Kunitz Type(庫尼茨型)到底是什麼？
Kunitz Type 庫尼茨型 - We verified that elevated serine threonine tyrosine kinase 1 (STYK1) or decreased serine peptidase inhibitor Kunitz type 2 (SPINT2/HAI-2) expression significantly correlated with poor prognosis, tumor invasion, and metastasis of NSCLC patients. [1] N-terminus sequencing of RsBBI and RsKI by MALDI-ISD ascertained the presence of Bowman Birk and Kunitz type isoinhibitors in R. [2] Purpose: The serine peptidase inhibitor, Kunitz type 1 antisense RNA1 (SPINT1-AS1), a long non-coding RNA , has been linked to cancer progression. [3] In the course of an earlier investigation into the crystallization of proteins based on the addition of intermolecular ligands, the Kunitz type trypsin inhibitor from soybean (SBTI) was crystallized as a complex with 1,5-disulfonylnaphthalene (ligand library 21D). [4] AbbreviationsBApNA Nα-Benzoyl-L-arginine 4-nitroanilideBPT bovine pancreatic trypsinCaTI2 Cicer arietinum L trypsin inhibitor 2DrTI Delonix regia Trypsin inhibitorEcTI Enterolobium contortisiliquum trypsin inhibitorETI Erythrina caffra trypsin inhibitorKTI Kunitz type inhibitorSTI soybean trypsin inhibitorTKI Tamarindus indica Kunitz inhibitor Communicated By Ramaswamy H. [5] Among them three finger toxins (58%), phosphoplipses A2 (19%), snake venom metalloproteinases (5%), l-amino acid oxidases (5%), helvepryns (3%), vespryns (2%), cobra venom factor (2%), 5′-nucleotidases (2%), venom nerve growth factor (2%), and Kunitz type serine protease inhibitor (2%) were included. [6] Overexpression of the APP domain coding for a Kunitz type serine protease inhibitor might explain this. [7] In an RNA‐sequencing approach of FACS sorted wt and HIF‐2α LysM−/− TAMs, serine protease inhibitor, Kunitz type‐1 ( Spint1) emerged as a promising candidate for HIF‐2α‐dependent regulation. [8] EgKI-1 is a potent Kunitz type protease inhibitor identified from the canine tapeworm Echinococcus granulosus that has shown anti-cancer activities in vivo. [9] Our results show that IrSPI harbours the typical conformational fold of Kunitz type I serine protease inhibitors and that it functionally inhibits the elastase and, to a lesser extent, chymotrypsin. [10]nan [1] 通過 MALDI-ISD 對 RsBBI 和 RsKI 的 N 端測序確定了 R 中 Bowman Birk 和 Kunitz 型同工抑製劑的存在。 [2] 目的：絲氨酸肽酶抑製劑 Kunitz 1 型反義 RNA1 (SPINT1-AS1) 是一種長鏈非編碼 RNA，與癌症進展有關。 [3] 在基於添加分子間配體的蛋白質結晶的早期研究過程中，來自大豆的 Kunitz 型胰蛋白酶抑製劑 (SBTI) 被結晶為與 1,5-二磺酰基萘的複合物（配體庫 21D）。 [4] nan [5] 其中三指毒素（58%）、磷脂酶A2（19%）、蛇毒金屬蛋白酶（5%）、L-氨基酸氧化酶（5%）、海維普林斯（3%）、維斯普林斯（2%）、眼鏡蛇毒因子包括 (2%)、5'-核苷酸酶 (2%)、毒液神經生長因子 (2%) 和 Kunitz 型絲氨酸蛋白酶抑製劑 (2%)。 [6] 編碼 Kunitz 型絲氨酸蛋白酶抑製劑的 APP 結構域的過度表達可以解釋這一點。 [7] nan [8] nan [9] nan [10]
serine protease inhibitor 絲氨酸蛋白酶抑製劑
Among them three finger toxins (58%), phosphoplipses A2 (19%), snake venom metalloproteinases (5%), l-amino acid oxidases (5%), helvepryns (3%), vespryns (2%), cobra venom factor (2%), 5′-nucleotidases (2%), venom nerve growth factor (2%), and Kunitz type serine protease inhibitor (2%) were included. [1] Overexpression of the APP domain coding for a Kunitz type serine protease inhibitor might explain this. [2] In an RNA‐sequencing approach of FACS sorted wt and HIF‐2α LysM−/− TAMs, serine protease inhibitor, Kunitz type‐1 ( Spint1) emerged as a promising candidate for HIF‐2α‐dependent regulation. [3] Our results show that IrSPI harbours the typical conformational fold of Kunitz type I serine protease inhibitors and that it functionally inhibits the elastase and, to a lesser extent, chymotrypsin. [4]其中三指毒素（58%）、磷脂酶A2（19%）、蛇毒金屬蛋白酶（5%）、L-氨基酸氧化酶（5%）、海維普林斯（3%）、維斯普林斯（2%）、眼鏡蛇毒因子包括 (2%)、5'-核苷酸酶 (2%)、毒液神經生長因子 (2%) 和 Kunitz 型絲氨酸蛋白酶抑製劑 (2%)。 [1] 編碼 Kunitz 型絲氨酸蛋白酶抑製劑的 APP 結構域的過度表達可以解釋這一點。 [2] nan [3] nan [4]
kunitz type serine 庫尼茨型絲氨酸
Among them three finger toxins (58%), phosphoplipses A2 (19%), snake venom metalloproteinases (5%), l-amino acid oxidases (5%), helvepryns (3%), vespryns (2%), cobra venom factor (2%), 5′-nucleotidases (2%), venom nerve growth factor (2%), and Kunitz type serine protease inhibitor (2%) were included. [1] Overexpression of the APP domain coding for a Kunitz type serine protease inhibitor might explain this. [2]其中三指毒素（58%）、磷脂酶A2（19%）、蛇毒金屬蛋白酶（5%）、L-氨基酸氧化酶（5%）、海維普林斯（3%）、維斯普林斯（2%）、眼鏡蛇毒因子包括 (2%)、5'-核苷酸酶 (2%)、毒液神經生長因子 (2%) 和 Kunitz 型絲氨酸蛋白酶抑製劑 (2%)。 [1] 編碼 Kunitz 型絲氨酸蛋白酶抑製劑的 APP 結構域的過度表達可以解釋這一點。 [2]