Late Endosome
후기 엔도솜

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Late Endosome sentence examples within autophagosome lysosome fusion

autophagosome lysosome fusion
자가포식소체 리소좀 융합

Importantly, TM inhibited autophagosome-lysosome fusion, accompanied by enhanced autophagosome-late endosome/multivesicular body (MVB) fusion to release HBsAg/SVPs through or along with exosome release.

중요하게도, TM은 엑소좀 방출을 통해 또는 엑소좀 방출과 함께 HBsAg/SVP를 방출하기 위해 강화된 자가포식소체-후기 엔도좀/다포체(MVB) 융합과 함께 자가포식소체-리소좀 융합을 억제했습니다.

ER stress promotes HBV production by enhancing utilization of the autophagosome- multivesicular body axis.

autophagosome lysosome fusion
자가포식소체 리소좀 융합

In summary, we identified a novel CEP55 regulation pathway mediated by TSG101 overexpression via lysosome degradation and revealed that UXT plays a role in the late endosome/autophagosome-lysosome fusion event, engaging in TSG101-mediated lysosome degradation.

요약하면, 우리는 리소좀 분해를 통해 TSG101 과발현에 의해 매개되는 새로운 CEP55 조절 경로를 확인하고 UXT가 TSG101 매개 리소좀 분해에 관여하는 후기 엔도좀/자가포식소체-리소좀 융합 이벤트에서 역할을 한다는 것을 밝혔습니다.

Depletion of UXT, a novel TSG101 interaction protein, leads to enhanced CEP55 attenuation through lysosome degradation.

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Late Endosome sentence examples within phosphatidylinositol 3 phosphate

phosphatidylinositol 3 phosphate
포스파티딜이노시톨 3 포스페이트

Abbreviations: ACR: autophagy-related circRNA; ADSCs: adipogenic mesenchymal stem cells; AMPK: AMP-activated protein kinase; ATG: autophagy related; BCL2: BCL2 apoptosis regulator; BECN1: beclin 1; ceRNA: competing endogenous RNA; circRNA: circular RNA; CMA: chaperone-mediated autophagy; EPCs: endothelial progenitor cells; LE/MVBs: late endosomes/multivesicular bodies; MAP1LC3/LC3: microtubule associated protein 1 light chain 3; MTOR: mechanistic target of rapamycin kinase; NSCLC: non-small cell lung cancer; PDLSCs: periodontal ligament stem cells; PE: phosphatidylethanolamine; PtdIns: phosphatidylinositol; PtdIns3K: phosphatidylinositol 3-kinase; PtdIns3P: phosphatidylinositol-3-phosphate 1,2-dipalmitoyl; PTEN: phosphatase and tensin homolog; RBPs: RNA-binding proteins; SiO2: silicon dioxide; TFEB: transcription factor EB; ULK: unc-51 like autophagy activating kinase 1.

약어: ACR: 자가포식 관련 circRNA; ADSCs: 지방생성 중간엽 줄기세포; AMPK: AMP 활성화 단백질 키나제; ATG: 자가포식 관련; BCL2: BCL2 세포자멸 조절제; BECN1: 베클린 1; ceRNA: 경쟁하는 내인성 RNA; circRNA: 원형 RNA; CMA: 샤페론 매개 자가포식; EPC: 내피 전구 세포; LE/MVB: 후기 엔도솜/다소포체; MAP1LC3/LC3: 미세소관 관련 단백질 1 경쇄 3; MTOR: 라파마이신 키나제의 기계적 표적; NSCLC: 비소세포폐암; PDLSC: 치주 인대 줄기 세포; PE: 포스파티딜에탄올아민; PtdIns: 포스파티딜이노시톨; PtdIns3K: 포스파티딜이노시톨 3-키나제; PtdIns3P: 포스파티딜이노시톨-3-포스페이트 1,2-디팔미토일; PTEN: 포스파타제 및 텐신 동족체; RBP: RNA 결합 단백질; SiO2: 이산화규소; TFEB: 전사 인자 EB; ULK: autophagy 활성화 키나제 1과 같은 unc-51.

The influence of circular RNAs on autophagy and disease progression.

phosphatidylinositol 3 phosphate
포스파티딜이노시톨 3 포스페이트

Conversion between phosphatidylinositol-3-phosphate and phosphatidylinositol-3,5-bisphosphate on endosomal membranes is critical for the maturation of early endosomes to late endosomes/lysosomes and is regulated by the PIKfyve-Vac14-Fig4 complex.

엔도솜 막에서 포스파티딜이노시톨-3-포스페이트와 포스파티딜이노시톨-3,5-비스포스페이트 간의 전환은 초기 엔도솜에서 후기 엔도솜/리소솜으로의 성숙에 중요하며 PIKfyve-Vac14-Fig4 복합체에 의해 조절됩니다.

Proximity Interactome Map of the Vac14-Fig4 Complex Using BioID.

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Late Endosome sentence examples within Positive Late Endosome

Positive Late Endosome
양성 후기 엔도솜

Co-localization of FcRn with RAB7-positive late endosomes and RAB11-positive recycling endosomes was reduced in ATG7 knockdown cells, resulting in decreased recycling of FcRn to the plasma membrane.

ATG7 녹다운 세포에서 RAB7-양성 후기 엔도솜 및 RAB11-양성 재활용 엔도좀과 함께 FcRn의 공동 국재화가 감소되어 원형질막으로의 FcRn 재활용이 감소했습니다.

