Introduction to Dissociation Constant
Sentence Examples
Discover more insights into Dissociation Constant
Keywords frequently search together with Dissociation Constant
Narrow sentence examples with built-in keyword filters
Dissociation Constant sentence examples within surface plasmon resonance
Surface plasmon resonance experiments showed that these RJ proteins can exhibit much higher binding affinity to LDL than Ox-LDL (the equilibrium dissociation constant, KD = 8.
Full Text
Based on surface plasmon resonance measurements, the apparent dissociation constant of the Tet-IgG-AuNC-tetanus toxoid complexes was measured to be 2.
Full Text
Dissociation Constant sentence examples within nuclear magnetic resonance
However, nuclear magnetic resonance spectroscopy (NMR) and native mass spectrometry (MS) analyses yielded incongruent dissociation constants (KD) for binding of HBGAs to P dimers and, in some cases, disagreed whether glycans bind at all.
Full Text
The best docking poses of EGCG with Hup were first evaluated for their solution stability using long run molecular dynamics simulations and then using fluorescence and nuclear magnetic resonance titration experiments which demonstrated that the binding of EGCG with Hup is fairly strong (the resultant apparent dissociation constant (kD) values were equal to 2.
Full Text
Dissociation Constant sentence examples within binding free energy
Each entry provides comprehensive information on sequence and structural features of a protein, nucleic acid and its complex, experimental conditions, thermodynamic parameters such as dissociation constant (Kd), binding free energy (ΔG) and change in binding free energy upon mutation (ΔΔG), and literature information.
Full Text
Using a rigorous absolute binding free-energy technique, we calculate a dissociation constant in the low millimolar range for binding of 8-mer beta-1,3 oligoglucan to this site on CD28.
Full Text
Learn more from Dissociation Constant
Dissociation Constant sentence examples within low nanomolar range
Highly selective DNA aptamers were identified that bind piperaquine and mefloquine with dissociation constants (Kd’s) measured in the low nanomolar range via two independent methods.
Full Text
All homologous NTDs showed a similarly fast association in the order of 10^9 M^−1 s^−1, while the resulting equilibrium dissociation constants were in the low nanomolar range.
Full Text
Dissociation Constant sentence examples within copies per cell
A specificity of binding of FAM-ME07 to the receptor on the tumor cells has been demonstrated by flow cytometry; an apparent dissociation constant for the complex of aptamer – EGFR on the cell has been determined; a number of EGFR molecules has been semi-quantitatively estimated for the tumor cell lines having different amount of EGFR: A431 (10 6 copies per cell), U87 (10 4 copies per cell), MCF7 (10 3 copies per cell), and ROZH, primary GBM cell culture derived from patient (10 4 copies per cell).
Full Text
Dissociation Constant sentence examples within Equilibrium Dissociation Constant
Dissociation Constant sentence examples within Acid Dissociation Constant
The recently proposed multiphase buffer theory provides a framework to reconstruct long-term trends and spatial variations of aerosol pH based on the effective acid dissociation constant of ammonia (Ka,NH3).
Full Text
The calculation of acid dissociation constants (pKa) is an important task in computational chemistry and chemoinformatics.
Full Text
Dissociation Constant sentence examples within Apparent Dissociation Constant
Based on surface plasmon resonance measurements, the apparent dissociation constant of the Tet-IgG-AuNC-tetanus toxoid complexes was measured to be 2.
Full Text
The TBA-4PI GQ affords the desired turn-on fluorescence response for detecting Pb2+ ions with an apparent dissociation constant (Kd) of 63 nM and a limit of detection (LOD) of 19 nM in an aqueous buffer.
Full Text
Dissociation Constant sentence examples within Lower Dissociation Constant
They differ from multi-enzyme complexes in that they are dynamic, rather than permanent, and as such have considerably lower dissociation constants.
