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Scalable characterization of the PAM requirements of CRISPR-Cas enzymes using HT-PAMDA.


Genome-wide detection and analysis of CRISPR-Cas off-targets.

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MiR-124 synergism with ELAVL3 enhances target gene expression to promote neuronal maturity


MicroRNA-199a-5p regulates FOXC2 to control human vascular smooth muscle cell phenotypic switch

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Polymer-Based Materials and Their Applications in Image-Guided Cancer Therapy.


MICROFLUIDIC DEVICES AS A TOOL FOR DRUG DELIVERY AND DIAGNOSIS: A REVIEW



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Analysis of association between MALAT1 haplotype and the severity of normal-tension glaucoma (NTG).


Genome-wide identification, phylogenetic analysis, and expression analysis of the SPL gene family in orchardgrass (Dactylis glomerata L.).

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Gene-specific MicroRNA antagonism protects against HIV Tat and TGF-β-mediated suppression of CFTR mRNA and function.


Three functional polymorphisms in CCDC170 were associated with osteoporosis phenotype

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Human iPSC-Based Model Reveals NOX4 as Therapeutic Target in Duchenne Cardiomyopathy


Quantitative analysis of CRISPR-del for complete gene knockout in human diploid cells

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Mechanism of DNA cleavage by the endonuclease SauUSI: a major barrier to horizontal gene transfer and antibiotic resistance in Staphylococcus aureus


Engineered DNase-inactive Cpf1 variants to improve targeting scope for base editing in E. coli

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Scalable characterization of the PAM requirements of CRISPR-Cas enzymes using HT-PAMDA.


Reading the chromatinized genome

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Multiplex Site-Directed Gene Editing Using Polyethylene Glycol-Mediated Delivery of CRISPR gRNA:Cas9 Ribonucleoprotein (RNP) Complexes to Carrot Protoplasts


A homing suppression gene drive with multiplexed gRNAs maintains high drive conversion efficiency and avoids functional resistance alleles

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CRISPR/Cas9 Guided Mutagenesis of Grain Size 3 Confers Increased Rice (Oryza sativa L.) Grain Length by Regulating Cysteine Proteinase Inhibitor and Ubiquitin-Related Proteins


Reciprocal stabilization of transcription factor binding integrates two signaling pathways to regulate fission yeast fbp1 transcription

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Cloud-Based Design of Short Guide RNA (sgRNA) Libraries for CRISPR Experiments.


Imaging cell lineage with a synthetic digital recording system

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Titanium dioxide nanotubes conjugated with quercetin function as an effective anticancer agent by inducing apoptosis in melanoma cells


In silico and multi-spectroscopic analyses on the interaction of 5-amino-8-hydroxyquinoline and bovine serum albumin as a potential anticancer agent

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Simultaneous Gene Excision and Integration by Dual-Guide CRISPR-Cas9.


Knockdown of miR393 Promotes the Growth and Biomass Production in Poplar

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Polymorphisms in MicroRNA Target Sites of TGF-β Signaling Pathway Genes and Susceptibility to Allergic Rhinitis


Comprehensive analysis of NAC transcription factor family uncovers drought and salinity stress response in pearl millet (Pennisetum glaucum)

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Pipeline for Generating Stable Large Genomic Deletions in Zebrafish, from Small Domains to Whole Gene Excisions


Pipeline for generating stable large genomic deletions in zebrafish, from small domains to whole gene excisions.

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Next-generation sequencing-based identification of EGFR and NOTCH2 complementary mutations in non-small cell lung cancer


Impact of CNS Diseases on Drug Delivery to Brain Extracellular and Intracellular Target Sites in Human: A “WHAT-IF” Simulation Study

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An siRNA-guided Argonaute protein directs RNA Polymerase V to initiate DNA methylation


Advances in Understanding of the Copper Homeostasis in Pseudomonas aeruginosa

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Localization of Angiotensin II Type 1 receptor gene expression in rodent and human kidneys.


Effective subthalamic and pallidal deep brain stimulation - are we modulating the same network?

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The dentin pellicle - A neglected topic in dental research.


Conformational coupling by trans-phosphorylation in calcium calmodulin dependent kinase II

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PIIKA 2.5: Enhanced quality control of peptide microarrays for kinome analysis


Phosphorylation of NFATC1 at PIM1 target sites is essential for its ability to promote prostate cancer cell migration and invasion

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Engineering polyphenols with biological functions via polyphenol-protein interactions as additives for functional foods


Dynamic control of plant water use using designed ABA receptor agonists

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Successively Triggered Rod-shaped Protocells for Enhanced Tumor Chemo-Photothermal Therapy.