Autophagy gene ATG7 regulates albumin transcytosis in renal tubule epithelial cells.

Positive Late Endosome
양성 후기 엔도솜

Blue light–induced Cry2–DAT multimerization increased colocalization with recycling endosomal marker Rab11 and had decreased presence in Rab5-positive early endosomes and Rab7-positive late endosomes.

청색광에 의해 유도된 Cry2-DAT 다량체화는 엔도솜 마커 Rab11을 재활용하여 colocalization을 증가시켰고 Rab5 양성 초기 엔도솜과 Rab7 양성 후기 엔도솜에서 존재를 감소시켰습니다.

Optogenetically-induced multimerization of the dopamine transporter increases uptake and trafficking to the plasma membrane

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Late Endosome sentence examples within Acidify Late Endosome

Acidify Late Endosome
후기 엔도솜 산성화

We show that these cargo-sorting defects are suppressed by mutations that disrupt Vph1, which is a subunit of Vacuolar H+-ATPase (V-ATPase) complexes that acidify late endosomes and vacuoles.

우리는 이러한 화물 분류 결함이 후기 엔도솜 및 액포를 산성화하는 Vacuolar H+-ATPase(V-ATPase) 복합체의 소단위인 Vph1을 방해하는 돌연변이에 의해 억제된다는 것을 보여줍니다.

Vacuolar H+-ATPase dysfunction rescues intralumenal vesicle cargo sorting in yeast lacking PI(3,5)P2 or Doa4.

Acidify Late Endosome
후기 엔도솜 산성화

We show that these cargo-sorting defects are suppressed by mutations that disrupt Vph1, a subunit of vacuolar H+-ATPase (V-ATPase) complexes that acidify late endosomes and vacuoles.

우리는 이러한 화물 분류 결함이 후기 엔도솜 및 액포를 산성화하는 액포 H+-ATPase(V-ATPase) 복합체의 소단위인 Vph1을 방해하는 돌연변이에 의해 억제된다는 것을 보여줍니다.

Vacuolar H+-ATPase dysfunction rescues intralumenal vesicle cargo sorting in yeast lacking PI(3,5)P2 or Doa4.

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Late Endosome sentence examples within late endosome maturation

late endosome maturation
늦은 엔도솜 성숙

Endosomal localization of DAF-16 is also increased by disrupting the Rab GTPase activating protein TBC-2, or decreased by inhibiting the RAB-5 or RAB-7 GTPases, key regulators of early to late endosome maturation.

DAF-16의 엔도솜 국소화는 또한 Rab GTPase 활성화 단백질 TBC-2를 방해함으로써 증가되거나 초기에서 후기 엔도솜 성숙의 주요 조절자인 RAB-5 또는 RAB-7 GTPase를 억제함으로써 감소됩니다.

The Rab GTPase activating protein TBC-2 extends longevity by facilitating release of FOXO/DAF-16 from endosomes

late endosome maturation
늦은 엔도솜 성숙

ovipneumoniae reduced ATP levels in AMs and impaired late endosome maturation and phagolysosome fusion.

ovipneumoniae는 AM에서 ATP 수준을 감소시키고 늦은 엔도솜 성숙 및 포식용해소체 융합을 손상시켰습니다.

Strategies of Mycoplasma ovipneumoniae to evade immune clearance by alveolar macrophages

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Late Endosome sentence examples within late endosome marker

late endosome marker
후기 엔도솜 마커

001) in islets from diabetic mice, and the colocalization of Stmn2, but not glucagon, with the late endosome marker, Rab7, significantly (p<0.

001) 당뇨병 마우스의 섬에서, 글루카곤이 아닌 Stmn2의 동시 국소화와 후기 엔도솜 마커 Rab7은 유의하게(p<0.

Misrouting of Glucagon and Stathmin-2 Towards Lysosomal System of α-Cells in Glucagon Hypersecretion of Diabetes

late endosome marker
후기 엔도솜 마커

We find that during Drosophila cleavage, the late endosome marker Rab7 is increasingly recruited to the yolk granules and promotes the formation of dynamic membrane tubules.

우리는 초파리 분열 동안 후기 엔도솜 마커 Rab7이 노른자 과립에 점점 더 모집되고 동적 막 세관의 형성을 촉진한다는 것을 발견했습니다.

Toll-Dorsal signaling regulates the spatiotemporal dynamics of yolk granule tubulation during Drosophila cleavage.

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Late Endosome sentence examples within late endosome route

late endosome route

ABA receptor targeting for vacuolar degradation occurs through the late endosome route and depends on FYVE DOMAIN PROTEIN REQUIRED FOR ENDOSOMAL SORTING1 (FYVE1) and VACUOLAR PROTEIN SORTING23A (VPS23A), components of the ENDOSOMAL SORTING COMPLEX REQUIRED FOR TRANSPORT-I (ESCRT-I) complexes.

Arabidopsis ALIX Regulates Stomatal Aperture and Turnover of Abscisic Acid Receptors

late endosome route

ABA receptor targeting for vacuolar degradation occurs through the late endosome route and depends on FYVE1 and VPS23A, components of endosomal sorting complex required for transport (ESCRT)-I complexes.

Stomatal aperture and turnover of ABA receptors are regulated by Arabidopsis ALIX.

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10.1038/s41467-021-24384-2

Here we follow intracellular trafficking of the EV markers CD9 and CD63 from the endoplasmic reticulum to their residency compartment, respectively PM and late endosomes.

