Receptor Related(수용체 관련)란 무엇입니까?
Receptor Related 수용체 관련 - CNGA1 encodes a membrane protein on rod photoreceptor related to phototransduction. [1]CNGA1은 광변환과 관련된 간상체 광수용체의 막 단백질을 암호화합니다. [1]
low density lipoprotein 저밀도 지단백질
In the analysis of combinatorial gene alterations, concomitant mutations of KRAS with low-density lipoprotein receptor related protein 1B (LRP1B) were associated with significantly worse disease-free survival after surgery (p = 0. [1] Two Aβ transporters, soluble form of low-density lipoprotein receptor related protein-1 (sLRP1) and soluble receptor of advanced glycation end products (sRAGE), are crucial in peripheral Aβ transport. [2] Also, active crossing and targeting are achieved by theranostic cHANPs decorated with angiopep-2 (Thera-ANG-cHANPs), a dual-targeting peptide interacting with low density lipoprotein receptor related protein-1(LRP-1) receptors overexpressed by both endothelial cells of the BBB and glioma cells. [3] Hepatic uptake of triglyceride-rich remnant lipoproteins is mediated by the low-density lipoprotein receptor, a low-density lipoprotein receptor related protein and the heparan sulfate proteoglycan, syndecan-1. [4] This was supported by the identification of an interaction with low density lipoprotein receptor related protein 1 (LRP1), an endocytic regulator of platelet-derived growth factor BB (PDGF-BB) signaling and VSMC proliferation. [5] Results A 52-year-old Caucasian female with idiopathic osteoporosis with recurrent fractures was identified with a heterozygous low-density lipoprotein receptor related protein 5 (LRP5) mutation. [6] The low-density lipoprotein receptor related protein 1 (LRP1) is highly expressed in the endothelial cells of the brain capillary and the glioma cells. [7] GalNAc-T11 specifically controls O-glycosylation of specific linker regions in the low-density lipoprotein receptor related proteins. [8] This was supported by identification of an interaction with Low density lipoprotein receptor related protein 1 (LRP1), an endocytic regulator of PDGF-BB signalling and VSMC proliferation. [9] Here, we investigated expressive changes of two main Aβ transport receptors low-density lipoprotein receptor related protein-1 (LRP1) and receptor for advanced glycation end products (RAGE) in a novel AD mice (APP23) with chronic cerebral hypoperfusion (CCH) model, moreover, examined a protective effect of a free radical scavenger edaravone (Eda). [10] Low-density lipoprotein Receptor Related Protein 1B (LRP1B) is homologous to the gigantic lipoprotein receptor-related protein 1 that belongs to the family of Low-density lipoprotein receptors. [11] Angiopep-2 ligates the low density lipoprotein receptor related protein 1 (LRP1) on brain microvascular endothelial cells (BMECs) to drive transcytosis for BBB crossing. [12] We identified an interaction between Tβ4 and Low density lipoprotein receptor related protein 1 (LRP1), an endocytic regulator of PDGFR? signalling which controls VSMC proliferation. [13] They typically antagonize Wnt/β-catenin signaling by binding and inhibiting Wnt co-receptors, LRP5/6 (low density lipoprotein receptor related protein 5/6). [14] This was supported by identification of an interaction with Low density lipoprotein receptor related protein 1 (LRP1), an endocytic regulator of PDGF-BB signalling and VSMC proliferation. [15] The aggregated protein Agrin promotes metastasis and invasion of cancer by interacting with low density lipoprotein receptor related protein 4(Lrp4). [16] Sclerostin is a protein secreted by osteocytes which acts as an antagonist to WNT/β-catenin signaling pathway through binding to WNT co-receptors low density lipoprotein receptor related protein 5 (LRP5) or 6 (LRP6), resulting in decreased osteoblastic bone formation. [17]조합 유전자 변형 분석에서 저밀도 지단백 수용체 관련 단백질 1B(LRP1B)와 KRAS의 동시 돌연변이는 수술 후 유의하게 더 나쁜 무병 생존과 관련이 있었습니다(p = 0. [1] 저밀도 지단백질 수용체 관련 단백질-1(sLRP1)의 가용성 형태와 최종 당화 최종 생성물의 가용성 수용체(sRAGE)인 2개의 Aβ 수송체는 말초 Aβ 수송에 중요합니다. [2] nan [3] nan [4] nan [5] 결과 재발성 골절을 동반한 특발성 골다공증이 있는 52세 백인 여성이 이형접합 저밀도 지단백 수용체 관련 단백질 5(LRP5) 돌연변이로 확인되었습니다. [6] 저밀도 지단백 수용체 관련 단백질 1(LRP1)은 뇌 모세혈관의 내피 세포와 신경교종 세포에서 고도로 발현됩니다. [7] nan [8] nan [9] nan [10] nan [11] nan [12] nan [13] nan [14] nan [15] nan [16] nan [17]
nuclear receptor subfamily
Estrogen-receptor related receptors (ERRs) which consists of ERRα, ERRβ and ERRγ belong to the orphan nuclear receptor subfamily 3, group B (NR3B) subfamily, and are constitutively active. [1] Abbreviations: Aβ, β-amyloid; AChE, acetylcholinesterase enzyme; AD, Alzheimer’s disease; ALS, amyotrophic lateral sclerosis; AMPA, α-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid; ApoE, human Apolipoprotein-E; APP, amyloid precursor protein; BH4, tetrahydrobiopterin; CaMKII, Ca2+and calmodulin-dependent protein kinase II; CREB, cyclic adenosine monophosphate response element-binding protein; GAG, glycosaminoglycans; EGb 761, a standardized Ginkgo biloba extract; GCH1, GTP cyclohydrolase I; GSK-3, glycogen synthase kinase-3; HD, Huntington’s disease; hIAPP, human islet amyloid polypeptide; H2O2, hydrogen