Schmidt Reaction(슈미트 반응)란 무엇입니까?
Schmidt Reaction 슈미트 반응 - Claisen–Schmidt reaction of 3 with 4-chlorobenzaldehyde furnished the corresponding thiazolyl-chalcone 4, which underwent cyclization upon treatment with hydrazine hydrate or phenyl hydrazine to produce the corresponding thiazolyl-pyrazoles 5 and 6, respectively. [1] Unexpected spiro cyclic products were obtained from the popular alkali catalyzed Claisen-Schmidt reaction of ketones with salicylaldehyde apart from the bis-chalcones. [2] A new series of coumarin-yl-chalcone derivatives (3a-m) had been designed and synthesized through different reactions such as aromatic addition, cyclization and Claisen-Schmidt reactions in good yields (54–78%). [3] A chalcone series (3a–f) with electron push–pull effect was synthesized via a one-pot Claisen–Schmidt reaction with a simple purification step. [4] Schmidt reaction by sulfonium ions is described. [5] Synthesis of monoketone curcumin analogs was performed through Claisen-Schmidt reaction by refluxing 3-benzyloxybenzaldehyde with acetone (analog A), cyclopentanone (analog B), and cyclohexanone (analog C) using potassium hydroxide 5% as a catalyst for an hour. [6] The expected (E)-but-3-en-2-ones compounds I and II (half curcuminoids) were obtained by the Claisen–Schmidt reaction between aldehydes 3,4-dimethoxybenzaldehyde or 4-nitrobenzaldehyde with acetone. [7] The chalcone synthesis involves the solvent-free solid-state trituration between acetophenone derivatives and substituted benzaldehydes in the presence of NaOH/KOH as a base (Claisen-Schmidt reaction). [8] Schmidt reaction by sulfonium ions is described. [9] The first stage was synthesis of monoketone curcumin analogue through Claisen–Schmidt reaction. [10] The chalcone was obtained using Claisen-Schmidt reaction. [11] In an attempt to develop active antimicrobial agents, a set of new thiazolyl chalcones has been synthesized by the Claisen–Schmidt reaction of 5-acetyl-4-methyl-2-(3-pyridyl)thiazole with various heterocyclic aldehydes in alkali media. [12] A type II photoinitiator (2E,6E)-2,6-bis((1H-pyrrol-2-yl)methylene)cyclohexan-1-one(BPC) was conveniently synthesized through Claisen-Schmidt reaction. [13] Methods: Claisen-schmidt reaction is used for the synthesis of 30 Indolylchalcone hybrids, it involves condensation of N-1 substituted indole-3-carboxaldehyde and N1 substituted 2-acetyl- benzimidazole. [14] The precursors, substituted α,β-unsaturated ketones were obtained by employing the Claisen-Schmidt reaction; and the final products, obtained by Michael condensation, were characterized by analytical and spectral data comprising IR, 1H NMR and mass spectral studies. [15] Methods: Claisen-schmidt reaction is used for the synthesis of 30 Indolylchalcone hybrids, it involves condensation of N-1 substituted indole-3-carboxaldehyde and