Introduction to Lysine Acetylation
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Lysine Acetylation sentence examples within post translational modification
Reversible post-translational modifications, as lysine acetylation, are a fast and economical way for cells to react to environmental conditions.
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Antibodies against post-translational modifications (PTMs) such as lysine acetylation, ubiquitin remnants, or phosphotyrosine have resulted in significant advances in our understanding of the fundamental roles of PTMs in biology.
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Lysine Acetylation sentence examples within important post translational
Lysine Acetylation sentence examples within reversible posttranslational modification
Protein lysine acetylation, a dynamic and reversible posttranslational modification, plays a crucial role in several cellular processes, including cell cycle regulation, metabolism, enzymatic activities, and protein interactions.
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Protein lysine acetylation is a reversible posttranslational modification and plays a pivotal role in a broad array of physiological functions.
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Lysine Acetylation sentence examples within major post translational
Lysine acetylation is a major post-translational modification that is required for various biological processes, and abnormal protein acetylation is associated with various diseases, including NSCLC.
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Lysine acetylation is one of the major post-translational modifications and plays critical roles in regulating gene expression and protein function.
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Lysine Acetylation sentence examples within Protein Lysine Acetylation
Lysine Acetylation sentence examples within Histone Lysine Acetylation
Although crosstalk between histone lysine acetylation and H3K4me3 has been reported, relationships between specific epigenetic marks during transcriptional activation remain largely unclear.
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Histone lysine acetylation has prevailed as one of the well characterised epigenetic modifications in these diseases.
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Lysine Acetylation sentence examples within Reversible Lysine Acetylation
In addition to protein abundance and phosphorylation changes, evidence suggests reversible lysine acetylation may also be important for abiotic stress responses.
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Reversible lysine acetylation regulates the activity of cardiac metabolic enzymes, including those controlling fuel substrate metabolism.
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Lysine Acetylation sentence examples within Posttranslational Lysine Acetylation
These effects were linked to metabolic changes through the increased production of acetyl-coenzyme A, which fueled the TCA cycle and promoted posttranslational lysine acetylation.
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The posttranslational lysine acetylation of proteins is increasingly appreciated as a key regulatory mechanism in fundamental cellular process such as transcription, cytoskeleton dynamics, metabolic flux, and cell survival/death signaling.
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Lysine Acetylation sentence examples within Identified Lysine Acetylation
Proteomics studies have identified lysine acetylation in WT IDH1, indicating post-translational regulation.
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Here we describe detailed protocols to process relatively small amounts of mouse liver tissue that integrate isolation of proteins, proteolytic digestion into peptides, immunoaffinity enrichment of acetylated peptides, identification of acetylation sites, and comprehensive quantification of relative abundance changes for thousands of identified lysine acetylation sites.
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Lysine Acetylation sentence examples within Specific Lysine Acetylation
Thereby, chemically equivalent, fully acetylated histone species are generated, enabling accurate relative quantification of site-specific lysine acetylation dynamics in tryptic peptides using high-resolution mass spectrometry.
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To study the functions of post-translational modifications, homogeneous HMGA1a protein with site-specific lysine acetylations (64/66/70/73) has been chemically synthesized.
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Lysine Acetylation sentence examples within Total Lysine Acetylation
The Clock mutation significantly inhibited the total lysine acetylation level in cartilage and inhibited NFκB acetylation at the Lys310 residue but promoted phosphorylation at the Ser276 residue.
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CAPE suppressed UV-induced acetyl-histone H3 (Lys9) as well as total lysine acetylation in HDF cells.
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Lysine Acetylation sentence examples within lysine acetylation site
In total, 986 lysine acetylation sites in 543 proteins were identified, of which 747 sites in 427 proteins were quantified.
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Here we describe detailed protocols to process relatively small amounts of mouse liver tissue that integrate isolation of proteins, proteolytic digestion into peptides, immunoaffinity enrichment of acetylated peptides, identification of acetylation sites, and comprehensive quantification of relative abundance changes for thousands of identified lysine acetylation sites.
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Lysine Acetylation sentence examples within lysine acetylation modification
Aberrant changes involving lysine acetylation modification are commonly reported in multiple types of cancers.
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In conclusion, this study systematically analysed the reveals critical features of placental proteins in pregnant women with PE, providing a resource for exploring the contribution of lysine acetylation modification to PE.
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Lysine Acetylation sentence examples within lysine acetylation contribute
We were particularly interested in how histone lysine acetylation contributes to the regulation of chromatin enzymes.
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Despite recent evidence suggesting that histone lysine acetylation contributes to base excision repair (BER) in cells, their exact mechanistic role remains unclear.
