Introduction to Cancer Models
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Cancer Models sentence examples within anti tumor activity
The crude extract of Vernonia cinerea as well as the active molecule obtained through the chemical route (ENZ302) showed anti-tumor activity against various cancer models including CML, AML, ALL, HER2+ breast cancer, colon cancer, etc.
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Subcutaneous immunization with the nanovaccine yielded a potent anti-tumor activity in several cancer models, including B16-F10, Lewis lung cancer (LLC), intracranial LLC xenograft, as well as CT-26 colon cancer.
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Cancer Models sentence examples within immune checkpoint blockade
Objectives: We have previously shown that PARP inhibition (PARPi) synergizes with CTLA-4 immune checkpoint blockade, improving survival in syngeneic high grade serous ovarian cancer models.
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In conclusion, our results enhance understanding of the function of VEGFR2 signaling on myeloid cells and suggest that selective inhibition of VEGF from binding VEGFR2 facilitates immune activation landscape in breast cancer models, which might enhance the efficacy of immune checkpoint blockade.
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Cancer Models sentence examples within triple negative breast
We chose intra-vital microscopy of mammary tumor windows to validate our approach in two orthotopic breast cancer models: a MYC-overexpressing, transgenic, triple-negative breast cancer (TNBC) model and a murine model of the 4T1 family.
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Here, we present a novel 3D, miniaturized assay for the evaluation of EGFR-targeted CAR-T cell cytotoxicity and specificity on tumor-stroma triple-negative breast cancer models in microfluidic devices.
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Cancer Models sentence examples within programmed cell death
Recent studies have shown that certain arsenic compounds including arsenic hexoxide (AS4O6; hereafter, AS6) induce programmed cell death and cell cycle arrest in human cancer cells and murine cancer models [3, 4].
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In the present study, we demonstrate that EZH2 inhibition in prostate cancer models activates a double-stranded RNA-STING-ISG stress response upregulating genes involved in antigen presentation, Th1 chemokine signaling and interferon response, including programmed cell death protein 1 (PD-L1) that is dependent on STING activation.
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Cancer Models sentence examples within small molecule inhibitor
Similarly, inhibiting BCL6 using a small molecule inhibitor enhanced paclitaxel treatment efficacy both in vitro and in vivo in breast cancer models.
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ResultsHere, we show that targeting BET bromodomains using the small molecule inhibitor JQ1 decreased PD-L1 expression and mitigated tumor progression in prostate cancer models.
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Cancer Models sentence examples within potent antitumor activity
A novel monoclonal antibody targeting cell-surface plectin has potent antitumor activity in ovarian cancer models [abstract].
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Noscapine is a phthalide isoquinoline alkaloid present in the latex of Papaver somniferum and has demonstrated potent antitumor activity in various cancer models.
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Cancer Models sentence examples within inhibited tumor growth
We showed that expression of EGFR, HER2 and HER3 was increased in these gemcitabine-resistant pancreatic cancer models, and that an antibody mixture against all three receptors inhibited tumor growth in mice and downregulated HER receptors.
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In in vivo studies, PSMA-1-VcMMAE significantly inhibited tumor growth leading to prolonged animal survival in different animal models, including metastatic prostate cancer models.
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Cancer Models sentence examples within enhanced anti tumor
Subsequently, we tested whether the combination protocol would result in enhanced anti-tumor activity and antifibrotic effect in mouse 4T1 breast cancer and CT26 colon cancer models.
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ABBV-176, which cross links DNA and causes DNA breaks by virtue of its PBD warhead, also demonstrates enhanced anti-tumor activity in several breast cancer models when combined with a poly-ADP ribose polymerase (PARP) inhibitor, a potentiator of DNA damage.
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Cancer Models sentence examples within tumor growth inhibition
14 μM and achieved exceptional antitumor efficacy with >99% tumor growth inhibition and 80% cure rates on two murine colon cancer models.
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Here we identified two human anti-CD25 antibodies, BA9 and BT942, which demonstrated strong tumor growth inhibition in both early and late-stage animal cancer models.
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Cancer Models sentence examples within grade serous ovarian
We first studied the abilities of a panel of high grade serous ovarian cancer models comprised of established cancer cell lines (murine ID8 and human CaOV3, OHSAHO, OVCAR8) and patient-derived high-grade serous ovarian cancer xenografts (4 PDX models) to recruit macrophages via microfluidic and collagen-droplet based 3D assays.
