Introduction to Dissociation Rates
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Dissociation Rates sentence examples within Slow Dissociation Rates
Real-time kinetic analysis of the ULD/AB protein complex to the BAP1-UCH domain, based on surface plasmon resonance, indicated that formation of the ULD/AB complex with the UCH domain is a single-step event with fast association and slow dissociation rates.
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However, they show similar slow dissociation rates leading to pseudo-irreversible binding kinetics at DAT.
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Dissociation Rates sentence examples within Slower Dissociation Rates
Slr0701 binds to cis‐regulatory element with faster association and slower dissociation rates in the presence of HgCl2.
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Mirogabalin showed potent and selective binding affinities for the α2δ subunits, and slower dissociation rates for the α2δ-1 subunit than for the α2δ-2 subunit.
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Dissociation Rates sentence examples within Higher Dissociation Rates
Antipsychotics with lower affinity and higher dissociation rates from the D2 receptor tend to induce less dopamine supersensitivity (Servonnet and Samaha, 2020) and can lead to a faster recovery of the neuroadaptation processes.
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Park’s two temperature model predicted higher dissociation rates and a higher degree of dissociation leading to lower peak vibrational temperatures compared to those predicted by the new nonequilibrium models.
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Dissociation Rates sentence examples within Increased Dissociation Rates
The IAA2-DT deletion reduced binding to TIR1 in vitro with both natural and synthetic auxins, causing reduced association and increased dissociation rates.
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Quantitation of drug-binding kinetics using live-cell imaging of Flutax-2 (fluorescently-labeled taxane) in native cytoskeletons, showed that CLIP1S caused Flutax-2 to have significantly reduced affinity and increased dissociation rates from MTs, as compared with cells expressing only the canonical CLIP1.
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Dissociation Rates sentence examples within Receptor Dissociation Rates
Dissociation Rates sentence examples within Exciton Dissociation Rates
The enhanced photovoltaic performance, realized by virtue of the improved shortcircuit current density, can be attributed to the slightly enhanced electron mobility, higher exciton dissociation rates, more efficient charge collection and better nanoscale phase separation of the PBDTbased device.
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In the present paper, we introduce a numerical procedure, based on exterior complex scaling, capable of computing field-induced exciton dissociation rates for a wider range of field strengths than previously reported in literature.
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Dissociation Rates sentence examples within Ligand Dissociation Rates
The ability of DcpG to differentially control GGDEF and EAL domain activity in response to ligand binding is likely due to the unusual properties of the globin domain, including rapid ligand dissociation rates and high midpoint potentials.
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τRAMD yields relative ligand dissociation rates in good accordance with experiments across this diverse set of complexes that differ with regard to measurement temperature, ligand identity, protein mutation and binding cavity.
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Dissociation Rates sentence examples within dissociation rates directly
Dissociation Rates sentence examples within dissociation rates koff
Dissociation Rates sentence examples within dissociation rates lead
It has been observed that change in amplitude of dissociation rates leads to non-monotonic behavior of stationary phase diagrams and significant modifications in the dynamic properties.
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Instead, increased association rates and decreased dissociation rates lead to a strong decrease in the effective maximal velocities Vmax and the effective Michaelis-Menten constants KM under physiologically relevant volume occupancies.
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To overcome the limitation in linker design, we reported herein dual responsive dynamic covalent peptide tags combining a pH responsive boronate ester with fast association and dissociation rates, and a redox-active disulfide with slow formation and dissociation rate.
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In spite of intensive studies on FABP-membrane interactions, the interaction mode remains elusive and the protein-membrane association and dissociation rates are inconsistent.
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Thermodynamic and kinetic Ca2+ binding studies showed that BP2 addition increased the Ca2+-binding affinity of CaM and slowed its Ca2+ dissociation rates (koff) in both the C- and N-lobe EF-hand domains, respectively.
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hydrate formation and dissociation rates) and the storage capacity.
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The dissociation rates of RBC- and HWPP-bound 212Bi were (0.
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Si-Si, C–C and Si-C are considered to be unstable dimers and the dissociation rates are determined by their binding energies, substrate temperature and the geometry of adsorption sites of Si and C on the surface.
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Labeling of analytes does not affect their association and dissociation rates (on and off rates) from GMR biosensors which enables kinetic measurements in biologically relevant matrices.
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We use quartz crystal microbalance (QCM) and develop novel temperature perturbation experiments based on differential scanning fluorimetry (DSF) to measure the temperature dependence of the fibril growth and dissociation rates, allowing us to quantitatively describe the thermodynamic stability of PI3K-SH3 amyloid fibrils between 10 and 75°C.
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Here we describe a DNA polymerase assay that allows retrieving, in a single experimental set, association and dissociation rates, as well as the catalytic rate of the enzyme.
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We analyzed the MC effect using a magnetoconductance model controlled by interconversion of the singlet and triplet (MIST) electron-hole (e-h) pairs states based on density matrix formalism using the stochastic Liouville equation considering that the singlet and triplet e-h pairs have different recombination and dissociation rates to theoretically reproduce the line shape of MC.
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Applications of the LTE cross sections to compute photodissociation rates in the standard interstellar radiation field and blackbody radiation field are briefly discussed.
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We also present evidence of polyad-specificity in the state-dependent predissociation rates, leading to free atomic and molecular fragments.
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By fitting to a desorption–release model, where the transmitters adsorbed to the vesicle membrane, the dissociation rates of DA and 5-HT from the liposome membrane were estimated.
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OBJECTIVE
Imaging activated glutamate N-methyl-D-aspartate receptor ion channels (NMDAR-ICs) using positron emission tomography (PET) has proved challenging due to low brain uptake, poor affinity and selectivity, and high metabolism and dissociation rates of candidate radioligands.
