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Cancer Agents sentence examples within metastatic renal cell
CONTEXT
Immune checkpoint inhibitors (ICIs) have reported unprecedented results in the treatment of metastatic renal cell carcinoma (mRCC) patients, as monotherapy or in combination with other anticancer agents.
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OBJECTIVE: To assess treatment utilization patterns of newly initiated oral anticancer agents across national samples of Medicare beneficiaries for 5 cancer types: chronic myeloid leukemia (CML), multiple myeloma (MM), metastatic prostate cancer (mPC), metastatic renal cell carcinoma (mRCC), and metastatic breast cancer (mBC).
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Cancer Agents sentence examples within structure activity relationship
By analyzing the results of the MTT assay together with the obtained docking results we designed a proposed structure-activity relationship (SAR) to be a guide for further identification of new anticancer agents in the future.
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In order to develop effective anticancer agents against various cancer cell lines, it is essential to study the structure activity relationship and the effect of different substituents on the activity of heterocyclic scaffolds which were known to have cytotoxic activities.
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Cancer Agents sentence examples within targeted drug delivery
Conclusion This work shows that Chloramb-CS-IONPs nanocomposite is a promising candidate for magnetically targeted drug delivery for leukemia anti-cancer agents.
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Therefore, smart nano-engineered targeted drug-delivery systems with tailored pharmacokinetics and biodistribution which can selectively deliver anti-cancer agents directly to the tumor site are the solution to most difficulties encountered with conventional therapeutic tools.
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Cancer Agents sentence examples within breast cancer treatment
AIM
The aim of this study was to develop new chemotherapeutic agents for breast cancer treatment, therefore, a novel series of Suberoylanilide hydroxamic acid (SAHA) analogs were investigated as anticancer agents.
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Although patients receiving renal replacement therapy (RRT) have more comorbidities and higher mortality and morbidity risks than the general population, surgery during breast cancer treatment is crucial because of limitations in anticancer agents for patients with renal insufficiency.
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Cancer Agents sentence examples within non small cell
This study reports the synthesis and in vitro biological assessment of two sets of 3-methylbenzofurans (4a–d, 6a–c, 8a–c and 11) and 3-(morpholinomethyl)benzofurans (15a–c, 16a–b, 17a–b and 18) as potential anticancer agents towards non-small cell lung carcinoma A549 and NCI-H23 cell lines, with VEGFR-2 inhibitory activity.
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The current review aims to summarize the importance of phytochemicals as anticancer agents, with a special mention on nano-formulations to treat non-small cell lung cancer (NSCLC).
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Cancer Agents sentence examples within anti cancer activity
Antioxidant and anti-cancer activity were significantly correlated with the total content of phenolics and flavonoids, suggest that the fractions could be the good source of antioxidant and anti-cancer agents.
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OBJECTIVE
To seek anti-cancer activity of the structures of triterpenoid compounds and their derivatives, we summarized a number of plants and their derivatives that are a source of potential novel therapeutic anti-cancer agents.
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Cancer Agents sentence examples within cancer cell death
80:20 SMO:PRO nanoemulsion could induce cancer cell death via the intrinsic apoptosis pathway, which was the desirable pathway for candidate anticancer agents.
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We found that metformin and the oral anti-prostate cancer agents together are more effective in inhibiting prostate cancer cell growth and inducing prostate cancer cell death than when used alone.
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Cancer Agents sentence examples within without affecting normal
Oncolytic viruses have attracted widespread attention as biological anticancer agents that can selectively kill tumor cells without affecting normal cells.
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The current review focuses on the achievement of improved targeting of anticancer agents at the tumor microenvironment without affecting normal tissues.
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Cancer Agents sentence examples within combines pre clinical
Separately, our group developed a numeric scoring tool of targeted anticancer agents, the Central Nervous System Targeted Agent Prediction (CNS TAP) tool, which combines pre-clinical, clinical, and CNS penetration data with patient-specific genomic information to generate a numeric score for each agent to objectively evaluate these targeted therapies for use in patients with CNS tumors.
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Separately, our group developed the Central Nervous System Targeted Agent Prediction (CNS-TAP) tool, which combines pre-clinical, clinical, and CNS penetration data with patient-specific genomic information to allow for numeric scoring of targeted anticancer agents to objectively evaluate these therapies for use in patients with CNS tumors.
