Single Drug(단일 약물)란 무엇입니까?
Single Drug 단일 약물 - The key principle of managing MDR TB is never to add a single drug to a failing regimen. [1] This also raises the speculation for developing a single drug or formulation effective in curbing all metabolic risk factors. [2] Conclusion: Dadima as a single drug or as an ingredient in 530 formulations have been indicated for its use as an Aushadha in 80 different diseased conditions. [3] 5%) were single drug. [4] In the Galleria mellonella infection model, the survival rate of the antibiotic combined was improved compared with that of the single drug. [5] Of 741 wipe samples with at least one drug above LOD, 60% had a single drug above LOD, 19% had two drugs, and 21% had three drugs or more; the maximum number of drugs found above LOD on one wipe was 8. [6] Multidrug resistance in bacteria can broadly be either due to accumulation of multiple genes, each coding for resistance to a single drug or by increased expression of genes that code for multidrug efflux pumps. [7] If a single drug does not control the seizures, epilepsy is defined as drug-resistant epilepsy (DRE). [8] Glioblastoma is the most common primary brain cancer and it is nearly impossible to remove the entire tumor with surgery or a single drug. [9] The result showed that the therapy for hypertension was dominated by combination drugs which consist of amlodipine and valsartan (88%) and single drugs were dominated by amlodipine (75%). [10] The cost ratio and percentage cost variation was calculated for single drug and fixed dose combinations. [11] Our results demonstrated that the response obtained through the combination of drugs, when compared with the single drugs, led to more synergic responses. [12] The synthetic hydrogel-based organoids suggest the regulatory role ECM may play in therapeutic response to targeted therapies in CRPC-NEPCs and enable the discovery of single drugs and combination therapies to overcome resistance. [13] Simple Summary When considering sedation or general anaesthesia in horses, a multimodal strategy is commonly preferred over a single drug. [14] Notably, polydrug mixtures were more common than single drugs, with 52. [15] Most currently available drug delivery materials typically carry a single drug, lack protection from drug loading, and face challenges in on-demand and precisely controlled drug release. [16] Effective intervention strategies for healthy aging are most desired, due to the complexity and diversity of genetic information, it is a pressing concern to find a single drug or treatment to improve longevity. [17] However, some combinations can be suppressive—that is, bacteria grow faster in some drug combinations than when treated with a single drug. [18] Moreover, a combination of NT1721 with gemcitabine reduced the tumor growth significantly better than the single drugs. [19] The samples were treated with single drugs and in combination. [20] The inhibitory and apoptosis rates of the cells were significantly increased as compared with those of the single drug-treated group after treated by the combination of itraconazole and AS2S2(P<0. [21] Since these tumors are highly hypoxic and Evo appears effective in hypoxic glioma cells as a single drug and in combination with radio- and chemotherapy, hypoxia-activated prodrugs could represent a promising therapeutic option for children with brain tumors. [22] Further, MLSynergy builds on DRonA to predict novel synergistic and antagonistic multi-drug combinations using