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Abstract 1345: Pharmacodynamic biomarkers for Pim inhibition with TP-3654 in patients with solid tumors


Insights into the Interaction Mechanisms of the Proviral Integration Site of Moloney Murine Leukemia Virus (Pim) Kinases with Pan-Pim Inhibitors PIM447 and AZD1208: A Molecular Dynamics Simulation and MM/GBSA Calculation Study

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PIM-induced phosphorylation of Notch3 promotes breast cancer tumorigenicity in a CSL-independent fashion


PIM kinases inhibit AMPK activation and promote tumorigenicity by phosphorylating LKB1

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PIM447 inhibits oncogenesis and potentiates cisplatin effects in hepatoblastoma.


PIM kinases facilitate lentiviral evasion from SAMHD1 restriction via Vpx phosphorylation


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10.2174/1385272825666210208142108

Indole: A Privileged Heterocyclic Moiety in the Management of Cancer



Crystal Structure-Guided Design of Bisubstrate Inhibitors and Photoluminescent Probes for Protein Kinases of the PIM Family



2-Thioxothiazolidin-4-one Analogs as Pan-PIM Kinase Inhibitors.


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10.1158/0008-5472.CAN-21-1023

Inhibition of PIM Kinases in DLBCL Targets MYC Transcriptional Program and Augments the Efficacy of Anti-CD20 Antibodies.


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10.1158/1078-0432.CCR-20-4898

Therapeutic Efficacy of Combined JAK1/2, Pan-PIM, and CDK4/6 Inhibition in Myeloproliferative Neoplasms


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10.1158/1538-7445.SABCS20-GS1-08

Abstract GS1-08: The MYC oncogene suppresses tumor immune infiltration and function which is reversible with combinatorial immunotherapies



Therapeutic targeting of PIM KINASE signaling in cancer therapy: Structural and clinical prospects.



Novel Pan-Pim Kinase Inhibitors With Imidazopyridazine and Thiazolidinedione Structure Exert Potent Antitumor Activities



Clinical Connections


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10.1158/1538-7445.AM2019-2056

Abstract 2056: Combined FLT3 and Pim kinase inhibitor treatment downregulates c-Myc early in apoptosis induction in acute myeloid leukemia with FLT3-ITD



PIM-1 kinase is a novel regulator of proinflammatory cytokine-mediated responses in rheumatoid arthritis fibroblast-like synoviocytes



Hypoxia-Induced PIM Kinase and Laminin-Activated Integrin α6 Mediate Resistance to PI3K Inhibitors in Bone-Metastatic CRPC



Discovery of ( R)-8-(6-Methyl-4-oxo-1,4,5,6-tetrahydropyrrolo[3,4- b]pyrrol-2-yl)-3-(1-methylcyclopropyl)-2-((1-methylcyclopropyl)amino)quinazolin-4(3 H)-one, a Potent and Selective Pim-1/2 Kinase Inhibitor for Hematological Malignancies.



PIM-Related Kinases Selectively Regulate Olfactory Sensations in Caenorhabditis elegans



Discovery of (R)-8-(6-Methyl-4-oxo-1,4,5,6-tetrahydropyrrolo[3,4-b]pyrrol-2-yl)-3-(1-methylcyclopropyl)-2-((1-methylcyclopropyl)amino)quinazolin-4(3H)-one, a Potent and Selective Pim-1/2 Kinase Inhibitor for Hematological Malignancies



Optimization of Pan-Pim Kinase Activity and Oral Bioavailability Leading to Diaminopyrazole (GDC-0339) for the Treatment of Multiple Myeloma.



Discovery of novel (+)-Usnic acid derivatives as potential anti-leukemia agents with pan-Pim kinases inhibitory activity.



Targeting PIM Kinases Affects Maintenance of CD133 Tumor Cell Population in Hepatoblastoma12



PIM-1 inhibition with AZD1208 to prevent osimertinib-induced resistance in EGFR-mutation positive non-small cell lung cancer



AZD1208, a Pan-Pim Kinase Inhibitor, Has Anti-Growth Effect on 93T449 Human Liposarcoma Cells via Control of the Expression and Phosphorylation of Pim-3, mTOR, 4EBP-1, S6, STAT-3 and AMPK



Anti‑survival and pro‑apoptotic effects of meridianin C derivatives on MV4‑11 human acute myeloid leukemia cells.


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10.1016/j.pharmthera.2019.107454

Current perspectives on targeting PIM kinases to overcome mechanisms of drug resistance and immune evasion in cancer.


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10.1200/JCO.2019.37.15_SUPPL.TPS7062

CLI24-001: First-in-human study of SEL24/MEN1703, an oral dual PIM/FLT3 kinase inhibitor, in patients with acute myeloid leukemia.


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10.1182/bloodadvances.2019000260

The pan-PIM inhibitor INCB053914 displays potent synergy in combination with ruxolitinib in models of MPN.



PIM kinases mediate resistance of glioblastoma cells to TRAIL by a p62/SQSTM1-dependent mechanism



PIM kinase inhibitors: Structural and pharmacological perspectives.


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10.1182/bloodadvances.2018027227

Leflunomide regulates c-Myc expression in myeloma cells through PIM targeting.


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10.1158/1535-7163.MCT-17-1234

A Kinase Inhibitor with Anti-Pim Kinase Activity is a Potent and Selective Cytotoxic Agent Toward Acute Myeloid Leukemia


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10.1016/j.leukres.2019.106166

The upregulation of Pim kinases is essential in coordinating the survival, proliferation, and migration of KIT D816V-mutated neoplastic mast cells.


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Pim Kinases 핌 키나제
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