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Cancer Agents sentence examples within determine whether patient
We aimed to determine whether patient-specific combination regimens with AGI and other anticancer agents when selected based on multi-analyte tumor interrogation (ETA: Encyclopedic Tumor Analysis) can expand the scope of AGIs in advanced refractory solid organ cancers with improved treatment responses.
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The present study aimed to determine whether patient-specific combination regimens with mTOR inhibitors and other anticancer agents selected based on multi-analyte molecular and functional tumor interrogation (ETA: Encyclopedic Tumor Analysis) yields significant treatment response and survival benefits in advanced or refractory solid organ cancers.
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Cancer Agents sentence examples within cancer cell proliferation
There is an urgent need to design new anticancer agents that can prevent cancer cell proliferation even with minimal side effects.
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METHODS
The antitumor effects of calcitriol and analogs in the treatment of cancer, either as single agents or in combination with other anticancer agents, are based on several mechanisms: inhibition of cancer cell proliferation and invasiveness, induction of differentiation and apoptosis, and promotion of angiogenesis, all recorded in a number of preclinical studies of several cancer types.
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Cancer Agents sentence examples within atmospheric pressure plasma
Cold atmospheric pressure plasma (CAP) and plasma-activated medium (PAM) induce cell death in diverse cancer cells and may function as powerful anti-cancer agents.
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Non-thermal atmospheric pressure plasma (NTAPP)-activated liquids have emerged as new promising anticancer agents because they preferentially injure malignant cells.
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Cancer Agents sentence examples within Breast Cancer Agents
Compounds 7a and 8e are promising anti-breast cancer agents exhibiting potent apoptosis-promoting properties.
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These surveyed compounds have the potential to be considered as useful anti-breast cancer agents due to the great cytotoxicity and apoptotic effects against related cancer cell lines and safety profile according to their rational selectivity index.
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Cancer Agents sentence examples within Prostate Cancer Agents
New derivatives of known anti-prostate cancer agents: abiraterone and galeterone, new derivatives of androstane and pregnane modified with nitrogen containing heterocycles, and some related steroid derived compounds are discussed in the review.
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We found that metformin and the oral anti-prostate cancer agents together are more effective in inhibiting prostate cancer cell growth and inducing prostate cancer cell death than when used alone.
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Cancer Agents sentence examples within Silent Cancer Agents
Cancer Agents sentence examples within Pancreatic Cancer Agents
Hence, this study had augmented the array of α-aminophosphonates by adding a new collection of 3-amino-2-hydroxybenzofused 2-phosphalactones, a class of cyclic α-aminophosphonates, to it, which proved them as potential anti-pancreatic cancer agents.
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As an integral part of all modern drug discovery campaigns, computer-aided approaches can represent a promising alternative change to accelerate the early discovery of potent anti-pancreatic cancer agents.
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Cancer Agents sentence examples within Lung Cancer Agents
The present work represents the design and synthesis of some azaheterocyclic coumarin derivatives which are evaluated as anti-lung cancer agents.
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A wide range of natural products can be considered promising anti-COVID-19 or anti-lung cancer agents have gained widespread attention, including natural products as monotherapy for the treatment of SARS-CoV-2 (ginkgolic acid, shiraiachrome A, resveratrol, and baicalein) or lung cancer (daurisoline, graveospene A, deguelin, and erianin) or in combination with FDA-approved anti-SARS-CoV-2 agents (cepharanthine plus nelfinavir, linoleic acid plus remdesivir) and anti-lung cancer agents (curcumin and cisplatin, celastrol and gefitinib).
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Cancer Agents sentence examples within cancer agents targeting
In this compendium, the authors review selected applications exploiting the metal–ligand interactions by focusing on understanding the mechanism and design of (i) inhibitors targeting iron and zinc-enzymes, and (ii) ruthenium and gold-based anticancer agents targeting the nucleosome and aquaporin protein, respectively.
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The aim of this review is to discuss the recent literature on the field in order to infer a rational combination strategy including cyclin-D1/CDK4-CDK6 inhibitors, RT, and/or other anticancer agents targeting G1-S phase cell cycle transition.
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Cancer Agents sentence examples within cancer agents vium
The results indicated the potency of marchantins to act as anticancer agents via induction of apoptosis by binding to TNF receptor.