transcriptomes of Mtb treated with single drugs. [23] The current treatment relies almost exclusively on a single drug, praziquantel (PZQ). [24] , hydroxychloroquine, paracetamol, and antibiotics are mostly used for the treatment of SARS but no single drug is effective for disease. [25] We have presented a targeted nanocarrier drug delivery system that can block the recruitment of inflammatory neutrophils, enabling specific inhibition of the core disease process and the potential to treat multiple diseases with a single drug. [26] Young male rats were orally dosed drug mixtures and single drugs in 14 consecutive days, each at the dose of 20, 80, and 400 mg/(kg·BW) for environmental toxicologic study. [27] TIVA was initially attempted with a single drug but no drug was found to give complete anaesthesia. [28] The development of burn treatment cannot consist only of the administration of a single drug. [29]다제내성 결핵 관리의 핵심 원칙은 실패한 요법에 단일 약물을 추가하지 않는 것입니다. [1] 이것은 또한 모든 대사 위험 요소를 억제하는 데 효과적인 단일 약물 또는 제제 개발에 대한 추측을 높입니다. [2] 결론: Dadima는 단일 약물 또는 530개 제형의 성분으로 80가지 다른 질병 상태에서 Aushadha로 사용하는 것으로 표시되었습니다. [3] 5%)는 단일 약물이었다. [4] Galleria mellonella 감염 모델에서 단일 약제에 비해 복합 항생제의 생존율이 향상되었다. [5] LOD를 초과하는 하나 이상의 약물이 포함된 741개의 와이프 샘플 중 60%에는 LOD를 초과하는 단일 약물이 있고, 19%에는 2가지 약물이 있고 21%에는 3가지 이상의 약물이 있습니다. 한 와이프에서 LOD 이상으로 발견된 약물의 최대 수는 8개였습니다. [6] 박테리아의 다제 내성은 일반적으로 단일 약물에 대한 내성을 코딩하는 여러 유전자의 축적 또는 다중 약물 유출 펌프를 코딩하는 유전자의 발현 증가로 인한 것일 수 있습니다. [7] 단일 약물로 발작이 조절되지 않는 경우, 간질은 약물 내성 간질(DRE)로 정의됩니다. [8] 교모세포종은 가장 흔한 원발성 뇌암으로 수술이나 단일 약물로 전체 종양을 제거하는 것은 거의 불가능합니다. [9] 그 결과, 고혈압 치료제는 암로디핀과 발사르탄의 복합제(88%)가, 단독제제는 암로디핀(75%)이 지배적이었다. [10] 비용 비율 및 비용 변동 백분율은 단일 약물 및 고정 용량 조합에 대해 계산되었습니다. [11] 우리의 결과는 단일 약물과 비교할 때 약물의 조합을 통해 얻은 반응이 더 높은 시너지 반응을 유도한다는 것을 보여주었습니다. [12] 합성 하이드로겔 기반 오르가노이드는 ECM이 CRPC-NEPC의 표적 요법에 대한 치료 반응에서 조절 역할을 할 수 있고 내성을 극복하기 위한 단일 약물 및 조합 요법의 발견을 가능하게 할 수 있음을 시사합니다. [13] 단순 요약 말의 진정 또는 전신 마취를 고려할 때 일반적으로 단일 약물보다 다중 모드 전략이 선호됩니다. [14] 특히, 복합약물 혼합물이 52개로 단일 약물보다 더 일반적이었습니다. [15] 현재 사용 가능한 대부분의 약물 전달 물질은 일반적으로 단일 약물을 운반하고 약물 로딩에 대한 보호 기능이 부족하며 주문형 및 정밀하게 제어되는 약물 방출의 문제에 직면합니다. [16] 유전 정보의 복잡성과 다양성으로 인해 건강한 노화를 위한 효과적인 개입 전략이 가장 요구되고 있으며, 장수를 향상시키기 위한 단일 약물 또는 치료법을 찾는 것이 시급한 관심사입니다. [17] 그러나 일부 조합은 억제할 수 있습니다. 즉, 단일 약물로 치료할 때보다 일부 약물 조합에서 박테리아가 더 빠르게 성장할 수 있습니다. [18] 또한 NT1721과 젬시타빈의 조합은 단일 약물보다 종양 성장을 훨씬 더 잘 감소시켰습니다. [19] 샘플은 단일 약물과 조합으로 처리되었습니다. [20] 이트라코나졸과 AS2S2를 병용 투여한 후, 단일 약물 투여군에 비해 세포의 억제율 및 세포자멸사 비율이 유의하게 증가하였다(P<0. [21] 이러한 종양은 고도로 저산소 상태이고 Evo는 단일 약물로 방사선 및 화학 요법과 함께 저산소 신경교종 세포에서 효과적인 것으로 나타나기 때문에 저산소 활성화 전구 약물은 뇌종양이 있는 어린이에게 유망한 치료 옵션이 될 수 있습니다. [22] 또한 MLSynergy는 DRonA를 기반으로 단일 약물로 처리된 Mtb의 전사체를 사용하여 새로운 시너지 및 길항 다중 약물 조합을 예측합니다. [23] 현재 치료법은 거의 독점적으로 단일 약물인 프라지콴텔(PZQ)에 의존합니다. [24] , 하이드록시클로로퀸, 파라세타몰, 항생제가 사스의 치료에 주로 사용되지만 단일 약물이 질병에 효과적이지 않습니다. [25] 우리는 염증성 호중구의 동원을 차단할 수 있는 표적 나노운반체 약물 전달 시스템을 제시하여 핵심 질병 과정의 특정 억제를 가능하게 하고 단일 약물로 여러 질병을 치료할 수 있는 가능성을 제시했습니다. [26] 어린 수컷 쥐에게 환경 독성 연구를 위해 각각 20, 80, 400 mg/(kg·BW) 용량의 약물 혼합물과 단일 약물을 연속 14일 동안 경구 투여했습니다. [27] TIVA는 처음에 단일 약물로 시도되었지만 완전한 마취를 제공하는 약물은 발견되지 않았습니다. [28] 화상 치료제의 개발은 단일 약물의 투여만으로 구성될 수 없습니다. [29]
cell cycle arrest 세포주기 정지
