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Preprocedural Ticagrelor Treatment was Associated with Improved Early Reperfusion and Reduced Short-term Heart Failure in East-Asian ST-segment Elevation Myocardial Infarction Patients Undergoing Primary Percutaneous Coronary Intervention


Comparison of Light Transmission Aggregometry and VerifyNow in Detecting Clopidogrel Resistance and Factors Affecting Clopidogrel Resistance in AMI-EST Patients Undergoing Percutaneous Coronary Intervention: A Cross-Sectional Study

Loading Dose sentence examples within 30 mg kg



High- versus low-dose tranexamic acid as part of a Patient Blood Management strategy for reducing blood loss in patients undergoing surgery for adolescent idiopathic scoliosis.


Evaluation of intraperitoneal vancomycin in peritoneal dialysis-associated peritonitis.

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The effect of ticagrelor on microarterial thrombosis in an experimental model


Effect of early withdrawal of phenobarbitone on the recurrence of neonatal seizures: An open-label randomized controlled trial



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Abstract MP4: Ticagrelor Plus Aspirin Versus Aspirin Alone in Acute Ischemic Stroke or TIA - Analysis of Bleeding Events in the THALES Trial


Treatment of COVID-19 pneumonia with glucocorticoids (CORTIVID): a structured summary of a study protocol for a randomised controlled trial

Loading Dose sentence examples within galcanezumab 120 mg



Galcanezumab in Patients with Multiple Previous Migraine Preventive Medication Category Failures: Results from the Open-Label Period of the CONQUER Trial


Shift from high-frequency to low-frequency episodic migraine in patients treated with Galcanezumab: results from two global randomized clinical trials

Loading Dose sentence examples within 6 mg kg



Three-Year Follow-up of Neoadjuvant Chemotherapy With or Without Anthracyclines in the Presence of Dual ERBB2 Blockade in Patients With ERBB2-Positive Breast Cancer: A Secondary Analysis of the TRAIN-2 Randomized, Phase 3 Trial.


Severe bleeding after haemorrhoidal banding in a haemophilia patient treated with emicizumab

Loading Dose sentence examples within 2 mg kg



Magnesium sulfate intravenous infusion versus intrathecal injection for prevention of post-spinal shivering during lower limb fracture surgery: a randomized controlled study


Constant Rate Infusion of Lidocaine, Tumescent Anesthesia and Their Combination in Dogs Undergoing Unilateral Mastectomy

Loading Dose sentence examples within 10 mg kg



Further insights for the role of Morin in mRTBI: Implication of non-canonical Wnt/PKC-α and JAK-2/STAT-3 signaling pathways.


The Effect of Tranexamic Acid Administration on Early Endothelial Damage Following Posterior Lumbar Fusion Surgery

Loading Dose sentence examples within diabetic macular edema



Predictors for 2-Year Functional and Morphological Outcomes of a Treat-and-Extend Regimen with Ranibizumab in Patients with Diabetic Macular Edema


The Effect of Ranibizumab Loading Treatment on Vision-Related Quality of Life in Diabetic Macular Edema

Loading Dose sentence examples within 1 μg kg



The correlation between the STOP-Bang score and oxygen saturation during spinal anesthesia with dexmedetomidine sedation


A comparative study of dexmedetomidine and propofol infusion during monitored anesthesia care (MAC) in endoscopic retrograde cholangiopancreatography (ERCP): a randomized controlled trial

Loading Dose sentence examples within 8 mg kg



Safety and efficacy study of oral metronomic vinorelbine combined with trastuzumab (mNH) in HER2-positive metastatic breast cancer: a phase II trial


Combination of trastuzumab, pertuzumab and docetaxel in patients with advanced non-small cell lung cancer (NSCLC) harboring HER2 mutation: Final results from the IFCT-1703 R2D2 trial.

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Effectiveness and safety of favipiravir compared to supportive care in moderately to critically ill COVID-19 patients: a retrospective study with propensity score matching sensitivity analysis


Pharmacokinetic modelling to estimate intracellular favipiravir ribofuranosyl-5′-triphosphate exposure to support posology for SARS-CoV-2

Loading Dose sentence examples within 4 mg kg



Challenge in treating COVID‐19 associate pulmonary aspergillosis: Supratherapeutic voriconazole levels


Efficacy and safety of enflicoxib for treatment of canine osteoarthritis: A 6-week randomised, controlled, blind, multicentre clinical trial.

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Management and outcomes of paediatric patients on emicizumab prophylaxis undergoing surgical procedures: Experience from a large haemophilia centre in the UK


Low-dose rapamycin does not impair vascular integrity and tubular regeneration after kidney transplantation in rats

Loading Dose sentence examples within ticagrelor 180 mg



Efficacy and Safety of Ticagrelor and Aspirin in Patients With Moderate Ischemic Stroke: An Exploratory Analysis of the THALES Randomized Clinical Trial.


