## What is/are Mediating Risk?

Mediating Risk - Here, informed from experiences and successes with understanding the role of the microbiome in mediating risk of Clostridioides difficile infection (CDI), we (1) review our understanding of the risk from ARO acquisition; (2) review our current understanding of the gut microbiome’s ability to resist colonization with AROs; (3) describe how experimental model systems can test these initial, global insights to arrive at more granular, mechanistic ones; and (4) suggest a path forward to make further progress in the field.^{[1]}Our results highlight that the severity of both positive/negative symptom-like PLEs is related with functional coupling between the DC and dorsolateral PFC, suggesting this neural circuit may play a role in mediating risk for general psychosis-related psychopathology.

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## Potential Mediating Risk

After additionally including potential mediating risk factors in the regression models, the estimated ORs changed only slightly in magnitude.^{[1]}Potential mediating risk factors were tested using multiple regression techniques.

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## mediating risk factor

Lower education status, family history of diabetes, hypercholesterolemia, high BMI, as well as tumor necrosis factor and total antioxidant capacity were revealed as mediating risk factors related to the tested associations.^{[1]}After additionally including potential mediating risk factors in the regression models, the estimated ORs changed only slightly in magnitude.

^{[2]}These observations indicate that there is a significant relationship between smoking, drinking alcohol, and sexual intercourse, and this information could be used to help the development of a combined adolescent health education program with mediating risk factors.

^{[3]}Potential mediating risk factors were tested using multiple regression techniques.

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