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Develop Novel Antitumor

In an attempt to develop novel antitumor candidates, a series of coumarin sulfonamides and amides derivatives were designed and synthetized.

Coumarin Sulfonamides and Amides Derivatives: Design, Synthesis, and Antitumor Activity In Vitro

Develop Novel Antitumor

Due to its interesting biological profile, (S)-1 represents a lead compound to develop novel antitumor agents for breast cancer treatment.

Role of the NMDA Receptor in the Antitumor Activity of Chiral 1,4-Dioxane Ligands in MCF-7 and SKBR3 Breast Cancer Cells.

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Potential Novel Antitumor

Conclusion These results indicate that at least for primary gastric cancer, statins and avasimibe are promising candidates as potential novel antitumor drugs that target the metabolism of isoprenoids and cholesterol of gastric tumors.

Importance of Mevalonate Pathway Lipids on the Growth and Survival of Primary and Metastatic Gastric Carcinoma Cells

Potential Novel Antitumor

Recently, drugs belonging to the biguanide class (including metformin) were reported to selectively inhibit CLIC1 activity in CSCs, impairing their viability and invasiveness, but sparing normal stem cells, thus representing potential novel antitumor drugs with a safe toxicological profile.

Repurposed Biguanide Drugs in Glioblastoma Exert Antiproliferative Effects via the Inhibition of Intracellular Chloride Channel 1 Activity

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Developing Novel Antitumor

Thus, modification of the diene moiety of Oligomycin A is a promising strategy for developing novel antitumor agents based on its scaffold.

Stereochemistries and Biological Properties of Oligomycin A Diels-Alder Adducts.

Developing Novel Antitumor

These results indicated that compound 8f may be used as a valuable skeleton structure for developing novel antitumor agents.

Design and Synthesis of Novel Betulin Derivatives Containing Thio-/Semicarbazone Moieties as Apoptotic Inducers through Mitochindria-Related Pathways

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Discover Novel Antitumor

It is necessary to discover novel antitumor agents for the treatment of esophageal cancers because of its poor prognosis.

Discovery of indoline derivatives as anticancer agents via inhibition of tubulin polymerization.

Discover Novel Antitumor

It is necessary to discover novel antitumor agents for the treatment of esophageal cancers because of its poor prognosis.

Discovery of indoline derivatives as anticancer agents via inhibition of tubulin polymerization.

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Novel Antitumor sentence examples within novel antitumor agent

novel antitumor agent

The data obtained suggest that OVN‑002 might be considered as a novel antitumor agent.

3‑HYDROXYQUINAZOLINE DERIVATIVE, AN ANALOGUE OF ERASTIN, INDUCES FERROPTOSIS IN METASTATIC MELANOMA CELLS

novel antitumor agent

Regorafenib and TAS-102 are novel antitumor agents for patients with refractory mCRC.

Retrospective Study of Regorafenib Versus TAS-102 Efficacy and Safety in Chemorefractory Metastatic Colorectal Cancer (mCRC) Patients: A Multi-institution Real Life Clinical Data.

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novel antitumor drug

Therefore, narciclasine might be a potential seed for a novel antitumor drug against malignant mesothelioma and other cancers in which hyperactivation and/or overexpression of YAP are observed.

Narciclasine is a novel YAP inhibitor that disturbs interaction between YAP and TEAD4

novel antitumor drug

The urea analogs of pretubulysin might represent a promising scaffold for the further development of novel antitumor drugs.

Design, synthesis, and antitumor activity evaluation of pretubulysin analogs

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novel antitumor therapy

Thus, an improved understanding of the regulatory mechanisms of COX-2 can facilitate the development of novel antitumor therapies.

Interplay between cyclooxygenase-2 and microRNAs in cancer

novel antitumor therapy

Conclusion Our findings demonstrated that circLDB2 impeded non‐squamous NSCLC development and enhanced cisplatin sensitivity partially by acting as a ceRNA, highlighting circLDB2 as a promising candidate for the development of novel antitumor therapies.