Successful Intravenous Thrombolysis and Endovascular Treatment for Acute Ischemic Stroke in a Patient Pretreated with Ticagrelor: A Case Report and Literature Review

Loading Dose sentence examples within trastuzumab 8 mg



Intravenous and subcutaneous administration of trastuzumab in a patient on peritoneal dialysis


Dual-targeted therapy with pyrotinib and trastuzumab for HER2-positive advanced colorectal cancer: Preliminary results from a multicenter phase 2 trial.

Loading Dose sentence examples within total body weight



A Large Impact of Obesity on the Disposition of Ivermectin, Moxidectin and Eprinomectin in a Canine Model: Relevance for COVID-19 Patients


Large Impact of obesity on the disposition of ivermectin, moxidectin and eprinomectin in a canine model: relevance for COVID-19 patients.

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A case of “purple glove syndrome”


Determining the Optimal Tranexamic Acid Dose for Cardiac Surgery With Cardiopulmonary Bypass: A Randomized Controlled Trial

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Chemotherapy de-escalation using an 18F-FDG-PET-based pathological response-adapted strategy in patients with HER2-positive early breast cancer (PHERGain): a multicentre, randomised, open-label, non-comparative, phase 2 trial.


Pharmacodynamics and Outcomes of a De-Escalation Strategy with Half-Dose Prasugrel or Ticagrelor in East Asians Patients with Acute Coronary Syndrome: Results from HOPE-TAILOR Trial

Loading Dose sentence examples within 25 mg kg



Development of a new pharmacokinetic model for target-concentration controlled infusion of vancomycin in critically ill patients.


Population pharmacokinetics of vancomycin in critically ill adult patients receiving extracorporeal membrane oxygenation (an ASAP ECMO study).

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A finding associated with favipiravir‐associated photosensitivity: Yellow‐green fluorescence in the lunulae, scalp, and face


Early Onset Favipiravir Saves Lives

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Pertuzumab and trastuzumab for HER2-positive, metastatic biliary tract cancer (MyPathway): a multicentre, open-label, phase 2a, multiple basket study.


MyPathway HER2 basket study: Pertuzumab (P) + trastuzumab (H) treatment of a large, tissue-agnostic cohort of patients with HER2-positive advanced solid tumors.

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Multiple drugs


Drug-Drug Interaction Study of Benznidazole and E1224 in Healthy Male Volunteers

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Efficacy of galcanezumab in patients with migraine who did not benefit from commonly prescribed preventive treatments


Imatinib in patients with severe COVID-19: a randomised, double-blind, placebo-controlled, clinical trial

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FC 049A RANDOMISED DOSE RANGING, PLACEBO-CONTROLLED, PHASE II STUDY ASSESSING THE EFFICACY AND SAFETY OF BI 655064, AN ANTAGONISTIC ANTI-CD40 ANTIBODY, IN PATIENTS WITH LUPUS NEPHRITIS


Clopidogrel with aspirin in High-risk patients with Acute Non-disabling Cerebrovascular Events II (CHANCE-2): rationale and design of a multicentre randomised trial

Loading Dose sentence examples within 1 mg kg



Plasma levels of a methadone constant rate infusion and their corresponding effects on thermal and mechanical nociceptive thresholds in dogs


Lidocaine Infusion Improves the Functionality of Intraoperative Nerve Monitoring During Thyroid Surgery: A Prospective, Randomized, Double-Blinded Study

Loading Dose sentence examples within 200 mg twice



BH07: Testosterone deficiency in men with female pattern hair loss


Efficacy of Tocilizumab in the treatment of severe COVID-19 patients with respiratory failure

Loading Dose sentence examples within 400 mg twice



Current fluconazole treatment regimens result in under-dosing of critically ill adults during early therapy.


Day-90 survival in critically-ill patients with COVID-19 and hydroxychloroquine: a propensity analysis.

Loading Dose sentence examples within paclitaxel 80 mg



Neoadjuvant weekly paclitaxel and carboplatin with trastuzumab and pertuzumab in HER2-positive breast cancer: a Brown University Oncology Research Group (BrUOG) study


Efficacy and Safety of Paclitaxel Combined With Cetuximab for Head and Neck Squamous Cell Carcinoma

Loading Dose sentence examples within 1 µg kg



Perineural Epinephrine for Brachial Plexus Block Increases the Incidence of Hypotension during Dexmedetomidine Infusion: A Single-Center, Randomized, Controlled Trial