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As a proof of concept, a biocompatible free radical nanogenerator with near-infrared (NIR) II laser-induced simultaneous NO and alkyl radical release property was elaborately fabricated.
As a proof of concept, a biocompatible free radical nanogenerator with near-infrared (NIR) II laser-induced simultaneous NO and alkyl radical release property was elaborately fabricated.
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Results In this work, a smart hypoxia-irrelevant free radical nanogenerator (AIPH/[email protected]/ZIF-8, denoted as APCZ) was synthesized in situ via coating copper sulphide (CuS)-embedded zeolitic imidazolate framework-8 (ZIF-8) on the free radical initiator 2,2′-azobis[2-(2-imidazolin-2-yl)propane]-dihydrochloride (AIPH)-loaded polydopamine (PDA).
Results In this work, a smart hypoxia-irrelevant free radical nanogenerator (AIPH/[email protected]/ZIF-8, denoted as APCZ) was synthesized in situ via coating copper sulphide (CuS)-embedded zeolitic imidazolate framework-8 (ZIF-8) on the free radical initiator 2,2′-azobis[2-(2-imidazolin-2-yl)propane]-dihydrochloride (AIPH)-loaded polydopamine (PDA).
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10.1016/J.CEJ.2021.131451
Notably, the nanocomplexes as hydroxyl-radical nanogenerators can reverse immunologically “cold” tumors to “hot” tumors by triggering immunogenic tumor cell death and enhance the therapeutic efficacy in combination with ICBs (Apt).
Notably, the nanocomplexes as hydroxyl-radical nanogenerators can reverse immunologically “cold” tumors to “hot” tumors by triggering immunogenic tumor cell death and enhance the therapeutic efficacy in combination with ICBs (Apt).
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