peroxide; INF-γ, interferon-γ; IL-1, interleukin-1; IL-6, interleukin-6; IL-β, interleukin-β; JNK, c-Jun N-terminal kinase; LPS, lipopolysaccharide; MPO, myeloperoxidase; MPTP, 1-methyl-4-phenyl-1,2,3,6tetrahydropyridine; nAChR, nicotinic acetylcholine receptor; NFκB, nuclear factor kappa B; NMDA, N-methyl-D-aspartate; NOX2, NADPH oxidase enzyme; NR4A2, nuclear receptor subfamily 4 group A member 2; Nurr1, nuclear receptor related 1 protein; polyQ, proteins containing glutamine repeats; ROS, reactive oxygen species; SOD1, superoxide dismutase 1; TBP, TATA box-binding protein; TFEB, transcription factor EB; TH, tyrosine hydroxylase; TLR4, tolllike receptor 4; TNF-α, tumor necrosis factor α. [2] Estrogen-receptor related receptors which consists of ERRα, ERRβ and ERRγ belong to the orphan nuclear receptor subfamily of NR3B (nuclear receptor subfamily 3, group B). [3]ERRα, ERRβ 및 ERRγ로 구성된 에스트로겐 수용체 관련 수용체(ERR)는 고아 핵 수용체 서브패밀리 3, 그룹 B(NR3B) 서브패밀리에 속하며 구성적으로 활성입니다. [1] 약어: Aβ, β-아밀로이드; AChE, 아세틸콜린에스테라제 효소; 알츠하이머병, 알츠하이머병; ALS, 근위축성 측삭 경화증; AMPA, α-아미노-3-히드록시-5-메틸-4-이속사졸프로피온산; ApoE, 인간 아포지단백질-E; APP, 아밀로이드 전구체 단백질; BH4, 테트라히드로바이오프테린; CaMKII, Ca2+및 칼모듈린 의존성 단백질 키나제 II; CREB, 환형 아데노신 모노포스페이트 반응 요소 결합 단백질; GAG, 글리코사미노글리칸; 표준화된 은행나무 추출물인 EGb 761; GCH1, GTP 사이클로하이드롤라제 I; GSK-3, 글리코겐 합성효소 키나제-3; HD, 헌팅턴병; hIAPP, 인간 섬 아밀로이드 폴리펩타이드; H2O2, 과산화수소; INF-γ, 인터페론-γ; IL-1, 인터루킨-1; IL-6, 인터루킨-6; IL-β, 인터루킨-β; JNK, c-Jun N-말단 키나제; LPS, 지질다당류; MPO, 골수페록시다제; MPTP, 1-메틸-4-페닐-1,2,3,6테트라하이드로피리딘; nAChR, 니코틴성 아세틸콜린 수용체; NFκB, 핵인자 카파 B; NMDA, N-메틸-D-아스파테이트; NOX2, NADPH 산화효소; NR4A2, 핵 수용체 서브패밀리 4 그룹 A 구성원 2; Nurr1, 핵 수용체 관련 1 단백질; 폴리Q, 글루타민 반복을 함유하는 단백질; ROS, 활성산소종; SOD1, 슈퍼옥사이드 디스뮤타제 1; TBP, TATA 상자 결합 단백질; TFEB, 전사 인자 EB; TH, 티로신 하이드록실라제; TLR4, 톨유사 수용체 4; TNF-α, 종양 괴사 인자 α. [2] ERRα, ERRβ 및 ERRγ로 구성된 에스트로겐 수용체 관련 수용체는 NR3B의 고아 핵 수용체 서브패밀리(핵 수용체 서브패밀리 3, 그룹 B)에 속합니다. [3]
Lipoprotein Receptor Related 지단백질 수용체 관련
In the analysis of combinatorial gene alterations, concomitant mutations of KRAS with low-density lipoprotein receptor related protein 1B (LRP1B) were associated with significantly worse disease-free survival after surgery (p = 0. [1] Two Aβ transporters, soluble form of low-density lipoprotein receptor related protein-1 (sLRP1) and soluble receptor of advanced glycation end products (sRAGE), are crucial in peripheral Aβ transport. [2] Also, active crossing and targeting are achieved by theranostic cHANPs decorated with angiopep-2 (Thera-ANG-cHANPs), a dual-targeting peptide interacting with low density lipoprotein receptor related protein-1(LRP-1) receptors overexpressed by both endothelial cells of the BBB and glioma cells. [3] Hepatic uptake of triglyceride-rich remnant lipoproteins is mediated by the low-density lipoprotein receptor, a low-density lipoprotein receptor related protein and the heparan sulfate proteoglycan, syndecan-1. [4] This was supported by the identification of an interaction with low density lipoprotein receptor related protein 1 (LRP1), an endocytic regulator of platelet-derived growth factor BB (PDGF-BB) signaling and VSMC proliferation. [5] Results A 52-year-old Caucasian female with idiopathic osteoporosis with recurrent fractures was identified with a heterozygous low-density lipoprotein receptor related protein 5 (LRP5) mutation. [6] The low-density lipoprotein receptor related protein 1 (LRP1) is highly expressed in the endothelial cells of the brain capillary and the glioma cells. [7] GalNAc-T11 specifically controls O-glycosylation of specific linker regions in the low-density lipoprotein receptor related proteins. [8] This was supported by identification of an interaction with Low density lipoprotein receptor related protein 1 (LRP1), an endocytic regulator of PDGF-BB signalling and VSMC proliferation. [9] Here, we investigated expressive changes of two main Aβ transport receptors low-density lipoprotein receptor related protein-1 (LRP1) and receptor for advanced glycation end products (RAGE) in a novel AD mice (APP23) with chronic cerebral hypoperfusion (CCH) model, moreover, examined a protective effect of a free radical scavenger edaravone (Eda). [10] Low-density lipoprotein Receptor Related Protein 1B (LRP1B) is homologous to the gigantic lipoprotein receptor-related protein 1 that belongs to the family of Low-density lipoprotein receptors. [11] Angiopep-2 ligates the low density lipoprotein receptor related protein 1 (LRP1) on brain microvascular endothelial cells (BMECs) to drive transcytosis for BBB crossing. [12] We identified an interaction between Tβ4 and Low density lipoprotein receptor related protein 1 (LRP1), an endocytic regulator of PDGFR? signalling which controls VSMC proliferation. [13] They typically antagonize Wnt/β-catenin signaling by binding and inhibiting Wnt co-receptors, LRP5/6 (low density lipoprotein receptor related protein 5/6). [14] This was supported by identification of an interaction with Low density lipoprotein receptor related protein 1 (LRP1), an endocytic regulator of PDGF-BB signalling and VSMC proliferation. [15] The aggregated protein Agrin promotes metastasis and invasion of cancer by interacting with low density