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Cancer Models sentence examples within cell cycle arrest
It is confirmed that PG and its metabolites regulated apoptosis, epithelial mesenchymal transition (EMT), angiogenesis, cell cycle arrest and multidrug resistance (MDR) in vitro and in vivo cancer models.
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Cancer Models sentence examples within Breast Cancer Models
These results supported further studies which showed significant in vitro and in vivo efficacy in pre-clinical breast cancer models.
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[18F]AlF-NOTA-FAPI-04 PET/CT imaging was performed in normal BALB/c mice (n = 3) and 4T1 breast cancer models (n = 3) to determine its biodistribution.
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Cancer Models sentence examples within Preclinical Cancer Models
Consistent with this, we proved that the combination of lapatinib with the autophagy inhibitor chloroquine increases the therapeutic response specifically in GSDMB-positive tumors in vitro and in vivo using zebrafish and mice preclinical cancer models.
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Remarkably, in preclinical cancer models, the administration of high doses of citrate showed various anti-cancer effects, such as the inhibition of glycolysis, the promotion of cytotoxic drugs sensibility and apoptosis, the neutralization of extracellular acidity, and the inhibition of tumors growth and of key signalling pathways (in particular, the IGF-1R/AKT pathway).
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Cancer Models sentence examples within Prostate Cancer Models
Combination treatment with NLG207, a nanoparticle–drug conjugate of camptothecin and inhibitor of HIF-1α, and enzalutamide was evaluated in preclinical prostate cancer models of enzalutamide resistance.
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Conclusions: We present a complete preclinical evaluation of radiolabeled hu5A10 in mouse prostate cancer models and NHPs, and establish hu5A10 as a new theranostic agent that allows highly specific and effective downstream targeting of AR in PSA-expressing tissue.
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Cancer Models sentence examples within Lung Cancer Models
Here, the authors demonstrate that the combination of MEK inhibition and PD-L1 blockade in KRAS mutant lung cancer models leads to a transient tumour regressions and resistance due to increased infiltration of Th17 cells and that the triple therapy targeting MEK, PD-L1 and IL-17 produced better in vivo responses.
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Cancer Models sentence examples within Pancreatic Cancer Models
We showed that expression of EGFR, HER2 and HER3 was increased in these gemcitabine-resistant pancreatic cancer models, and that an antibody mixture against all three receptors inhibited tumor growth in mice and downregulated HER receptors.
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Remarkably, intratumoral IMO-2125 in combination with systemic anti-PD1 causes a potent antitumor effect on primary injected and distant sites also in pancreatic cancer models with low immunogenic potential, preceded by a transition toward an immunopermissive microenvironment, with increase in tumor-infiltrating dendritic and T cells in tumor and lymph nodes.
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Cancer Models sentence examples within Colon Cancer Models
After intraperitoneal and intratumoral injection of the DMP/mIL-22BP complex, strong inhibition effects on C26 colon cancer models were observed, with high therapeutic efficiency and safety when systemically administrated.
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By genetic depletion and pharmacological inhibition of BCL9 in tumors, we found that BCL9 suppression reduced tumor growth, promoted CD8 + T cell tumor infiltration, and enhanced response to anti-PD-1 treatment in mouse colon cancer models.
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Cancer Models sentence examples within Murine Cancer Models
Recent studies have shown that certain arsenic compounds including arsenic hexoxide (AS4O6; hereafter, AS6) induce programmed cell death and cell cycle arrest in human cancer cells and murine cancer models [3, 4].
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Using murine cancer models and patient-derived TNBC tumors, we showed that only simultaneous targeting of Her2 and cMet was successful in sensitizing TNBC to RT and preventing its regrowth.
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Cancer Models sentence examples within Mouse Cancer Models
The circuit proved effective in cell culture and mouse cancer models, offering hope of extending the CAR T cell strategy against solid tumors.
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These findings in mouse cancer models suggest that targeting these sub-populations of immune cells holds therapeutic promise in treating metastatic disease.
