Randomized Observational(隨機觀察)到底是什麼？
Randomized Observational 隨機觀察 - METHODS Prospective nonrandomized observational/interventional case series of consecutive families of 131 RB patients. [1] A nonrandomized observational, real-life human factors study in RA patients (N = 54) assessed user (RA patients, caregivers, health care providers) ability to administer tocilizumab effectively by AI. [2]方法 131 名 RB 患者的連續家庭的前瞻性非隨機觀察/干預病例係列。 [1] 在 RA 患者（N = 54）中進行的一項非隨機觀察性、現實生活中的人為因素研究評估了用戶（RA 患者、護理人員、醫療保健提供者）通過 AI 有效管理托珠單抗的能力。 [2]
Prospective Randomized Observational 前瞻性隨機觀察
METHODS In this prospective randomized observational study, 72 parturients were assigned to two groups (combined or palpation group). [1] It is a prospective randomized observational single blind study. [2] Patients and Methods: This prospective randomized observational comparative clinical study included 52 pregnant women with symptoms and signs of preterm labor that were randomly allocated into two groups each group consisted of 26 patients. [3] CONCLUSIONS In women with DOR who wish to conceive, three months' application of ZGNZC can improve ovarian function and oocyte quality by adjusting the neuroendocrine system, can improve endometrial properties and proliferation, necessary for a healthy pregnancy, and increased the clinical pregnancy rate in our prospective randomized observational study. [4] Methods: This was prospective randomized observational study that was conducted in the delivery room and NICU of A in shames University hospital from February 2019 to September 2019. [5] Article History Received: April’ 2019 Accepted: May’ 2019 Objective: A prospective randomized observational study to assess the importance of early intervention with pharmacotherapy to control B. [6] Material and methods: A prospective randomized observational study was carried out, in women with single or multiple uterine leiomyoma. [7] Materials and Methods: In this prospective randomized observational study, 40 American Society of Anesthesiologists I and II patients, aged 18–65 years scheduled for elective surgical procedures were allocated either to PLMA group (Group P, n = 20) or the I-gel group (Group I, n = 20). [8] A real world long term (10 years) prospective randomized observational study to monitor changes in CIMT of T2DM patients who achieved the target glycaemic goal of HbA1c ≤ 7%, with those who did not achieve it. [9]方法 在這項前瞻性隨機觀察研究中，72 名產婦被分為兩組（聯合組或觸診組）。 [1] 這是一項前瞻性隨機觀察單盲研究。 [2] 患者和方法：這項前瞻性隨機觀察性比較臨床研究包括 52 名有早產症狀和體徵的孕婦，隨機分為兩組，每組 26 名患者。 [3] 結論 在希望懷孕的 DOR 女性中，應用 ZGNZC 三個月可以通過調節神經內分泌系統來改善卵巢功能和卵母細胞質量，可以改善子宮內膜特性和增殖，這是健康妊娠所必需的，並在我們的前瞻性研究中提高臨床妊娠率隨機觀察研究。 [4] 方法：這是一項前瞻性隨機觀察研究， 2019 年 2 月至 9 月在羞士大學醫院 A 的產房和 NICU 進行 2019 年。 [5] 文章歷史 接收時間：2019 年 4 月 接受時間：2019 年 5 月 目的：一項前瞻性隨機觀察研究，評估早期干預藥物治療對控制 B. [6] 材料和方法：對患有單發或多發子宮平滑肌瘤的女性進行了一項前瞻性隨機觀察研究。 [7] 材料和方法：在這項前瞻性隨機觀察研究中，40 名美國麻醉醫師協會 I 和 II 患者，年齡 18-65 歲，計劃進行擇期外科手術，被分配到 PLMA 組（P 組，n = 20）或 I-gel組（第一組，n = 20）。 [8] 一項真實世界的長期（10 年）前瞻性隨機觀察研究，用於監測達到目標血糖目標 HbA1c ≤ 7% 的 T2DM 患者與未達到目標的患者 CIMT 的變化。 [9]
