Introduction to Egyptian Patients

Objectives: to evaluate the association between single nucleotide polymorphism of AIRE gene (SNP rs2075876) and risk of RA in Egyptian patients.

We aimed to evaluate the usefulness of the reference single nucleotide polymorphism (rs12979860) interleukin 28B (CC genotype) for predicting sustained virological response to sofosbuvir plus daclatasvir in Egyptian patients infected with HCV‐4.

Methods Cross-sectional study based on a questionnaire; 308 Egyptian patients with confirmed positive polymerase chain reaction (PCR) tests were included in the study after exclusion criteria.

Methods an observational, cross-sectional study carried on 340 Egyptian patients with active epilepsy.

The current study aimed at measuring the plasma levels of long non-coding RNAs (H19) expression in chronic liver disease (CLD) due to HCV genotype 4 infections with/without cirrhosis and Hepatocellular carcinoma (HCC) patients in an attempt to evaluate the potential benefits of these new circulating, noninvasive, diagnostic, prognostic and epigenetic markers for liver cirrhosis and carcinogenesis of Egyptian patients.

In our current work, we examined the miRNA-152 and DNMT-1 expression in chronic liver disease (CLD) due to HCV genotype 4 infection with/without cirrhosis and HCC patients as an attempt to evaluate the potential benefits of these new circulating, noninvasive, prognostic, epigenetic markers for liver cirrhosis and carcinogenesis of Egyptian patients.

We aimed to study the expression of podocyte-associated genes in urinary sediment and their relation to disease severity in type 2 diabetic Egyptian patients with diabetic nephropathy.

A total of 96 Egyptian patients with type 2 diabetic dyslipidemia were treated with atorvastatin 20 mg/day for 3 months.

We aimed to assess plasma BNP in HCV-positive Egyptian patients prior and after HCV eradication by direct-acting antiviral agents (DAAs) therapy.

The aim of this study was to investigate changes in some parameters of liver fibrosis progression after successful HCV eradication by direct acting antiviral (DAA) therapy in Egyptian patients.

Purpose The aim of this study was to assess the relationship of coronary artery disease (CAD) with levels of homocysteine and sortilin in Egyptian patients.

Aim of the Study: This study explored the correlation between the alleles of the rs505151 (E670G) locus of the PCSK9 gene and its expression levels with coronary artery disease (CAD) risk in Egyptian patients with type 2 diabetes mellitus (T2DM).

Patients and Methods: This was a case-control study done at Bab El-Sharia University Hospital, Al-Azhar University, arranged to conduct 90 Egyptian patients underwent elective coronary angiography for suspected CAD.

Using PCR-RFLP for TLR4 gene polymorphisms (rs11536858, rs1927911, and rs1927914), both alleles and genotypes were determined after extraction of DNA in a case-control study of 100 vitiligo Egyptian patients and 100 matched age and sex controls.

It included 120 Egyptian patients with decompensated HCV cirrhosis which was diagnosed by HCVab and polymerase chain reaction (PCR).

MATERIAL AND METHODS A questionnaire survey was performed on 665 Egyptian patients who were confirmed COVID-19-positive based on the polymerase chain reaction (PCR) test.

CONCLUSION The findings from this study suggest that 12 weeks' treatment of sofosbuvir plus daclatasvir and sofosbuvir plus ledipasvir was both efficacious and well tolerated treatment in Egyptian patients with HCV genotype 4 infection.

Purpose The study aimed to detect the frequencies of allelic variants (TPMT*3A, TPMT*3C, and TPMT*3G) in the TPMT genes in the Egyptian population and assess the association between TPMT polymorphisms and azathioprine (AZA)—clinical efficacy and adverse drug reactions among Egyptian patients with autoimmune diseases.

This study aimed to investigate the association between ELMO1 rs741301 gene polymorphism and the development of DKD among Egyptian patients with type 2 diabetes mellitus (T2DM).

This study aimed at the assessment of safety and efficacy of sofosbuvir-daclatasvir treatment regimens in HIV/HCV co-infected Egyptian patients.

Here, we aimed to test whether polymorphisms in IL10, MTP, SOD2, and APOE genes correlated with the severity of fibrosis induced by HCV genotype 4 (HCV-gt4) in a cohort of chronically infected Egyptian patients.