Compared to the single drug dox, the CDZ nanocomplex was demonstrated to possess higher activity of killing colorectal tumor cells by confocal laser scanning microscopy and cytotoxicity, which could be attributed to spermine concentration, spermine synthase, free radical damage, and G1 cell cycle arrest. [1] G2/M cell cycle arrest was induced by each single drug, and further augmented by their combination in U-87 cells. [2] The pH-responsive dual drug release was instigated the higher glioblastoma cell death instead of the single drug release through G0/G1 phase cell cycle arrest. [3]단일 약물 dox와 비교하여 CDZ 나노복합체는 공초점 레이저 스캐닝 현미경으로 대장 종양 세포를 죽이는 활성이 더 높은 것으로 입증되었으며 세포 독성은 정자 농도, 정자 합성 효소, 자유 라디칼 손상 및 G1 세포 주기 정지에 기인할 수 있습니다. [1] G2/M 세포 주기 정지는 각각의 단일 약물에 의해 유도되었으며 U-87 세포에서 이들의 조합에 의해 더욱 증가되었습니다. [2] nan [3]
Active Single Drug 활성 단일 약물
5 compared to the most active single drug. [1] Discovery of novel drug against tuberculosis is inevitable since resistant bacterial strains are evolved against existing drugs and rapidly active single drug in short period is necessary for effective treatment. [2] Our work promoted inflammatory-targeted delivery and intestinal drug accumulation for active single drug quercetin and improved the therapeutic effect of IBD. [3]5 가장 활동적인 단일 약물과 비교. [1] 기존 약제에 대해 내성균이 진화하고, 단기간에 빠르게 활성을 보이는 단일 약제가 효과적인 치료를 위해서는 결핵에 대한 새로운 약제의 개발이 불가피하다. [2] nan [3]
Component Single Drug 성분 단일 약물
Moreover, mathematical modeling based on human oral PK projects that the combinations would be more active in humans than their component single drugs. [1] Moreover, mathematical modeling based on human oral PK projects that the combinations would be more active in humans than their component single drugs. [2]더욱이, 인간 경구 PK에 기반한 수학적 모델링은 조합이 구성 요소 단일 약물보다 인간에서 더 활성일 것으로 예상합니다. [1] 더욱이, 인간 경구 PK에 기반한 수학적 모델링은 조합이 구성 요소 단일 약물보다 인간에서 더 활성일 것으로 예상합니다. [2]
Dose Single Drug 용량 단일 약물
High dose antipsychotic prescribing may arise as a result of EITHER single antipsychotic drug prescribed at a daily dose above the recommended limit (High Dose single drug) OR More than one antipsychotic prescribed concurrently where the sum of doses given expressed as a percentage of the SPC maximum of each drug exceeds 100% (High-Dose through the prescribing of multiple drugs). [1] The NORDIC9-study established that moderately dose-reduced combination chemotherapy improved survival without extra side-effects compared to full dose single drug therapy. [2]고용량 항정신병 약물 처방은 권장 한도를 초과하는 일일 용량으로 처방된 단일 항정신병 약물(고용량 단일 약물) 또는 주어진 용량의 합계가 SPC 최대치의 백분율로 표시되는 경우 동시에 처방된 둘 이상의 항정신병 약물의 결과로 발생할 수 있습니다. 각 약물의 100% 초과(복수 약물 처방을 통한 고용량). [1] NORDIC9 연구는 적당히 용량을 줄인 병용 화학 요법이 전체 용량의 단일 약물 요법과 비교하여 추가 부작용 없이 생존을 개선한다는 것을 확인했습니다. [2]
single drug treatment 단일 약물 치료
Additionally, AE@NPs could also activate the ROS-p38 axis, which is not observed in the single drug treatments. [1] In this review we describe the development of chemotherapy from its origins as a single drug treatment with cytotoxic agents to polydrug therapy that includes targeted drugs. [2] Conclusion The combination of methylprednisolone sodium succinate and tropisetron can effectively prevent PONV under microvascular decompression of hemifacial spasm,with the performance superior to single drug treatment. [3] The combination of bufalin and hydroxycampothecin also increased the expression of apoptosis-related proteins Bax, p53, PDCD4 and GSK-3β, and decreased the expression of Bcl-XL and p-AKT compared with a single drug treatment. [4] In addition, combined 5-FU and TI-12403 treatment synergistically inhibited proliferation to a greater extent than that in a single drug treatment. [5] Combination therapy provides significantly better outcomes than a single drug treatment and becomes an efficient strategy for cancer therapy at present. [6] RESULTS Numbers of linezolid-resistant mutants increased at therapeutic and sub-therapeutic