Lysine Methyltransferase 라이신 메틸트랜스퍼라제

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domain bifurcated histone domain containing protein domain containing histone Explore More

Lysine Methyltransferase sentence examples within domain bifurcated histone

domain bifurcated histone 10.3390/life11080817

도메인 분기 히스톤

The SET Domain Bifurcated Histone Lysine Methyltransferase 1 (SETDB1) is a prominent member of the Suppressor of Variegation 3–9 (SUV39)-related protein lysine methyltransferases (PKMTs), comprising three isoforms that differ in length and domain composition.

SET 도메인 분기 히스톤 라이신 메틸트랜스퍼라제 1(SETDB1)은 길이와 도메인 구성이 다른 3개의 이소폼으로 구성된 SUV39(Suppressor of Variegation 3-9) 관련 단백질 라이신 메틸트랜스퍼라제(PKMT)의 두드러진 구성원입니다.

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domain bifurcated histone 10.1158/2326-6066.CIR-21-0543

도메인 분기 히스톤

We found that disruption of the genes encoding either of the chromatin modifiers activating transcription factor 7 interacting protein (Atf7ip) or its interacting partner SET domain bifurcated histone lysine methyltransferase 1 (Setdb1) in tumor cells restored tumor antigen expression.

우리는 종양 세포에서 전사 인자 7 상호 작용 단백질(Atf7ip) 또는 상호 작용 파트너 SET 도메인 분기된 히스톤 라이신 메틸트랜스퍼라제 1(Setdb1)을 활성화하는 염색질 수정자 중 하나를 인코딩하는 유전자의 파괴가 종양 항원 발현을 회복한다는 것을 발견했습니다.

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Lysine Methyltransferase sentence examples within domain containing protein

domain containing protein 10.1038/s41598-021-92075-5

도메인 함유 단백질

Here, we identify that SET domain-containing protein 4 (SETD4), a histone lysine methyltransferase, is expressed in a small cell population in the adult mouse pancreas.

여기에서 우리는 히스톤 라이신 메틸트랜스퍼라제인 SET 도메인 함유 단백질 4(SETD4)가 성인 마우스 췌장의 작은 세포 집단에서 발현된다는 것을 확인합니다.

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domain containing protein 10.1080/08927022.2021.1957882

도메인 함유 단백질

ABSTRACT SET and MYND domain-containing protein 2 (SMYD2) is a protein lysine methyltransferases (PKMTs) from family SMYD.

ABSTRACT SET 및 MYND 도메인 함유 단백질 2(SMYD2)는 SMYD 계열의 단백질 라이신 메틸트랜스퍼라제(PKMT)입니다.

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Lysine Methyltransferase sentence examples within domain containing histone

domain containing histone 10.1101/2021.02.10.429309

히스톤을 포함하는 도메인

Here, we showed that SET domain containing histone lysine methyltransferase 7 (SETD7) interacts with KRAS and methylates KRAS at lysine 182 and 184.

여기에서 우리는 히스톤 라이신 메틸트랜스퍼라제 7(SETD7)을 포함하는 SET 도메인이 KRAS와 상호 작용하고 라이신 182 및 184에서 KRAS를 메틸화한다는 것을 보여주었습니다.

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domain containing histone 10.1111/cge.14014

히스톤을 포함하는 도메인

SET-domain containing histone lysine methyltransferases have been shown to contribute to the balance between osteogenesis and adipogenesis in MSCs and mice with loss of Setd2 causes a propensity for adipogenesis and loss of osteoblasts, thus raising the possibility of other SET-domain containing histone methyltransferases also having an impact on bone density.

히스톤 라이신 메틸트랜스퍼라제를 함유하는 SET-도메인은 MSC 및 마우스에서 골형성과 지방형성 사이의 균형에 기여하는 것으로 나타났으며 Setd2가 손실된 마우스는 지방형성 및 조골세포 손실에 대한 경향을 유발하여 히스톤 메틸트랜스퍼라제를 함유하는 다른 SET-도메인의 가능성을 높입니다. 골밀도에 영향을 미칩니다.