Circular RNA circLDB2 functions as a competing endogenous RNA to suppress development and promote cisplatin sensitivity in non‐squamous non‐small cell lung cancer

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novel antitumor strategy

These findings indicate that Cyr61 derived from ADSCs plays a critical role in promoting CRC progression via integrin αV β5 and provide a novel antitumor strategy by targeting Cyr61/αV β5.

Cyr61 from adipose-derived stem cells promotes colorectal cancer metastasis and vasculogenic mimicry formation via integrin αV β5.

novel antitumor strategy

Conclusions: This study provides strong evidence of the involvement of CD73 in the Warburg effect and indicates that it could be a novel antitumor strategy to target tumor metabolism in gastric cancer.

CD73 is a hypoxia-responsive gene and promotes the Warburg effect of human gastric cancer cells dependent on its enzyme activity

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novel antitumor mechanism

Overall, this work provides valuable leads and novel antitumor mechanisms for the treatment of the SAHA-resistant triple-negative breast cancers.

Discovery of Novel Pyrrolo[2,3-d]pyrimidine-based Derivatives as Potent JAK/HDAC Dual Inhibitors for the Treatment of Refractory Solid Tumors.

novel antitumor mechanism

Together, our data revealed a novel antitumor mechanism of melatonin in modulating the immunosuppressive tumor microenvironment by suppressing the YAP/PD-L1 axis and suggest the therapeutic potential of melatonin for treating NSCLC.

Melatonin Downregulates PD-L1 Expression and Modulates Tumor Immunity in KRAS-Mutant Non-Small Cell Lung Cancer

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novel antitumor treatment

Further studies are needed to figure out their roles in tumor activity and provide insight for novel antitumor treatment development.

DNA and RNA sequencing analysis revealed alterations of ANK3, PKHD1 and olfactory transduction as potential biomarker of three-year survival in gastric cancer.

novel antitumor treatment

BACKGROUND Pancreatic cancer is a highly malignant tumor of the gastrointestinal system whose emerging resistance to chemotherapy has necessitated the development of novel antitumor treatments.

Scoparone inhibits pancreatic cancer through PI3K/Akt signaling pathway

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novel antitumor factor

These data indicated that miR-495 might be a novel antitumor factor of GC and provide a new method for the treatment of GC.

MicroRNA 495 Inhibits Proliferation and Metastasis and Promotes Apoptosis by Targeting Twist1 in Gastric Cancer Cells.

novel antitumor factor

Here, we described the molecular feature of LATS2 as a novel antitumor factor in liver cancer cells in vitro.

Anti-tumor effect of LATS2 on liver cancer death: Role of DRP1-mediated mitochondrial division and the Wnt/β-catenin pathway.

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novel antitumor therapeutic

Herein we describe the design and biological evaluation of a novel antitumor therapeutic platform that combines the most favorable properties of small-molecule drug conjugates (SMDCs) and antibody drug conjugates (ADCs).

Enhancing the Pharmacokinetics and Antitumor Activity of an α-Amanitin-Based Small-Molecule Drug Conjugate via Conjugation with an Fc Domain.

novel antitumor therapeutic

The HCP5 antisense retroviral transcript also interacts with regulatory microRNA and immune and cellular checkpoints in cancers suggesting its potential as a drug target for novel antitumor therapeutics.

Long Noncoding RNA HCP5, a Hybrid HLA Class I Endogenous Retroviral Gene: Structure, Expression, and Disease Associations

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novel antitumor effect

e16511Background: Inactivated Sendai virus particles (hemagglutinating virus of Japan envelope (HVJ-E)) have a novel antitumor effect: HVJ-E fused to prostate cancer cells via cell surface receptor.