N1 substituted 2-acetyl-benzimidazole. [16] Ozonolysis of lupanes afforded 20-oxo-derivatives with the following condensation using different aromatic aldehydes by Claisen‒Schmidt reaction to the target compounds. [17] Chemists have been using the Schmidt reaction, which transforms aldehydes and ketones into amides, for nearly 100 years. [18] Mechanistic studies reveal an initial alkyne hydration to ketone followed by the Schmidt reaction to afford the amide. [19] The title compound has been synthesized by a Claisen–Schmidt reaction. [20] In the first step, the chalcones were synthesized by Claisen-Schmidt reaction. [21] A new series of benzofuran substituted chalcone derivatives was synthesized by the base-catalyzed Claisen-Schmidt reaction of the 1-(7-methoxy-1-benzofuran-2-yl) ethanone with different aromatic aldehydes to yield 1-(7-methoxy-1-benzofuran-2-yl) substituted chalcone derivatives 3a-e. [22] The Schmidt reaction of ω-azido valeryl chlorides in the presence of an additional nucleophile was explored. [23] A continuous-flow synthesis of nitriles by Schmidt reaction has been developed. [24] 6% by applying the classical Claisen-Schmidt reaction. [25] A rapid and efficient methodology was performed for the synthesis of α,β-unsaturated ketones 2a–k containing benzoazonine core through Claisen-Schmidt reaction of the benzoazonine-2,7-dione 1 and v. [26]3과 4-클로로벤즈알데하이드의 Claisen-Schmidt 반응은 상응하는 thiazolyl-chalcone 4를 제공했으며, 이는 히드라진 수화물 또는 페닐 히드라진으로 처리하여 고리화를 거쳐 각각 상응하는 티아졸릴-피라졸 5 및 6을 생성합니다. [1] 비스-칼콘과는 별도로 케톤과 살리실알데히드의 인기 있는 알칼리 촉매 Claisen-Schmidt 반응에서 예상치 못한 스피로 고리형 생성물이 얻어졌습니다. [2] 새로운 일련의 쿠마린-일-칼콘 유도체(3a-m)는 방향족 첨가, 고리화 및 Claisen-Schmidt 반응과 같은 다양한 반응을 통해 우수한 수율(54-78%)로 설계 및 합성되었습니다. [3] 전자 푸시-풀 효과가 있는 chalcone 계열(3a-f)은 간단한 정제 단계가 있는 1포트 Claisen-Schmidt 반응을 통해 합성되었습니다. [4] 설포늄 이온에 의한 슈미트 반응에 대해 설명합니다. [5] 모노케톤 커큐민 유사체의 합성은 5% 수산화칼륨을 촉매로 사용하여 3-benzyloxybenzaldehyde를 acetone(analog A), cyclopentanone(analog B), cyclohexanone(analog C)과 1시간 동안 환류시켜 Claisen-Schmidt 반응을 통해 수행하였다. [6] 예상되는 (E)-but-3-en-2-ones 화합물 I 및 II(하프 커큐미노이드)는 알데히드 3,4-디메톡시벤즈알데히드 또는 4-니트로벤즈알데히드와 아세톤 사이의 Claisen-Schmidt 반응에 의해 얻어졌습니다. [7] chalcone 합성은 염기로서 NaOH/KOH의 존재하에 아세토페논 유도체와 치환된 벤즈알데히드 사이의 무용매 고체 상태 분쇄를 포함합니다(Claisen-Schmidt 반응). [8] 설포늄 이온에 의한 슈미트 반응에 대해 설명합니다. [9] 첫 번째 단계는 Claisen-Schmidt 반응을 통한 모노케톤 커큐민 유사체의 합성이었습니다. [10] chalcone은 Claisen-Schmidt 반응을 사용하여 얻었다. [11] 활성 항균제를 개발하기 위한 시도에서 새로운 thiazolyl chalcones 세트는 알칼리 매질에서 5-acetyl-4-methyl-2-(3-pyridyl)thiazole과 다양한 heterocyclic aldehyde의 Claisen-Schmidt 반응에 의해 합성되었습니다. [12] II형 광개시제(2E,6E)-2,6-비스((1H-피롤-2-일)메틸렌)사이클로헥산-1-온(BPC)은 Claisen-Schmidt 반응을 통해 편리하게 합성되었다. [13] 방법: Claisen-schmidt 반응은 30개의 Indolylchalcone 하이브리드 합성에 사용되며, 여기에는 N-1 치환된 indole-3-carboxaldehyde와 N1 치환된 2-acetyl-benzimidazole의 축합이 포함됩니다. [14] 선구자, Claisen-Schmidt 반응을 이용하여 치환된 α,β-불포화 케톤을 얻었다; 