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Induces Apoptosis sentence examples within cell cycle arrest
Conclusions: Data from our study demonstrate that the ETS inhibitor TK216 induces apoptosis and cell cycle arrest in pediatric leukemia cells at physiologically relevant concentrations.
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These results indicated that MOAE inhibits the proliferation and migration of A549 cells and induces apoptosis and cell cycle arrest through a mechanism that is related to the inhibition of JAK2/STAT3 pathway activation.
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Induces Apoptosis sentence examples within inhibits cell proliferation
Our results show that NBP-J significantly inhibits cell proliferation and changes morphology, induces cell cycle arrest, inhibits the survival pathway, and induces apoptosis.
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Furthermore, DHM treatment inhibits cell proliferation, induces apoptosis and autophagy and regulates redox balance in liver cancer cells, thus exhibiting remarkable anti-cancer effects.
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Induces Apoptosis sentence examples within cancer cell line
S65487/VOB560 induces apoptosis in a panel of hematological cancer cell lines and inhibits cell proliferation with IC50s in the low nM range.
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Conclusion Aqueous extract of TcE induces apoptosis-mediated cell death in the oral cancer cell line AW13516 while attenuating its potential for epithelial mesenchymal transition.
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Induces Apoptosis sentence examples within dose dependent manner
Additionally, MEK inhibitor in a dose-dependent manner induces apoptosis and blocks cell cycle progression in NB cells in comparison to control, as determined by Annexin V apoptosis assays and Click-iT EdU cell proliferation assay respectively.
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Additionally, flow cytometry and TUNEL assay revealed that tannic acid induces apoptosis in UMUC3 cells in a dose-dependent manner.
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Induces Apoptosis sentence examples within breast cancer cell
α-Mangostin induces apoptosis, suppresses the migration and invasion of breast cancer cells through the PI3K/AKT signaling pathway by targeting RXRα, and cyclin D1 has involved in this process.
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This study reveals that piR-651 promotes proliferation and migration and induces apoptosis of breast cancer cells by facilitating DNMT1-mediated PTEN promoter methylation, which may provide a potential therapeutic mechanism for breast cancer.
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Induces Apoptosis sentence examples within tumor necrosis factor
Tumor necrosis factor-related apoptosis-induced ligand (TRAIL) shows little or no toxicity in most normal cells and preferentially induces apoptosis in a variety of malignant cells.
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Tumor Necrosis Factor-Related Apoptosis-Inducing Ligand (TRAIL) induces apoptosis of many cancer cells, including CRC cells, being non-harmful for normal ones.
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Induces Apoptosis sentence examples within inhibits cell growth
Induces Apoptosis sentence examples within mitochondrial membrane potential
The results exhibited that RLX-loaded SSNES induces apoptosis via the activation of caspase-3 and loss of mitochondrial membrane potential.
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In this study, we observed that delphinidin treatment alters the mitochondrial membrane potential, thereby induces apoptosis was closely associated with the induction of pro‐apoptotic Bax, Caspase‐ 3,8 & 9, cytochrome C, and inhibition of anti‐apoptotic protein expression.
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Induces Apoptosis sentence examples within mitogen activated protein
Further western blot assays suggested that quercetin induces apoptosis but does not affect Akt or mitogen-activated protein kinases, factors related to cell proliferation.
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In vitro experimental results showed that TMBPS arrests the cell cycle in the G2/M phase by inactivating the protein kinase B (AKT) and extracellular signal-regulated kinase 1/2 (ERK1/2) signaling pathways and induces apoptosis by activating the p38/mitogen-activated protein kinase (MAPK) signaling pathway.
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Induces Apoptosis sentence examples within causes cell cycle
Induces Apoptosis sentence examples within cleaved caspase 3
Induces Apoptosis sentence examples within suppresses cell proliferation
miR-299-3p suppresses cell proliferation and invasion as well as induces apoptosis by regulating PAX3 expression in GC, representing desirable biomarkers for GC diagnosis and therapy.
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EMP1 promotes tumor cell migration and metastasis via activation of the small GTPase Rac1, while stomatin strongly suppresses cell proliferation and induces apoptosis of cancer cells via inhibition of Akt signaling.
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Induces Apoptosis sentence examples within inhibits proliferation migration
Induces Apoptosis sentence examples within human breast cancer
Induces Apoptosis sentence examples within time dependent manner
Induces Apoptosis sentence examples within cancer cell growth
We and others have shown that farnesyl dimethyl chromanol (FDMC) inhibits cancer cell growth and induces apoptosis in vitro and in vivo.