lipoprotein receptor related protein 4(Lrp4). [16] Sclerostin is a protein secreted by osteocytes which acts as an antagonist to WNT/β-catenin signaling pathway through binding to WNT co-receptors low density lipoprotein receptor related protein 5 (LRP5) or 6 (LRP6), resulting in decreased osteoblastic bone formation. [17]조합 유전자 변형 분석에서 저밀도 지단백 수용체 관련 단백질 1B(LRP1B)와 KRAS의 동시 돌연변이는 수술 후 유의하게 더 나쁜 무병 생존과 관련이 있었습니다(p = 0. [1] 저밀도 지단백질 수용체 관련 단백질-1(sLRP1)의 가용성 형태와 최종 당화 최종 생성물의 가용성 수용체(sRAGE)인 2개의 Aβ 수송체는 말초 Aβ 수송에 중요합니다. [2] nan [3] nan [4] nan [5] 결과 재발성 골절을 동반한 특발성 골다공증이 있는 52세 백인 여성이 이형접합 저밀도 지단백 수용체 관련 단백질 5(LRP5) 돌연변이로 확인되었습니다. [6] 저밀도 지단백 수용체 관련 단백질 1(LRP1)은 뇌 모세혈관의 내피 세포와 신경교종 세포에서 고도로 발현됩니다. [7] nan [8] nan [9] nan [10] nan [11] nan [12] nan [13] nan [14] nan [15] nan [16] nan [17]
Nuclear Receptor Related 핵수용체 관련
Additional activities were found against the pregnane X receptor, nuclear receptor related-1 protein, and nuclear factor erythroid 2-related factor 2, a sensor of oxidative stress. [1] Five different molecular targets namely Peroxisome Proliferator-Activated Receptor- Gamma (PPARγ), Liver-X receptor beta (LXR- β), Human Monoamine Oxidase-B (MAO-B), Human Nuclear receptor related-1 protein (Nurr1) and Human Lipoprotein-associated phospholipase A2 (Lp-PLA2) were obtained from RCSB-PDB, which has some leading association in the inhibition of the OS-induced neurodegeneration. [2] The ligand-sensing transcription factor nuclear receptor related 1 (Nurr1) evolves as an appealing target to treat neurodegenerative diseases. [3] GM1 also significantly enhances expression of tyrosine hydroxylase (TH) in the substantia nigra pars compacta of the A53T aSyn overexpressing mouse, following restored nuclear expression of nuclear receptor related 1 (Nurr1, also known as NR4A2), an essential transcription factor for differentiation, maturation, and maintenance of midbrain dopaminergic neurons. [4] The ligand-activated transcription factor nuclear receptor related-1 (Nurr1) exhibits great potential for neurodegenerative disease treatment, but potent Nurr1 modulators to further probe and validate the nuclear receptor as a therapeutic target are lacking. [5] As a member of the orphan nuclear receptor family, nuclear receptor related 1 (Nurr1) plays a vital role in some neuropathological diseases and several types of benign or malignant tumors. [6] To investigate the relationship of Nurr1 with synaptic and social deficit, we activated the expression level of nuclear receptor related 1 protein (Nurr1) by i. [7] We also found that TSG enhanced the expression of nuclear receptor related factor 1, a transcription factor specific for the development and maintenance of midbrain DA neurons in inducing NSC differentiation into TH -immunoreactive DA neurons. [8] Background: Orphan nuclear receptor related-1 protein (Nurr1) belonging to the NR4A family is important for carcinogenesis in multiple biological processes such as cell proliferation and apoptosis. [9] Objective: The aim of our study is to explore the pathological role of nuclear receptor related 1 protein (NURR1) in regulating cardiomyocyte viability under hypoxia stress. [10] Nuclear receptor related 1 protein (Nurr1), a member of the nuclear receptor 4 family of orphan nuclear receptors, has been reported to display anti-inflammatory properties. [11] Nuclear receptor related-1 (Nurr1) protein performs a crucial role in hippocampal neural stem cell (hNSC) development as well as cognitive functions. [12] Real time RT-qPCR analysis indicated that expressions of brain derived neurotrophic factor (BDNF), glial cell line derived neurotropic factor (GNDF), matrix associated protein 2 (MAP2), nuclear receptor related 1 protein (NURR1) and dopamine transporter (DAT) were increased, especially in the first 7 days of dopaminergic induction when 660 nm laser light was applied with a total energy density of 1. [13] Abbreviations: Aβ, β-amyloid; AChE, acetylcholinesterase enzyme; AD, Alzheimer’s disease; ALS, amyotrophic lateral sclerosis; AMPA, α-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid; ApoE, human Apolipoprotein-E; APP, amyloid precursor protein; BH4, tetrahydrobiopterin; CaMKII, Ca2+and calmodulin-dependent protein kinase II; CREB, cyclic adenosine monophosphate response element-binding protein; GAG, glycosaminoglycans; EGb 761, a standardized Ginkgo biloba extract; GCH1, GTP cyclohydrolase I; GSK-3, glycogen synthase kinase-3; HD, Huntington’s disease; hIAPP, human islet amyloid polypeptide; H2O2, hydrogen peroxide; INF-γ, interferon-γ; IL-1, interleukin-1; IL-6, interleukin-6; IL-β, interleukin-β; JNK, c-Jun N-terminal kinase; LPS, lipopolysaccharide; MPO, myeloperoxidase; MPTP, 1-methyl-4-phenyl-1,2,3,6tetrahydropyridine; nAChR, nicotinic acetylcholine receptor; NFκB, nuclear factor kappa B; NMDA, N-methyl-D-aspartate; NOX2, NADPH oxidase enzyme; NR4A2, nuclear receptor subfamily 4 group A member 2; Nurr1, nuclear receptor related 1 protein; polyQ, proteins containing glutamine repeats; ROS, reactive oxygen species; SOD1, superoxide dismutase 1; TBP, TATA box-binding protein; TFEB, transcription