## What is/are First Validated?

First Validated - The obtained nonlocal nonlinear frequencies of the nanobeam are first validated based on published analytical results that use linear mode shapes.^{[1]}The FE model was first validated by comparing its capability to predict the compressive strength with the analytical solution for concrete short columns reinforced with conventional steel bars.

^{[2]}The non-reacting case is first validated using the mixture fraction and the velocity fields.

^{[3]}These models are first validated by comparing numerical predictions in terms of load-deflection response, crack propagation, reaction distribution, and failure mode against that of measured experimental data reported in literature.

^{[4]}The method was first validated using simulations and then applied to resting state fMRI data obtained in-house (N = 21), wherein we performed dynamic clustering of DEC matrices across multiple levels [using adaptive evolutionary clustering (AEC)] – spatial location, time, and subjects.

^{[5]}The proposed model was first validated by experimental data in terms of input power.

^{[6]}The approach is first validated by a comparison with Finite Element Analysis, and the results show a low error in estimating the tip deflection (less than 1% of the manipulator length).

^{[7]}The Computational Fluid Dynamics (CFD) simulation was first validated against the wind tunnel experiment in the street canyon with tree planting.

^{[8]}The method was first validated on a tissue-mimicking phantom, for which an 18%-21% reduction in the standard deviation of ACE and a 14%-24% reduction in the ACE error, expressed as a percentage of reported ACE, were obtained.

^{[9]}The factors were first validated in a 2-year pilot study before being implemented in a road agency’s computerized road management system.

^{[10]}The proposed hydraulic solving framework, which explicitly calculates the flow rate and fluid pressure of a compressible viscous fluid based on the cubic law and a linear fluid compressibility model, is first validated against analytical solutions for uncoupled transient and steady flow examples.

^{[11]}Candidate circRNAs identified were first validated by quantitative reverse-transcription (qRT)-PCR in PBMC samples from a training-phase cohort of five SLE patients and five HCs.

^{[12]}This is obtained from a macroscopic model for the coupled diffusion-reaction process that is first validated with voltammetry experiments of H 2 O 2 /H 2 O reduction reaction carried out with a series of porous electrodes elaborated in this work.

^{[13]}The chevron notch geometry was first validated by measurement of the $$ (111) $$ cleavage toughness in single-crystal Si, then fracture resistance curves (R-curves) were calculated via EPFM analysis of fracture data obtained from a semibrittle W-1%Ta alloy.

^{[14]}Our experimental methods are first validated against a Newtonian fluid of glycerol + water in which the sphere velocities remained equal.

^{[15]}The proposed indicator was first validated by using a benchmark numerical model.

^{[16]}The Gpyro model is first validated against experiments and another code, both from the literature, for pure PBT-GF.

^{[17]}Predictions were first validated by performing an exhaustive search of SEPs present in Mycoplasma pneumoniae proteome via mass spectrometry, which illustrated the limitations of shotgun approaches.

^{[18]}A multiresidue procedure based on QuEChERS extraction and ultra-high-performance liquid chromatography tandem mass spectrometry (UHPLC-MS/MS) was first validated for its robustness.

^{[19]}The numerical modeling is first validated against available experimental results from the literature.

^{[20]}The method is first validated using AHLs for which XRD data of their complexes with their cognate receptor are available, then extended to examples for which the binding mode is still unknown.

^{[21]}The framework is first validated on synthetic data, and then tested on two cases at high Mach number and low angle of attack using pressure coefficients on the model’s surface as the reference measurements.

^{[22]}The integrated model is first validated with the experimental data available in the literature.

^{[23]}The proposed algorithm is first validated by simulations conducted using synthetic datasets for which good performance is obtained.

^{[24]}The quantification method was first validated for the targeted analysis of 21 contaminants including some pharmaceutically active compounds, with the relative recoveries ranging from 88 to 123%, and method detection limits generally below 1 ng g-1 on the wet weight (ww) basis.

^{[25]}The XFEM/fatigue crack growth (FCG) procedure employed in the study was first validated against constant amplitude HCF experiments on notched steel plates from other researchers.

^{[26]}The numerical analyses are first validated using data from dynamic centrifuge experiments that included cases with and without large foundation settlements and localized crushing of the soil-cement grids.

^{[27]}The proposed SPH method is first validated by solving non-isothermal Couette flow and non-isothermal injection molding of a circular disc with a core and comparing the SPH results with those obtained by other numerical methods or experiments.