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Lysine Acetylation sentence examples within lysine acetylation stoichiometry
Lysine Acetylation sentence examples within lysine acetylation regulate
Lysine Acetylation sentence examples within lysine acetylation level
SIRT3 and cyclophilin D (CypD) expression and protein lysine acetylation levels in alveolar bones were detected by western blot.
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The Clock mutation significantly inhibited the total lysine acetylation level in cartilage and inhibited NFκB acetylation at the Lys310 residue but promoted phosphorylation at the Ser276 residue.
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Lysine Acetylation sentence examples within lysine acetylation may
In addition to protein abundance and phosphorylation changes, evidence suggests reversible lysine acetylation may also be important for abiotic stress responses.
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Taken together, these findings provide the first report of succinylome in SRMV infection, lysine acetylation may have a more important effect than succinylation in SRMV infection.
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Lysine Acetylation sentence examples within lysine acetylation play
Lysine Acetylation sentence examples within lysine acetylation change
Secondary end points included safety, objective response rate, and lysine acetylation change in peripheral blood mononuclear cells between baseline and cycle 1 day 15.
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In a recent lysine acetylome of silkworm infected with BmNPV, we focused on the heat shock cognate protein 70-4 (HSC70-4) lysine acetylation change due to the consequent nuclear accumulation and viral structure assembly.
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coelicolor acylomes and laid a foundation for characterizing the regulatory roles of the crosstalk between lysine acetylation and succinylation in the future.
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Lysine acetylation and deacetylation are critical for regulation of many cellular proteins.
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Background
Lysine acetylation (Kac) favors gene transcription and activates various genes involved in the regulation of oncogenesis, whereas the acetylation profiling of oral squamous cell carcinoma (OSCC) is unknown.
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There may be some crosstalks among Khib, lysine acetylation and lysine succinylation modification because some proteins and sites were modified by all these three acylations.
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A remarkable finding showed that the NAD+-dependent sirtuin deacetylase Sir2 has an impact on replicative lifespan in Saccharomyces cerevisiae suggesting that lysine acetylation has a direct role in the ageing process.
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Metabolism-mediated epigenetic changes represent an adapted mechanism for cellular signaling, in which lysine acetylation and methylation have been the historical focus of interest.
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GENERAL CONTROL NON-REPRESSIBLE 5 (GCN5), a well-known enzymatic protein responsible for the lysine acetylation of histone H3 and H4, is a universal and crucial histone acetyltransferase involved in gene transcription and plant development.
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However, in contrast to lysine acetylation, the N-terminal acetylation is elusive for its cellular functions.
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It can increase histone acetylation or lysine acetylation of other signaling molecules.
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These results indicate that a simple chemical modification such as lysine acetylation is sufficient to inhibit kinase activity.
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Lysine acetylation is an important mechanism in controlling gene expression.
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Consistent with lysine acetylation and succinylation in Apicomplexa, Kcr was associated with various metabolic pathways, including carbon metabolism, pyrimidine metabolism, glycolysis, gluconeogenesis, and proteasome.
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Despite their use, little is known about their effects on chromatin regulators, particularly those that signal through lysine acetylation.
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Even compared with the reported numbers of lysine acetylation (Kac) and succinylation (Ksuc) sites, the numbers of Khib-modified sites on ribosomal proteins remained the highest for C.
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Chemical modifications of histones, such as lysine acetylation and ubiquitination, play pivotal roles in epigenetic regulation of gene expression.
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The mammalian MYST family contains five members and has been shown to be critical for maintaining DNA histone acetylation and lysine acetylation.
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Nε-lysine acetylation is an important, dynamic regulatory posttranslational modification (PTM) that is common in bacteria.
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Introduction The modification of lysine crotonylation (Kcr) is another biological function of histone in addition to modification of lysine acetylation (Kac), which may play a specific regulatory role in diseases.
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Lysine acetylation (Kac) is well known to occur in histones for chromatin function and epigenetic regulation.
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Objective: We test the hypothesis that lysine acetylation is involved in the metabolic process of glioma-associated seizures (GAS).
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Lysine acetylation is one of the major histone chemical modifications essential for epigenetic gene expression.
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Lysine acetylation (Kac) as an important posttranslational modification of histones is essential for the regulation of gene expression in hepatocellular carcinoma (HCC).
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Additionally, Nrf2-KEAP1 protein-protein interactions and Nrf2 PTMs, including serine phosphorylation and lysine acetylation, were responsive to cycles of torpor-arousal with peak responses occurring during arousal.
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Histone modification by lysine acetylation is another major epigenetic mechanism associated with gene regulation.
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Lysine acetylation is a ubiquitous modification permeating the proteomes of organisms from all domains of life.
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Lysine acetylation in particular plays a key role in interactions between respiratory cytochrome c and its metabolic partners.