그리고 Michael 응축에 의해 얻은 최종 제품은 분석 및 스펙트럼 IR, 1H NMR 및 질량 스펙트럼 연구를 포함하는 데이터. [15] 방법: Claisen-schmidt 반응은 30개의 Indolylchalcone 하이브리드 합성에 사용되며 N-1 치환된 indole-3-carboxaldehyde와 N1 치환된 2-acetyl-benzimidazole의 축합을 포함합니다. [16] 루판의 오존 분해는 표적 화합물에 대한 Claisen-Schmidt 반응에 의해 다른 방향족 알데히드를 사용하여 다음과 같은 축합으로 20-옥소-유도체를 제공했습니다. [17] 화학자들은 거의 100년 동안 알데히드와 케톤을 아미드로 전환시키는 슈미트 반응을 사용해 왔습니다. [18] 기계론적 연구는 케톤으로의 초기 알킨 수화 후 아미드를 제공하기 위한 슈미트 반응을 나타냅니다. [19] 표제 화합물은 Claisen-Schmidt 반응에 의해 합성되었습니다. [20] 첫 번째 단계에서 칼콘은 Claisen-Schmidt 반응에 의해 합성되었습니다. [21] 1-(7-methoxy-1-benzofuran-2-yl) 에타논과 다른 방향족 알데히드의 염기 촉매 Claisen-Schmidt 반응에 의해 1-(7-methoxy- 1-벤조푸란-2-일) 치환된 칼콘 유도체 3a-e. [22] 추가 친핵체의 존재하에 ω-azido valeryl chlorides의 Schmidt 반응을 조사했습니다. [23] 슈미트 반응에 의한 니트릴의 연속 흐름 합성이 개발되었습니다. [24] 고전적인 Claisen-Schmidt 반응을 적용하여 6%. [25] 벤조아조닌-2,7-디온 1 및 v의 Claisen-Schmidt 반응을 통해 벤조아조닌 코어를 함유하는 α,β-불포화 케톤 2a-k의 합성을 위한 신속하고 효율적인 방법이 수행되었습니다. [26]
2 en 1 1에서 2
In this paper, two type II photoinitiators (1E,4E)1,5-di(furan-2-yl) penta-1,4-dien-3-one (DFP) and (E)-1,3-di(furan-2-yl) prop-2-en-1-one (DFP-e) were synthesized via Claisen-Schmidt reaction. [1] Five chalcone-based molecules denominated by C-3 ((E)-1-(4-methoxyphenyl)-3-phenylprop-2-en-1-one), C-4 ((E)-1,3-bis(4-methoxyphenyl)prop-2-en-1-one), C-5 ((E)-1-(benzo[d][1,3]dioxol-5-yl)-3-(4-methoxyphenyl)prop-2-en-1-one), C-6 ((E)-3-(naphthalen-1-yl)-1-phenylprop-2-en-1-one) and C-7 ((E)-1-(4-methoxyphenyl)-3-(naphthalen-1-yl)prop-2-en-1-one) were synthesized by Claisen-Schmidt reaction in solution of NaOH in water/ethanol 2:1. [2]이 논문에서는 두 가지 유형 II 광개시제(1E,4E)1,5-di(furan-2-yl) penta-1,4-dien-3-one(DFP) 및 (E)-1,3-di( 푸란-2-일)프로프-2-엔-1-온(DFP-e)은 Claisen-Schmidt 반응을 통해 합성되었습니다. [1] C-3((E)-1-(4-메톡시페닐)-3-페닐프로프-2-엔-1-온), C-4((E)-1,3-비스( 4-메톡시페닐)프로프-2-엔-1-온), C-5((E)-1-(벤조[d][1,3]디옥솔-5-일)-3-(4-메톡시페닐)프로프 -2-엔-1-온), C-6((E)-3-(나프탈렌-1-일)-1-페닐프로프-2-엔-1-온) 및 C-7((E)-1 -(4-메톡시페닐)-3-(나프탈렌-1-일)프로프-2-엔-1-온)은 물/에탄올 2:1 중 NaOH 용액에서 Claisen-Schmidt 반응에 의해 합성되었습니다. [2]
Intramolecular Schmidt Reaction 분자내 슈미트 반응
A Lewis acid promoted intramolecular Schmidt reaction of N-acylbenzotriazoles with alkyl azides was designed and realized. [1] Electrostatic drag in the intramolecular Schmidt reactions of azidopropylcyclohexanones is characterized using density functional theory (DFT) calculations and direct dynamics simulations. [2] The stereoselectivity and stereospecificity of the triflate‐mediated intramolecular Schmidt reaction of substituted 3‐(1‐azidocyclohexyl)propanol derivatives leading to octahydro‐1H‐pyrrolo[1,2‐a]azepine, the structural skeleton of several important families of alkaloids such as the Stemona alkaloids, has been examined. [3]루이스 산 촉진 N-아실벤조트리아졸과 알킬 아지드의 분자내 슈미트 반응이 설계되고 실현되었습니다. [1] azidopropylcyclohexanones의 분자 내 Schmidt 반응에서 정전기 항력은 밀도 기능 이론(DFT) 계산 및 직접 역학 시뮬레이션을 사용하여 특성화됩니다. [2] nan [3]