Intratumoral and subcutaneous injection of HVJ-E (GEN0101) for metastatic castration-resistant prostate cancer: Open-label, phase I, dose escalation study.

novel antitumor effect

Taken together, our findings reveal that frugoside exhibits a novel antitumor effect based on a ROS-mediated cell death in melanoma cells, which may have therapeutic implications.

Frugoside Induces Mitochondria-Mediated Apoptotic Cell Death through Inhibition of Sulfiredoxin Expression in Melanoma Cells

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novel antitumor candidate

In an attempt to develop novel antitumor candidates, a series of coumarin sulfonamides and amides derivatives were designed and synthetized.

Coumarin Sulfonamides and Amides Derivatives: Design, Synthesis, and Antitumor Activity In Vitro

novel antitumor candidate

Herein, our study provides a novel antitumor candidate and approach for treating AML.

The novel thioredoxin reductase inhibitor A-Z2 triggers intrinsic apoptosis and shows efficacy in the treatment of acute myeloid leukemia.

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10.1007/S10812-021-01189-1

A microwave-assisted, chemoselective synthesis of novel antitumor and antimicrobial (3E)-5-hydroxy-1-isopropyl-3-[(5-methyl-2-thienyl)methylene]-5-phenylpyrrolidin-2-one has been achieved via the solvent-free one-pot reaction of (3E)-3-[(5-methyl-2-thienyl)methylene]-5-phenylfuran-2(3H)-one with isopropylamine.

Efficient One-Pot Microwave-Assisted Synthesis, Crystallographic, and Spectroscopic Characterization of Novel Antitumor and Antimicrobial (3E)-5-Hydroxy-1-Isopropyl-3-[(5-Methyl-2-Thienyl)Methylene]-5-Phenylpyrrolidin-2-One

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10.1074/jbc.RA120.015769

These findings indicate that TRPC6 downregulation might be involved in melatonin's inhibitory effects on Ca2+ influx and the maintenance of cancer hallmarks, and point toward a novel antitumoral mechanism of melatonin in TNBC cells.

Melatonin downregulates TRPC6, impairing store-operated calcium entry in triple negative breast cancer cells.

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10.6092/UNIBO/AMSDOTTORATO/8837

So far, the molecular basis of the drugs mechanism has focused primarily on DNA damage, but recently the novel antitumoral strategies highlighted the cell membranes as a relevant site of the drug’s multitarget reactivity towards the unsaturated lipids.

Novel Antitumoral Strategies Inducing Membrane Lipid and DNA Damage:Artificial Chemical Nucleases & the ‘ClickGene’ Project

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10.3390/ph12030134

The focus of this Special Issue of Pharmaceuticals is on the design, synthesis, and molecular mechanism of action of novel antitumor, drugs with a special emphasis on the relationship between the chemical structure and the biological activity of the molecules.

Special Issue “Anticancer Drugs”

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10.1007/s40336-019-00329-0

Whereas it appears that the use of old and new PET radiopharmaceuticals can advance the non-invasive assessment of treatment response in GBM, the optimal match of biomarker–probe pairs although highly needed is still being sought in particular with the active development of new highly specific treatments characterized by novel antitumoral targeting strategies.

PET biomarkers and probes for treatment response assessment in glioblastoma: a work in progress

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Novel Antitumor
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What is/are Novel Antitumor?