^{[28]}The method is first validated and tuned by solving two benchmark problems: The pressure-driven flow in an elliptical tube, and the three-dimensional lid-driven cavity flow.

^{[29]}The models are first validated against known results for normal shocks, showing good agreement for species density and temperature profiles.

^{[30]}In this study, we first validated our existing SPE method for the chemical recovery of an extended set of compounds.

^{[31]}The method for estimating FetOe was first validated using a bench simulation in which tracheal oxygen was measured directly.

^{[32]}The modeled ETa rates were first validated against 13 eddy‐covariance measurements, producing Nash‐Sutcliffe efficiency values in the range of 0.

^{[33]}In this paper, the reconstruction technique was first validated by comparing the results evaluated using this technique with those obtained by computational simulation for the case of a standard horn antenna.

^{[34]}The proposed z-T2-T2 method is first validated against bulk T2-T2 measurements on homogeneous phantom consisting of cyclohexane uniformly imbibed in finely-sized α-Al2O3 particles at a spatial resolution of 0.

^{[35]}The developed FE model is first validated against two-dimensional (2D) analytical solutions.

^{[36]}Our approximate formulae are first validated by ABAQUS-based numerical simulations, and then specialized to the particular case of a fibre-reinforced composite half-space.

^{[37]}Our numerical methodology is first validated in comparison with theoretical results in purely Newtonian fluid, and then a series of numerical experiments is conducted to study the effects of different dimensionless parameters on the vesicle motions.

^{[38]}The method is first validated at Al/crystal-SiO2 (Al/c-SiO2) interface against experimental data and then extended to Al/amorphous-SiO2 (Al/a-SiO2) interface.

^{[39]}The model is first validated using the survival data of two clinical trials.

^{[40]}

## step towards personalised

Conclusion This is the first validated prognostic biomarker that can predict prognosis in newly-diagnosed IBD patients, and represents a step towards personalised therapy.^{[1]}Conclusion This is the first validated prognostic biomarker that can predict prognosis in newly diagnosed patients with IBD and represents a step towards personalised therapy.

^{[2]}Conclusion This is the first validated prognostic biomarker that can predict prognosis in newly-diagnosed IBD patients, and represents a step towards personalised therapy.

^{[3]}

## We First Validated

We first validated the stability of the BANG3 polymer gel dosimeter and performed a pre-clinical verification of this device for brain SRT.^{[1]}We first validated, in vitro, the anti-inflammatory and chondroprotective properties of the extract on primary cultured human articular chondrocytes stimulated by interleukin-1 beta (IL-1 β).

^{[2]}We first validated the CLM-Microbe model against static-chamber measured CO2 and CH4 fluxes in 2013 for three landscape types: trough, LCP center, and LCP rim.

^{[3]}We first validated its accuracy for atrial fibrillation detection compared to a 12-lead ECG.

^{[4]}We first validated lower expression of Siglec-15 in CN-deficient leukemia cells by RT-qPCR.

^{[5]}We first validated the capability of each component by precisely metering various fluid samples and controlling flow rates in a range from 219.

^{[6]}We first validated the FEKO antenna model by showing that the simulated magnetic fields match well with the measured magnetic fields from the actual antenna.

^{[7]}We first validated the upregulation of LINC00324 in OS tissues and cell lines and established its correlation with OS tumor progression and metastasis.

^{[8]}We first validated the detection of microchimerism by ddPCR and then used these assays to detect and quantify microchimerism in pre- and postinfusion liver biopsies.

^{[9]}We first validated our approach by successfully predicting positions that mediate small molecule binding or catalytic activity across different protein classes.

^{[10]}We first validated use of an α-MSH assay kit with lizard plasma.

^{[11]}We first validated our approach by investigating recombinant wildtype VWF and a previously studied mutant (p.

^{[12]}We first validated two different infection assays, a survival assay and a competition assay, using mutants containing disruptions in known B.

^{[13]}We first validated the influence of prosocial lyrics (relative to neutral lyrics) on prosocial cognition and prosocial emotion (Study 1).

^{[14]}We first validated a rapid method to estimate πₜₗₚ for grassland species, using osmometry measurements (πₜₗₚ‐ₒₛₘ) of osmotic potential at full hydration (πₒ‐ₒₛₘ), originally proposed for woody species.