여기에서 우리는 EV 마커 CD9 및 CD63의 세포내 인신매매를 소포체에서 거주 구획, 각각 PM 및 후기 엔도솜으로 따릅니다.

Specificities of exosome versus small ectosome secretion revealed by live intracellular tracking of CD63 and CD9

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10.1242/dev.194258

Mutations of either gene result in the accumulation of unesterified cholesterol and other lipids in the late endosome/lysosome, and reduction of cellular cholesterol bioavailability.

두 유전자의 돌연변이는 후기 엔도솜/리소솜에 에스테르화되지 않은 콜레스테롤 및 기타 지질이 축적되고 세포 콜레스테롤 생체이용률이 감소합니다.

The role of Niemann-Pick type C2 in zebrafish embryonic development.

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10.1093/plcell/koab235

The best-characterized membrane trafficking organelles include the endoplasmic reticulum (ER), Golgi apparatus, early and recycling endosomes, multivesicular body (MVB) or late endosome (LE), lysosome/vacuole, and plasma membrane (PM).

가장 잘 규명된 막 밀매 소기관에는 소포체(ER), 골지체, 초기 및 재활용 엔도솜, 다포체(MVB) 또는 후기 엔도솜(LE), 리소솜/액포 및 원형질막(PM)이 포함됩니다.

Molecular mechanisms of endomembrane trafficking in plants.

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10.1080/15548627.2021.1990669

Therefore, autophagy induction or early-stage autophagosome formation (as compared to decreased later-stage autophagosome maturation or autophagosome-late endosome/lysosome fusion) is normal or increased.

따라서 자가포식 유도 또는 초기 단계의 자가포식소체 형성(감소된 후기단계 자가포식소체 성숙 또는 자가포식소체-후기 엔도솜/리소좀 융합과 비교하여)은 정상이거나 증가합니다.

Human platelets display dysregulated sepsis-associated autophagy, induced by altered LC3 protein-protein interaction of the Vici-protein EPG5.

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10.1016/j.cub.2021.01.081

WDR45/45B interact with the tether protein EPG5 and target it to late endosomes/lysosomes to promote autophagosome maturation.

WDR45/45B는 테더 단백질 EPG5와 상호작용하고 이를 후기 엔도솜/리소솜으로 표적화하여 자가포식솜 성숙을 촉진합니다.

β-propeller proteins WDR45 and WDR45B regulate autophagosome maturation into autolysosomes in neural cells

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10.1016/j.nbd.2021.105360

Furthermore, some genes that cause FTD or ALS when mutated encode proteins that localize to the lysosome or modulate endosome-lysosome function, including lysosomal fusion, cargo trafficking, lysosomal acidification, autophagy, or TFEB activity.

또한, 돌연변이될 때 FTD 또는 ALS를 유발하는 일부 유전자는 리소좀 융합, 화물 수송, 리소좀 산성화, 자가포식 또는 TFEB 활성을 포함하여 리소좀에 국한되거나 엔도좀-리소좀 기능을 조절하는 단백질을 암호화합니다.

Lysosome dysfunction as a cause of neurodegenerative diseases: Lessons from frontotemporal dementia and amyotrophic lateral sclerosis

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10.1080/15548627.2021.1883886

Recent work by our group shows that ER elements could also be incorporated into late endosomes and later be released by a secretory mechanism which we will herein refer to as secretory reticulophagy/ER-phagy (SERP).

우리 그룹의 최근 작업은 ER 요소가 후기 엔도솜에 통합될 수 있고 나중에 분비 메커니즘에 의해 방출될 수 있음을 보여줍니다.

Introducing secretory reticulophagy/ER-phagy (SERP), a VAMP7-dependent pathway involved in neurite growth

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10.1016/j.exer.2021.108793

We have found that upregulation of protrudin with gene therapy significantly increases the number of mitochondria-ER and mitochondria-Rab7-late endosomes contact sites in optic nerves.

우리는 유전자 치료에 의한 프로트루딘의 상향 조절이 시신경에서 미토콘드리아-ER 및 미토콘드리아-Rab7-late 엔도솜 접촉 부위의 수를 유의하게 증가시킨다는 것을 발견했습니다.

Quantifying inter-organelle membrane contact sites using proximity ligation assay in fixed optic nerve sections.

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10.1080/15548627.2021.1911017

The truncation of LAMP2A impaired the recruitment of GAPDH (a CMA-substrate) fused to the HaloTag protein to the surface of late endosomes/lysosomes (LE/Lys) and affected a process that generates LE/Lys.

LAMP2A의 절단은 HaloTag 단백질에 융합된 GAPDH(CMA 기질)를 후기 엔도좀/리소좀(LE/Lys)의 표면에 모으는 것을 손상시켰고 LE/Lys를 생성하는 과정에 영향을 미쳤습니다.

Direct homophilic interaction of LAMP2A with the two-domain architecture revealed by site-directed photo-crosslinks and steric hindrances in mammalian cells.

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10.2147/IJGM.S317785

GO analysis showed that the biological functions of DEARGs focused primarily on autophagy, cellular response to external stimulus, fibroblast proliferation, late endosome, and ubiquitin protein ligase binding.

GO 분석은 DEARG의 생물학적 기능이 주로 자가포식, 외부 자극에 대한 세포 반응, 섬유아세포 증식, 후기 엔도솜 및 유비퀴틴 단백질 리가제 결합에 초점을 맞춘 것으로 나타났습니다.