Non Randomized Observational
Material and methods: The advanced rectal cancer (AJCC Stage group IV) patients with pelvic symptoms (rectal bleeding, pain or obstructive features) aged 18 – 75 years with ECOG PS 0 – 3 were included in this prospective non randomized observational study. [1] METHODS: This is a prospective non randomized observational study carried over a period of 2 years and 5 months. [2]材料和方法：這項前瞻性非隨機觀察研究包括年齡在 18-75 歲、ECOG PS 0-3 的晚期直腸癌（AJCC IV 組）患者，伴有盆腔症狀（直腸出血、疼痛或阻塞性特徵）。 [1] 方法：這是一項為期 2 年零 5 個月的前瞻性非隨機觀察研究。 [2]
randomized observational study 隨機觀察研究
STUDY DESIGN This is a prospective non-randomized observational study. [1] In a non-randomized observational study, we measured antibodies against the SARS-CoV-2 RBD in plasma and saliva from convalescent or vaccinated individuals and tested their neutralizing potential using a replication competent rVSV-eGFP-SARS-CoV-2. [2] Conclusions: Baseline data from this nonrandomized observational study suggest that patients prescribed sertraline are reflective of a more mentally ill study population compared with patients receiving psychotherapy. [3] Patient randomization between right and left hepatectomy has not been possible due to anatomic constraints; however, a number of published, nonrandomized observational studies summarize donor outcomes between 2 anatomic living donor hepatectomies. [4] Results: Sixteen nonrandomized observational studies with a total of 4581 patients were analyzed. [5] MAIN RESULTS Two non-randomized observational studies, conducted in rural Bangladesh, involving a total of 252,631 participants, met the inclusion criteria for this review. [6] Methylprednisolone showed a reduction in a composite of mortality, intensive care admission, and noninvasive ventilation initiation in a partially randomized observational study. [7] Material and methods: The advanced rectal cancer (AJCC Stage group IV) patients with pelvic symptoms (rectal bleeding, pain or obstructive features) aged 18 – 75 years with ECOG PS 0 – 3 were included in this prospective non randomized observational study. [8] As expected from a nonrandomized observational study, baseline characteristics in patients prescribed warfarin were different from those on LMWH. [9] METHODS In this prospective randomized observational study, 72 parturients were assigned to two groups (combined or palpation group). [10] METHODS This nonrandomized observational study included 88 patients (mean age, 60 years; 69% were men) who underwent transventricular mitral valve repair for severe degenerative mitral regurgitation between 2011 and 2017. [11] The outcome evaluation consists of a non-randomized observational study, using quantitative data from questionnaires and accelerometers. [12] Methods: In this randomized observational study conducted over 2 years, 20 patients each with intra-capsular neck femur fracture were enrolled as per predefined selection criteria and treated with hemiarthroplasty (bipolar) either by posterior approach or by direct anterior approach. [13] Therefore, we have carried out this prospective observational cohort to see the overall outcomes of LM Stem, PCI in our population Methods and materials: Patients who underwent elective CAG and found LM stem disease and planned for PCI, were enrolled in this non-randomized observational study between November 2013 to September 2019. [14] Methods: This randomized observational study was conducted on 110 patients for a 6 month period from February to July 2019, having diagnosed AR and attending the outpatient clinic in CHC Chenani, district Udhampur, Jammu and Kashmir. [15] STUDY DESIGN Randomized observational study. [16] Through this search, 42 articles met the inclusion criteria including 13 randomized controlled trials and 29 non-randomized observational studies encompassing 13,901 patients. [17] CONCLUSIONS In women with DOR who wish to conceive, three months' application of ZGNZC can improve ovarian function and oocyte quality by adjusting the neuroendocrine system, can improve endometrial properties and proliferation, necessary for a healthy pregnancy, and increased the clinical pregnancy rate in our prospective randomized observational study. [18] METHODS In this non-randomized observational study, we recruited 105 patients who underwent TR or TP software-based MRI-ultrasound fusion prostate biopsies between April and August 2020. [19] A number of non-randomized observational studies suggest that HBOT may be beneficial in the treatment of NSTI while other studies report no change in mortality with HBOT. [20] Methods: The present single center retrospective, non-randomized observational study involved 221 REBEL in 201 patients. [21] This was a retrospective, nonrandomized observational study. [22] [1] pooled data from 5 non-randomized observational studies comparing SLNB with END to report on comparative effectiveness using neck recurrence rate (NRR), disease-free survival (DFS), and overall survival (OS) as efficacy endpoints. [23] This was a randomized observational study, in which two visits were required. [24] An open, non-randomized observational study with the inclusion of patients with hepatitis C virus (HCV) chronic infection and cryoglobulinemia (CG) was conducted. [25] Methods: This was prospective randomized observational study that was conducted in the delivery room and NICU of A in shames University hospital from February 2019 to September 2019. [26] As a consequence, non-randomized observational studies have an important role in comparative effectiveness and safety research since they can address issues that would not be possible using conventional RCT methodology. [27] The single-center, prospective, non-randomized observational study included 111 men with CHD, admitted for CABG. [28] In a prospectivenon-randomized observational study, the efficacy of Mannheim peritonitis Index (MPI) was analyzed inpredicting the outcome in patients who were treated for