AUC24s, whereas daptomycin-resistant mutants were enriched only at sub-therapeutic AUC24 in single drug treatments. [7] While single drug treatment only mildly impaired virus replication, combination treatments reduced virus yields by at least two orders of magnitude. [8] This review will summarize the most recent advances with these strategies, describing advantages and limitations of single drug treatment vs combination regimens. [9] While FC101 is potent as a single drug treatment across many cancer cell lines, current cancer therapies often incorporate a combination of drugs in order to increase efficacy and decrease the development of drug resistance. [10] Taking clues from our findings, we tested a combination treatment of RB cells with carboplatin and MYCN inhibitors to find enhanced therapeutic efficacy compared to single drug treatment. [11] In the TCS/GrzB-treated group, expression of Ki67 was further downregulated, while the level of activated caspase-3 was increased, compared with their expression in either of the single drug treatment groups. [12] Dual blockade with ERBB2 and BCL2 inhibitors triggers additional reductions of BCL2 phosphorylation and myeloid cell leukemia-1 (MCL1) expression compared with single drug treatment. [13] Interestingly, the combination of MDC and sorafenib significantly inhibited the invasion and metastasis of HCC cell lines SMMC-7721 and SK-Hep1 compared with the single drug treatment via the activated transcription factor FOXO1. [14] KEY FINDING Single drug treatment of 5-FU and SioA effectively inhibited CCA cell growth in dose and time dependent fashions. [15] We examined the effect of combined drug treatment vs single drug treatment on cell survival. [16] The combination therapy also exhibited stronger anti-tumor effects compared with single drug treatments in vivo. [17] It has become clear that single drug treatments are limited in their effectiveness. [18] Combination treatment with bivalirudin and subtherapeutic concentrations of heparin completely inhibited the residual platelet activation observed with single drug treatment at all time-points. [19] We demonstrate that treating lymphoma cells with drug combinations has superior efficacy in comparison with single drug treatments, both in cell cultures and in mice. [20] Further, the mycolactone-bortezomib combination demonstrated superior therapeutic efficacy over single drug treatments in immunodeficient mice engrafted with MM cells, without inducing toxic side effects. [21] Moreover, NE-PTX+BEZ235 treatment increased apoptosis, decreased Pgp and ABCC1 expression, and reduced tumor weights compared to the single drug treatment and the control group. [22] However, the multimodal therapeutic regimen by contemporary use of alphablockers, antibiotics and anti-inflammatory showed a better control of prostatitis symptoms than single drug treatment. [23] In comparison to single drug treatment, the co-treatment also increased the number of cells in G0/G1 phase by downregulating the expression of CDK4 and CDK6 as compared to single drug treatment. [24] Dxs plus penehyclidine hydrochloride or alfacalcidol have been reported more effective in therapy compared with any single drug treatment. [25]또한 AE@NPs는 단일 약물 치료에서는 관찰되지 않는 ROS-p38 축을 활성화할 수도 있습니다. [1] 이 리뷰에서 우리는 세포독성제를 사용한 단일 약물 치료에서 표적 약물을 포함하는 다중 약물 요법으로의 화학 요법의 발전을 설명합니다. [2] 결론 methylprednisolone sodium succinate와 tropisetron의 조합은 단일 약물 치료보다 우수한 성능으로 반쪽 안면 경련의 미세 혈관 감압 하에서 PONV를 효과적으로 예방할 수 있습니다. [3] bufalin과 hydroxycampothecin의 조합은 또한 단일 약물 치료에 비해 세포 사멸 관련 단백질 Bax, p53, PDCD4 및 GSK-3β의 발현을 증가시켰고 Bcl-XL 및 p-AKT의 발현을 감소시켰다. [4] nan [5] nan [6] nan [7] nan [8] nan [9] nan [10] nan [11] nan [12] nan [13] nan [14] nan [15] nan [16] nan [17] nan [18] nan [19] nan [20] nan [21] nan [22] nan [23] nan [24] nan [25]