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Local delivery of anticancer agents via injectable hydrogels could be a promising method for achieving spatiotemporal control on drug release as well as minimizing the disadvantages related to the systemic mode of drug delivery.
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Cancer Agents sentence examples within cancer agents may
Immune activation by anticancer agents may contribute to residual tumor cell eradication with postsurgical (neo)adjuvant chemotherapy.
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Combination therapy with CnP and existing anticancer agents may be a promising strategy for treating refractory HCC associated with activated CAFs.
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Cancer Agents sentence examples within cancer agents derived
Traditional treatment strategies have several side effects that inspire the development of novel anticancer agents derived from natural sources, like chalcone derivatives.
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Background Recently, there is increasing awareness focused on the identification of naturally occurring anticancer agents derived from natural products.
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Cancer Agents sentence examples within cancer agents include
The distinguishing features of this universal target for anticancer agents include presence of mitochondria in the overwhelming majority, if not all types of transformed cells, crucial importance of these cytoplasmic organelles in energy production, regulation of cell death pathways, as well as generation of reactive oxygen species and maintenance of calcium homeostasis.
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Bacteria tested as potential anticancer agents include the Gram-positive obligate anaerobes Bifidobacterium and Clostridium, as well as the gram-negative facultative anaerobe Salmonella.
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Cancer Agents sentence examples within cancer agents currently
Cancer Agents sentence examples within cancer agents acros
OBJECTIVE: To assess treatment utilization patterns of newly initiated oral anticancer agents across national samples of Medicare beneficiaries for 5 cancer types: chronic myeloid leukemia (CML), multiple myeloma (MM), metastatic prostate cancer (mPC), metastatic renal cell carcinoma (mRCC), and metastatic breast cancer (mBC).
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OBJECTIVE
In this systematic review and meta-analysis, we aimed at assessing the predictive value of PD-L1 in mUC patients receiving first-line ICIs as monotherapy or in combination with other anticancer agents across randomized controlled clinical trials (RCTs).
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Cancer Agents sentence examples within cancer agents showed
Exploratory analyses of a drug screen library of 33 investigational anticancer agents showed the strongest ex vivo sensitivity to the SMAC mimetic LCL161 in PDOs of recurrent disease compared to those of the initial metastasis.
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Both of these anti-cancer agents showed slow and sustained release profile in non-physiological buffer (PBS, pH 7.
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Cancer Agents sentence examples within cancer agents administered
The molecular bases accounting for mechanisms of chemoresistance (MOCs) to classical anticancer agents administered in unresectable or metastatic CCAs or as adjuvant treatment after surgery have been recently revised [2].
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one, two or three steps ahead in the near future the tumor growth under the effects of anticancer agents administered in combination was explored and through the same two numerical experiments was evaluated and confirmed.
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Cancer Agents sentence examples within cancer agents directly
Therefore, smart nano-engineered targeted drug-delivery systems with tailored pharmacokinetics and biodistribution which can selectively deliver anti-cancer agents directly to the tumor site are the solution to most difficulties encountered with conventional therapeutic tools.
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By observing the activity of anti-cancer agents directly in tumors, there is potential to greatly expand our understanding of drug response and develop more personalized cancer treatments.
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Cancer Agents sentence examples within cancer agents per
Patients received nivolumab, pembrolizumab, atezolizumab or durvalumab alone or in combination with other anticancer agents per each trial’s protocol.
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The therapeutic properties of Bee Venom (BV) and its active component, Melittin (Mel), make them suitable candidates as potential anti-cancer agents per-se or as adjuvants for cancer chemotherapy.
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Cancer Agents sentence examples within cancer agents known
Plain Language Summary Risk of colitis (inflammation of the large intestine) in elderly patients with melanoma treated with immune-checkpoint inhibitors (a group of medications that uses the patient’s immune system to fight cancer) While the anti-cancer agents known as immune-checkpoint inhibitors have had a great impact on the treatment of melanoma, they may also have side effects.
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Tubulysin M is one of the most potent anticancer agents known with an excellent IC50 of 0.
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Cancer Agents sentence examples within cancer agents show
CONCLUSIONS
This first cost-efficiency and expanded access study of biosimilar therapeutic cancer agents shows that trastuzumab-dkst is cost-efficient over trastuzumab-IV and trastuzumab-SC across all patient weights in both monotherapy and in combination with pertuzumab and paclitaxel.
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Cancer Agents sentence examples within cancer agents owing