Novel Antitumor - A microwave-assisted, chemoselective synthesis of novel antitumor and antimicrobial (3E)-5-hydroxy-1-isopropyl-3-[(5-methyl-2-thienyl)methylene]-5-phenylpyrrolidin-2-one has been achieved via the solvent-free one-pot reaction of (3E)-3-[(5-methyl-2-thienyl)methylene]-5-phenylfuran-2(3H)-one with isopropylamine. [1] These findings indicate that TRPC6 downregulation might be involved in melatonin's inhibitory effects on Ca2+ influx and the maintenance of cancer hallmarks, and point toward a novel antitumoral mechanism of melatonin in TNBC cells. [2] So far, the molecular basis of the drugs mechanism has focused primarily on DNA damage, but recently the novel antitumoral strategies highlighted the cell membranes as a relevant site of the drug’s multitarget reactivity towards the unsaturated lipids. [3] The focus of this Special Issue of Pharmaceuticals is on the design, synthesis, and molecular mechanism of action of novel antitumor, drugs with a special emphasis on the relationship between the chemical structure and the biological activity of the molecules. [4] Whereas it appears that the use of old and new PET radiopharmaceuticals can advance the non-invasive assessment of treatment response in GBM, the optimal match of biomarker–probe pairs although highly needed is still being sought in particular with the active development of new highly specific treatments characterized by novel antitumoral targeting strategies. [5]

Develop Novel Antitumor

In an attempt to develop novel antitumor candidates, a series of coumarin sulfonamides and amides derivatives were designed and synthetized. [1] Due to its interesting biological profile, (S)-1 represents a lead compound to develop novel antitumor agents for breast cancer treatment. [2] This paper focuses on the thermochemical behavior of two derivatives of 1,2,4-triazole which is often considered as a potential synthetic platform to develop novel antitumor or antimicrobial drugs, i. [3]

Potential Novel Antitumor

Conclusion These results indicate that at least for primary gastric cancer, statins and avasimibe are promising candidates as potential novel antitumor drugs that target the metabolism of isoprenoids and cholesterol of gastric tumors. [1] Recently, drugs belonging to the biguanide class (including metformin) were reported to selectively inhibit CLIC1 activity in CSCs, impairing their viability and invasiveness, but sparing normal stem cells, thus representing potential novel antitumor drugs with a safe toxicological profile. [2]

Developing Novel Antitumor

Thus, modification of the diene moiety of Oligomycin A is a promising strategy for developing novel antitumor agents based on its scaffold. [1] These results indicated that compound 8f may be used as a valuable skeleton structure for developing novel antitumor agents. [2]

Discover Novel Antitumor

It is necessary to discover novel antitumor agents for the treatment of esophageal cancers because of its poor prognosis. [1] It is necessary to discover novel antitumor agents for the treatment of esophageal cancers because of its poor prognosis. [2]