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Dissociation rates of the aptamer–thrombin complexes were drastically slowed due to these modifications.
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By fitting to a desorption-release model, where the transmitters adsorbed to the vesicle membrane, the dissociation rates of DA and 5-HT from liposome membrane were estimated.
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The model does remarkably well in quantitatively explaining a complex data set with just the addition of drug binding and dissociation rates for the R and T conformations.
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To overcome this, we designed dual responsive peptide tags combining: (1) a pH responsive boronate ester with fast association and dissociation rates, and (2) a redox-active disulfide with slow formation and dissociation rate.
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Based on the calculated LTE cross-sections, the photodissociation rates in the interstellar, solar, and blackbody radiation fields were obtained as well.
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Knowledge on amino acid’s dissociation rates by solar wind is relevant for the study of biomaterial resistance in space.
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Using the computed cross sections, temperature-dependent photodissociation rates of AlCl in the interstellar and blackbody radiation fields are determined.
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BIAcore allows to study association and dissociation rates in real time without the use of labeling.
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The analysis of the growth and dissociation rates of the C-terminal truncated FtsZ (FtsZt) filaments indicate the net growth and dissociation of FtsZt filaments in the growth and dissociation conditions, respectively.
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The reported PICS on benzonitrile and cyanotoluene isomers in the present work could contribute to the near-threshold PIMS experiments and determine the ionization and dissociation rates in interstellar space for these crucial species.
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For larger ligands, crowding decreases the accuracy of the receptor's estimate primarily by decreasing the microscopic association and dissociation rates.
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Our detailed kinetic data on the association and dissociation rates of nsAmgs and ADP shed light on the biophysical processes underlying the enzyme's Theorell-Chance reaction mechanism.
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Biolayer interferometry using eEF1A paralogs showed different association and dissociation rates with RT.
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Correlating the measured survival yields of five of the R,R'-BhPy+ ions with the computed threshold energies including explicit consideration of their dissociation rates, we derive energy distributions with maxima at 2.
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Theoretical calculations suggest that the association and dissociation rates of the GBPs depend on their sequence-dependent conformations and interactions with the gold surface.
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Whereas the CO binding rates are similar to those of other heme-based sensor proteins, the dissociation rates are two to three orders of magnitude lower.
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However, receptor-ligand association and dissociation rates in the case of SCF-Lα-GCSF ligand are about 10 times lower than that of mGCSF.
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It has been shown that the dissociation rates and the equilibrium dissociation constants vary significantly even with similar warheads, due to noncovalent interactions.
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We find that a rise in metallicity basically leads to a reduction of the photodissociation rates of the hydrocarbons and therefore the haze monomer production rates.
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New data on collisional rate coefficients for the (de-)excitation of H$_2$ molecule in collisions with H atoms and new H$_2$ dissociation rates are used.
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Both the binding and dissociation rates of Reb1 and Cbf1 are significantly slower at the nucleosomal sites relative to those for naked DNA, demonstrating that the high affinities are achieved by increasing the dwell time on nucleosomes in order to compensate for reduced binding.
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The dissociation rates of five EuII-containing cryptates in water were measured using UV-visible spectroscopy and murexide at pH 6.
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We then review the experimental literature with regard to properties that have been described as characteristic for IDP binding, such as affinity and specificity, as well as association and dissociation rates.
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The significance of the characteristic timescales governing the formation and dissociation rates of metal-nanoparticle complexes in defining the relaxation properties and the complete equilibration of the metal/nanoparticulate complex dispersion is described.
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This unique dissociation feature was attributed to the significant difference in the dissociation rates as obtained by the Rice-Ramsperger-Kassel-Marcus theory calculations as well as structural restriction.
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FISIK consists of (I) devising a mathematical model of molecular movement and interactions, mimicking the biological system and data-acquisition setup, and (II) estimating the unknown model parameters, including molecular association and dissociation rates, by fitting the model to experimental single-molecule data.
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By subtracting residual high‐affinity binding in δKO mice and measuring the slow association and dissociation rates we show that native δ‐GABAARs in WT mice exhibit high‐affinity [3H]muscimol‐binding sites (KD ~1.
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We will then consider the molecular characteristics of a ligand and if these can be linked to association and dissociation rates.
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Fluorescence Correlation Spectroscopy (FCS) has been extensively used to measure equilibrium binding constants (K) or association and dissociation rates in many reversible chemical reactions across chemistry and biology.
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The cation and halide ion are the main parts of the charge transfer from the dynamic viewpoint, while the exciton formation/dissociation rates, Rd/Ra, are mainly affected by BX3 anion.
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On the basis of the key fingerprints extracted it can be inferred that the dissociation rates of 37 HIV-1 PIs are basically determined in the first half of the dissociation processes and that the H-bond interactions with active-site Asp25 and van der Waals interactions with flap-region Ile47 and Ile50 have important influences on the dissociation processes.
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The use of DGTs with different diffusion domain thicknesses provides information to quantify labilities and dissociation rates of metal complex pools.
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RESULTS
We isolated DDR1-collagen interactions and quantified the association and dissociation rates of the DDR1-collagen I complex.
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Computational modeling of RAF1 dynamics revealed that RAF1 membrane abundance is controlled most prominently by association and dissociation rates from RAS-GTP and by RAS-GTP concentration.
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The PSMA-specific association and dissociation rates of Ga-PSMA-11 were measured using surface plasmon resonance technology.
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Compared to the unlabeled target, these labels can slow the association and dissociation rates by as much as a factor 5.
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