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Targeted Redesign of Suramin Analogs for Novel Antimicrobial Lead Development



Potential Novel Thioether-Amide or Guanidine-Linker Class of SARS-CoV-2 Virus RNA-Dependent RNA Polymerase Inhibitors Identified by High-Throughput Virtual Screening Coupled to Free-Energy Calculations



Baicalein and Baicalin Inhibit SARS-CoV-2 RNA-Dependent-RNA Polymerase



Computationally repurposed drugs and natural products against RNA dependent RNA polymerase as potential COVID-19 therapies



Water-soluble tocopherol derivatives inhibit SARS-CoV-2 RNA-dependent RNA polymerase



Targeting SARS-CoV-2 Polymerase with New Nucleoside Analogues



Inhibitory activity of marine sponge metabolites on SARS-CoV-2 RNA dependent polymerase: virtual screening and molecular dynamics simulation.



In silico evaluation of isatin-based derivatives with RNA-dependent RNA polymerase of the novel coronavirus SARS-CoV-2.



Structural basis for inhibition of the SARS-CoV-2 RNA polymerase by suramin.



Structure of the SARS-CoV-2 RNA-dependent RNA polymerase in the presence of favipiravir-RTP



HISNAPI: a bioinformatic tool for dynamic hot spot analysis in nucleic acid-protein interface with a case study



CoViTris2020 and ChloViD2020: a striking new hope in COVID-19 therapy



A strategy combining 3D-DNA Walker and CRISPR-Cas12a trans-cleavage activity applied to MXene based electrochemiluminescent sensor for SARS-CoV-2 RdRp gene detection



Ultra-fast and recyclable DNA biosensor for point-of-care detection of SARS-CoV-2 (COVID-19)



Discovery and optimization of 2-((1H-indol-3-yl)thio)-N-benzyl-acetamides as novel SARS-CoV-2 RdRp inhibitors



Electron Density Analysis of SARS-CoV-2 RNA-Dependent RNA Polymerase Complexes



NMPylation and de-NMPylation of SARS-CoV-2 nsp9 by the NiRAN domain



Sandacrabins – Structurally unique antiviral RNA polymerase inhibitors from a rare myxobacterium



Exploiting the antiviral properties of selected phytochemicals from leaf extracts of Spondias mombin (Linn): A computational repurposing approach toward the discovery of potential SARS-CoV-2 inhibitors.



Structural basis for backtracking by the SARS-CoV-2 replication-transcription complex



Global Genomic Analysis of SARS-CoV-2 RNA Dependent RNA Polymerase Evolution and Antiviral Drug Resistance



Remdesivir MD Simulations Suggest a More Favourable Binding to SARS-CoV-2 RNA Dependent RNA Polymerase Mutant P323L Than Wild-Type



Antiviral drugs against severe acute respiratory syndrome coronavirus 2 infection triggering the coronavirus disease-19 pandemic



Targeted redesign of suramin analogs for novel antimicrobial lead development



Silencing of SARS-CoV-2 with modified siRNA-peptide dendrimer formulation



Natural coumarins as potential anti-SARS-CoV-2 agents supported by docking analysis



Reductionism Ad Absurdum: The Misadventures of Structural Biology in the Time of Coronavirus



Early combination treatment with existing HIV antivirals: an effective treatment for COVID-19?



Chemical Synthesis of the Antiviral Nucleotide Analogue ddhCTP.



Surface plasmon resonance approach to study drug interactions with SARS-CoV-2 RNA-dependent RNA polymerase highlights treatment potential of suramin



NMPylation and de-NMPylation of SARS-CoV-2 Nsp9 by the NiRAN domain



Phyto-compounds from a rather poisonous plant, Strychnos nux-vomica, show high potency against SARS-CoV-2 RNA-dependent RNA polymerase.



Global surveillance of potential antiviral drug resistance in SARS-CoV-2: proof of concept focussing on the RNA-dependent RNA polymerase



Allosteric activation of SARS-CoV-2 RdRp by remdesivir triphosphate and other phosphorylated nucleotides


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