novel antitumor agent

The data obtained suggest that OVN‑002 might be considered as a novel antitumor agent. [1] Regorafenib and TAS-102 are novel antitumor agents for patients with refractory mCRC. [2] The present study highlighted the importance of A-azepano-ring in the triterpenic core for the development of novel antitumor agents, and a future aim to increase the selectivity profile will thus lie in the area of modifications of azepano-triterpenic acids at their carboxyl group. [3] Thus, modification of the diene moiety of Oligomycin A is a promising strategy for developing novel antitumor agents based on its scaffold. [4] These results indicated that compound 8f may be used as a valuable skeleton structure for developing novel antitumor agents. [5] It represents as a promising lead for further optimization and a template for development of novel antitumor agents. [6] Thus, compound MSN54 is a promising candidate for the development of novel antitumor agents. [7] With the aim to discover potent and novel antitumor agents, a series of thiourea compounds bearing 3-(4-methoxyphenyl)azetidine moiety were designed according to the essential pharmacophoric features of the reported VEGFR-2 inhibitors and synthesized. [8] It is necessary to discover novel antitumor agents for the treatment of esophageal cancers because of its poor prognosis. [9] In this review, we demonstrate the efficacy and safety of H2 as a novel antitumor agent and show that its mechanisms may not only involve the direct scavenging of ·OH, but also other indirect biological defense mechanisms via the regulation of gene expression. [10] Therefore, it is supposed that HO-1 inhibitors could become a novel antitumor agent. [11] Drug development of novel antitumor agents is conventionally divided by phase and cancer indication. [12] It is necessary to discover novel antitumor agents for the treatment of esophageal cancers because of its poor prognosis. [13] Thus, the novel unsaturated pyrrolidone p53-MDM2 inhibitors could be developed as novel antitumor agents. [14] Romidepsin (FK228) and vorinostat (SAHA) are histone deacetylase inhibitors (HDACi) approved by the Food and Drug Administration as novel antitumor agents. [15] A series of O-substituted analogs of the C-ring-truncated scaffold of deguelin designed as heat shock protein 90 (HSP90) C-terminal inhibitors were investigated as novel antitumor agents against human epidermal growth factor receptor 2 (HER2)-positive breast cancer. [16] The purpose of this study was to explore the possibilities of using MRS5698 as a novel antitumor agent through experiments on Ishikawa and HEC-1A cells. [17] Although the introduction of novel antitumor agents, such as dinutuximab, isotretinoin, irinotecan, or I-131- metaiodobenzylguanidine, has increased survival rates, the situation in high-risk NB remains dismal. [18] Conclusion Derivative 10 is an novel antitumor agent with potential for further clinical applications to treat gastric cancer. [19] Due to its interesting biological profile, (S)-1 represents a lead compound to develop novel antitumor agents for breast cancer treatment. [20] Our results also suggest that Rhein has a promising potential to be used as a novel antitumor agent for the treatment of NSCLC. [21] These results indicated that EGLP showed stronger antitumor activity with lower toxic effects and had the potential to be a novel antitumor agent. [22] We also suggest that CGRP antibodies may also be used as novel antitumor agents by suppressing tumor-associated angiogenesis. [23] Thus, MnSbW-bpp, as a new compound, possesses the potent inhibition of cancer cells, which indicates that the MnSbW-bpp has potential merit for the further evaluation of a novel antitumor agent. [24] Overall, the current study provides a potential new approach for the discovery of a novel antitumor agent against HCC. [25] Research efforts are focusing on deciphering the distinct molecular mechanisms underlying drug resistance, which should prompt the development of novel antitumor agents that surmount such chemoresistance modalities. [26] Here we show the efficacy and biological mechanism of a novel antitumor agent, NCT compound. [27] Organometallic rhenium complexes have recently been considered in the development of novel antitumor agents due to their suitable properties. [28] Oncolytic viruses are novel antitumor agents with the ability to selectively replicate and lyse tumor cells while sparing healthy tissue. [29] To find novel antitumor agents, a series of 1H-benzofuro[3,2-c]pyrazole derivatives 4a-e were designed and synthesized. [30] Results indicated that as a novel antitumor agent, 1G exhibited acceptable pharmacokinetic properties for further in vivo pharmacologic evaluation. [31] Chemotherapy resistance is one of the most common causes of death among patients with ovarian cancer, and identifying novel antitumor agents is a priority. [32]