factor EB; TH, tyrosine hydroxylase; TLR4, tolllike receptor 4; TNF-α, tumor necrosis factor α. [14] Nuclear receptor related 1 protein (Nurr1) is an important transcription factor required for differentiation and maintenance of midbrain dopaminergic (DA) neurons. [15]임신 X 수용체, 핵 수용체 관련-1 단백질 및 산화 스트레스 센서인 핵 인자 적혈구계 2 관련 인자 2에 대해 추가 활성이 발견되었습니다. [1] Peroxisome Proliferator-Activated Receptor-Gamma (PPARγ), Liver-X receptor beta (LXR-β), Human Monoamine Oxidase-B (MAO-B), Human Nuclear receptor related-1 protein (Nurr1) and Human의 5가지 다른 분자 표적 RCSB-PDB에서 지단백질 관련 포스포리파제 A2(Lp-PLA2)를 얻었으며, 이는 OS 유발 신경변성의 억제에 일부 선도적인 연관성이 있습니다. [2] 리간드 감지 전사 인자 핵 수용체 관련 1(Nurr1)은 신경퇴행성 질환을 치료하는 매력적인 표적으로 진화하고 있습니다. [3] GM1은 또한 분화, 성숙에 필수적인 전사 인자인 핵 수용체 관련 1(Nurr1, NR4A2로도 알려짐)의 핵 발현을 회복시킨 후 A53T aSyn 과발현 마우스의 흑색질 콤팩타에서 티로신 수산화효소(TH)의 발현을 크게 향상시킵니다. , 및 중뇌 도파민성 뉴런의 유지. [4] nan [5] nan [6] nan [7] nan [8] 배경: NR4A 계열에 속하는 희귀 핵 수용체 관련-1 단백질(Nurr1)은 세포 증식 및 세포 사멸과 같은 여러 생물학적 과정에서 발암에 중요합니다. [9] 목적: 우리 연구의 목적은 저산소증 스트레스 하에서 심근세포 생존을 조절하는 핵 수용체 관련 1 단백질(NURR1)의 병리학적 역할을 탐구하는 것입니다. [10] 고아 핵 수용체의 핵 수용체 4 패밀리의 구성원인 핵 수용체 관련 1 단백질(Nurr1)은 항염 특성을 나타내는 것으로 보고되었습니다. [11] nan [12] nan [13] 약어: Aβ, β-아밀로이드; AChE, 아세틸콜린에스테라제 효소; 알츠하이머병, 알츠하이머병; ALS, 근위축성 측삭 경화증; AMPA, α-아미노-3-히드록시-5-메틸-4-이속사졸프로피온산; ApoE, 인간 아포지단백질-E; APP, 아밀로이드 전구체 단백질; BH4, 테트라히드로바이오프테린; CaMKII, Ca2+및 칼모듈린 의존성 단백질 키나제 II; CREB, 환형 아데노신 모노포스페이트 반응 요소 결합 단백질; GAG, 글리코사미노글리칸; 표준화된 은행나무 추출물인 EGb 761; GCH1, GTP 사이클로하이드롤라제 I; GSK-3, 글리코겐 합성효소 키나제-3; HD, 헌팅턴병; hIAPP, 인간 섬 아밀로이드 폴리펩타이드; H2O2, 과산화수소; INF-γ, 인터페론-γ; IL-1, 인터루킨-1; IL-6, 인터루킨-6; IL-β, 인터루킨-β; JNK, c-Jun N-말단 키나제; LPS, 지질다당류; MPO, 골수페록시다제; MPTP, 1-메틸-4-페닐-1,2,3,6테트라하이드로피리딘; nAChR, 니코틴성 아세틸콜린 수용체; NFκB, 핵인자 카파 B; NMDA, N-메틸-D-아스파테이트; NOX2, NADPH 산화효소; NR4A2, 핵 수용체 서브패밀리 4 그룹 A 구성원 2; Nurr1, 핵 수용체 관련 1 단백질; 폴리Q, 글루타민 반복을 함유하는 단백질; ROS, 활성산소종; SOD1, 슈퍼옥사이드 디스뮤타제 1; TBP, TATA 상자 결합 단백질; TFEB, 전사 인자 EB; TH, 티로신 하이드록실라제; TLR4, 톨유사 수용체 4; TNF-α, 종양 괴사 인자 α. [14] nan [15]
Ldl Receptor Related LDL 수용체 관련
Abbreviations: ACTB: actin, beta; ATF4: activating transcription factor 4; CMA: chaperone-mediated autophagy; DYNC1LI1: dynein cytoplasmic 1 light intermediate chain 1; DYNC1LI2: dynein cytoplasmic 1 light intermediate chain 2; ER: endoplasmic reticulum; LAMP1: lysosomal associated membrane protein 1; LAMP2A: lysosomal associated membrane protein 2A; LIC: light-intermediate chains; LRP2/Megalin: LDL receptor related protein 2; PTCs: proximal tubule cells; RAB: RAB, member RAS oncogene family; RAB11FIP3: RAB11 family interacting protein 3; RILP: Rab interacting lysosomal protein. [1] The homozygous autosomal recessive truncating mutations of LDL receptor related protein associated protein 1 (LRPAP1) is a possible reason for Nonsyndromic Extreme Myopia, patients with which show typical chorioretinal degeneration. [2] Fisher’s exact testing revealed significant relationships between the minor T allele of LDL receptor related protein 5 (LRP5) rs3736228 and the prevalence of knee/hip OA and osteoporosis. [3] e15507 Background: LDL receptor related protein 2 (LRP2), a multi-ligand endocytic receptor, has been implicated in the tumourigenesis of various human cancers. [4] The expression levels of LDL receptor related protein 5 (Lrp5), lymphoid enhancer binding factor 1 (Lef1) and transcription factor 1 in C3H10T1/2 cells were significantly increased in shCkip-1 cells following 7-day osteoinduction compared with shCtrl cells. [5] Recently, we identified LDL receptor related protein associated protein 1 (LRPAP1) as frequent autoantigen of recombinant B-cell receptors (BCRs) of mantle cell lymphoma (MCL). [6] siRNA/RNAi-mediated knockdown in generic human iPSC-derived cardiac progenitors and in the in vivo Drosophila heart model revealed that LDL receptor related protein LRP2 and apolipoprotein APOB are required for robust hiPSC-derived cardiomyocyte proliferation and normal hear structure and function, possibly involving an oligogenic mechanism via growth-promoting WNT and SHH signaling. [7] LDL receptor related protein 4 (LRP4) and carbonic anhydrase 12 (CA12) were hypomethylated and had an increased expression level. [8] ②In vitro experiment: HCT 116 cells were treated with resveratrol at 10 mg/ml, the expressions of β-catenin, LDL receptor related protein-6 (LRP-6), frizzled-3 (FZD3) and c-Myc were detected. [9] Wnt signaling co-receptor LDL receptor related protein 6 (LRP6) was identified as a cell membrane binding partner of VSTM2A. [10] Isolated liver cysts are caused by mutations in Protein Kinase C Substrate 80K-H (PRKCSH), SEC63, and LDL Receptor Related Protein 5 (LRP5), whereas Polycystic Kidney Disease (PKD)1, PKD2, and PKHD1 mutations cause kidney cysts often accompanied by liver cysts. [11]약어: ACTB: 액틴, 베타; ATF4: 전사 인자 4 활성화; CMA: 샤페론 매개 자가포식; DYNC1LI1: 다이네인 세포질 1 경쇄 중간쇄 1; DYNC1LI2: 다이네인 세포질 1 경쇄 중간쇄 2; ER: 소포체; LAMP1: 리소좀 관련 막 단백질 1; LAMP2A: 리소좀 관련 막 단백질 2A; LIC: 가벼운 중간 사슬; LRP2/메갈린: LDL 수용체 관련 단백질 2; PTC: 근위 세뇨관 세포; RAB: RAB, 구성원 RAS 종양유전자 패밀리; RAB11FIP3: RAB11 패밀리 상호작용 단백질 3; RILP: Rab 상호작용 리소좀 단백질. [1] LDL 수용체 관련 단백질 관련 단백질 1(LRPAP1)의 동형접합 상염색체 열성 절단 돌연변이는 전형적인 맥락망막 변성을 나타내는 비증후군성 극도 근시의 가능한 원인입니다. [2] nan [3] nan [4] nan [5] nan [6] 일반 인간 iPSC 유래 심장 전구세포 및 생체내 초파리 심장 모델에서 siRNA/RNAi 매개 녹다운은 LDL 수용체 관련 단백질 LRP2 및 아포지단백 APOB가 강력한 hiPSC 유래 심근세포 증식 및 정상적인 청력 구조 및 기능에 필요함을 밝혔습니다. 성장 촉진 WNT 및 SHH 신호 전달을 통한 올리고제닉 메커니즘. [7] LDL 수용체 관련 단백질 4(LRP4)와 탄산탈수효소 12(CA12)는 저메틸화되어 발현 수준이 증가했습니다. [8] nan [9] nan [10] nan [11]
