Intravenous Dose(정맥 주사)란 무엇입니까?
Intravenous Dose 정맥 주사 - We evaluated human-like the efficacy of intravenous doses of fosfomycin of 8 g every 8 h (8 g/Q8h) and of amikacin (15 mg/kg/Q24h) in monotherapy and in combination against six fosfomycin-heteroresistant Escherichia coli isolates using a hollow-fiber infection model (HFIM). [1] 0 mg/kg and intravenous dose of 2. [2] After an intravenous dose, the plasma exposure was 5-fold higher than that in the skin. [3] Oseltamivir in intravenous doses of 3 (n = 6) and 30 mg/kg (n = 7) was administered in conscious state to the persistent atrial fibrillation model dogs to confirm its anti-atrial fibrillatory action. [4] Following administration of an intravenous dose of 140 MBq of [68Ga]Ga-RM2,imaging was conducted at 60 min. [5] Participants were stratified by age (2 to <6 years and 6 to <12 years) to receive a single oral or intravenous dose of tedizolid phosphate. [6] Participants were symptomatic infants with SMA type 1 and 2 copies of SMN2 previously treated with an intravenous dose of onasemnogene abeparvovec (low dose, 6. [7] Oral and intravenous doses of 33P and serial blood and urine sampling determined intestinal phosphorus absorption during the final 2 days. [8] The method was applied to study the pharmacokinetics, metabolism, and bioavailability of trans-resveratrol in healthy rats following a single oral or intravenous dose. [9] [3], intravenous doses ≥ 2 mg. [10] A scoping review was performed to evaluate whether existing literature on methadone bioavailability in human subjects support the current recommendation that an equivalent enteral dose is twice the intravenous dose. [11] To induce diabetes, rats were administered an intravenous dose of streptozotocin (65 mg/kg) and a 5% D-glucose solution as drinking water. [12] QIVIVE showed that up to 4600 times lower intrathecal doses than oral and intravenous doses induce comparable neurological effects. [13] The pharmacokinetic assay was performed with ICR mice strain, in which the mice were administrated with a single oral or intravenous dose (400 mg/kg with 7. [14] Poyendarone hydrochloride (n = 4) and dronedarone hydrochloride (n = 4) in intravenous doses of 0. [15] To investigate the possibility of prolonging the anesthesia, six of the pigs also received an intravenous dose of the drug combination after one hour. [16] First, the intravenous dose and concentration were set at 2. [17] Almost 80% of an oral or intravenous dose is excreted as metabolites in urine; the remainder is found in feces and originates from biliary secretion. [18] All the patients used Berlithione: Group 1 received its intravenous doses of 600 mg for 14 days, then oral ones of 600 mg for other 16 days; Group 2 took oral doses of 600 mg for 30 days. [19] Intravenous dose of 20 mg/kg intravenously every six hours is likely to provide a better therapeutic effect than the existing dosing regimen. [20] All patients received an intravenous dose of 6 mg/kg, followed by subcutaneous administration of 90 mg every 8 (90%) or 12 weeks (10%) according to clinical judgment. [21] A jugular catheter was placed, and the following day llamas were given an intravenous dose of 1 mg of NGF isolated from seminal plasma. [22] Birds received transmucosal pentobarbital at five (430 mg/kg), six (516 mg/kg), and seven times (602 mg/kg) the intravenous dose for mammals. [23] Twelve pigs received an intravenous dose of 100 µg/kg body weight (BW) U-47700 or 1000 µg/kg BW tramadol, respectively. [24] Albino rats were divided into four groups and supplied with either; distilled water, daily 10% (w/v) AG, an intravenous dose of TBX (1600 mg I/kg b. [25] Plasma concentrations of gliclazide (single oral and intravenous dose of 33 and 26. [26]우리는 6개의 포스포마이신-이종내성 대장균 분리주에 대해 8시간마다 8g의 포스포마이신(8g/Q8h) 및 아미카신(15 mg/kg/Q24h)을 정맥 주사했을 때와 단독 요법에서 인간과 유사한 효능을 평가했습니다. 