novel antitumor drug

Therefore, narciclasine might be a potential seed for a novel antitumor drug against malignant mesothelioma and other cancers in which hyperactivation and/or overexpression of YAP are observed. [1] The urea analogs of pretubulysin might represent a promising scaffold for the further development of novel antitumor drugs. [2] In this study, a novel antitumor drug cabozantinib (CZN) was estimated by a validated green reversed-phase high-performance thin-layer chromatography (RP-HPTLC) and normal-phase high-performance thin-layer chromatography (NP-HPTLC) techniques in the marketed tablets and capsules. [3] Conclusion These results indicate that at least for primary gastric cancer, statins and avasimibe are promising candidates as potential novel antitumor drugs that target the metabolism of isoprenoids and cholesterol of gastric tumors. [4] This research work reports new equilibrium solubility data for a novel weakly soluble tyrosine kinase inhibitor cabozantinib malate (CBZM) (a novel antitumor drug) in twelve different monosolvents (MS) of pharmaceutical importance including “water, methanol (MeOH), ethanol (EtOH), isopropanol (IPA), 1-butanol (1-BuOH), 2-butanol (2-BuOH), ethylene glycol (EG), propylene glycol (PG), polyethylene glycol-400 (PEG-400), ethyl acetate (EA), Transcutol-HP (THP) and dimethyl sulfoxide (DMSO)” within the temperature range “T = 298. [5] Our findings provide insights into the dynamics of integrin αvβ3 interactions with linear and cyclic RGD ligands and offer some new therapeutic approaches for the design and development of novel antitumor drugs. [6] Taken together, these results indicated that polyphyllin VII could be a novel antitumor drug for the treatment of CRC. [7] Background Colorectal cancer (CRC) is recognized as one of the most common malignancies with a high mortality rate worldwide, supporting the necessity for an effective novel antitumor drug to improve current therapy's effectiveness. [8] The simple design of zwitterionic prodrug micelles provides a new strategy for designing novel antitumor drug delivery systems with enhanced cellular uptake rates. [9] Due to their potent immune stimulation, tumor necrosis factor alpha (TNFα) variants with tumor-homing activity are attractive as novel antitumor drugs. [10] This initiated the increased demand for novel antitumor drugs that are active against untreatable tumors with fewer side effects, and with the greater therapeutic efficiency. [11] CONCLUSION Compound 5h might represent a promising scaffold for the further development of novel antitumor drugs. [12] This phenomenon may provide grounds for the development of novel antitumor drugs that are capable of selectively inducing oxidative stress in tumor cells. [13] Polydatin could be a potential compound to synthesize novel antitumor drugs. [14] This finding provides novel clues to exploring a novel antitumor drug for bile duct cancer. [15] The focus is mainly on the potential exploitation of the (DH)PIq scaffold in design and development of novel antitumor drugs. [16] Recently, drugs belonging to the biguanide class (including metformin) were reported to selectively inhibit CLIC1 activity in CSCs, impairing their viability and invasiveness, but sparing normal stem cells, thus representing potential novel antitumor drugs with a safe toxicological profile. [17] Spectroscopy experiments and cytotoxic assays against S-180 and Ehrlich cancer cell lines were performed and showed promising results as novel antitumor drugs. [18] BACKGROUND Ibrutinib is a novel antitumor drug that targets Bruton tyrosine kinase for treatment of chronic lymphocytic leukemia. [19]

novel antitumor therapy

Thus, an improved understanding of the regulatory mechanisms of COX-2 can facilitate the development of novel antitumor therapies. [1] Conclusion Our findings demonstrated that circLDB2 impeded non‐squamous NSCLC development and enhanced cisplatin sensitivity partially by acting as a ceRNA, highlighting circLDB2 as a promising candidate for the development of novel antitumor therapies. [2] These results indicate that CD73 has a dual effect on CD8+ T cells depending on whether they are subject to an antigenic or homeostatic stimulus, and thus, special attention should be given to these aspects when considering CD73 blockade in the design of novel antitumor therapies. [3] Despite considerable progress in early detection and treatment, there is still an unmet need for novel antitumor therapies, particularly in advanced colorectal cancer. [4] Along with the substantial progress in understanding of the role of tumor-derived vesicles in intercellular communication, novel antitumor therapy strategies based on vesicle inhibition in a tumor microenvironment are likely to appear very soon. [5] In this Perspectives Article, we focus on the following aspects: (1) the added value of IFN-I for enhancing the antitumor impact of standard anticancer treatments (chemotherapy and radiotherapy) and new therapeutic approaches, such as check point inhibitors and epigenetic drugs; (2) the role of IFN-I in the control of cancer stem cells growth and its possible implications for the development of novel antitumor therapies; and (3) the role of IFN-I in the development of cancer vaccines and the intriguing therapeutic possibilities offered by in situ delivery of ex vivo IFN-stimulated dendritic cells. [6] Taken together, overexpression of HOXA10 may be associated with poor prognosis in BC, and may serve as a novel antitumor therapy target for the treatment of this disease. [7] Although immune checkpoint blockade has recently emerged as a novel antitumor therapy, PDAC is less sensitive to immunotherapy due to small number of tumor-infiltrating T cells. [8]

