Introduction to Fluorescent Agents

Several fluorescent dyes including near-infrared (NIR) fluorescent agents have been already well studied in the field of photodynamic therapy (PDT).

Thus, beyond the use of intraoperative diagnostic evaluation, the use of fluorescent agents (e.

In this review, i) the development of NIR fluorescence as an imaging modality and fluorescent agents is discussed; ii) the recent development of NIR‐I fluorophore‐based nano‐medicine systems for thrombosis theranostics is comprehensively summarized; iii) the state‐of‐the‐art NIR‐II fluorophores that are designed for the specific purpose of affording thrombotic diagnosis is highlighted; iv) possible forward avenues for the use of NIR‐II fluorophores toward thrombosis diagnosis and therapy are speculated; and v) the potential for their clinical translation is discussed.

Our work will inspire more insight into the improvement of the working wavelength of fluorescent agents and traditional 2PFLM.

Theoretically, any antibody or small molecule targeting cancer can be labeled with bioluminescent or fluorescent agents.

Thus, the use of fluorescent agents (e.

Over the years, fluorescent agents such as fluorescein sodium have been explored as a means of more reliably delineating the boundary between tumor core, tumor-infiltrated brain, and surrounding cortex.

The extraordinary flexibility in tuning their properties via composition, size- and dimensionality-related quantum confinement effects and surface engineering combined with their scalable bottom-up manufacturing has already led to their commercialization in different light-emitting applications, such as materials for displays and as fluorescent agents for imaging and sensing.

Previous studies monitor total fluorescence intensity for this purpose, since it can take into account the effect of fluorescent agents in dental tissues.

Replicating the information from Gd-MRI in the visual surgical field using fluorescent agents that behave similar to gadolinium in vivo would represent a major advance for surgical intervention of these tumors, and could provide robust compensation information to update pre-operative MRI images during surgery.

Fluorescence‐guided surgery using epidermal growth factor receptor (EGFR) targeting has been performed successfully in clinical trials using a variety of fluorescent agents.

Fluorescent agents are mainly administered intravenously at a given time prior or during surgery, in order to enable real-time imaging during the procedure.

The mesophase matrices can be loaded with fluorescent agents as a drug and release it with different rates depending on the pH of the volume.

Here, we address this demand by exploring novel multilayered nanocomposites (MNCs) with plasmonic nanoparticles and absorbing dyes in thin nonabsorbing shells as supercontrast multimodal photoacoustic (PA) and fluorescent agents in the near-infrared range.