Identification of Autophagy-Related Genes in the Progression from Non-Alcoholic Fatty Liver to Non-Alcoholic Steatohepatitis

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10.1523/JNEUROSCI.1244-20.2021

M6PRs accumulate in late endosomes, suggesting defective M6PR recycling and retromer function in NHE6-null neurons.

M6PR은 후기 엔도솜에 축적되어 NHE6-null 뉴런에서 결함이 있는 M6PR 재활용 및 레트로머 기능을 시사합니다.

Loss of Christianson Syndrome Na+/H+ Exchanger 6 (NHE6) Causes Abnormal Endosome Maturation and Trafficking Underlying Lysosome Dysfunction in Neurons.

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10.1038/s41598-021-98419-5

The membrane contact sites (MCSs) between the ER and late endosomes (LEs) are essential for the regulation of endosomal protein sorting, dynamics, and motility.

ER과 후기 엔도솜(LE) 사이의 막 접촉 부위(MCS)는 엔도솜 단백질 분류, 역학 및 운동성의 조절에 필수적입니다.

Structural basis of human PDZD8–Rab7 interaction for the ER-late endosome tethering

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10.1016/J.NANTOD.2021.101271

The results of our experiments show that the infection pathway of the JEV is dependent on actin and microtubules, and viral fusion events predominantly occur in maturing endosomes that represent the intermediate stage between early and late endosomes.

우리 실험의 결과는 JEV의 감염 경로가 액틴과 미세소관에 의존하고 바이러스 융합 사건은 초기 엔도좀과 후기 엔도좀 사이의 중간 단계를 나타내는 성숙 엔도좀에서 주로 발생한다는 것을 보여줍니다.

In-situ quantitation of genome release of Japanese encephalitis viruses by quantum dot-based single-virus tracking

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10.1038/s41598-021-88737-z

NPC1 is a protein that mediates cholesterol export from late endosomes/lysosomes in mammalian cells.

NPC1은 포유류 세포의 후기 엔도좀/리소좀에서 콜레스테롤 내보내기를 매개하는 단백질입니다.

Phagocytic and pinocytic uptake of cholesterol in Tetrahymena thermophila impact differently on gene regulation for sterol homeostasis

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10.1016/j.jsb.2021.107795

5, corresponding to the pH in the late endosome, proposed required for VP1u externalization to facilitate endosomal escape.

후기 엔도솜의 pH에 ​​해당하는 5는 엔도솜 탈출을 촉진하기 위해 VP1u 외부화에 필요한 것으로 제안되었습니다.

Comparative Structural, Biophysical, and Receptor Binding Study of True Type and Wild type AAV2.

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10.20944/PREPRINTS202103.0426.V1

Aβ42 were internalized and oligomerized into the lysosomes/late endosomes in a concentration-dependent manner.

Aβ42는 농도 의존적 ​​방식으로 리소좀/후기 엔도좀으로 내재화 및 올리고머화되었다.

Live Cell FRET Imaging Reveals Amyloid β-Peptide Oligomerization in Hippocampal Neurons

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10.1021/acs.nanolett.1c02274

Importantly, it is more easily internalized into antigen-presenting cells and accumulates in the late endosome, where TLR9 is located.

중요한 것은 항원 제시 세포로 더 쉽게 내재화되고 TLR9가 위치한 후기 엔도솜에 축적된다는 것입니다.

Precision Wormlike Nanoadjuvant Governs Potency of Vaccination.

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10.3390/v13040675

Tetraspanin CD63 is a cluster of cell surface proteins with four transmembrane domains; it is associated with tetraspanin-enriched microdomains and typically localizes to late endosomes and lysosomes.

Tetraspanin CD63은 4개의 막관통 도메인을 가진 세포 표면 단백질 클러스터입니다. 이것은 테트라스파닌이 풍부한 마이크로도메인과 연관되어 있으며 일반적으로 후기 엔도솜 및 리소솜에 국한됩니다.

Epstein-Barr Virus LMP1 Modulates the CD63 Interactome

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10.1101/2021.01.07.425786

In tracheal terminal cells of the Drosophila respiratory system, endocytosis and trafficking through late endosomes balances membrane delivery between the basal plasma membrane and the apical membrane that forms a subcellular tube, but it has been unclear how the direction of growth of the subcellular tube with the overall growth of the cell is coordinated.

초파리 호흡기계의 기관 말단 세포에서 엔도사이토시스와 후기 엔도좀을 통한 이동은 기저 원형질막과 세포하관을 형성하는 정점막 사이의 막 전달 균형을 유지하지만, 세포의 전반적인 성장이 조정됩니다.

An endosome-associated actin network involved in directed apical plasma membrane growth

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10.1002/ajmg.a.62382

Mutations in either NPC1 or NPC2, two genes encoding lysosomal proteins, lead to an intracellular accumulation of unesterified cholesterol and sphingolipids in late endosomes/lysosomes.

리소좀 단백질을 암호화하는 두 유전자인 NPC1 또는 NPC2의 돌연변이는 후기 엔도좀/리소좀에서 에스테르화되지 않은 콜레스테롤 및 스핑고리피드의 세포내 축적을 초래합니다.

Hepatocellular carcinoma as a complication of Niemann‐Pick disease type C1

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10.3389/fimmu.2021.729851

Unfortunately, this site is shielded in extracellular GP and only uncovered by proteolytic cleavage by host proteases in late endosomes and lysosomes, which are generally inaccessible to antibodies.