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Histone Lysine Methyltransferase Protein Lysine Methyltransferase Containing Lysine Methyltransferase Explore More

Lysine Methyltransferase sentence examples within Histone Lysine Methyltransferase

Histone Lysine Methyltransferase 10.1101/2021.03.24.436787

히스톤 라이신 메틸트랜스퍼라제

The polycomb group (PcG) protein enhancer of zeste homologue 2 (Ezh2), a histone lysine methyltransferase is associated with epigenetic regulation of numerous cellular processes, it is not yet clear on its involvement in bone cell development and homeostasis.

히스톤 라이신 메틸트랜스퍼라제인 zeste homologue 2(Ezh2)의 polycomb group(PcG) 단백질 인핸서는 수많은 세포 과정의 후성 유전적 조절과 관련되어 있지만 뼈 세포 발달 및 항상성에 관여하는지에 대해서는 아직 명확하지 않습니다.

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Histone Lysine Methyltransferase 10.1016/j.pneurobio.2020.101968

히스톤 라이신 메틸트랜스퍼라제

SETDB1 is a histone lysine methyltransferase responsible for the di- and tri-methylation of histone 3 (H3) at lysine (K) 9 in euchromatic regions further promoting gene silencing through heterochromatin formation.

SETDB1은 히스톤 라이신 메틸트랜스퍼라제로서 진색성 영역의 라이신(K) 9에서 히스톤 3(H3)의 디- 및 트리-메틸화를 담당하며 이질염색질 형성을 통해 유전자 침묵을 추가로 촉진합니다.

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Lysine Methyltransferase sentence examples within Protein Lysine Methyltransferase

Protein Lysine Methyltransferase 10.1080/08927022.2021.1957882

단백질 라이신 메틸트랜스퍼라제

ABSTRACT SET and MYND domain-containing protein 2 (SMYD2) is a protein lysine methyltransferases (PKMTs) from family SMYD.

ABSTRACT SET 및 MYND 도메인 함유 단백질 2(SMYD2)는 SMYD 계열의 단백질 라이신 메틸트랜스퍼라제(PKMT)입니다.

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Protein Lysine Methyltransferase 10.1177/24725552211019409

단백질 라이신 메틸트랜스퍼라제

SMYD3 (SET and MYND domain-containing protein 3) is a protein lysine methyltransferase that was initially described as an H3K4 methyltransferase involved in transcriptional regulation.

SMYD3(SET 및 MYND 도메인 함유 단백질 3)은 처음에 전사 조절에 관여하는 H3K4 메틸트랜스퍼라제로 기술된 단백질 라이신 메틸트랜스퍼라제입니다.

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Lysine Methyltransferase sentence examples within Containing Lysine Methyltransferase

Containing Lysine Methyltransferase 10.1016/j.ejphar.2021.174097

라이신 메틸트랜스퍼라제 함유

Renal fibrosis is the common pathological hallmark of chronic kidney disease, and SET domain containing lysine methyltransferase 7 (SETD7) promote considerably renal fibrosis.

신장 섬유증은 만성 신장 질환의 일반적인 병리학적 특징이며 라이신 메틸트랜스퍼라제 7(SETD7)을 포함하는 SET 도메인은 신장 섬유증을 상당히 촉진합니다.

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Containing Lysine Methyltransferase 10.11817/j.issn.1672-7347.2021.190400

라이신 메틸트랜스퍼라제 함유

OBJECTIVES Silence of SET domain containing lysine methyltransferase 7 (SET7) alleviates myocardial tissue injury caused by ischemia-reperfusion.

목표 리신 메틸트랜스퍼라제 7(SET7)을 포함하는 SET 도메인의 침묵은 허혈 재관류로 인한 심근 조직 손상을 완화합니다.

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Lysine Methyltransferase sentence examples within lysine methyltransferase 2a

lysine methyltransferase 2a 10.3892/or.2021.8101

라이신 메틸트랜스퍼라제 2a

Lysine methyltransferase 2A (KMT2A, also known as MLL) translocations (MLL-t) are frequently associated with mutations in RAS pathway genes in acute myeloid leukemia (AML).