single drug therapy 단일 약물 요법
Results: The minimum and maximum percentage price variation for different classes of drugs respectively is as followsin single drug therapy, the price variation between a sulfonylurea group of drugs glibenclamide (5 mg) shows maximum price variation of 400%, while glipizide (2. [1] Conclusions: Combination therapies are most effective than single drug therapies. [2] After fi ve days of single drug therapy the mean drop in the heart rate was 35. [3] The NORDIC9-study established that moderately dose-reduced combination chemotherapy improved survival without extra side-effects compared to full dose single drug therapy. [4] Glipizide was administrated to each rabbit as a single drug therapy on day 1 and it was co-administrated with Cimetidine to each rabbit as a combinational drug therapy on day 7. [5] The anti-diabetic studies showed the significant inhibition of glucose level in treated diabetic mice by SNEDDS combined dose compared to the single drug therapy. [6] Use of Haritaki as a single drug therapy has been evidenced at various instances in Brihatrayee. [7] Background Existing research shows that ABT-199, as a first-line drug, have been widely used in hematological malignancies, especially in leukemia, but the clinical efficacy of single drug therapy was limited part of the reason was that BCL-2 inhibitors failure to target other anti-apoptotic BCL-2 family proteins, such as MCL-1. [8] Due to the multi-targeted nature of the virus, it is clear that drugs providing anti-COVID-19 effects need to be developed at an accelerated rate, and a combinatorial approach may stand to be more successful than a single drug therapy. [9] Use of amaltaas as a single drug therapy has been evidenced at various instances in Brihatrayee which is being reviewed in this article. [10] CONCLUSIONSMRA administration as single drug therapy or in combination with standard of care heart failure therapy may prevent the progression of left ventricular dysfunction in childhood cancer survivors with late anthracycline-induced cardiomyopathy. [11]결과: 각각 다른 종류의 약물에 대한 최소 및 최대 백분율 가격 변동은 단일 약물 요법에서 다음과 같으며, 술포닐우레아 약물 글리벤클라미드(5mg) 그룹 간의 가격 변동은 400%의 최대 가격 변동을 나타내는 반면 글리피자이드(2. [1] 결론: 병용 요법은 단일 약물 요법보다 가장 효과적입니다. [2] nan [3] NORDIC9 연구는 적당히 용량을 줄인 병용 화학 요법이 전체 용량의 단일 약물 요법과 비교하여 추가 부작용 없이 생존을 개선한다는 것을 확인했습니다. [4] nan [5] nan [6] nan [7] nan [8] nan [9] nan [10] nan [11]
single drug group 단일 약물 그룹
In addition, the plasma concentrations of EFV and TDF in Sprague Dawley rats showed no significant difference between single drug group and combination with HCFP group, suggesting that HCFP has no effect on the plasma level of antiretroviral drugs. [1] Evaluation of hepatic isoprenoid levels revealed decreased GGPP levels in the single drug groups and undetectable GGPP levels in the combination groups. [2] The difference of renal efficacy and survival benefit between the patients treated with bortezomib, thalidomide (combination group) and chemotherapy regimen containing only one of them (single drug group) in RI group was compared. [3] In the blank control group, single drug group, and combination drug group, the relative expression of TFEB mRNA and protein in the cytoplasm decreased