Acid Receptor Related 산 수용체 관련
25), retinoid acid receptor related orphan receptor α (7. [1] In addition, they decreased the elevated expression level of miRNA-155, 146a and increased the expression level of miRNA-34 and they decreased the expression level of retinoic acid receptor related orphan receptor γT (RORγT) and increased that of fork head box P3 (FOXP3), correcting Th17/Treg cells balance. [2] Identified key contact points are different forms of retinoic acid receptor related orphan receptors (ROR) and LXRs. [3] Sirtuin‐1 (Sirt1), a member of the NAD‐dependent sirtuin family of histone/protein deacetylases (HDAC), is an important target for immunotherapy due to its role in deacetylating the transcription factors Foxp3 and thymic retinoid acid receptor related orphan receptor gamma (RORγt). [4]25), 레티노이드산 수용체 관련 고아 수용체 α(7. [1] 또한 miRNA-155, 146a의 증가된 발현량을 감소시키고 miRNA-34의 발현량을 증가시켰으며, retinoic acid receptor related orphan receptor γT(RORγT)의 발현량을 감소시키고 fork head box P3의 발현량을 증가시켰다( FOXP3), Th17/Treg 세포 균형을 수정합니다. [2] 확인된 주요 접점은 다양한 형태의 레티노산 수용체 관련 고아 수용체(ROR) 및 LXR입니다. [3] NAD 의존성 히스톤/단백질 탈아세틸화효소(HDAC) 계열의 Sirtuin-1(Sirt1)은 전사 인자 Foxp3 및 흉선 레티노이드산 수용체 관련 고아 수용체 감마를 탈아세틸화하는 역할 때문에 면역 요법의 중요한 표적입니다. (RORγt). [4]
Coupled Receptor Related 결합 수용체 관련
The immune inhibitory and longevity stimulatory functions of PITX/UNC-30 require the sensory neuron ASG and a signaling pathway controlled by NPR-1, which is a G protein-coupled receptor related to mammalian neuropeptide Y receptors. [1] The immune inhibitory and longevity stimulatory functions of PITX/UNC-30 required the sensory neuron ASG and a neurotransmitter signaling pathway controlled by NPR-1, which is a G protein-coupled receptor related to mammalian neuropeptide Y receptors. [2] With the GCNs analysis, two second messenger G protein-coupled receptor related genes that respond to gibberellin signals in the cell were discovered. [3]PITX/UNC-30의 면역 억제 및 장수 자극 기능은 감각 뉴런 ASG와 포유류 신경 펩티드 Y 수용체와 관련된 G 단백질 결합 수용체인 NPR-1에 의해 제어되는 신호 전달 경로를 필요로 합니다. [1] PITX/UNC-30의 면역 억제 및 장수 자극 기능은 감각 뉴런 ASG와 포유류 신경 펩티드 Y 수용체와 관련된 G 단백질 결합 수용체인 NPR-1에 의해 제어되는 신경 전달 물질 신호 전달 경로를 필요로 했습니다. [2] nan [3]
Polioviru Receptor Related
2504 Background: COM701 is a novel first in class humanized IgG4 monoclonal antibody that binds with high affinity to poliovirus receptor related immunoglobulin domain containing (PVRIG), blocking its interaction with its ligand, PVRL2. [1] COM701 is a novel first-in-class humanized IgG4 monoclonal antibody that binds with high affinity to PVRIG (poliovirus receptor related immunoglobulin domain containing) blocking its interaction with its ligand, PVRL2. [2]Stimulatory Receptor Related
Apart from inhibitory checkpoints, OX40, the co-stimulatory receptor related to T cell priming and proliferation, was valued identically. [1] Apart from inhibitory checkpoints, OX40, the co-stimulatory receptor related to T cell priming and proliferation, was valued identically. [2]억제 체크포인트를 제외하고, T 세포 프라이밍 및 증식과 관련된 공동 자극 수용체인 OX40은 동일하게 평가되었습니다. [1] 억제 체크포인트를 제외하고, T 세포 프라이밍 및 증식과 관련된 공동 자극 수용체인 OX40은 동일하게 평가되었습니다. [2]
1 Receptor Related
Interleukin 1 receptor related protein, Suppression of tumorigenicity 2 (ST2) is a biomarker related to the pathophysiology of fibrosis, having shown promise in the study of heart failure. [1] When injected with apelin-13 for 12 weeks, the hyperuricemia rats had ameliorated oxidative stress, downregulated RAS components and upregulated angiotensin type 1 receptor related protein (APJ) expression in adipose tissue. [2]receptor related protein 수용체 관련 단백질
Moreover, it is unclear whether NG2 glia express auxiliary transmembrane AMPA receptor related proteins (TARPs), which modify AMPA receptor properties, including their Ca2+ permeability. [1] Proprotein-convertase-subtilisin/kexin type-9 (PCSK9) was found to decrease neuronal cholesterol uptake by degradation of LDL-receptor related protein 1 (LRP-1) responsible for neuronal cholesterol uptake. [2] In the analysis of combinatorial gene alterations, concomitant mutations of KRAS with low-density lipoprotein receptor related protein 1B (LRP1B) were associated with significantly worse disease-free survival after surgery (p = 0. [3] Two Aβ transporters, soluble form of low-density lipoprotein receptor related protein-1 (sLRP1) and soluble receptor of advanced glycation end products (sRAGE), are crucial in peripheral Aβ transport. [4] Although it was not statistically significant, turmeric supplementation showed a trend of reducing serum total cholesterol and LDL-cholesterol as well as liver expression levels of genes involved in cholesterol metabolism, HMG CoA reductase (HMGR) and LDL-receptor related protein-1 (LRP-1). [5] Abbreviations: ACTB: actin, beta; ATF4: activating transcription factor 4; CMA: chaperone-mediated autophagy; DYNC1LI1: dynein cytoplasmic 1 light intermediate chain 1; DYNC1LI2: dynein cytoplasmic 1 light intermediate chain 2; ER: endoplasmic reticulum; LAMP1: lysosomal associated membrane protein 1; LAMP2A: lysosomal associated membrane protein 2A; LIC: light-intermediate chains; LRP2/Megalin: LDL receptor related protein 2; PTCs: proximal tubule cells; RAB: RAB, member RAS oncogene family; RAB11FIP3: RAB11 family interacting protein 3; RILP: Rab interacting lysosomal protein. [6] The homozygous autosomal recessive truncating mutations of LDL receptor related protein associated protein 1 (LRPAP1) is a possible reason for Nonsyndromic Extreme Myopia, patients with which show typical chorioretinal degeneration. [7] Interleukin 1 receptor related protein, Suppression of tumorigenicity 2 (ST2) is a biomarker related to the pathophysiology of fibrosis, having shown promise in the study of heart failure. [8] Fisher’s exact testing revealed significant relationships between the minor T allele of LDL receptor related protein 5 (LRP5) rs3736228 and the prevalence of knee/hip OA and osteoporosis. [9] Also, active crossing and targeting are achieved by theranostic cHANPs decorated with angiopep-2 (Thera-ANG-cHANPs), a dual-targeting peptide interacting with low density lipoprotein receptor related protein-1(LRP-1) receptors overexpressed by both endothelial cells of the BBB and glioma cells. [10] e15507 Background: LDL receptor related protein 2 (LRP2), a multi-ligand endocytic receptor, has been implicated in the tumourigenesis of various human cancers. [11] The expression levels of LDL receptor related protein 5 (Lrp5), lymphoid enhancer binding factor 1 (Lef1) and transcription factor 1 in C3H10T1/2 cells were significantly increased in shCkip-1 cells following 7-day osteoinduction compared with shCtrl cells. [12] Hepatic uptake of triglyceride-rich remnant lipoproteins is mediated by the low-density lipoprotein receptor, a low-density lipoprotein receptor related protein and the heparan sulfate proteoglycan, syndecan-1. [13] This was supported by the identification of an interaction with low density lipoprotein receptor related protein 1 (LRP1), an endocytic regulator of platelet-derived growth factor BB (PDGF-BB) signaling and VSMC proliferation. [14] Recently, we identified LDL receptor related protein associated protein 1 (LRPAP1) as frequent autoantigen of recombinant B-cell receptors (BCRs) of mantle cell lymphoma (MCL). [15] Results A 52-year-old Caucasian female with idiopathic osteoporosis with recurrent fractures was identified with a heterozygous low-density lipoprotein receptor related protein 5 (LRP5) mutation. [16] The low-density lipoprotein receptor related protein 1 (LRP1) is highly expressed in the endothelial cells of the brain capillary and the glioma cells. [17] GalNAc-T11 specifically controls O-glycosylation of specific linker regions in the low-density lipoprotein receptor related proteins. [18] siRNA/RNAi-mediated knockdown in generic human iPSC-derived cardiac progenitors and in the in vivo Drosophila heart model revealed that LDL receptor related protein LRP2 and apolipoprotein APOB are required for robust hiPSC-derived cardiomyocyte proliferation and normal hear structure and function, possibly involving an oligogenic mechanism via growth-promoting WNT and SHH signaling. [19] This was supported by identification of an interaction with Low density lipoprotein receptor related protein 1 (LRP1), an endocytic regulator of PDGF-BB signalling and VSMC proliferation. [20] LDL receptor related protein 4 (LRP4) and carbonic anhydrase 12 (CA12) were hypomethylated and had an increased expression level. [21] When injected with apelin-13 for 12 weeks, the hyperuricemia rats had ameliorated oxidative stress, downregulated RAS components and upregulated angiotensin type 1 receptor related protein (APJ) expression in adipose tissue. [22] Here, we investigated expressive changes of two main Aβ transport receptors low-density lipoprotein receptor related protein-1 (LRP1) and receptor for advanced glycation end products (RAGE) in a novel AD mice (APP23) with chronic cerebral hypoperfusion (CCH) model, moreover, examined a protective effect of a free radical scavenger edaravone (Eda). [23] Low-density lipoprotein Receptor Related Protein 1B (LRP1B) is homologous to the gigantic lipoprotein receptor-related protein 1 that belongs to the family of Low-density lipoprotein receptors. [24] Angiopep-2 ligates the low density lipoprotein receptor related protein 1 (LRP1) on brain microvascular endothelial cells (BMECs) to drive transcytosis for BBB crossing. [25] We identified an interaction between Tβ4 and Low density lipoprotein receptor related protein 1 (LRP1), an endocytic regulator of PDGFR? signalling which controls VSMC proliferation. [26] They typically antagonize Wnt/β-catenin signaling by binding and inhibiting Wnt co-receptors, LRP5/6 (low density lipoprotein receptor related protein 5/6). [27] ②In vitro experiment: HCT 116 cells were treated with resveratrol at 