Determinants Influencing Awareness and Healthy Practices among a Sample of Insulin-dependent Diabetic Egyptian Patients: A Rural Community-based Study.

Subjects and Methods: A crosssectional study was conducted on 245 diabetic Egyptian patients.

We performed whole-genome high throughput sequencing on isolates from 50 Egyptian patients to see if the variation in clinical symptoms was related to mutations in the SARS-CoV-2 genome.

Aim In this study, the characteristics and outcomes of 50 Egyptian patients admitted to the first PICU in the Middle East region between April 2015 and October 2018 were retrospectively examined.

The aim of the study is to elucidate changes in gut microbiome in cirrhotic HCV Egyptian patients with and without HCC.

The aim of this work was to assess the prevalence of hepatic steatosis among HCV Egyptian patients and the long term changes occur after viral eradication.

Methods: Different TIM-3 and CEACACM-1 expressions were evaluated in immunohistochemically stained paraffin embedded sections from 60 Egyptian patients with bladder urothelial carcinoma.

Methods: this study was conducted on 60 Egyptian patients (study group); Group I comprise 20 patients with chronic HCV infection, Group II comprise 20 patients with HCV cirrhosis, Group III comprise 20 patients with HCC due to HCV infection, and also, control group comprise 20 apparently healthy individuals.

Sixty Egyptian patients diagnosed according to the International Study Group (ISG) criteria for Behçet disease and 160 healthy geographic and ethnic‐matched controls were genotyped for HLA class I loci (HLA‐A, B, C).

Patients and Methods: Sixty Egyptian patients presented with melasma were enrolled into our study and divided into 2 equal groups: group A with intradermal injection of tranexamic acid, and group B were injected with intradermal saline.

This study aimed to evaluate the efficacy and safety of ombitasvir / paritaprevir / ritonavir with or without ribavirin in treatment of chronic hepatitis C Egyptian hemodialysis patients to compare it with the same treatment result in chronic hepatitis C Egyptian patients with normal renal functions.

Aim of this Work: This study aimed to assess IFNL4 polymorphism among hepatitis C Egyptian patients who were exposed to radiation, compared to normal by a polymerase chain reaction with restriction of fragment length polymorphism (PCR-RFLP) technique.

One hundred twenty adult Egyptian patients presented with NOS were enrolled in a hospital-based cross-sectional observational study within a time period of 6 months from March till September 2018.

This study aims to identify the etiology of NOS among different age and sex groups of adult Egyptian patients.

Patients and methods A multicenter study included Egyptian patients with different RDs; nutrition measurements and common features of deficiency were assessed; general appearance, skin, hair/nail changes, spooning of nails, night blindness, mouth problems, edema, tetany, dysphagia, diarrhea, thyromegaly, loss of appetite and weight loss.

The present pilot study included Egyptian patients with type 2 diabetes (T2D): A total of 84 patients with T2D (age 49-64 years; 20 men) were included in the analysis of the present study.

This study was conducted on 100 Egyptian patients who presented during the first 3 h of AMI in the emergency department and 98 healthy volunteers as a control group.

Patients and Methods: The present study was conducted on study on 100 Egyptian patients diagnosed as primary fibromyalgia categorized according to drug medication into two 2 groups, 50 patients on SSRIs and 50 patients on SNRIs, recruited from Rheumatology, Physical Medicine and Rehabilitation Departments at Al-Hussein and Sayed Galal, Al-Azhar University Hospitals.

This study included one hundred Egyptian patients, divided into two groups 50 patients each.

MATERIALS AND METHODS One hundred Egyptian patients with NAFLD selected from outpatient's clinics of Mansoura University Hospitals underwent histological examination through liver biopsy after approval and consent.

In this study, we aimed to evaluate the changes in thyroid functions after gastric sleeve operation for morbidly obese Egyptian patients.

Methods The study included 120 obese Egyptian patients with MAFLD, which were diagnosed and classified according to ultra-sonographic liver findings.

Patients and Methods: This study was conducted on fifty Egyptian patients with Lupus Nephritis (LN) and 10 healthy subjects as a control.