sequentially (P<0. [4] Furthermore, expression levels of GRP78 and CHOP decreased in the combination therapy group, and it was more effective than the single drug group. [5] The patients in single drug group were given simply hormone therapy, the patients in combined drug group were given gamma globulin and thrombopoietin. [6] RESULTS The treatment of MV4-11 cells with low dose triptolide and sorafenib alone and in combination for 48 hours could inhibit cell proliferation and induce cell apoptosis, moreover the inhibitory rate and apoptotic rate of MV4-11 cells in drug-combination group both were higher than those in single drug group. [7]또한, Sprague Dawley 쥐에서 EFV 및 TDF의 혈장 농도는 단일 약물군과 HCFP와의 조합 간에 유의한 차이를 보이지 않았으며, 이는 HCFP가 항레트로바이러스 약물의 혈장 수준에 영향을 미치지 않음을 시사한다. [1] 간 이소프레노이드 수치의 평가는 단일 약물 그룹에서 감소된 GGPP 수치와 조합 그룹에서 검출할 수 없는 GGPP 수치를 나타냈다. [2] nan [3] nan [4] nan [5] nan [6] nan [7]
single drug alone 단일 약물 단독
Therefore, combination therapy is preferable to using a single drug alone in high-risk patients. [1] Combination of verteporfin and CA4 was also more effective in suppressing angiogenesis in an in vivo zebrafish model than single drug alone. [2] In multiple HCC patient-derived organoids and human tumor xenograft models, the drug combination, but neither single drug alone, markedly reduced tumor-initiating cancer cell frequency. [3] These effects were stronger in the combination drug group compared with groups treated with a single drug alone. [4] The combination of two drugs proved better than the use of single drug alone. [5]따라서 고위험군에서는 단일제제를 단독으로 사용하는 것보다 병용요법을 시행하는 것이 바람직하다. [1] verteporfin과 CA4의 조합은 단일 약물 단독보다 생체 내 zebrafish 모델에서 혈관 신생을 억제하는 데 더 효과적이었습니다. [2] nan [3] nan [4] nan [5]
single drug delivery 단일 약물 전달
Within the past decade, several theranostic nanoparticles have been developed as a multifunctional nanosystems which combine the diagnostic and therapeutic functionalities into a single drug delivery platform. [1] Codelivery of OXA and MDC1-AS enhanced the inhibition of cervical cancer cell growth in vitro and in vivo, compared with single drug delivery. [2] Programmable delivery of immunotherapy-involving combinations through a single drug delivery system is highly promising, yet greatly challenging, to reverse postoperative immunosuppression. [3] We propose to combine two therapeutic anti-inflammatory approaches with different mechanisms of action in a single drug delivery system consisting of cationic dexamethasone palmitate nanoparticles (CDXP-NP) associated with TNF-α siRNA. [4] Here we explain the IMoT structure for a single drug delivery network. [5]지난 10년 동안 진단 및 치료 기능을 단일 약물 전달 플랫폼으로 결합하는 다기능 나노시스템으로 여러 가지 테라노스틱 나노입자가 개발되었습니다. [1] OXA와 MDC1-AS의 공동 전달은 단일 약물 전달과 비교하여 시험관 내 및 생체 내에서 자궁 경부암 세포 성장의 억제를 강화했습니다. [2] nan [3] nan [4] nan [5]
single drug administration 단일 약물 투여
Multivariable models, with a cut-off at day 2 for early COVID-19 therapy administration, did not disclose any significant association of a single drug administration on the clinical outcome. [1] Nano carrier-based combination chemotherapy has improved pharmacokinetics of drugs compared to single drug administration. [2] In BTBR autistic mice, we found that both ALAC and NaB improve animal sociability, and memory in the passive avoidance (PA); drug combination was more effective in almost all tests also reducing immobility time in the forced swimming test (FST), which was not affected by single drug administration. [3] Drug combinations have demonstrated high efficacy and low adverse side effects compared to single drug administration in cancer therapies and thus have drawn intensive attention from researchers and pharmaceutical enterprises. [4]초기 COVID-19 치료 투여를 위한 2일차에 컷오프가 있는 다변수 모델은 임상 결과에 대한 단일 약물 투여의 유의한 연관성을 공개하지 않았습니다. [1] 나노담체 기반 복합 화학요법은 단일 약물 투여에 비해 약물의 약동학을 개선했다. [2] nan [3] nan [4]