라이신 메틸트랜스퍼라제 2A(KMT2A, MLL로도 알려짐) 전위(MLL-t)는 급성 골수성 백혈병(AML)에서 RAS 경로 유전자의 돌연변이와 자주 연관됩니다.

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lysine methyltransferase 2a 10.1007/s00277-021-04562-4

라이신 메틸트랜스퍼라제 2a

Whole-exome sequencing was conducted, and a germline heterozygous mutation in lysine methyltransferase 2A (KMT2A, also known as MLL1), G3131S (c.

전체 엑솜 시퀀싱이 수행되었으며, 라이신 메틸트랜스퍼라제 2A(KMT2A, MLL1로도 알려짐), G3131S(c.

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Lysine Methyltransferase sentence examples within lysine methyltransferase g9a

lysine methyltransferase g9a 10.1021/acs.jmedchem.0c02255

라이신 메틸트랜스퍼라제 G9a

Additionally, lysine methyltransferase G9a inhibitory activity is achieved (from a low nanomolar range) by introduction of a key lysine mimic group at the 7-position of the quinoline ring.

추가로, 라이신 메틸트랜스퍼라제 G9a 억제 활성은 퀴놀린 고리의 7-위치에 주요 라이신 모방 그룹의 도입에 의해 (낮은 나노몰 범위에서) 달성됩니다.

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lysine methyltransferase g9a 10.1186/s40035-021-00247-0

라이신 메틸트랜스퍼라제 G9a

The addition of H3K9me2/3 is mainly catalyzed by lysine methyltransferase G9a, which functions as a heteromeric complex with G9a-like protein (GLP).

H3K9me2/3의 추가는 주로 G9a 유사 단백질(GLP)과의 이종 복합체로 기능하는 라이신 메틸트랜스퍼라제 G9a에 의해 촉매됩니다.

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Lysine Methyltransferase sentence examples within lysine methyltransferase 7

lysine methyltransferase 7 10.1016/j.ejphar.2021.174097

라이신 메틸트랜스퍼라제 7

Renal fibrosis is the common pathological hallmark of chronic kidney disease, and SET domain containing lysine methyltransferase 7 (SETD7) promote considerably renal fibrosis.

신장 섬유증은 만성 신장 질환의 일반적인 병리학적 특징이며 라이신 메틸트랜스퍼라제 7(SETD7)을 포함하는 SET 도메인은 신장 섬유증을 상당히 촉진합니다.

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lysine methyltransferase 7 10.1101/2021.02.10.429309

라이신 메틸트랜스퍼라제 7

Here, we showed that SET domain containing histone lysine methyltransferase 7 (SETD7) interacts with KRAS and methylates KRAS at lysine 182 and 184.

여기에서 우리는 히스톤 라이신 메틸트랜스퍼라제 7(SETD7)을 포함하는 SET 도메인이 KRAS와 상호 작용하고 라이신 182 및 184에서 KRAS를 메틸화한다는 것을 보여주었습니다.

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Lysine Methyltransferase sentence examples within lysine methyltransferase 2

lysine methyltransferase 2 10.3390/ijms222011292

라이신 메틸트랜스퍼라제 2

The histone methyltransferase G9a (euchromatic histone lysine methyltransferase 2, EHMT2), which mostly mediates mono- and dimethylation by histone H3 lysine 9 (H3K9), influences gene expression involved in embryonic development and tissue differentiation.

주로 히스톤 H3 라이신 9(H3K9)에 의한 모노 및 디메틸화를 매개하는 히스톤 메틸트랜스퍼라제 G9a(유색성 히스톤 라이신 메틸트랜스퍼라제 2, EHMT2)는 배아 발달 및 조직 분화와 관련된 유전자 발현에 영향을 미칩니다.

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lysine methyltransferase 2 10.20944/preprints202108.0335.v1

라이신 메틸트랜스퍼라제 2

The histone methyltransferase G9a (euchromatic histone lysine methyltransferase 2, EHMT2), which mediates mono- and dimethylation by histone H3 lysine 9 (H3K9), regulates changes in gene expression involved in embryonic development and differentiation of normal tissues.