Full Text
However, compounds that stabilize Aβ monomers displayed higher association constants (Ka) and lower dissociation constants (Kd) in comparison to partial and noninhibitors, as corroborated by ITC.
Full Text
Dissociation Constant sentence examples within Calculated Dissociation Constant
Dissociation Constant sentence examples within Base Dissociation Constant
The acid-base dissociation constants of these compounds were determined in an aqueous solution.
Full Text
We performed Metropolis Monte Carlo simulations to investigate the impact of varying acid and base dissociation constants on the pH-dependent ionization and conformation of weak polyampholyte microgels under salt-free conditions and under explicit consideration of the chemical ionization equilibria of the acidic and basic groups and their electrostatic interaction.
Full Text
Dissociation Constant sentence examples within Micromolar Dissociation Constant
It was shown that aptamers bind neither isocarbophos nor phorate in free solution with the claimed micromolar dissociation constants.
Full Text
We predict that oligotrophs can attain nanomolar half-saturation concentrations using binding proteins with only micromolar dissociation constants and while closely matching transport and metabolic capacities.
Full Text
Dissociation Constant sentence examples within Average Dissociation Constant
Dissociation Constant sentence examples within Showed Dissociation Constant
HSQC NMR titration experiments showed dissociation constants of this series in the high µM to low mM range and X-ray crystallography produced three co-structures, showing binding in the hydrophobic groove, comparable with that of the previously reported benzofurans.
Full Text
In ITC binding assay, dioscin, celastrol, saikosaponin C, epimedin C, torvoside K, and amentoflavone showed dissociation constant (K
d) = 0.
Full Text
Dissociation Constant sentence examples within Determined Dissociation Constant
The MST-determined dissociation constant of the FTO homodimer was consistent with their in vivo formation in human cells.
Full Text
Herein, we performed a structural investigation using molecular dynamics simulations and determined dissociation constant (KD) values using surface plasmon resonance (SPR) assays of three fastspreading SARS-CoV-2 variants, Alpha, Beta and Gamma ones, as well as genetic factors in the host cells that may be related to the viral infection.
Full Text
Dissociation Constant sentence examples within Acidic Dissociation Constant
The target pesticides comprise 75 compounds, including phenoxy acid, sulfonylurea, imidazoline, and triazolopyrimidine herbicides, with acidic dissociation constant (pKa) values of 1.
Full Text
Acidic dissociation constant (pKa) is an important physicochemical parameter in absorption, dissociation and elimination mechanisms of drugs in body.
Full Text
Dissociation Constant sentence examples within Experimental Dissociation Constant
Dissociation Constant sentence examples within Μm Dissociation Constant
Aminoanilinyltriazine 22 was particularly notable as it shows no detectable binding to JAK2 JH1, and it has a 65-μM dissociation constant K d with V617F JAK2 JH2.
Full Text
Biophysical characterization of adhesion suggests that identified peptides bind hPSCs through α6-integrin with sub-μM dissociation constants similar to laminin.
Full Text
Dissociation Constant sentence examples within Binding Dissociation Constant
These chimeras form high-affinity interactions with GPER and ER with binding dissociation constants of ∼30 nM and 10-20 nM, respectively.
Full Text
Also, the binding dissociation constants (Kd) of the flavonoids presenting a specific wavelength for the ternary complexes were determined using UV-VIS spectroscopy, showing that the lack of a hydroxyl group on C3 only slightly reduces the affinity (Kd increased from 13.
Full Text
Dissociation Constant sentence examples within Incongruent Dissociation Constant
However, nuclear magnetic resonance spectroscopy (NMR) and native mass spectrometry (MS) analyses yielded incongruent dissociation constants (KD) for binding of HBGAs to P dimers and, in some cases, disagreed whether glycans bind at all.
Full Text
However, nuclear magnetic resonance spectroscopy (NMR) and native mass spectrometry (MS) analyses yielded incongruent dissociation constants (KD) for the binding of HBGAs to P dimers and, in some cases, disagreed on whether glycans bind at all.