single drug loaded 로드된 단일 약물
In vitro experiments show that the killing efficiency of two drugs co-loaded HIPPEs against the leukemia cell is two times higher than that of single drug loaded systems. [1] Tf-CIS/DTX-PLHN exhibited obviously better antitumor ability in vitro and in vivo compared with the non Tf contained CIS and DTX co-loaded lipid nanoparticles (CIS/DTX-LN), single drug loaded nanoparticles, and free drugs. [2] D/O-NPs could significantly enhance in vitro cell toxicity and in vivo antitumor effect against A549/DDP cells and lung cancer animal model compared to the single drug loaded NPs and free drugs. [3] ORL/HA-CBZ/LPNs demonstrated an enhanced in vitro and in vivo antitumor effect compared with single drug loaded LPNs and free drug formulations. [4]시험관 내 실험에서 백혈병 세포에 대한 HIPPE를 함께 로드한 두 가지 약물의 사멸 효율이 단일 약물 로드 시스템보다 2배 더 높은 것으로 나타났습니다. [1] Tf-CIS/DTX-PLHN은 비 Tf 함유 CIS 및 DTX 공동 로딩 지질 나노입자(CIS/DTX-LN), 단일 약물 로딩 나노입자 및 자유 약물과 비교하여 시험관내 및 생체내에서 분명히 더 나은 항종양 능력을 나타냈다. [2] nan [3] nan [4]
single drug use 단일 약물 사용
Overall, the present results demonstrated that nigericin combined with cisplatin might serve as a novel therapeutic strategy in patients with metastatic EOC because the combined therapy had higher effectiveness than single drug use. [1] Much research on addiction focuses on the neurobiology underlying single drug use. [2] The ratio of single drug use to more than one drug was about 4:1, showing predominant use of single drug. [3]전반적으로, 현재 결과는 병합 요법이 단일 약물 사용보다 더 높은 효과를 가졌기 때문에 시스플라틴과 결합된 니제리신이 전이성 EOC 환자에서 새로운 치료 전략으로 작용할 수 있음을 보여주었습니다. [1] 중독에 대한 많은 연구는 단일 약물 사용의 기저에 깔린 신경생물학에 초점을 맞추고 있습니다. [2] nan [3]
single drug dose
This was a randomized, open label, blind-endpoint analysis, truncated, crossover study with single drug doses administered in the fasting condition in each of the two treatment periods, separated by a two-week washout period. [1] In conclusion, PGA gel is expected to be a useful excipient in formulations contained various drugs, especially basic drugs; it also has advantage for not only increasing ease of swallowing but also masking the bitterness of drugs even though a small amount of a single drug dose might be preferred. [2] Furthermore, we defined a synergy score based on the difference between the drug combination and the single drug dose-response curves. [3]이것은 2주의 휴약 기간으로 분리된 2개의 치료 기간 각각에서 공복 상태에서 투여된 단일 약물 용량을 사용한 무작위, 공개 라벨, 맹점 분석, 절단, 교차 연구였습니다. [1] nan [2] nan [3]
single drug resistance 단일 약물 내성
Reconstructing ancestral whole genomes on time-calibrated phylogenetic trees we identified no single drug resistance in Peru predating 1940. [1] Amongst these studies, 32 involved single drug resistance and 16 involved in multidrug resistance (MDR). [2] Three profiles of resistance — single drug resistance, multidrug resistance and heteroresistance — seem to occur, probably with overlapping fundamental mechanisms and clinical implications. [3]시간 보정된 계통 발생 나무에서 조상의 전체 게놈을 재구성함으로써 1940년 이전에 페루에서 단일 약물 내성이 확인되지 않았습니다. [1] 이 연구들 중 32건은 단일 약물 내성과 16건은 다제 내성(MDR)과 관련되어 있습니다. [2] nan [3]
single drug formulation 단일 약물 제형