Patients and methods Fifty Egyptian patients with UC were divided into two groups: group I including 40 patients with active UC (newly diagnosed) and group II including 10 patients with inactive UC (previously diagnosed); disease activity was assessed according to the Mayo activity scoring index; fecal BAFF and fecal calprotectin were measured for all patients using enzyme-linked immunosorbent assay.

The current study aimed to measure the levels of serum IP-10 and SAA in positive COVID-19 Egyptian patients to explore their clinical values and significance in discrimination between moderate and severe COVID-19 infection and predicting the severity and prognosis of COVID-19 disease.

Purpose Study the role of the neutrophil lymphocyte ratio (NLR), derived NLR ratio (d-NLR), platelet lymphocyte ratio (PLR), and lymphocyte monocyte ratio (LMR) in predicting the outcome of COVID-19 Egyptian patients.

Here, we report three unrelated Egyptian patients with variable severity of MAD features.

Aim The authors report four unrelated Egyptian patients with MBS presented with variable oral and dental abnormalities.

This study was performed on 40 Egyptian patients who have Chronic viral hepatitis C, divided into 3 groups: GROUP I includes: 20 patients with Chronic viral hepatitis C on Sofosbovir- Daclatasvir before start of treatment and Sustained viral response after 12 weeks [SVR 12].

Material and methods The study includes 40 Egyptian patients who were diagnosed with FMF according to Tel-Hashomer criteria.

Methods This prospective interventional study enrolled 25 Egyptian patients presenting to the Main Alexandria University Hospital who had clinical and radiological features of DPLD, but insufficient elements to achieve definite features of usual interstitial pneumonia on chest high-resolution computed tomography.

Methods: A prospective interventional study that enrolled 25 Egyptian patients presented to Main Alexandria University Hospital (Egypt) who had clinical and radiologic features of DPLD, but insufficient elements to achieve definite features of usual interstitial pneumonia (UIP/IPF) in chest high resolution computed tomography (HRCT).

Conclusion Compared to healthy controls, recently diagnosed SLE Egyptian patients have an altered fecal microbiota profile with significant lowering of both F/B ratio and Lactobacillus abundance, which is weakly correlated with disease activity.

Methods 82 newly diagnosed SLE Egyptian patients.

It included 120 Egyptian patients with decompensated HCV cirrhosis which was diagnosed by HCVab and polymerase chain reaction (PCR).

Patients and Methods: The study population was 120 Egyptian patients from both sexes undergoing laparoscopic surgery under general anesthesia with endotracheal intubation at Al-Azhar University Hospitals (El Hussein Hospital and Bab Al-Sharya Hospital).

Patients and Methods: Two hundred and three Egyptian patients with the diagnosis of RRMS were recruited consecutively from MS Unit of Neurology department at Ain Shams University Hospital which is the biggest MS unit in Egypt, Cross sectional pilot study.

Methods: This study included forty three Egyptian patients with HCV infection diagnosed by HCV RNA real time quantitative PCR whose ages were ranged from 29-71 , All patients took anti-viral treatment according to the rules of the committee responsible for hepatitis c virus control in Egypt.

This work was planned to contribute to the description of the possible causative mutations of CYP1B1 gene that are related to PCG affected Egyptian patients.

This work was planned to contribute to the description of the possible causative mutations of CYP1B1 gene that are related to PCG affected Egyptian patients.

Objectives To examine the frequency of comorbidity and the degree of severity of depressive and anxiety disorders with SUDs in a sample of upper Egyptian patients.

In this study, we tried to investigate the probable relationship between type and number of used substances with the degree of severity of substance used disorders in a sample of upper Egyptian patients.

Our study aimed at identifying the association of NOS3 (rs 2070744) and SOD2 Val16Ala (rs4880) gene polymorphisms within ESRD Egyptian patients.

Objectives: We aimed at revealing the association between CC genotype of MicroRNA-30a rs1358379 polymorphism and occult HBV infection in ESRD Egyptian patients.

METHODS Sixty clinically diagnosed HCC Egyptian patients and 25 healthy volunteers were enrolled in the study.

Conclusion Our findings suggest for the first time the HPSE gene SNP characterization in HCC Egyptian patients, and our findings reveal there were associations between the HPSE rs12503843 (T allele) and the susceptibility to HCC.

Patients and Methods: This was a case-control study done at Bab El-Sharia University Hospital, Al-Azhar University, arranged to conduct 90 Egyptian patients underwent elective coronary angiography for suspected CAD.