peritonitis due to hollow viscous perforation. [29] STUDY DESIGN In this non-randomized observational study, children aged 5-18 years who were diagnosed with GI between January 2014 and December 2019 were included in the study. [30] In real-world non-randomized observational studies with greater number of patients (but with admitted the potential for a presence of selection bias and residual confounders), caudal blocks were not associated with postoperative complications including urethrocutaneous fistula and glans dehiscence. [31] Methods We conducted a prospective, multicenter, nonrandomized observational study. [32] Materials and Methods This prospective, nonrandomized observational study included 1446 participants (mean age, 60. [33] METHODS: This is a prospective non randomized observational study carried over a period of 2 years and 5 months. [34] METHODS This was a prospective, nonrandomized observational study of children newly diagnosed with VKC. [35] Methods: In this retrospective, non-randomized observational study, the medical notes of children from our previous cohort were reviewed after 2–3 years. [36] Article History Received: April’ 2019 Accepted: May’ 2019 Objective: A prospective randomized observational study to assess the importance of early intervention with pharmacotherapy to control B. [37] Conclusions This randomized controlled trial failed to replicate previous nonrandomized observational studies, which had suggested that ratings of female physical attractiveness by males are sensitive to the levels of hunger. [38] Methods Non-randomized observational study since October 2014 - ongoing, for evaluation concordance of RAS/BRAF status between LB and TA and monitoring every 8 weeks using the IdyllaMT, in patients with metastatic CRC. [39] A single-arm nonrandomized observational study was performed for the treatment of alveolar process fractures of maxilla and mandible. [40] Our secondary aim was to provide a critical overview of the concerns raised with both study designs – randomized clinical trials versus nonrandomized observational studies – regarding the assessment of the safety of glucocorticoids in rheumatoid arthritis. [41] In this prospective, intra-patient randomized observational study, Hydrofilm polyurethane films were prophylactically applied to either the medial or lateral breast-half of 74 patients with breast cancer undergoing hypofractionated whole-breast irradiation following breast-preserving surgery. [42] METHODS We performed a systematic review and meta-analysis of 2 randomized clinical trials (RCT) and 7 non-randomized observational studies (nROS). [43] Propensity score analysis is a statistical approach to reduce bias often present in non-randomized observational studies. [44] Objectives The present prospective non-randomized observational study was designed to analyze the proficiency and efficiency of robotic assisted type-1 extrafascial pan hysterectomy with pelvic and paraaortic lymphadenectomy in treatment