불행히도, 이 부위는 세포외 GP에서 보호되고 일반적으로 항체에 접근할 수 없는 후기 엔도좀 및 리소좀에서 숙주 프로테아제에 의한 단백질 분해 절단에 의해서만 밝혀집니다.

Two Distinct Lysosomal Targeting Strategies Afford Trojan Horse Antibodies With Pan-Filovirus Activity

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10.1242/jcs.259221

We have previously identified myosin II as a direct interactor of Rab7b, a small GTPase that mediates the transport from late endosomes/lysosomes to the trans-Golgi network (TGN).

우리는 이전에 미오신 II를 후기 엔도솜/리소좀에서 트랜스 골지 네트워크(TGN)로의 수송을 매개하는 작은 GTPase인 Rab7b의 직접적인 상호작용자로 식별했습니다.

Rab7b regulates dendritic cell migration by linking lysosomes to the actomyosin cytoskeleton

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10.1523/jneurosci.1211-20.2020

Lgmn is a cysteine protease of late endosomes and lysosomes that can be secreted; it exhibits maximal activity in acidic environments.

Lgmn은 분비될 수 있는 후기 엔도좀 및 리소좀의 시스테인 프로테아제입니다. 산성 환경에서 최대 활성을 나타냅니다.

Legumain Induces Oral Cancer Pain by Biased Agonism of Protease-Activated Receptor-2

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10.1111/cas.15000

Importantly, PC9/GR harbored high levels of nuclear EGFR, and overexpression of TIP30 restored irregular EGFR trafficking and degradation from early endosomes to the late endosomes, decreasing the nuclear accumulation of EGFR, which may partly or totally inhibit EGFR‐mediated induction of c‐Myc transcription.

중요하게도, PC9/GR은 높은 수준의 핵 EGFR을 보유하고 TIP30의 과발현은 초기 엔도솜에서 후기 엔도솜으로의 불규칙한 EGFR 트래피킹 및 분해를 복원하여 EGFR의 핵 축적을 감소시켜 c-의 EGFR 매개 유도를 부분적으로 또는 전체적으로 억제할 수 있습니다. Myc 전사.

TIP30 overcomes gefitinib resistance by regulating cytoplasmic and nuclear EGFR signaling in non–small‐cell lung cancer

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10.1101/2021.09.26.461887

While some viruses exit this compartment early, others must reach the degradative, acidic environment of the late endosome.

일부 바이러스는 이 구획을 일찍 빠져나가지만, 다른 바이러스는 후기 엔도솜의 분해성, 산성 환경에 도달해야 합니다.

A CRISPR-Cas9 screen reveals a role for WD repeat-containing protein 81 (WDR81) in the entry of late penetrating viruses

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10.1093/glycob/cwaa120

We have used immunofluorescence microscopy, flow cytometry, and SDS-PAGE-western blotting with antibodies recognizing the released HS, APP, amyloid ᵝ(Aᵝ), late endosomes (Rab7), autophagosomes (LC3) and neurons (Tuj1).

우리는 방출된 HS, APP, 아밀로이드 ᵝ(Aᵝ), 후기 엔도솜(Rab7), 자가포식소체(LC3) 및 뉴런(Tuj1)을 인식하는 항체와 함께 면역형광 현미경, 유세포 분석 및 SDS-PAGE-서부 블로팅을 사용했습니다.

Reversal of apolipoprotein E4-dependent or chemical-induced accumulation of APP degradation products by vitamin C-induced release of heparan sulfate from glypican-1.

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10.3390/ijms22084009

NPC2 is a small, soluble protein consisting of 151 amino acids, primarily expressed in late endosomes and lysosomes (LE/LY).

NPC2는 151개의 아미노산으로 구성된 작은 가용성 단백질로 주로 후기 엔도솜과 리소솜(LE/LY)에서 발현됩니다.

Pathophysiological In Vitro Profile of Neuronal Differentiated Cells Derived from Niemann-Pick Disease Type C2 Patient-Specific iPSCs Carrying the NPC2 Mutations c.58G>T/c.140G>T

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10.21203/rs.3.rs-79475/v1

The vacuoles acquired some characteristics of late endosomes supported that EKC-induced cell death could be described as methuosis.

액포는 후기 엔도솜의 일부 특성을 획득하여 EKC에 의해 유발된 세포 사멸이 뮤토시스로 기술될 수 있음을 뒷받침했습니다.

Epimedokoreanin C, a prenylated flavonoid isolated from Epimedium koreanum, induces non-apoptotic cell death with the characteristics of methuosis in lung cancer cells.

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10.1101/2021.02.11.430673

Endosomal sorting complexes required for transport (ESCRT) are membrane-deforming proteins associated with the late endosome/multivesicular body (MVB).

수송에 필요한 엔도솜 분류 복합체(ESCRT)는 후기 엔도솜/다포체(MVB)와 관련된 막 변형 단백질입니다.

Unexpected organellar locations of ESCRT machinery in Giardia intestinalis and complex evolutionary dynamics spanning the transition to parasitism in the lineage Fornicata

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10.1101/2021.02.09.430442

These data suggest that tSNARE1 regulates endosomal trafficking in cortical neurons, likely through negatively regulating endocytic trafficking or maturation of early endosomes to late endosomes.

이러한 데이터는 tSNARE1이 초기 엔도솜에서 후기 엔도솜으로의 성숙을 부정적으로 조절하는 것을 통해 아마도 피질 뉴런에서 엔도솜 인신매매를 조절함을 시사합니다.