Snuhi Kshara is a single drug formulation of Upavisha Snuhi mentioned in Rasatarangini and Ayurvedsarasangraha. [1] Compared to single drug formulations, only combination of PKC and MEK inhibitors have been reported to translate into meaningful antitumor responses, presumably due to feedbackmediated pathway reactivation in vivo (Chen et al. [2] Separate analyses were performed for (i) days when no medication, (ii) days with monotherapy (single drug formulation), and (iii) days with comedication (more than one drug formulation) were used. [3]Snuhi Kshara는 Rasatarangini 및 Ayurvedsarasangraha에 언급된 Upavisha Snuhi의 단일 약물 제형입니다. [1] 단일 약물 제형과 비교하여, PKC 및 MEK 억제제의 조합만이 의미 있는 항종양 반응으로 해석되는 것으로 보고되었으며, 이는 아마도 생체내 피드백 매개 경로 재활성화로 인한 것으로 추정된다(Chen et al. [2] nan [3]
single drug target 단일 약물 표적
Most of the Structure-based Drug Discovery (SBDD) works reported earlier had screened compounds against a single drug target to avoid any off-target binding and related complications. [1] In this consideration, a single drug target (magic bullet) is only a slightly superior option for all patients with a lot of pathognomic signs. [2]이전에 보고된 대부분의 SBDD(Structure-based Drug Discovery) 작업은 표적 외 결합 및 관련 합병증을 피하기 위해 단일 약물 표적에 대해 화합물을 스크리닝했습니다. [1] 이러한 점에서 단일 약물 표적(마법의 총알)은 병리학적 징후가 많은 모든 환자에게 약간 우수한 옵션일 뿐입니다. [2]
single drug exposure 단일 약물 노출
The ratio of multiple to single drug exposure cases, however, increased from 1. [1] When exposed to HCQ and AZM polytherapy, this MPS faithfully reflected clinical findings, in that the combination of drugs synergistically increased QT interval when compared to single drug exposure, while not worsening the overall frequency of arrhythmic events. [2]그러나 다중 약물 노출 대 단일 약물 노출 사례의 비율은 1에서 증가했습니다. [1] HCQ와 AZM 다중요법에 노출되었을 때, 이 MPS는 단일 약물 노출에 비해 약물의 조합이 상승적으로 QT 간격을 증가시키면서 부정맥 사건의 전체 빈도를 악화시키지 않는다는 임상 결과를 충실히 반영했습니다. [2]
single drug regimen 단일 약물 요법
The tumor mutation burden (TMB) was correlated with the effectiveness of single drug regimens, while the outgrowth time of tumorgrafts was associated with the effectiveness of combined regimens. [1] The tumor mutation burden (TMB) was correlated with the effectiveness of single drug regimens, while the outgrowth time of tumorgrafts was associated with the effectiveness of combined regimens. [2]종양 돌연변이 부담(TMB)은 단일 약물 요법의 효과와 상관관계가 있는 반면, 종양 이식편의 성장 시간은 복합 요법의 효과와 관련이 있었습니다. [1] 종양 돌연변이 부담(TMB)은 단일 약물 요법의 효과와 상관관계가 있는 반면, 종양 이식편의 성장 시간은 복합 요법의 효과와 관련이 있었습니다. [2]
single drug clas 단일 약물 클래스
Changing the anti-retroviral regime completely to a single drug class (Protease Inhibitors) of Ritonavir and Darunavir, resulted in a dramatic improvement in her symptomatology. [1] 40%, n = 34) of HIV-1-infected patients with TDRM had mutation that conferred resistance to a single drug class. [2]항레트로바이러스 요법을 리토나비르와 다루나비르의 단일 약물 계열(프로테아제 억제제)로 완전히 변경한 결과 그녀의 증상이 극적으로 개선되었습니다. [1] 40%, n = 34) TDRM이 있는 HIV-1 감염 환자는 단일 약물 클래스에 대한 내성을 부여하는 돌연변이가 있었습니다. [2]
single drug molecule 단일 약물 분자
Hence there is a need to concentrate on all folk natural products effective in urolithiasis for their pharmacological evaluation, isolation of single drug molecule responsible for anti-urolithiatic activity to developed suitable formulations used against urolithiasis. [1] The present nanodrugs comprise 2 nm core gold nanoparticles (AuNPs) covered completely with multivalent hydrocarbon chains to a final diameter of ∼10 nm as single drug molecules. [2]따라서 요로결석에 효과적인 모든 민간 천연물에 대한 약리학적 평가, 항요로결석 활성을 담당하는 단일 약물 분자의 분리에 집중하여 요로결석에 사용되는 적합한 제제를 개발할 필요가 있습니다. [1] 본 나노약물은 단일 약물 분자로서 ~10 nm의 최종 직경까지 다가 탄화수소 사슬로 완전히 덮인 2 nm 코어 금 나노입자(AuNP)를 포함한다. [2]