probes in native-state and disease-relevant proteins.

Conclusion: According to recent antibiotic susceptibility against salmonella typhi, the most sensitive drugs are Carbapenems (imipenem or meropenem) these days.

9%) were the two most sensitive drugs.

Vancomycin and Linezolid were the most sensitive drugs showing 100 % sensitivity.

This research study utilized a light-sensitive drug, nifedipine (NFD), to understand the impact of processing parameters and formulation composition on drug degradation, crystallinity, and quality attributes (dimensions, hardness, disintegration time) of selective laser sintering (SLS)-based three-dimensional (3D)-printed dosage forms.

Furthermore, Mn(CO)5Br (COMn, gas fuel generator) is loaded on PDA nanobowls to form a nanomotor to carry zinc phthalocyanine (ZnPc, photosensitive drug) (denoted PCZN), which can migrate efficiently in cancer cells.

This study suggests that the use of maghemite iron oxide as a nanoexcipient could act as a photoprotector of photosensitive drugs such as MTK.

Generally, PDT involves the administration of light and a photosensitive drug (photosensitizer).

Results We successfully established an individualized and sensitive drug-screening system for the 12 patients.

Freeze-drying technology is an interdisciplinary and complex technology, combined with freezing and vacuum drying, It has become an important technology for heat-sensitive drugs and food preservation.

Furthermore, the disulfide-group-containing nanohydrogel exhibited good reduction-sensitive drug-release behavior.

2%) were the most sensitive drugs.

Imipenem drug showed 100% sensitivity for Gram negative, while Gram-positive isolates, linezolid antibiotic was the most sensitive drug.

We have designed and prepared a tumor therapeutic nanoplatform for improving PDT based on defective TiO[Formula: see text] (d-TiO[Formula: see text] with the consideration that the continuous PDT would cause hypoxic tumor microenvironment (HTM) in which many hypoxia-sensitive drugs might be activated to exert the antitumor activities.

Streptomycin is the most sensitive drug against the Gram negative organisms isolated with a sensitivity of 87.

Based on the consideration that the TME deteriorated by the PDT oxygen consumption could activate the hypoxic-sensitive small-molecule drug, we designed and prepared an integrated nanocomposite including zirconium ion metal organic framework (carrier), pyropheophorbide-a (PPa, photosensitizer), and 6-amino flavone (AF, hypoxic-sensitive drug), aiming to exert a cascaded PDT-chemotherapy (CT) antitumor effect and to solve the hypoxic challenge.

Phenothiazine derivatives, normally used to treat mental and emotional disorders, are photosensitive drugs and in solutions undergo molecular modifications by exposure to UV laser radiation, which leads to transformation of a parent-compound into photoproducts with increased antimicrobial activity when compared to unirradiated solutions.

We constructed a forty-four-gene predictive signature and identified MST-321, SB-743921, Neuronal Differentiation Inducer III, romidepsin, vindesine, and YM-155 as high-sensitive drugs for high-risk SKCM patients.

The most sensitive drug in our study was Imipenem followed by Amikacin for gram negative isolates.

Therefore, we synthesized a type of Fe3O4 nanoparticle with manganese dioxide grown on the surface and then prepared it by loading photosensitive drugs and traditional Chinese medicine monomers to create an integrated diagnosis/treatment multifunctional nanoplatform: Fe3O4@MnO2-celastrol (CSL)/Ce6.

Pregnant women and participants, who used systemic corticosteroids, antiandrogens, or insulin-sensitive drugs in the last 3 months were also excluded from the study.

ResultsPostoperative individualized medication was used according to the drug sensitivity test and T-SOPT to select 3 kinds of sensitive drugs for 2 courses of treatment, and the patients were clinically cured 3 to 9 months.

Taken together, the thermosensitive drug-releasing nanofibrous hydrogel, showed a great potential for wound care.

Subsequently, a drug-release behavior assay was carried out to carefully investigate the acid-sensitive drug-delivery property of the prodrug.

Systemic absorption of many therapeutic moieties, for example, acid-sensitive drugs, protein, and peptides, are routed through colonic delivery as a means to protect them from harsh environment in stomach and enzymatic activities in small intestine.

This study showed Fosfomycin and Nitrofurantoin were the most sensitive drug.

In addition, we identified 103 tumor-sensitive drugs in the CellMiner database that may be available for the treatment of HCC patients targeting ER stress and constructed a nomogram combining ER stress-related feature, TNM stage, age and gender.

This can implicate the addition of a drying step, which may compromise the integrity of moisture- or temperature-sensitive drugs, and open the door for additional quality control challenges.

However, those target-sensitive drugs suffer from ongoing resistances resulting from mutations and moreover they are affected by the cancer phenomenon of multidrug resistance.

The most sensitive drug in BFP’s were Imipenem (82.

This research study utilized a light-sensitive drug, nifedipine (NFD), to understand the impact of processing parameters, and formulation composition on drug degradation, crystallinity, and quality attributes (dimensions, hardness, disintegration time) of selective laser sintering (SLS) based 3D printed dosage forms.

With the identification of BChE-like protein in zebrafish, this study could shed light on the origin of BChE and may contribute towards the development of a BChE knockout zebrafish model for sensitive drug or toxin screening.

CD133 and hyaluronic acid provide the nanoprobe with dual tumor targeting, while the hyaluronic acid also protects photosensitive drugs from photodegradation.

Thermosensitive drugs compose a considerable segment of available medications in the market requiring strict temperature control during processing to ensure their efficacy and safety.

Results: Of 1506 isolates, the most sensitive drug was collistin (100%).

Linezolid, teicoplanin, and vancomycin were the most sensitive drugs for Staphylococcus spp.

Cebranopadol (CBP) is a novel analgesic acting as agonist at the nociceptin (NOP) and μ-opioid (MOP) receptors, exhibiting high potency and efficacy as an antinociceptive and antihypersensitive drug.

This provides a mechanistic explanation for the somewhat controversial reports of “sonodynamic” therapy, in which light-sensitive drugs have been shown to be activated by ultrasound-induced cavitation.

Melt granulation as a solvent-free technology has attracted increasing interest for the granulation of moisture-sensitive drugs.

Stemness phenotype mammospheres established from cell lines and tissues taken from autopsy can be used to test and to identify the most sensitive drugs for chemotherapy.

We demonstrate the applicability of the thermal lens technique for the photochemical characterization of photosensitive drugs at low concentration levels.

MIC displayed high resistance against β-lactams drugs including carbapenems, and the most sensitive drugs were tigecycline and colistin.