90 Egyptian patients were recruited and were divided into 3 Group I included 30 patients with liver cirrhosis, HCC was excluded in these patients at time of recruitment in the study, exclusion of HCC was based on the absence of any hepatic focal lesion in abdominal ultrasonography scanning.

PATIENTS AND METHODS This cross-sectional study included 197 Egyptian patients with CHC.

Patients and methods: a case control study included 197 Egyptian patients with prediabetes; 113 patients with iron deficiency versus 84 patients without iron deficiency (control group) during the period (May 2019 - October 2019).

One hundred twenty adult Egyptian patients presented with NOS were enrolled in a hospital-based cross-sectional observational study within a time period of 6 months from March till September 2018.

Aim of Study: The aim of the study is to evaluate the epidemiological and the endoscopic features of colorectal masses in Egyptian patients presented to “Kasr Al-Ainy” Endoscopy Unit.

The present retrospective case-control aimed to study INSR H1085H C > T (rs 1799817) SNP in Egyptian patients suffering from chronic HCV infection with DM.

Since novel insights have been gained with the advent of functional magnetic resonance imaging, we aimed to explore potential functional alterations in various areas of the brain in a sample of Egyptian patients suffering from conversion disorder.

Sixty Egyptian patients diagnosed according to the International Study Group (ISG) criteria for Behçet disease and 160 healthy geographic and ethnic‐matched controls were genotyped for HLA class I loci (HLA‐A, B, C).

The aim of the present study is to describe the neurological manifestations in a group of Egyptian patients diagnosed with Covid-19.

Owing to their potential morbidity, these diseases need to be considered in Egyptian patients presenting with intermediate uveitis.

Methods This prospective interventional study enrolled 25 Egyptian patients presenting to the Main Alexandria University Hospital who had clinical and radiological features of DPLD, but insufficient elements to achieve definite features of usual interstitial pneumonia on chest high-resolution computed tomography.

CONCLUSION FokI AA genotype is more associated with HT in Egyptian patients compared to hypothyroid non-HT controls.

Objective: To evaluate the role of reticulocyte hemoglobin content and soluble transferrin receptor concentration for detection of iron deficiency anemia in chronic kidney disease in Egyptian patients compared to conventional markers.

We aimed to evaluate the usefulness of the reference single nucleotide polymorphism (rs12979860) interleukin 28B (CC genotype) for predicting sustained virological response to sofosbuvir plus daclatasvir in Egyptian patients infected with HCV‐4.

The aim of this study was to evaluate the efficacy of a sofosbuvir-based treatment protocol composed of sofosbuvir and daclatasvir with or without the addition of ribavirin in Egyptian patients infected with HCV genotype 4 in Sharkia governorate.

pylori infection in Egyptian patients undergoing endoscopy and complaining of persistent upper gastrointestinal symptoms directly in biopsy specimens using PCR technique and to study the associated virulence-related genes in H.

OBJECTIVE To determine the association between pre-operative frailty through multidimentional assessment score, and the incidence of post-operative complications and to validate Robinson score in geriatric Egyptian patients undergoing elective cardiac surgery.

Patients and Methods: This was a case-control study done at Bab El-Sharia University Hospital, Al-Azhar University, arranged to conduct 90 Egyptian patients underwent elective coronary angiography for suspected CAD.

Methods: this study included 52 Egyptian patients underwent radical cystectomy and orthotopic neobladder reconstruction with sigmoid (25 patients) and ileal (27 patients) segments.

We used characterized SARS-COV-2 strain, severe acute respiratory syndrome coronavirus 2 isolates (SARS-CoV-2/human/EGY/Egy-SERVAC/2020) with accession numbers; MT981440; MT981439; MT981441; MT974071; MT974069 and MW250352 at GenBank that isolated from Egyptian patients SARS-CoV-2-positive.

Methods Characterized SARS-COV-2 strain, severe acute respiratory syndrome coronavirus 2 isolates (SARS-CoV-2/human/EGY/Egy-SERVAC/2020) with accession numbers; MT981440; MT981439; MT981441; MT974071; MT974069; and MW250352 at GenBank were isolated from Egyptian patients SARS-CoV-2-positive.