Schizophrenia-linked protein tSNARE1 regulates endolysosomal trafficking in cortical neurons

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10.1038/s41598-021-91818-8

Transport of ligand-bound EGFR from early endosome to late endosome/MVB and lysosome is diminished in CPAP-depleted cells.

리간드 결합 EGFR의 초기 엔도솜에서 후기 엔도솜/MVB 및 리소솜으로의 수송은 CPAP가 고갈된 세포에서 감소합니다.

Centrosomal P4.1-associated protein (CPAP) positively regulates endocytic vesicular transport and lysosome targeting of EGFR

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10.1038/s41598-021-87876-7

Mitochondria receive cholesterol from late endosomes and lysosomes (LE/LYSs) or from the plasma membrane for production of oxysterols and steroid hormones.

미토콘드리아는 옥시스테롤과 스테로이드 호르몬 생산을 위해 후기 엔도솜과 리소솜(LE/LYS) 또는 원형질막에서 콜레스테롤을 받습니다.

Quantitative imaging of membrane contact sites for sterol transfer between endo-lysosomes and mitochondria in living cells

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10.1111/tra.12813

Fixed and live imaging shows newly made MT1‐MMP is packaged into vesicles that traffic to and fuse with LBPA+LAMP1+ late endosomes en route to the surface.

고정 및 라이브 이미징은 새로 만들어진 MT1-MMP가 표면으로 가는 도중에 LBPA+LAMP1+ 후기 엔도솜으로 이동하고 융합하는 소포에 포장되어 있음을 보여줍니다.

The trans‐SNARE complex VAMP4/Stx6/Stx7/Vti1b is a key regulator of Golgi to late endosome MT1‐MMP transport in macrophages

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10.17912/micropub.biology.000380

Atg27p, a single-pass transmembrane protein that functions in autophagy, localizes to a variety of cellular compartments including the pre-autophagosomal structure, late Golgi, vacuolar membrane, as well as early and late endosomes.

Autophagy에서 기능하는 단일 통과 막횡단 단백질인 Atg27p는 pre-autophagosomal 구조, 후기 골지체, 액포막, 초기 및 후기 엔도솜을 비롯한 다양한 세포 구획에 국한됩니다.

Atg27p co-fractionates with clathrin-coated vesicles in budding yeast

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10.3389/fncel.2021.757482

The disease is caused by loss-of-function mutations in the Npc1 or Npc2 gene which both result into lipid accumulation in the late endosomes and lysosomes.

이 질병은 Npc1 또는 Npc2 유전자의 기능 상실 돌연변이로 인해 발생하며 둘 다 후기 엔도솜 및 리소솜에 지질 축적을 초래합니다.

Involvement of the Choroid Plexus in the Pathogenesis of Niemann-Pick Disease Type C

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10.1016/j.bbamcr.2021.119096

In our previous study, we revealed Rab11b negatively regulated osteoclastogenesis by promoting the lysosomal proteolysis of c-fms and RANK surface receptors via the axis of early endosome-late endosome-lysosomes.

우리의 이전 연구에서 우리는 초기 엔도좀-후기 엔도좀-리소좀의 축을 통해 c-fms 및 RANK 표면 수용체의 리소좀 단백질 분해를 촉진함으로써 Rab11b가 파골세포 생성을 부정적으로 조절함을 밝혔습니다.

A novel role of HSP90 in regulating osteoclastogenesis by abrogating Rab11b-driven transport.

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10.1007/s11259-021-09831-1

These data suggest that movement of Cy5-Ova through the late endosomes to the lysosomes was much reduced in the ileum of 1-h gavaged piglets.

이러한 데이터는 후기 엔도좀을 통한 Cy5-Ova의 리소좀으로의 이동이 1시간 위관 영양 공급 새끼 돼지의 회장에서 훨씬 감소되었음을 시사합니다.

Assessment of intestinal macromolecular absorption in young piglets to pave the way to oral vaccination: preliminary results

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10.1002/jev2.12132

We have described that after endocytosis, EVs reach Rab7+ late endosomes and a fraction of these enter the nucleoplasmic reticulum and transport EV biomaterials to the host cell nucleoplasm.

우리는 엔도사이토시스 후 EV가 Rab7+ 후기 엔도솜에 도달하고 이들 중 일부가 핵질 세망에 들어가 EV 생체 재료를 숙주 세포 핵질로 수송한다고 설명했습니다.

Itraconazole inhibits nuclear delivery of extracellular vesicle cargo by disrupting the entry of late endosomes into the nucleoplasmic reticulum

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10.1016/j.neuint.2021.105152

Previous studies showed that MAGI2 participates in formation of tetrameric complexes with PDZ-GEF1, TrkA receptor, and ankyrin repeat-rich membrane spanning (ARMS) protein at late endosomes and is crucial for neurite outgrowth.

이전 연구에서는 MAGI2가 PDZ-GEF1, TrkA 수용체 및 ARMS(ankyrin repeat-rich membrane spanning) 단백질과 후기 엔도솜에서 사량체 복합체 형성에 참여하고 신경돌기 파생물에 결정적인 것으로 나타났습니다.

Crystal structure of the PDZ4 domain of MAGI2 in complex with PBM of ARMS reveals a canonical PDZ recognition mode

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10.1016/j.antiviral.2021.105193

Further mechanistic experiments revealed that ML-SA1 and SN-2 decreased the expression of the late endosomal marker Rab7, dependent on TRPML2 and TRPML3, indicating that these two compounds likely inhibit viral infection by promoting vesicular trafficking from late endosomes to lysosomes and then accelerating lysosomal degradation of the virus.