히스톤 H3 라이신 9(H3K9)에 의한 모노 및 디메틸화를 매개하는 히스톤 메틸트랜스퍼라제 G9a(유색성 히스톤 라이신 메틸트랜스퍼라제 2, EHMT2)는 배아 발달 및 정상 조직의 분화와 관련된 유전자 발현의 변화를 조절합니다.

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Lysine Methyltransferase sentence examples within lysine methyltransferase 5a

lysine methyltransferase 5a 10.1186/s10020-021-00339-7

라이신 메틸트랜스퍼라제 5a

Moreover, ETS proto-oncogene 1 (ets1) and lysine methyltransferase 5A (KMT5A) have been reported to contribute to high glucose-mediated endothelial injury and epithelial-to-mesenchymal transition.

더욱이, ETS 원종양유전자 1(ets1) 및 라이신 메틸트랜스퍼라제 5A(KMT5A)는 높은 포도당 매개 내피 손상 및 상피에서 중간엽으로의 전이에 기여하는 것으로 보고되었습니다.

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lysine methyltransferase 5a 10.1038/s41419-021-03629-4

라이신 메틸트랜스퍼라제 5a

cAMP response element-binding protein (CREB) and lysine methyltransferase 5A (KMT5A) have been reported to participate in the maintenance of a healthy endothelium.

cAMP 응답 요소 결합 단백질(CREB) 및 라이신 메틸트랜스퍼라제 5A(KMT5A)는 건강한 내피의 유지에 참여하는 것으로 보고되었습니다.

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Lysine Methyltransferase sentence examples within lysine methyltransferase 1

lysine methyltransferase 1 10.3390/life11080817

라이신 메틸트랜스퍼라제 1

The SET Domain Bifurcated Histone Lysine Methyltransferase 1 (SETDB1) is a prominent member of the Suppressor of Variegation 3–9 (SUV39)-related protein lysine methyltransferases (PKMTs), comprising three isoforms that differ in length and domain composition.

SET 도메인 분기 히스톤 라이신 메틸트랜스퍼라제 1(SETDB1)은 길이와 도메인 구성이 다른 3개의 이소폼으로 구성된 SUV39(Suppressor of Variegation 3-9) 관련 단백질 라이신 메틸트랜스퍼라제(PKMT)의 두드러진 구성원입니다.

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lysine methyltransferase 1 10.1158/2326-6066.CIR-21-0543

라이신 메틸트랜스퍼라제 1

We found that disruption of the genes encoding either of the chromatin modifiers activating transcription factor 7 interacting protein (Atf7ip) or its interacting partner SET domain bifurcated histone lysine methyltransferase 1 (Setdb1) in tumor cells restored tumor antigen expression.

우리는 종양 세포에서 전사 인자 7 상호 작용 단백질(Atf7ip) 또는 상호 작용 파트너 SET 도메인 분기된 히스톤 라이신 메틸트랜스퍼라제 1(Setdb1)을 활성화하는 염색질 수정자 중 하나를 인코딩하는 유전자의 파괴가 종양 항원 발현을 회복한다는 것을 발견했습니다.

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Lysine Methyltransferase sentence examples within lysine methyltransferase activity

lysine methyltransferase activity 10.1002/cbic.202000736

SMYD3 is a multifunctional epigenetic enzyme with lysine methyltransferase activity and various interaction partners.

SMYD3는 라이신 메틸트랜스퍼라제 활성 및 다양한 상호작용 파트너를 갖는 다기능 후성유전적 효소입니다.

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lysine methyltransferase activity 10.3390/biom9090422

The N6AMT1 (HEMK2) protein has DNA N6-methyladenine as well as the protein glutamine and histone lysine methyltransferase activities.

nan

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Lysine Methyltransferase sentence examples within lysine methyltransferase 2b

lysine methyltransferase 2b 10.14218/JCTH.2021.00062

라이신 메틸트랜스퍼라제 2b

TERT], lysine methyltransferase 2B [i.

TERT], 라이신 메틸트랜스퍼라제 2B[i.