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Our research shows that KLF9 is lower in androgen-independent cell lines than in androgen-dependent cell lines; Overexpression of KLF9 dramatically suppresses the proliferation, anchorage-independent growth, and induces apoptosis in androgen-dependent cells; KLF9 inhibition on prostate cancer cell growth may be acting through the AR pathway.
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Induces Apoptosis sentence examples within necrosis factor related
Tumour necrosis factor-related apoptosis inducing ligand (TRAIL) is a promising anti-tumour agent that induces apoptosis of malignant cells through activation of death receptors.
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Induces Apoptosis sentence examples within cell cycle progression
The combination dose regimen of Br‐Bn‐Nos and DOX blocks the cell cycle progression at the G2/M phase and induces apoptosis to cancer cells more effectively compared with the single regimen.
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Induces Apoptosis sentence examples within proliferation migration invasion
Further, overexpression of RRM2 in HT1080 cells induces proliferation, migration, invasion, and colony formation, whereas its silencing arrest the cell cycle at G0/G1 phase and induces apoptosis.
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Induces Apoptosis sentence examples within Inhibition Induces Apoptosis
Induces Apoptosis sentence examples within Treatment Induces Apoptosis
Induces Apoptosis sentence examples within Synergistically Induces Apoptosis
This well-tolerated drug combination potently and synergistically induces apoptosis in both zebrafish and human NF1/PTEN-deficient melanoma cells, providing preclinical evidence justifying an early-stage clinical trial in patients with NF1/PTEN-deficient melanoma.
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Osimertinib combined with MET inhibition synergistically induces apoptosis in the MET-amplified EGFR mutant NSCLC cells accompanied with augmented DR4 reduction both in vitro and in vivo.
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Induces Apoptosis sentence examples within Also Induces Apoptosis
Induces Apoptosis sentence examples within Cell Induces Apoptosis
Induces Apoptosis sentence examples within Subsequently Induces Apoptosis
Bulky drug-DNA adducts formed by cisplatin elicits DNA damage response (DDR) which either subsequently induces apoptosis in the cervical cancer cells or enables them to adapt with drug assault by invigorating pro-survival molecular cascades.
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Overall, this study suggests that COVID-19 infection causes spermatogenesis disruption, probably through the oxidative stress pathway and subsequently induces apoptosis.
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Induces Apoptosis sentence examples within Thereby Induces Apoptosis
In this study, we observed that delphinidin treatment alters the mitochondrial membrane potential, thereby induces apoptosis was closely associated with the induction of pro‐apoptotic Bax, Caspase‐ 3,8 & 9, cytochrome C, and inhibition of anti‐apoptotic protein expression.
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In addition, XNT treatment alters the ΔΨm, thereby induces apoptosis was closely coordinated with the induction of pro-apoptotic markers Bax, Bad, caspase- 3, 9 and cytochrome c, and suppression of anti-apoptotic (Bcl-2, Bcl-XL) protein expression.
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Induces Apoptosis sentence examples within Stres Induces Apoptosis
The conclusion of this review is T2D is directly related to ER stress induced apoptosis, and some suggested future perspectives are the cause of T2D and the exact mechanism and pathway of how ER stress induces apoptosis.
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Induces Apoptosis sentence examples within Dramatically Induces Apoptosis
Furthermore, inhibition of glucose metabolism with low dose 2-deoxyglucose (2DG) in combination with MEK inhibitor dramatically induces apoptosis in KrasG12D-driven PDAC cell in vitro, inhibits xenograft tumor growth and prolongs the overall survival of genetically engineered mouse PDAC model.
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Upregulation of GADD45g impairs homologous recombination (HR) DNA repair, leading to DNA damage accumulation, and dramatically induces apoptosis, differentiation, growth arrest and increases sensitivity of AML cells to chemotherapeutic drugs, without affecting normal cells.
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Induces Apoptosis sentence examples within Ck Induces Apoptosis
Overall, these findings suggest that CK induces apoptosis via suppression of PI3K/PDK1/SGK1 and NF‐κB signaling axis.
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Overall, these findings provide evidence that CK induces apoptosis via inhibition of glycolysis and AKT/mTOR/c‐Myc signaling in HCC cells as a potent anticancer candidate for liver cancer clinical translation.
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Induces Apoptosis sentence examples within It Induces Apoptosis
Induces Apoptosis sentence examples within Signaling Induces Apoptosis
Induces Apoptosis sentence examples within Ceramide Induces Apoptosis
Recent studies have shown that ceramide induces apoptosis due to its increased levels in the cells.
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