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B591, a novel specific pan-PI3K inhibitor, preferentially targets cancer stem cells


Class 1 PI3K Clinical Candidates and Recent Inhibitor Design Strategies: A Medicinal Chemistry Perspective.


Buparlisib is a novel inhibitor of daunorubicin reduction mediated by aldo-keto reductase 1C3.



Unbiased screening reveals that blocking exportin 1 overcomes resistance to PI3Kα inhibition in breast cancer


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10.1158/1535-7163.TARG-19-A116

Abstract A116: HRASG12S mutant mediates resistance to a PI3Kα inhibitor CYH33 in esophageal squamous cell carcinomas


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10.1158/1538-7445.AM2019-529

Abstract 529: A PI3Kαδ inhibitor combined with irradiation enhance the effect of PD-1 blockade in syngenic triple negative breast cancer model


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10.2174/1573406415666190222125333

Discovery of new Phosphoinositide 3-kinase delta (PI3Kδ) inhibitors via virtual screening using crystallography-derived pharmacophore modelling and QSAR analysis.


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10.1021/acs.jmedchem.9b00390

Design, Synthesis, and Biological Evaluation of 4-Methyl Quinazoline Derivatives as Anticancer Agents Simultaneously Targeting Phosphoinositide 3-Kinases and Histone Deacetylases.


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10.4062/biomolther.2019.153

PBT-6, a Novel PI3KC2γ Inhibitor in Rheumatoid Arthritis


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10.1016/j.intimp.2019.105756

The PI3Kδ selective inhibitor AS2541019 suppresses donor-specific antibody production in rat cardiac and non-human primate renal allotransplant models.


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10.1021/acsmedchemlett.8b00530

Synthesis of a 6-Aza-Isoindolinone-Based Inhibitor of Phosphoinositide 3-Kinase γ via Ruthenium-Catalyzed [2 + 2 + 2] Cyclotrimerization.


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10.1016/j.bioorg.2019.103525

Design, synthesis and biological evaluation of substituted 2-(thiophen-2-yl)-1,3,5-triazine derivatives as potential dual PI3Kα/mTOR inhibitors.


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10.1080/17425255.2019.1663169

Molecular basis for class side effects associated with PI3K/AKT/mTOR pathway inhibitors



FKBP4 connects mTORC2 and PI3K to activate the PDK1/Akt-dependent cell proliferation signaling in breast cancer



Antitumor Activity of DFX117 by Dual Inhibition of c-Met and PI3Kα in Non-Small Cell Lung Cancer


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Novel Pi3k 소설 Pi3k


Novel Pi3k 소설 Pi3k
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