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lysine methyltransferase 2b 10.1016/j.cellsig.2021.110165

라이신 메틸트랜스퍼라제 2b

Here, we aimed to investigate if lysine methyltransferase 2B (KMT2B) silencing could confer 131I resistance to THCA cells and the epigenetic mechanism behind.

여기에서 우리는 라이신 메틸트랜스퍼라제 2B(KMT2B) 침묵이 THCA 세포에 대한 131I 내성과 그 뒤에 있는 후성 유전 메커니즘을 부여할 수 있는지 조사하는 것을 목표로 했습니다.

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Lysine Methyltransferase sentence examples within lysine methyltransferase setdb1

lysine methyltransferase setdb1 10.21203/RS.3.RS-145869/V1

라이신 메틸트랜스퍼라제 Setdb1

The major lysine methyltransferase Setdb1 is essential for the self-renewal and viability of ESCs.

주요 라이신 메틸트랜스퍼라제 Setdb1은 ESC의 자가 재생 및 생존에 필수적입니다.

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lysine methyltransferase setdb1 10.1111/gtc.12868

라이신 메틸트랜스퍼라제 Setdb1

The lysine methyltransferase SETDB1, an enzyme responsible for methylation of histone H3 at lysine 9, plays a key role in H3K9 tri‐methylation‐dependent silencing of endogenous retroviruses and developmental genes.

라이신 9에서 히스톤 H3의 메틸화를 담당하는 효소인 라이신 메틸트랜스퍼라제 SETDB1은 내인성 레트로바이러스 및 발달 유전자의 H3K9 트리메틸화 의존적 침묵에 중요한 역할을 합니다.

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Lysine Methyltransferase sentence examples within lysine methyltransferase kmt2d

lysine methyltransferase kmt2d 10.18632/oncotarget.27988

Notably, the histone lysine methyltransferase KMT2D (a COMPASS/ Set1 family member; also known as MLL4, ALR, and MLL2) is among the most frequently mutated genes in many different types of cancer.

특히, 히스톤 라이신 메틸트랜스퍼라제 KMT2D(COMPASS/Set1 계열 구성원, MLL4, ALR 및 MLL2라고도 함)는 다양한 유형의 암에서 가장 빈번하게 돌연변이되는 유전자 중 하나입니다.

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lysine methyltransferase kmt2d 10.1016/j.celrep.2019.02.111

We have previously reported that the PI3K pathway regulates estrogen receptor (ER)-dependent transcription in breast cancer through the phosphorylation of the lysine methyltransferase KMT2D by AKT.

nan

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Lysine Methyltransferase sentence examples within lysine methyltransferase setd8

lysine methyltransferase setd8 10.1186/s13148-021-01160-z

Results Here, we show that a higher expression of the lysine methyltransferase SETD8, which is responsible for the mono-methylation of histone H4 at lysine 20, is an adverse prognosis factor associated with a poor outcome in two cohorts of newly diagnosed patients.

결과 여기에서 우리는 라이신 20에서 히스톤 H4의 단일 메틸화를 담당하는 라이신 메틸트랜스퍼라제 SETD8의 더 높은 발현이 새로 진단된 환자의 2개 코호트에서 좋지 않은 결과와 관련된 불리한 예후 인자임을 보여줍니다.

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lysine methyltransferase setd8 10.1101/776930

Here we show that a higher expression of the lysine methyltransferase SETD8, which is responsible for histone H4K20 mono-methylation, is an adverse prognosis factor associated with a poor outcome in two cohorts of newly diagnosed patients.

nan

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Lysine Methyltransferase sentence examples within lysine methyltransferase enzyme

lysine methyltransferase enzyme 10.1021/jacs.1c05429

In addition, ADP-ribosylated nucleosomes were utilized in biochemical experiments employing a panel of lysine methyltransferase enzymes, revealing a context-dependent inhibition of histone H3K9 methylation.

또한, ADP-리보실화된 뉴클레오솜은 라이신 메틸트랜스퍼라제 효소 패널을 사용하는 생화학적 실험에 활용되었으며, 이는 히스톤 H3K9 메틸화의 상황에 따른 억제를 나타냅니다.