^{[15]}We first validated patterns across all networks, consistent with well-established functional connectivity reports.

^{[16]}We first validated the immunogenicity of these peptides for priming Tcells with synthesized peptides in healthy HLA-A*02:01+ donors.

^{[17]}METHODS We first validated the accuracy of the system's measurement and localization capabilities by comparing known versus KODEX - EPD™-measured distances and locations at 12 different anatomical landmarks in both the atria and ventricles of four swine.

^{[18]}We first validated our simulator with two well-known model problems and the numerical results show good agreement with the existing analytical solutions.

^{[19]}We first validated that the plant we obtained in Palau was truly P.

^{[20]}We first validated the binding assay-based approach using the agonist relaxin-3, then applied it to the chimeric antagonist R3(ΔB23-27)R/I5.

^{[21]}Results: We first validated the presence of age-associated murine ovarian fibrosis.

^{[22]}We first validated that our model could generate gaits that reproduced experimentally observed kinematic, kinetic, and metabolic trends for two cases: 1) walking at prescribed speeds between 0.

^{[23]}Results We first validated the accuracy of small RNA-seq for tRNA quantification across five human cell lines.

^{[24]}We first validated our protocol comparing the obtained RNA expression pattern with the gene expression levels of RNA-seq raw data experiments from the BioProject NCBI database, using Spearman's correlation coefficients calculation.

^{[25]}We first validated this approach across two landscapes using an independent dataset of forest composition in 49 forest census plots (0.

^{[26]}We first validated this methodology using simulated illuminance-response curve data in which the intrinsic period was known.

^{[27]}We first validated the proposed strategy in simulations, and then applied it to a treatment study of heroin dependence which would have been impossible with previous methods due to a number of missing-data patterns.

^{[28]}We first validated the occipital-zone model with a test using synthetic EEG data to evaluate its performance for local brain mapping with a small number of electrodes.

^{[29]}We first validated the performances of mEASS model by using observations from six flux tower sites with different land cover and three metrics of the coefficient of determination (R2), the root mean square error (RMSE) and the difference between the simulated and observed data (bias).

^{[30]}

## first validated prognostic

To our knowledge, these are the first validated prognostic proteomic signatures.^{[1]}Conclusion This is the first validated prognostic biomarker that can predict prognosis in newly-diagnosed IBD patients, and represents a step towards personalised therapy.

^{[2]}Conclusion This is the first validated prognostic biomarker that can predict prognosis in newly diagnosed patients with IBD and represents a step towards personalised therapy.

^{[3]}Conclusion This is the first validated prognostic biomarker that can predict prognosis in newly-diagnosed IBD patients, and represents a step towards personalised therapy.

^{[4]}

## first validated method

It is the first validated method that provides the simultaneous and accurate analysis of five bioactive phytoconstituents of D.^{[1]}The present study is the first validated method which deals with the assay of Cliv-92 in mouse plasma.

^{[2]}This is the first validated method for distinguishing elephant from mammoth ivory and it provides forensic support for investigation of ivory laundering cases.

^{[3]}This is the first validated method for thiafentanil analysis in plasma.

^{[4]}

## first validated vium

The developed tool was first validated via a Charrette test involving ten participants with a total of close to forty years of project management experience in cross-functional organizations.^{[1]}FDEM was first validated via a mesh size analysis of a spherical particle and calibrated by in-situ experimental compressions of the single quartz sand particle, where the particle shape was obtained by X-ray micro-computed tomography (XCT) and then imported into the numerical model.

^{[2]}The model is first validated via using both the analytical functions and experimental data.

^{[3]}

## first validated assessment

The EPSI is the first validated assessment to predict 12-month psychotic conversion.^{[1]}CONCLUSIONS This study has developed the first validated assessment tool applicable to causes of CC.

^{[2]}

## first validated tool

Conclusions: Our study provides the first validated tool to assess RB1 biallelic loss across cancer types based on gene expression.^{[1]}ConclusionsVECTOR may represent the first validated tool for the screening of RA patients who are suspected for ILD and who should be directed to HRCT for the diagnosis.

^{[2]}

## first validated instrument

Also, it constitutes the first validated instrument in this field worldwide.^{[1]}Recent findings The recently developed Ageing Voice Index (AVI) constitutes the first validated instrument for voice complaints specifically for the elderly.

^{[2]}