추가 기계 실험에서 ML-SA1 및 SN-2가 TRPML2 및 TRPML3에 의존하는 후기 엔도솜 마커 Rab7의 발현을 감소시키는 것으로 밝혀졌으며, 이는 이 두 화합물이 후기 엔도좀에서 리소좀으로의 소포 트래피킹을 촉진한 다음 리소좀을 가속화함으로써 바이러스 감염을 억제할 가능성이 있음을 나타냅니다. 바이러스의 분해.

ML-SA1 and SN-2 inhibit endocytosed viruses through regulating TRPML channel expression and activity.

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10.1126/sciimmunol.abg0791

Sustained activation of mTORC1 at late endosomes in primary CD4+ T cell responses of older individuals impairs T helper cell function.

나이든 개인의 1차 CD4+ T 세포 반응에서 후기 엔도솜에서 mTORC1의 지속적인 활성화는 T 도우미 세포 기능을 손상시킵니다.

Activation of mTORC1 at late endosomes misdirects T cell fate decision in older individuals

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10.1016/j.biomaterials.2021.120966

However, endosome co-localization studies revealed that D-90-C12-103 nanoparticles resided in late endosomes to a greater extent than DD-90-C12-103.

그러나 엔도솜 공동-국재화 연구에 따르면 D-90-C12-103 나노입자가 DD-90-C12-103보다 후기 엔도솜에 더 많이 존재하는 것으로 나타났습니다.

Systemic delivery of mRNA and DNA to the lung using polymer-lipid nanoparticles.

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10.1371/journal.ppat.1009488

Arenavirus entry into host cells occurs through a low pH-dependent fusion with late endosomes that is mediated by the viral glycoprotein complex (GPC).

숙주 세포로의 아레나바이러스 진입은 바이러스 당단백질 복합체(GPC)에 의해 매개되는 후기 엔도솜과의 낮은 pH 의존적 융합을 통해 발생합니다.

The late endosome-resident lipid bis(monoacylglycero)phosphate is a cofactor for Lassa virus fusion

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10.3390/pharmaceutics13050738

Ultrastructural analysis of pericytes revealed AuNPs in late endosomes, autolysosomes, and mitochondria.

혈관주위세포의 미세구조 분석은 후기 엔도솜, 자가용해소체 및 미토콘드리아에서 AuNP를 밝혀냈습니다.

Gold Nanoparticles Affect Pericyte Biology and Capillary Tube Formation

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10.1039/d0dt04114a

According to fluorescence microscopy, this compound is presumably located in late endosomes or lysosomes.

형광현미경에 따르면 이 화합물은 후기 엔도좀이나 리소좀에 위치하는 것으로 추정된다.

Fluorescent palladium(II) and platinum(II) NHC/1,2,3-triazole complexes: antiproliferative activity and selectivity against cancer cells.

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10.21203/RS.3.RS-495830/V1

These data suggest that movement of Cy5-Ova through the late endosomes to the lysosomes was much reduced in the ileum of 1 hour gavaged piglets, possibly impacted by prior processing of colostral macromolecules.

이러한 데이터는 후기 엔도좀을 통한 Cy5-Ova의 리소좀으로의 이동이 1시간 위관 영양 공급을 받은 새끼 돼지의 회장에서 훨씬 감소되었으며, 아마도 초유 거대분자의 사전 처리에 의해 영향을 받을 수 있음을 시사합니다.

Assessment of Intestinal Permeability in Young Piglet to Pave the Way to Oral Vaccination

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10.1007/s00204-021-03131-y

Intriguingly, METH induced autophagosome accumulation and autophagic flux disturbance was incredibly retarded by overexpression of Stx17, which was validated by the restoration of the fusion autophagosome-late endosome/lysosome fusion.

흥미롭게도 METH 유도 autophagosome 축적 및 autophagic 플럭스 교란은 융합 autophagosome-late endosome/lysosome 융합의 복원에 의해 검증된 Stx17의 과발현에 의해 엄청나게 지연되었습니다.

Mystery of methamphetamine-induced autophagosome accumulation in hippocampal neurons: loss of syntaxin 17 in defects of dynein-dynactin driving and autophagosome-late endosome/lysosome fusion.

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10.1038/s41580-021-00392-4

In multicellular organisms, newly formed autophagosomes undergo a process called ‘maturation’, in which they fuse with vesicles originating from endolysosomal compartments, including early/late endosomes and lysosomes, to form amphisomes, which eventually become degradative autolysosomes.

다세포 유기체에서 새로 형성된 자가포식소체는 초기/후기 엔도좀 및 리소좀을 포함하는 엔도리소좀 구획에서 유래하는 소포와 융합하여 양각체를 형성하고 결국 분해성 자가용해소체가 되는 '성숙'이라는 과정을 거칩니다.

Machinery, regulation and pathophysiological implications of autophagosome maturation

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10.1242/dev.194258

Mutations of either gene result in the accumulation of unesterified cholesterol and other lipids in the late endosome/lysosome, while reducing cellular cholesterol bioavailability.

두 유전자의 돌연변이는 후기 엔도솜/리소솜에 에스테르화되지 않은 콜레스테롤 및 기타 지질을 축적하는 동시에 세포 콜레스테롤 생체이용률을 감소시킵니다.