10 mg/ml, the expressions of β-catenin, LDL receptor related protein-6 (LRP-6), frizzled-3 (FZD3) and c-Myc were detected. [28] Wnt signaling co-receptor LDL receptor related protein 6 (LRP6) was identified as a cell membrane binding partner of VSTM2A. [29] This was supported by identification of an interaction with Low density lipoprotein receptor related protein 1 (LRP1), an endocytic regulator of PDGF-BB signalling and VSMC proliferation. [30] The aggregated protein Agrin promotes metastasis and invasion of cancer by interacting with low density lipoprotein receptor related protein 4(Lrp4). [31] Sclerostin is a protein secreted by osteocytes which acts as an antagonist to WNT/β-catenin signaling pathway through binding to WNT co-receptors low density lipoprotein receptor related protein 5 (LRP5) or 6 (LRP6), resulting in decreased osteoblastic bone formation. [32] Isolated liver cysts are caused by mutations in Protein Kinase C Substrate 80K-H (PRKCSH), SEC63, and LDL Receptor Related Protein 5 (LRP5), whereas Polycystic Kidney Disease (PKD)1, PKD2, and PKHD1 mutations cause kidney cysts often accompanied by liver cysts. [33]더욱이, NG2 glia가 Ca2+ 투과성을 포함하여 AMPA 수용체 특성을 수정하는 보조 막횡단 AMPA 수용체 관련 단백질(TARP)을 발현하는지 여부는 불분명합니다. [1] Proprotein-convertase-subtilisin/kexin type-9(PCSK9)는 신경 콜레스테롤 흡수를 담당하는 LDL-수용체 관련 단백질 1(LRP-1)의 분해에 의해 신경 콜레스테롤 흡수를 감소시키는 것으로 밝혀졌습니다. [2] 조합 유전자 변형 분석에서 저밀도 지단백 수용체 관련 단백질 1B(LRP1B)와 KRAS의 동시 돌연변이는 수술 후 유의하게 더 나쁜 무병 생존과 관련이 있었습니다(p = 0. [3] 저밀도 지단백질 수용체 관련 단백질-1(sLRP1)의 가용성 형태와 최종 당화 최종 생성물의 가용성 수용체(sRAGE)인 2개의 Aβ 수송체는 말초 Aβ 수송에 중요합니다. [4] 통계적으로 유의하지는 않았지만 심황 보충제는 콜레스테롤 대사, HMG CoA 환원효소(HMGR) 및 LDL-수용체 관련 단백질-1(LRP)과 관련된 유전자의 간 발현 수준뿐만 아니라 혈청 총 콜레스테롤 및 LDL-콜레스테롤을 감소시키는 경향을 보였습니다. -1). [5] 약어: ACTB: 액틴, 베타; ATF4: 전사 인자 4 활성화; CMA: 샤페론 매개 자가포식; DYNC1LI1: 다이네인 세포질 1 경쇄 중간쇄 1; DYNC1LI2: 다이네인 세포질 1 경쇄 중간쇄 2; ER: 소포체; LAMP1: 리소좀 관련 막 단백질 1; LAMP2A: 리소좀 관련 막 단백질 2A; LIC: 가벼운 중간 사슬; LRP2/메갈린: LDL 수용체 관련 단백질 2; PTC: 근위 세뇨관 세포; RAB: RAB, 구성원 RAS 종양유전자 패밀리; RAB11FIP3: RAB11 패밀리 상호작용 단백질 3; RILP: Rab 상호작용 리소좀 단백질. [6] LDL 수용체 관련 단백질 관련 단백질 1(LRPAP1)의 동형접합 상염색체 열성 절단 돌연변이는 전형적인 맥락망막 변성을 나타내는 비증후군성 극도 근시의 가능한 원인입니다. [7] nan [8] nan [9] nan [10] nan [11] nan [12] nan [13] nan [14] nan [15] 결과 재발성 골절을 동반한 특발성 골다공증이 있는 52세 백인 여성이 이형접합 저밀도 지단백 수용체 관련 단백질 5(LRP5) 돌연변이로 확인되었습니다. [16] 저밀도 지단백 수용체 관련 단백질 1(LRP1)은 뇌 모세혈관의 내피 세포와 신경교종 세포에서 고도로 발현됩니다. [17] nan [18] 일반 인간 iPSC 유래 심장 전구세포 및 생체내 초파리 심장 모델에서 siRNA/RNAi 매개 녹다운은 LDL 수용체 관련 단백질 LRP2 및 아포지단백 APOB가 강력한 hiPSC 유래 심근세포 증식 및 정상적인 청력 구조 및 기능에 필요함을 밝혔습니다. 성장 촉진 WNT 및 SHH 신호 전달을 통한 올리고제닉 메커니즘. [19] nan [20] LDL 수용체 관련 단백질 4(LRP4)와 탄산탈수효소 12(CA12)는 저메틸화되어 발현 수준이 증가했습니다. [21] nan [22] nan [23] nan [24] nan [25] nan [26] nan [27] nan [28] nan [29] nan [30] nan [31] nan [32] nan [33]
receptor related 1 수용체 관련 1
The ligand-sensing transcription factor nuclear receptor related 1 (Nurr1) evolves as an appealing target to treat neurodegenerative diseases. [1] GM1 also significantly enhances expression of tyrosine hydroxylase (TH) in the substantia nigra pars compacta of the A53T aSyn overexpressing mouse, following restored nuclear expression of nuclear receptor related 1 (Nurr1, also known as NR4A2), an essential transcription factor for differentiation, maturation, and maintenance of midbrain dopaminergic neurons. [2] As a member of the orphan nuclear receptor family, nuclear receptor related 1 (Nurr1) plays a vital role in some neuropathological diseases and several types of benign or malignant tumors. [3] To investigate the relationship of Nurr1 with synaptic and social deficit, we activated the expression level of nuclear receptor related 1 protein (Nurr1) by i. [4] Objective: The aim of our study is to explore the pathological role of nuclear receptor related 1 protein (NURR1) in regulating cardiomyocyte viability under hypoxia stress. [5] Nuclear receptor related 1 protein (Nurr1), a member of the nuclear receptor 4 family of orphan nuclear receptors, has been reported to display anti-inflammatory properties. [6] Real time RT-qPCR analysis indicated that expressions of brain derived neurotrophic factor (BDNF), glial cell line derived neurotropic factor (GNDF), matrix associated protein 2 (MAP2), nuclear receptor related 1 protein (NURR1) and dopamine transporter (DAT) were increased, especially in the first 7 days of dopaminergic induction when 660 nm laser light was applied with a total energy density of 1. [7] Abbreviations: Aβ, β-amyloid; AChE, acetylcholinesterase enzyme; AD, Alzheimer’s disease; ALS, amyotrophic lateral sclerosis; AMPA, α-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid; ApoE, human Apolipoprotein-E; APP, amyloid precursor protein; BH4, tetrahydrobiopterin; CaMKII, Ca2+and calmodulin-dependent protein kinase II; CREB, cyclic adenosine monophosphate response element-binding protein; GAG, glycosaminoglycans; EGb 761, a standardized Ginkgo biloba extract; GCH1, GTP cyclohydrolase I; GSK-3, glycogen synthase kinase-3; HD, Huntington’s disease; hIAPP, human islet amyloid polypeptide; H2O2, hydrogen peroxide; INF-γ, interferon-γ; IL-1, interleukin-1; IL-6, interleukin-6; IL-β, interleukin-β; JNK, c-Jun