novel antitumor strategy

These findings indicate that Cyr61 derived from ADSCs plays a critical role in promoting CRC progression via integrin αV β5 and provide a novel antitumor strategy by targeting Cyr61/αV β5. [1] Conclusions: This study provides strong evidence of the involvement of CD73 in the Warburg effect and indicates that it could be a novel antitumor strategy to target tumor metabolism in gastric cancer. [2] Conclusions: This study provides strong evidence of the involvement of PP2A in the Warburg effect and indicates that it could be a novel antitumor strategy to target tumor metabolism in gastric cancer. [3] The selective induction of tumor vascular thrombosis using truncated tissue factor (tTF) delivered via a target ligand is a promising novel antitumor strategy. [4] Given the multifaceted effects of VEGF-NRP interactions on tumor initiation and progression, the exploration of new chemical entities that selectively block these interactions has recently attracted considerable interest as a novel antitumor strategy. [5] For this reason, pharmacological targeting of Hsp90 has emerged as a novel antitumor strategy. [6]

novel antitumor mechanism

Overall, this work provides valuable leads and novel antitumor mechanisms for the treatment of the SAHA-resistant triple-negative breast cancers. [1] Together, our data revealed a novel antitumor mechanism of melatonin in modulating the immunosuppressive tumor microenvironment by suppressing the YAP/PD-L1 axis and suggest the therapeutic potential of melatonin for treating NSCLC. [2] These findings reveal a novel antitumor mechanism and a new combination regimen of the M1 oncolytic virus in TNBC, and highlight a need to bridge molecular diagnosis with virotherapy. [3] The current study revealed that the novel antitumor mechanism of metformin is mediated by regulation of mitochondrial E3 ubiquitin protein ligase 1 (MUL1) expression that negatively regulates AKT. [4]

novel antitumor treatment

Further studies are needed to figure out their roles in tumor activity and provide insight for novel antitumor treatment development. [1] BACKGROUND Pancreatic cancer is a highly malignant tumor of the gastrointestinal system whose emerging resistance to chemotherapy has necessitated the development of novel antitumor treatments. [2] The present study highlights the great potential of biocompatible natural polysaccharide-based materials for biomedical applications, and provides a new strategy for reducing the toxicity and side effects associated with traditional chemotherapy, demonstrating a novel antitumor treatment paradigm with high-efficiency but with only minor side effects. [3]

novel antitumor factor

These data indicated that miR-495 might be a novel antitumor factor of GC and provide a new method for the treatment of GC. [1] Here, we described the molecular feature of LATS2 as a novel antitumor factor in liver cancer cells in vitro. [2]

novel antitumor therapeutic

Herein we describe the design and biological evaluation of a novel antitumor therapeutic platform that combines the most favorable properties of small-molecule drug conjugates (SMDCs) and antibody drug conjugates (ADCs). [1] The HCP5 antisense retroviral transcript also interacts with regulatory microRNA and immune and cellular checkpoints in cancers suggesting its potential as a drug target for novel antitumor therapeutics. [2]

novel antitumor effect

e16511Background: Inactivated Sendai virus particles (hemagglutinating virus of Japan envelope (HVJ-E)) have a novel antitumor effect: HVJ-E fused to prostate cancer cells via cell surface receptor. [1] Taken together, our findings reveal that frugoside exhibits a novel antitumor effect based on a ROS-mediated cell death in melanoma cells, which may have therapeutic implications. [2]

novel antitumor candidate

In an attempt to develop novel antitumor candidates, a series of coumarin sulfonamides and amides derivatives were designed and synthetized. [1] Herein, our study provides a novel antitumor candidate and approach for treating AML. [2]