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Cancer Models sentence examples within Variou Cancer Models
Epigenetic targeting drugs such as DNA methyltransferase inhibitors, histone deacetylase, and methyltransferase inhibitors have demonstrated the potential to reverse immune suppression in various cancer models.
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The crude extract of Vernonia cinerea as well as the active molecule obtained through the chemical route (ENZ302) showed anti-tumor activity against various cancer models including CML, AML, ALL, HER2+ breast cancer, colon cancer, etc.
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Cancer Models sentence examples within Vivo Cancer Models
Recent Findings Much of the existing research has focused on the use of cell culture models of disease, demonstrating Olea europaea extracts, and specific compounds within these extracts, have efficacy in a range of in vitro and in vivo cancer models.
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In the two different in vivo cancer models, KAI1 supplementation significantly inhibited tumor angiogenesis and growth.
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Cancer Models sentence examples within Ovarian Cancer Models
The aim of this study was to identify the potential role of tissue factor (TF)-bearing extracellular vesicles (EVs) originated from cancer cells in venous thrombosis in ovarian cancer models.
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We performed a study on a series of well-characterized in vitro ovarian cancer models including TOV21G, TOV112D and OV90 originally derived from clear cell, endometrioid and high grade serous carcinoma respectively.
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Cancer Models sentence examples within Colorectal Cancer Models
A novel IAP antagonist tolinapant (ASTX660) potently and rapidly downregulated cIAP1 in colorectal cancer models, demonstrating its robust on-target efficacy.
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By enabling biological investigation in a clinically relevant experimental context, patient-derived colorectal cancer models have proved useful to examine the causal role of such biomarkers in dictating drug sensitivity and are providing fresh knowledge on new actionable targets, dynamics of tumor evolution and adaptation, and mechanisms of drug resistance.
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Cancer Models sentence examples within Vitro Cancer Models
Cancer Models sentence examples within Liver Cancer Models
Moreover, we present a recent collection of 2D and 3D in vitro liver cancer models and address the next generation of in vitro systems recapitulating the tumor microenvironment complexity in more detail.
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In this review, we provide a comprehensive summary of our findings with these inducible zebrafish liver cancer models in tumour initiation, oncogene addiction, tumour microenvironment, gender disparity, cancer cachexia, drug screening and others.
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Cancer Models sentence examples within Animal Cancer Models
Challenges range from lack of confidence in animal cancer models, inter-tumor heterogeneity and the absence of cellular microenvironment.
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Experimental animal cancer models are essential for gaining insights into the complex interactions of different cells and genes in tumor initiation, promotion, and progression.
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Cancer Models sentence examples within Human Cancer Models
Development of organoid raft cultures of cervical, breast and glioblastoma tumors as quick economical ex vivo human cancer models for pre-clinical drug evaluation [abstract].
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The experimental human cancer models the established cell lines UMUC3 (bladder), FaDu (hypopharynx), and primary cultures of head and neck tumor cells.
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Cancer Models sentence examples within 3d Cancer Models
These multicellular spheroids can be used to recapitulate the tumor microenvironment and the phenotype of tumor-associated macrophages in vitro and provide more realistic 3D cancer models allowing the in vitro screening of immunotherapeutic compounds.
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Cancer Models sentence examples within Mammary Cancer Models
Employing hormone-independent mammary cancer models, Gö6976 and ATRA combined treatment induced a synergistic reduction in proliferative potential that correlated with an increased apoptosis and RARs modulation towards an anti-oncogenic profile.
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Results For the mammary cancer models, there was no significant change in the tumor latency or metastasis in silicon-irradiated mice compared to controls.
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Cancer Models sentence examples within Gastric Cancer Models
In vitro and in vivo experiments were conducted in breast and gastric cancer models to characterize this original ADC and gain insight about the drug-linker structure–activity relationship.
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In this study, we explored the effect of propranolol, a non-selective β-blocker , on the antitumor efficacy of T1012G virus in gastric cancer models.
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Cancer Models sentence examples within Several Cancer Models
The PGC1a-driven metabolic adaptations with increased electron transport chain activity and superoxide levels are essential for metastasis in several cancer models.
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Subcutaneous immunization with the nanovaccine yielded a potent anti-tumor activity in several cancer models, including B16-F10, Lewis lung cancer (LLC), intracranial LLC xenograft, as well as CT-26 colon cancer.
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