Supramolecular Assembly of Aminoethylene‐Lipopeptide PMO Conjugates into RNA Splice‐Switching Nanomicelles

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Comparing the Impact of Multi-Session Left Dorsolateral Prefrontal and Primary Motor Cortex Neuronavigated Repetitive Transcranial Magnetic Stimulation (nrTMS) on Chronic Pain Patients


Recollection in the human hippocampal-entorhinal cell circuitry

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Atlas-informed computational processing pipeline for individual targeting of brain areas for therapeutic navigated transcranial magnetic stimulation


CReVIS-Seq: A highly accurate and multiplexable method for genome-wide mapping of lentiviral integration sites

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Permethrin resistance in Aedes aegypti: Genomic variants that confer knockdown resistance, recovery, and death


Identification of whitefly (Bemisia tabaci) proteins interacting with Tomato leaf curl Bangalore virus coat protein gene using Y2H system

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Quaternary ammonium silane (k21) based intracanal medicament triggers biofilm destruction


Trapping efficiency of random walks on weighted scale-free trees

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PIM-induced phosphorylation of Notch3 promotes breast cancer tumorigenicity in a CSL-independent fashion


PIM kinases inhibit AMPK activation and promote tumorigenicity by phosphorylating LKB1

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Investigating the Efficacy of Potential Diet-Derived Phytochemicals on LNCaP Cell Lines Under Physiological Conditions


Abstract 2875: Metastases arise as new cancers from cells of target organs transformed by cell-free chromatin particles released from dying circulating tumor cells

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Combined Epicardial and Endocardial Sinus Node Modification Using the Orion™ Mini-basket Mapping Catheter


Cardiac Magnetic Resonance Imaging and Ventricular Tachycardias Involving the Sinuses of Valsalva in Patients With Nonischemic Cardiomyopathy.

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Therapeutic potential of C1632 by inhibition of SARS-CoV-2 replication and viral-induced inflammation through upregulating let-7


FMR1 expression in human granulosa cells and variable ovarian response: control by epigenetic mechanisms.

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Double lesion MRgFUS treatment of essential tremor targeting the thalamus and posterior sub-thalamic area: preliminary study with two year follow-up.


Two year data from a preliminary study of double lesion site MRgFUS treatment of Essential Tremor targeting the thalamus and the posterior subthalamic area.

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Chikungunya nsP4 homology modeling reveals a common motif with Zika and Dengue RNA polymerases as a potential therapeutic target


Novel mapping techniques for rotor core detection using simulated intracardiac electrograms

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Genome-wide landscape of RNA-binding protein target site dysregulation reveals a major impact on psychiatric disorder risk


Robust single-cell discovery of RNA targets of RNA-binding proteins and ribosomes

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Disruption of mitochondrial open reading frame 352 partially restores pollen development in cytoplasmic male sterile rice


Disruption of the mitochondrial gene orf352 partially restores pollen development in cytoplasmic male sterile rice

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Study on the mechanism of potential pharmacological action of Daphne Genkwa of anti-tumor based on data mining, network pharmacology and molecular docking


AGO-accessible anticancer siRNAs designed with synergistic miRNA-like activity

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Identification of evolutionarily stable functional and immunogenic sites across the SARS-CoV-2 proteome and greater coronavirus family


Identification of evolutionarily stable functional and immunogenic sites across the SARS-CoV-2 proteome and the greater coronavirus family

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11-year follow-up outcomes of catheter ablation of para-hisian accessory pathways


Six-Year Follow-Up Outcomes of Catheter Ablation of Para-Hisian Accessory Pathways

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Deep enzymology studies on DNA methyltransferases reveal novel connections between flanking sequences and enzyme activity.


Recovery from heat shock requires the microRNA pathway in Caenorhabditis elegans

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Evaluation of sample pooling for the detection of SARS-CoV-2 in a resource-limited setting, Dominican Republic.


Evaluation of sample pooling for the detection of SARS-CoV-2 in a resource-limited setting, Dominican Republic

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CRISPR-Cas9 bends and twists DNA to read its sequence


Cardiac Magnetic Resonance Imaging and Ventricular Tachycardias Involving the Sinuses of Valsalva in Patients With Nonischemic Cardiomyopathy.

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Pax7 pioneer factor action requires both paired and homeo DNA binding domains


Epigenetic Footprints of CRISPR/Cas9-Mediated Genome Editing in Plants

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Three functional polymorphisms in CCDC170 were associated with osteoporosis phenotype


Population modification strategies for malaria vector control are uniquely resilient to observed levels of gene drive resistance alleles

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Improving the Precision of Base Editing by Bubble Hairpin Single Guide RNA


Double lesion MRgFUS treatment of essential tremor targeting the thalamus and posterior sub-thalamic area: preliminary study with two year follow-up.

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Identification and Expression Analysis of the SBP-box Gene Family Related to Abiotic Stress in Tea Plant (Camellia sinensis (L.) O. Kuntze)


Disruption of mitochondrial open reading frame 352 partially restores pollen development in cytoplasmic male sterile rice

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Mapping genetic variability in mature miRNAs and miRNA binding sites in prostate cancer


Overview of Innervation of Knee Joint.

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Competition for DNA binding between paralogous transcription factors determines their genomic occupancy and regulatory functions.


GOANA: A Universal High-Throughput Web Service for Assessing and Comparing the Outcome and Efficiency of Genome Editing Experiments.

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An siRNA-guided Argonaute protein directs RNA Polymerase V to initiate DNA methylation


Introduction to the Special Issue on Histotripsy: Approaches, Mechanisms, Hardware, and Applications

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Engineered nanocellulose-based hydrogels for smart drug delivery applications.


Preparation of docetaxel-loaded, glycyrrhetinic acid-modified nanoparticles and their liver-targeting and antitumor activity

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Frequencies and mechanisms of pesticide resistance in Tetranychus urticae field populations in China.


iGUIDE Method for CRISPR Off-Target Detection.

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Selection and characterization of siderophores of pathogenic Escherichia coli intestinal and extraintestinal isolates


Nanoantibiotics: Functions and Properties at the Nanoscale to Combat Antibiotic Resistance

Target Sites 대상 사이트


Target Sites 대상 사이트
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