N-terminal kinase; LPS, lipopolysaccharide; MPO, myeloperoxidase; MPTP, 1-methyl-4-phenyl-1,2,3,6tetrahydropyridine; nAChR, nicotinic acetylcholine receptor; NFκB, nuclear factor kappa B; NMDA, N-methyl-D-aspartate; NOX2, NADPH oxidase enzyme; NR4A2, nuclear receptor subfamily 4 group A member 2; Nurr1, nuclear receptor related 1 protein; polyQ, proteins containing glutamine repeats; ROS, reactive oxygen species; SOD1, superoxide dismutase 1; TBP, TATA box-binding protein; TFEB, transcription factor EB; TH, tyrosine hydroxylase; TLR4, tolllike receptor 4; TNF-α, tumor necrosis factor α. [8] Nuclear receptor related 1 protein (Nurr1) is an important transcription factor required for differentiation and maintenance of midbrain dopaminergic (DA) neurons. [9]리간드 감지 전사 인자 핵 수용체 관련 1(Nurr1)은 신경퇴행성 질환을 치료하는 매력적인 표적으로 진화하고 있습니다. [1] GM1은 또한 분화, 성숙에 필수적인 전사 인자인 핵 수용체 관련 1(Nurr1, NR4A2로도 알려짐)의 핵 발현을 회복시킨 후 A53T aSyn 과발현 마우스의 흑색질 콤팩타에서 티로신 수산화효소(TH)의 발현을 크게 향상시킵니다. , 및 중뇌 도파민성 뉴런의 유지. [2] nan [3] nan [4] 목적: 우리 연구의 목적은 저산소증 스트레스 하에서 심근세포 생존을 조절하는 핵 수용체 관련 1 단백질(NURR1)의 병리학적 역할을 탐구하는 것입니다. [5] 고아 핵 수용체의 핵 수용체 4 패밀리의 구성원인 핵 수용체 관련 1 단백질(Nurr1)은 항염 특성을 나타내는 것으로 보고되었습니다. [6] nan [7] 약어: Aβ, β-아밀로이드; AChE, 아세틸콜린에스테라제 효소; 알츠하이머병, 알츠하이머병; ALS, 근위축성 측삭 경화증; AMPA, α-아미노-3-히드록시-5-메틸-4-이속사졸프로피온산; ApoE, 인간 아포지단백질-E; APP, 아밀로이드 전구체 단백질; BH4, 테트라히드로바이오프테린; CaMKII, Ca2+및 칼모듈린 의존성 단백질 키나제 II; CREB, 환형 아데노신 모노포스페이트 반응 요소 결합 단백질; GAG, 글리코사미노글리칸; 표준화된 은행나무 추출물인 EGb 761; GCH1, GTP 사이클로하이드롤라제 I; GSK-3, 글리코겐 합성효소 키나제-3; HD, 헌팅턴병; hIAPP, 인간 섬 아밀로이드 폴리펩타이드; H2O2, 과산화수소; INF-γ, 인터페론-γ; IL-1, 인터루킨-1; IL-6, 인터루킨-6; IL-β, 인터루킨-β; JNK, c-Jun N-말단 키나제; LPS, 지질다당류; MPO, 골수페록시다제; MPTP, 1-메틸-4-페닐-1,2,3,6테트라하이드로피리딘; nAChR, 니코틴성 아세틸콜린 수용체; NFκB, 핵인자 카파 B; NMDA, N-메틸-D-아스파테이트; NOX2, NADPH 산화효소; NR4A2, 핵 수용체 서브패밀리 4 그룹 A 구성원 2; Nurr1, 핵 수용체 관련 1 단백질; 폴리Q, 글루타민 반복을 함유하는 단백질; ROS, 활성산소종; SOD1, 슈퍼옥사이드 디스뮤타제 1; TBP, TATA 상자 결합 단백질; TFEB, 전사 인자 EB; TH, 티로신 하이드록실라제; TLR4, 톨유사 수용체 4; TNF-α, 종양 괴사 인자 α. [8] nan [9]
receptor related orphan 수용체 관련 고아
25), retinoid acid receptor related orphan receptor α (7. [1] In addition, they decreased the elevated expression level of miRNA-155, 146a and increased the expression level of miRNA-34 and they decreased the expression level of retinoic acid receptor related orphan receptor γT (RORγT) and increased that of fork head box P3 (FOXP3), correcting Th17/Treg cells balance. [2] Identified key contact points are different forms of retinoic acid receptor related orphan receptors (ROR) and LXRs. [3] Sirtuin‐1 (Sirt1), a member of the NAD‐dependent sirtuin family of histone/protein deacetylases (HDAC), is an important target for immunotherapy due to its role in deacetylating the transcription factors Foxp3 and thymic retinoid acid receptor related orphan receptor gamma (RORγt). [4]25), 레티노이드산 수용체 관련 고아 수용체 α(7. [1] 또한 miRNA-155, 146a의 증가된 발현량을 감소시키고 miRNA-34의 발현량을 증가시켰으며, retinoic acid receptor related orphan receptor γT(RORγT)의 발현량을 감소시키고 fork head box P3의 발현량을 증가시켰다( FOXP3), Th17/Treg 세포 균형을 수정합니다. [2] 확인된 주요 접점은 다양한 형태의 레티노산 수용체 관련 고아 수용체(ROR) 및 LXR입니다. [3] NAD 의존성 히스톤/단백질 탈아세틸화효소(HDAC) 계열의 Sirtuin-1(Sirt1)은 전사 인자 Foxp3 및 흉선 레티노이드산 수용체 관련 고아 수용체 감마를 탈아세틸화하는 역할 때문에 면역 요법의 중요한 표적입니다. (RORγt). [4]
receptor related gene 수용체 관련 유전자
We also observed that the levels of GABA receptor related genes including gabrg2, gabbr1α, gabbr1 and gabra6α were inhibited by PCM exposure. [1] Conclusions The significant differential expression of SARS-COV-2 receptor related genes and immune response related genes between male and female patients may be the reason for the difference in COVID-19 infection rate and mortality. [2] With the GCNs analysis, two second messenger G protein-coupled receptor related genes that respond to gibberellin signals in the cell were discovered. [3]우리는 또한 gabrg2, gabbr1α, gabbr1 및 gabra6α를 포함한 GABA 수용체 관련 유전자의 수준이 PCM 노출에 의해 억제되었음을 관찰했습니다. [1] 결론 SARS-COV-2 수용체 관련 유전자 및 면역 반응 관련 유전자의 현저한 차별적 발현은 남성과 여성 환자 사이에서 COVID-19 감염률 및 사망률의 차이의 원인일 수 있다. [2] nan [3]
receptor related immunoglobulin
2504 Background: COM701 is a novel first in class humanized IgG4 monoclonal antibody that binds with high affinity to poliovirus receptor related immunoglobulin domain containing (PVRIG), blocking its interaction with its ligand, PVRL2. [1] COM701 is a novel first-in-class humanized IgG4 monoclonal antibody that binds with high affinity to PVRIG (poliovirus receptor related immunoglobulin domain containing) blocking its interaction with its ligand, PVRL2. [2]receptor related receptor
Estrogen-receptor related receptors (ERRs) which consists of ERRα, ERRβ and ERRγ belong to the orphan nuclear receptor subfamily 3, group B (NR3B) subfamily, and are constitutively active. [1] Estrogen-receptor related receptors which consists of ERRα, ERRβ and ERRγ belong to the orphan nuclear receptor subfamily of NR3B (nuclear receptor subfamily 3, group B). [2]ERRα, ERRβ 및 ERRγ로 구성된 에스트로겐 수용체 관련 수용체(ERR)는 고아 핵 수용체 서브패밀리 3, 그룹 B(NR3B) 서브패밀리에 속하며 구성적으로 활성입니다. [1] ERRα, ERRβ 및 ERRγ로 구성된 에스트로겐 수용체 관련 수용체는 NR3B의 고아 핵 수용체 서브패밀리(핵 수용체 서브패밀리 3, 그룹 B)에 속합니다. [2]