of high-risk endometrial cancer patients. [45] In the medical literature, there has been an increased interest in evaluating association between exposure and outcomes using nonrandomized observational studies. [46] IPSW was utilized to minimize confounding variables inherent in retrospective non-randomized observational studies. [47] DESIGN Non-randomized observational study using Hurricane Katrina as a natural experiment to determine whether residential relocation induced by the hurricane affected the likelihood of re-incarceration among drug-dependent former prisoners. [48] Methods Non-randomized observational study based on clinical analysis of 73 patients, M:F ratio 3:1, aged 18 to 45 years, the average age was 29 years, operated between January 2008 and December 2014 due to the occurrence of PSP. [49] Material and methods: A prospective randomized observational study was carried out, in women with single or multiple uterine leiomyoma. [50]學習規劃 這是一項前瞻性非隨機觀察研究。 [1] 在一項非隨機觀察性研究中，我們測量了恢復期或接種疫苗者血漿和唾液中針對 SARS-CoV-2 RBD 的抗體，並使用具有復制能力的 rVSV-eGFP-SARS-CoV-2 測試了它們的中和潛力。 [2] 結論：這項非隨機觀察性研究的基線數據表明，與接受心理治療的患者相比，服用舍曲林的患者反映了更多的精神病患者。 [3] 由於解剖學的限制，左右肝切除術之間的患者隨機化是不可能的；然而，一些已發表的非隨機觀察性研究總結了 2 次解剖活體肝切除術之間的供體結果。 [4] 結果：共分析了 16 項非隨機觀察性研究，共 4581 名患者。 [5] 主要結果 在孟加拉國農村進行的兩項非隨機觀察性研究共涉及 252,631 名參與者，符合本次審查的納入標準。 [6] 在一項部分隨機觀察研究中，甲基強的松龍顯示死亡率、重症監護和無創通氣開始的綜合因素降低。 [7] 材料和方法：這項前瞻性非隨機觀察研究包括年齡在 18-75 歲、ECOG PS 0-3 的晚期直腸癌（AJCC IV 組）患者，伴有盆腔症狀（直腸出血、疼痛或阻塞性特徵）。 [8] 正如一項非隨機觀察性研究所預期的那樣，使用華法林的患者的基線特徵與使用 LMWH 的患者不同。 [9] 方法 在這項前瞻性隨機觀察研究中，72 名產婦被分為兩組（聯合組或觸診組）。 [10] 方法 這項非隨機觀察性研究包括 88 名患者（平均年齡 60 歲；69% 為男性），他們在 2011 年至 2017 年間因嚴重退行性二尖瓣關閉不全接受了經心室二尖瓣修復術。 [11] 結果評估包括一項非隨機觀察研究，使用來自問捲和加速度計的定量數據。 [12] 方法：在這項為期 2 年的隨機觀察研究中，根據預先確定的選擇標準招募了 20 名股骨頸內骨折患者，並通過後路或直接前路進行半關節置換術（雙極）治療。 [13] 因此，我們開展了這一前瞻性觀察隊列，以了解我們人群中 LM 幹、PCI 的總體結果 方法和材料：接受選擇性 CAG 並發現 LM 幹疾病併計劃進行 PCI 的患者被納入本非隨機觀察研究時間為 2013 年 11 月至 2019 年 9 月。 [14] 方法：這項隨機觀察研究於 2019 年 2 月至 2019 年 7 月對 110 名患者進行了為期 6 個月的研究，這些患者診斷出 AR，並在 CHC Chenani、Udhampur、查謨和克什米爾地區的門診就診。 [15] 學習規劃 隨機觀察研究。 [16] 通過這次搜索，42 篇文章符合納入標準，包括 13 項隨機對照試驗和 29 項非隨機觀察性研究，涉及 13,901 名患者。 [17] 結論 在希望懷孕的 DOR 女性中，應用 ZGNZC 三個月可以通過調節神經內分泌系統來改善卵巢功能和卵母細胞質量，可以改善子宮內膜特性和增殖，這是健康妊娠所必需的，並在我們的前瞻性研究中提高臨床妊娠率隨機觀察研究。 [18] 方法 在這項非隨機觀察性研究中，我們招募了 105 名在 2020 年 4 月至 2020 年 8 月期間接受基於 TR 或 TP 軟件的 MRI 超聲融合前列腺活檢的患者。 [19] 許多非隨機觀察性研究表明，HBOT 可能對 NSTI 的治療有益，而其他研究報告 HBOT 對死亡率沒有變化。 [20] 方法：目前的單中心回顧性、非隨機觀察性研究涉及 201 名患者中的 221 名 REBEL。 [21] 這是一項回顧性、非隨機觀察性研究。 [22] [1] 匯總了 5 項比較 SLNB 與 END 的非隨機觀察性研究的數據，以報告使用頸部復發率 (NRR)、無病生存期 (DFS) 和總生存期 (OS) 作為療效終點的比較有效性。 [23] 這是一項隨機觀察研究，需要兩次訪問。 [24] 進行了一項開放的、非隨機的觀察性研究，納入了丙型肝炎病毒 (HCV) 慢性感染和冷球蛋白血症 (CG) 患者。 [25] 方法：這是一項前瞻性隨機觀察研究， 2019 年 2 月至 9 月在羞士大學醫院 A 的產房和 NICU 進行 2019 年。 [26] 因此，非隨機觀察性研究在比較有效性和安全性研究中具有重要作用，因為它們可以解決使用傳統 RCT 方法無法解決的問題。 [27] 這項單中心、前瞻性、非隨機觀察性研究包括 111 名因 CABG 入院的 CHD 男性。 [28] 在一項前瞻性非隨機觀察性研究中，分析了曼海姆腹膜炎指數 (MPI) 的療效，以預測因空心粘性穿孔而接受腹膜炎治療的患者的預後。 [29] 學習規劃 在這項非隨機觀察性研究中，2014 年 1 月至 2019 年 12 月期間被診斷為 GI 的 5-18 歲兒童被納入研究。 [30] 在涉及更多患者的真實世界非隨機觀察研究中（但承認可能存在選擇偏倚和殘餘混雜因素），尾部阻滯與包括尿道皮膚瘺和龜頭裂開在內的術後並發症無關。 [31] 方法 我們進行了一項前瞻性、多中心、非隨機的觀察性研究。 [32] 材料和方法 這項前瞻性、非隨機的觀察性研究包括 1446 名參與者（平均年齡 60. [33] 方法：這是一項為期 2 年零 5 個月的前瞻性非隨機觀察研究。 [34] 方法 這是一項針對新診斷為 VKC 的兒童的前瞻性、非隨機觀察性研究。 [35] 方法：在這項回顧性、非隨機觀察性研究中，我們之前隊列中兒童的醫學記錄在 2-3 年後進行了審查。 [36] 文章歷史 接收時間：2019 年 4 月 接受時間：2019 年 5 月 目的：一項前瞻性隨機觀察研究，評估早期干預藥物治療對控制 B. [37] 結論 這項隨機對照試驗未能複制以前的非隨機觀察性研究，這些研究表明男性對女性身體吸引力的評分對飢餓程度很敏感。 [38] 方法 自 2014 年 10 月以來的非隨機觀察性研究 - 正在進行中，用於評估 LB 和 TA 之間 RAS/BRAF 狀態的一致性，並使用 IdyllaMT 每 8 週監測轉移性 CRC 患者。 [39] 對治療上頜和下頜牙槽突骨折進行了單臂非隨機觀察性研究。 [40] 我們的次要目的是對兩種研究設計（隨機臨床試驗與非隨機觀察性研究）提出的關於類風濕性關節炎中糖皮質激素安全性評估的關注提供批判性概述。 [41] 在這項前瞻性、患者體內隨機觀察研究中，Hydrofilm 聚氨酯薄膜被預防性地應用於 74 名在保乳手術後接受大分割全乳照射的乳腺癌患者的內側或外側乳房。 [42] 方法 我們對 2 項隨機臨床試驗 (RCT) 和 7 項非隨機觀察研究 (nROS) 進行了系統回顧和薈萃分析。 [43] 傾向評分分析是一種減少非隨機觀察研究中經常出現的偏倚的統計方法。 [44] 目的 本前瞻性非隨機觀察性研究旨在分析機器人輔助 1 型筋膜外全子宮切除術聯合盆腔和腹主動脈旁淋巴結清掃術治療高危子宮內膜癌患者的熟練程度和有效性。 [45] 在醫學文獻中，人們越來越關注使用非隨機觀察性研究評估暴露與結果之間的關聯。 [46] IPSW 用於最小化回顧性非隨機觀察研究中固有的混雜變量。 [47] 設計 使用卡特里娜颶風作為自然實驗的非隨機觀察性研究，以確定颶風引起的住宅搬遷是否會影響吸毒成癮的前囚犯重新入獄的可能性。 [48] 方法 非隨機觀察性研究基於73例患者的臨床分析，男：女比3：1，年齡18～45歲，平均年齡29歲，因PSP的發生於2008年1月至2014年12月之間進行手術。 [49] 材料和方法：對患有單發或多發子宮平滑肌瘤的女性進行了一項前瞻性隨機觀察研究。 [50]
randomized observational cohort
Seftel and his colleague reported a prospective, non-randomized observational cohort study of fluvoxamine in outpatients (n = 113) infected with SARS-CoV-2 at the Golden Gate Fields horse racing track in Berkeley, California [3]. [1] METHODS This is a prospective, long-term, non-randomized observational cohort study. [2] Methods- We studied a retrospective nonrandomized observational cohort of oral anticoagulant naïve nonvalvular patients with atrial fibrillation treated with warfarin or NOACs (rivaroxaban, dabigatran, apixaban, or edoxaban) from January 2015 to December 2017, based on the Korean Health Insurance Review and Assessment database. [3]Seftel 和他的同事報告了一項關於氟伏沙明的前瞻性、非隨機觀察性隊列研究，該研究在加利福尼亞州伯克利的金門球場賽馬場上感染了 SARS-CoV-2 的門診患者 (n = 113) [3]。 [1] 方法 這是一項前瞻性、長期、非隨機的觀察性隊列研究。 [2] 方. [3]
randomized observational clinical
A total of seventeen non-randomized observational clinical studies involving 2133 patients satisfied the eligibility criteria. [1] RESULTS A total of seven non-randomized observational clinical articles including 443 patients were analyzed. [2] Result: Four randomized controlled trials (RCTs) and eight non-randomized observational clinical studies (OCS) were included. [3]共有 17 項非隨機觀察性臨床研究，涉及 2133 名患者，符合資格標準。 [1] 結果 共分析了 7 篇非隨機觀察性臨床文章，包括 443 名患者。 [2] 結果：納入了四項隨機對照試驗（RCT）和八項非隨機觀察性臨床研究（OCS）。 [3]
randomized observational datum
Alternatively, CER can be performed through indirect comparisons via network meta-analyses of randomized controlled trials or through direct comparisons using non-randomized observational data which provides a real-world view of comparisons. [1] This study is based on non-randomized observational data six months after Traumatic Brain Injury (TBI) that were collected in 18 countries. [2]或者，CER 可以通過隨機對照試驗的網絡薈萃分析進行間接比較，或通過使用提供真實世界比較視圖的非隨機觀察數據的直接比較來進行。 [1] 本研究基於在 18 個國家收集的創傷性腦損傷 (TBI) 後六個月的非隨機觀察數據。 [2]