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lysine methyltransferase enzyme 10.1038/s41586-019-1877-9

Z-containing nucleosomes bind directly to the histone lysine methyltransferase enzyme SUV420H1, promoting H4K20me2 deposition, which is in turn required for ORC1 binding.

nan

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Lysine Methyltransferase sentence examples within lysine methyltransferase set1

lysine methyltransferase set1 10.3390/genes12081182

라이신 메틸트랜스퍼라제 세트1

We find that this signature is indeed conserved on the planarian genome and that the lysine methyltransferase Set1 is largely responsible for creating it at both cell identity and putative TSG loci.

우리는 이 시그니처가 플라나리아 게놈에서 실제로 보존되고 라이신 메틸트랜스퍼라제 Set1이 세포 동일성과 추정 TSG 유전자좌 모두에서 생성하는 데 주로 책임이 있음을 발견했습니다.

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lysine methyltransferase set1 10.1111/1462-2920.15701

라이신 메틸트랜스퍼라제 세트1

In Beauveria bassiana, mono/di/trimethylation of histone H3 Lys 4 (H3K4me1/me2/m3) abolished by inactivation of the histone lysine methyltransferase SET1/KMT2 led to marked virulence loss, reductions in conidial hydrophobicity and adherence to insect cuticle, impeded proliferation in vivo, severe defects in growth and conidiation, and increased sensitivities to cell wall perturbation, H2 O2 and heat shock.

Beauveria Bassiana에서 히스톤 라이신 메틸트랜스퍼라제 SET1/KMT2의 비활성화에 의해 히스톤 H3 Lys 4(H3K4me1/me2/m3)의 모노/디/트리메틸화가 제거되어 현저한 독성 손실, 분생자 소수성 감소 및 곤충 표피에 대한 부착, 증식 방해 생체 내, 성장 및 분생의 심각한 결함, 세포벽 교란, H2O2 및 열 충격에 대한 감도 증가.

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Lysine Methyltransferase sentence examples within lysine methyltransferase 2c

lysine methyltransferase 2c 10.1200/JCO.2021.39.15_SUPPL.3538

라이신 메틸트랜스퍼라제 2c

3538 Background: Lysine Methyltransferase 2C (KMT2C), a member of the myeloid/lymphoid or mixed-lineage leukemia (MLL) family, possesses histone methylation activity and is involved in transcriptional co-activation.

3538 배경: 라이신 메틸트랜스퍼라제 2C(KMT2C)는 골수/림프성 또는 혼합 계통 백혈병(MLL) 계열의 구성원이며 히스톤 메틸화 활성을 갖고 전사 공동 활성화에 관여합니다.

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lysine methyltransferase 2c 10.21037/jgo-21-28

라이신 메틸트랜스퍼라제 2c

Among the 18 genes, NOTCH3, histone lysine methyltransferase 2C (KMT2C), and cAMP-response element binding protein-BP (CREBBP) were respectively associated with tumor position, stage, and PFS (P<0.

18개의 유전자 중 NOTCH3, 히스톤 라이신 메틸트랜스퍼라제 2C(KMT2C) 및 cAMP-반응 요소 결합 단백질-BP(CREBBP)는 각각 종양 위치, 병기 및 PFS와 관련이 있었습니다(P<0.

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Lysine Methyltransferase sentence examples within lysine methyltransferase setd1a

lysine methyltransferase setd1a 10.3389/fcell.2021.657888

라이신 메틸트랜스퍼라제 Setd1a

The histone lysine methyltransferase SETD1A, which specifically methylates histone 3 lysine 4 (H3K4), is involved in tumor growth and metastasis, and its ectopic expression has been detected in aggressive malignancies.

히스톤 3 라이신 4(H3K4)를 특이적으로 메틸화하는 히스톤 라이신 메틸트랜스퍼라제 SETD1A는 종양 성장 및 전이에 관여하며, 이의 이소성 발현은 공격성 악성 종양에서 검출되었습니다.

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lysine methyltransferase setd1a 10.1200/JCO.2021.39.3_SUPPL.241

라이신 메틸트랜스퍼라제 Setd1a