The role of Niemann-Pick type C2 in zebrafish embryonic development.

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Late Endosome(후기 엔도솜)란 무엇입니까?

Late Endosome 후기 엔도솜 - Here we follow intracellular trafficking of the EV markers CD9 and CD63 from the endoplasmic reticulum to their residency compartment, respectively PM and late endosomes. [1] Mutations of either gene result in the accumulation of unesterified cholesterol and other lipids in the late endosome/lysosome, and reduction of cellular cholesterol bioavailability. [2] The best-characterized membrane trafficking organelles include the endoplasmic reticulum (ER), Golgi apparatus, early and recycling endosomes, multivesicular body (MVB) or late endosome (LE), lysosome/vacuole, and plasma membrane (PM). [3] Therefore, autophagy induction or early-stage autophagosome formation (as compared to decreased later-stage autophagosome maturation or autophagosome-late endosome/lysosome fusion) is normal or increased. [4] WDR45/45B interact with the tether protein EPG5 and target it to late endosomes/lysosomes to promote autophagosome maturation. [5] Furthermore, some genes that cause FTD or ALS when mutated encode proteins that localize to the lysosome or modulate endosome-lysosome function, including lysosomal fusion, cargo trafficking, lysosomal acidification, autophagy, or TFEB activity. [6] Recent work by our group shows that ER elements could also be incorporated into late endosomes and later be released by a secretory mechanism which we will herein refer to as secretory reticulophagy/ER-phagy (SERP). [7] We have found that upregulation of protrudin with gene therapy significantly increases the number of mitochondria-ER and mitochondria-Rab7-late endosomes contact sites in optic nerves. [8] The truncation of LAMP2A impaired the recruitment of GAPDH (a CMA-substrate) fused to the HaloTag protein to the surface of late endosomes/lysosomes (LE/Lys) and affected a process that generates LE/Lys. [9] GO analysis showed that the biological functions of DEARGs focused primarily on autophagy, cellular response to external stimulus, fibroblast proliferation, late endosome, and ubiquitin protein ligase binding. [10] M6PRs accumulate in late endosomes, suggesting defective M6PR recycling and retromer function in NHE6-null neurons. [11] The membrane contact sites (MCSs) between the ER and late endosomes (LEs) are essential for the regulation of endosomal protein sorting, dynamics, and motility. [12] The results of our experiments show that the infection pathway of the JEV is dependent on actin and microtubules, and viral fusion events predominantly occur in maturing endosomes that represent the intermediate stage between early and late endosomes. [13] NPC1 is a protein that mediates cholesterol export from late endosomes/lysosomes in mammalian cells. [14] 5, corresponding to the pH in the late endosome, proposed required for VP1u externalization to facilitate endosomal escape. [15] Aβ42 were internalized and oligomerized into the lysosomes/late endosomes in a concentration-dependent manner. [16] Importantly, it is more easily internalized into antigen-presenting cells and accumulates in the late endosome, where TLR9 is located. [17] Tetraspanin CD63 is a cluster of cell surface proteins with four transmembrane domains; it is associated with tetraspanin-enriched microdomains and typically localizes to late endosomes and lysosomes. [18] In tracheal terminal cells of the Drosophila respiratory system, endocytosis and trafficking through late endosomes balances membrane delivery between the basal plasma membrane and the apical membrane that forms a subcellular tube, but it has been unclear how the direction of growth of the subcellular tube with the overall growth of the cell is coordinated. [19] Mutations in either NPC1 or NPC2, two genes encoding lysosomal proteins, lead to an intracellular accumulation of unesterified cholesterol and sphingolipids in late endosomes/lysosomes. [20] Unfortunately, this site is shielded in extracellular GP and only uncovered by proteolytic cleavage by host proteases in late endosomes and lysosomes, which are generally inaccessible to antibodies. [21] We have previously identified myosin II as a direct interactor of Rab7b, a small GTPase that mediates the transport from late endosomes/lysosomes to the trans-Golgi network (TGN). [22] Lgmn is a cysteine protease of late endosomes and lysosomes that can be secreted; it exhibits maximal activity in acidic environments. [23] Importantly, PC9/GR harbored high levels of nuclear EGFR, and overexpression of TIP30 restored irregular EGFR trafficking and degradation from early endosomes to the late endosomes, decreasing the nuclear accumulation of EGFR, which may partly or totally inhibit EGFR‐mediated induction of c‐Myc transcription. [24] While some viruses exit this compartment early, others must reach the degradative, acidic environment of the late endosome. [25] We have used immunofluorescence microscopy, flow cytometry, and SDS-PAGE-western blotting with antibodies recognizing the released HS, APP, amyloid ᵝ(Aᵝ), late endosomes (Rab7), autophagosomes (LC3) and neurons (Tuj1). [26] NPC2 is a small, soluble protein consisting of 151 amino acids, primarily expressed in late endosomes and lysosomes (LE/LY). [27] The vacuoles acquired some characteristics of late endosomes supported that EKC-induced cell death could be described as methuosis. [28] Endosomal sorting complexes required for transport (ESCRT) are membrane-deforming proteins associated with the late endosome/multivesicular body (MVB). [29] These data suggest that tSNARE1 regulates endosomal trafficking in cortical neurons, likely through negatively regulating endocytic trafficking or maturation of early endosomes to late endosomes. [30] Transport of ligand-bound EGFR from early endosome to late endosome/MVB and lysosome is diminished in CPAP-depleted cells. [31]<