Full Text
Dissociation Constant sentence examples within Larger Dissociation Constant
Such a scenario is consistent with the six times larger dissociation constant of oxidized as compared to reduced Pc and mechanistically explains how this molecular machine optimized electron transfer for fast turnover.
Full Text
Such a scenario is consistent with the six times larger dissociation constant of oxidized as compared with reduced Pc and mechanistically explains how this molecular machine optimized electron transfer for fast turnover.
Full Text
Dissociation Constant sentence examples within Low Dissociation Constant
NMR binding-target results shows that the 4,2-Ethylamino-Pyridine group is spatially closer to hAChE surface chemical arrangement than 2,2' bipyridine counterpart, exerting an efficient intermolecular interaction, with a low dissociation constant (KD ≈ 55 μM), probing that 4,2-Ethylamino-pyridine motif plays a key role in the inhibitory action.
Full Text
Dissociation Constant sentence examples within Thermodynamic Dissociation Constant
An estimate is made of the limiting values of electrical conductivity, the degree of dissociation, and the thermodynamic dissociation constants of hydrogen chloride in n-alcohols in the temperature range of 278–328 K with a step of 10 K.
Full Text
It is known that the ionic strength of a solution, which is a fundamental component in assessing the activity coefficient and the thermodynamic dissociation constant of an electrolyte, is influenced by the ions present in the system.
Full Text
Dissociation Constant sentence examples within Lowest Dissociation Constant
Our study shows that natural phytoconstituents in Triphala (a blend of Emblica Officinalis fruit, Terminalia bellerica fruit, and Terminalia chebula fruit), namely chebulagic acid, chebulinic acid, and elagic acid, exhibited the highest binding affinity and lowest dissociation constants (Ki), against the conserved 3CLpro main protease of SARSCoV-2, SARS-CoV, HCoV-HKU1, and HCoV-229E.
Full Text
Dissociation Constant sentence examples within Estimated Dissociation Constant
Dissociation Constant sentence examples within High Dissociation Constant
Tetraspanin 8 dimerization is described by a high dissociation constant (Kd = 14700 ± 1100 Tspan/μm2), one of the highest dissociation constants measured for membrane proteins in live cells.
Full Text
Moreover, this reduced fluoresceinamine-based sensor has a high photostability and high dissociation constant, which is an indication that the complex obtained between reduced fluoresceinamine (RFL) and Fe(II) is highly stable.
Full Text
Dissociation Constant sentence examples within Appropriate Dissociation Constant
The results demonstrate that CBD-based probes have tunable reactivities and appropriate dissociation constants for GSH, and are highly GSH-selective and suitable for bioimaging.
Full Text
Herein, we prepared K+ fluorescent nanoprobes (KFK-Cat NPs) with appropriate dissociation constant (Kd) value (127 mM K+) and excellent stability, especially photostability, for intracellular K+ sensing and imaging.
Full Text
Dissociation Constant sentence examples within Stepwise Dissociation Constant
Dissociation Constant sentence examples within dissociation constant kd
We also discuss some overall considerations for a successful pull-down experiment, with a focus on practical applications of the dissociation constant KD between the protein and the tRNA and the off-rate.
Full Text
Dissociation Constant sentence examples within dissociation constant value
The higher ΔG values with lesser dissociation constant values also affirm the stronger and spontaneous interaction by SARS-CoV2 proteins with MHCs.
Full Text
Importantly, comparing the three drugs, the formation of NPs occurred at significantly lower absolute concentration and significantly lower drug / polymer ratio as the cac takes lower values, indicating a stronger binding to the polymer, as also deduced from the respective drug / polymer dissociation constant values.
Full Text
Dissociation Constant sentence examples within dissociation constant around
We show that RACT dimerizes with a dissociation constant around 100 nM, over an order of magnitude stronger than GL3ACT.
Full Text