중공사 감염 모델(HFIM). [1] 0 mg/kg 및 2의 정맥내 투여. [2] 정맥 투여 후 혈장 노출은 피부 노출보다 5배 더 높았다. [3] 항심방세동 작용을 확인하기 위해 3(n = 6) 및 30 mg/kg(n = 7)의 정맥내 용량의 Oseltamivir를 지속성 심방세동 모델 개에게 의식 상태에서 투여했습니다. [4] 140 MBq의 [68Ga]Ga-RM2를 정맥내 투여한 후 60분에 영상화를 수행했습니다. [5] 참가자는 테디졸리드 포스페이트의 단일 경구 또는 정맥내 용량을 받기 위해 연령(2세에서 6세 미만 및 6세에서 12세 미만)으로 계층화되었습니다. [6] 참가자는 이전에 onasemnogene abeparvovec(저용량, 6.6) 정맥내 용량으로 치료받은 SMN2의 SMA 유형 1 및 2 사본을 가진 증상이 있는 유아였습니다. [7] 33P의 경구 및 정맥내 투여 및 연속 혈액 및 소변 샘플링은 최종 2일 동안 장내 인 흡수를 결정했습니다. [8] 이 방법은 단일 경구 또는 정맥 투여 후 건강한 쥐에서 트랜스-레스베라트롤의 약동학, 대사 및 생체이용률을 연구하기 위해 적용되었습니다. [9] [3], 정맥내 용량 ≥ 2 mg. [10] 인간 피험자의 메타돈 생체이용률에 대한 기존 문헌이 등가 장내 용량이 정맥내 용량의 2배라는 현재 권장 사항을 지지하는지 여부를 평가하기 위해 범위 지정 검토를 수행했습니다. [11] 당뇨병을 유도하기 위해 쥐에게 스트렙토조토신(65mg/kg)과 5% D-포도당 용액을 식수로 정맥 주사했습니다. [12] QIVIVE는 경구 및 정맥 투여보다 척수강 내 투여량을 최대 4600배까지 낮추어 유사한 신경학적 효과를 유도하는 것으로 나타났습니다. [13] 약동학 분석은 ICR 마우스 계통으로 수행되었으며, 여기서 마우스는 단일 경구 또는 정맥내 용량(400 mg/kg 및 7. [14] Poyendarone 염산염(n = 4) 및 드로네다론 염산염(n = 4)을 0의 정맥내 투여합니다. [15] 마취 연장 가능성을 조사하기 위해 6마리의 돼지에게도 1시간 후에 약물 조합을 정맥내 투여했습니다. [16] 먼저 정맥주사 용량과 농도를 2로 설정했다. [17] 경구 또는 정맥 투여량의 거의 80%가 대사 산물로 소변으로 배설됩니다. 나머지는 대변에서 발견되며 담즙 분비에서 유래합니다. [18] 모든 환자는 Berlithione을 사용했습니다. 그룹 1은 14일 동안 600mg의 정맥내 용량을 받은 다음 다른 16일 동안 600mg의 경구 용량을 받았습니다. 그룹 2는 30일 동안 600mg을 경구 복용했습니다. [19] 6시간마다 20mg/kg의 정맥내 투여는 기존의 투여 요법보다 더 나은 치료 효과를 제공할 가능성이 있다. [20] 모든 환자는 6 mg/kg의 정맥내 투여량을 받은 후 임상적 판단에 따라 8주마다(90%) 또는 12주마다 90mg(10%)을 피하 투여했습니다. [21] 경정맥 카테터를 삽입하고 다음 날 라마에게 정액 혈장에서 분리된 1 mg의 NGF를 정맥 주사했습니다. [22] 조류는 포유동물의 경우 5회(430mg/kg), 6회(516mg/kg), 7배(602mg/kg)의 경점막 펜토바르비탈을 투여받았습니다. [23] 12마리의 돼지에게 각각 100μg/kg 체중(BW) U-47700 또는 1000μg/kg BW 트라마돌을 정맥 주사했습니다. [24] 흰둥이 쥐를 4개 그룹으로 나누고 둘 중 하나를 제공했습니다. 증류수, 매일 10%(w/v) AG, 정맥내 TBX(1600 mg I/kg b. [25] 글리클라자이드의 혈장 농도(단회 경구 및 정맥내 용량 33 및 26. [26]
10 mg kg 10mg kg
Fasted control and TS, jugular-vein-cannulated, male Sprague-Dawley rats received either a single 5 mg/kg intravenous dose or a single 10 mg/kg oral dose of moxifloxacin alone or with a 0. [1] Dosing included five weekly intravenous doses of ALXN1830 (10 mg/kg), and follow-up through day 112 (study termination). [2] Pharmacokinetics of a single intravenous dose of naproxen (10 mg kg −1 ) was studied at days 1 and 15 post-surgery. [3] Immunogenicity to bezlotoxumab was evaluated following a single intravenous dose (≤20 mg/kg) or 2 consecutive doses (10 mg/kg) given 84 days apart in healthy participants across 3 phase 1 trials (Protocol MK‐3415A‐004, N = 30; Protocol CA‐GCDX‐05‐01, N = 54; Protocol MK‐3415A‐006, N = 12) and following a single 10 mg/kg dose in 1 phase 2 trial (Protocol CA‐GCDX‐06‐02, ClinicalTrials. [4]금식한 대조군 및 TS, 경정맥 캐뉼러 삽입, 수컷 Sprague-Dawley 쥐에게 단일 5mg/kg 정맥내 용량 또는 단일 10mg/kg 경구 용량의 목시플록사신을 단독으로 또는 0과 함께 투여했습니다. [1] 투여에는 ALXN1830(10mg/kg)의 5주간 정맥내 투여 및 112일째(연구 종료)까지의 추적 관찰이 포함되었습니다. [2] nan [3] nan [4]
randomized double blind 무작위 이중 맹검
METHODS In this phase 1, randomized, double blind, single dose, parallel group study, 114 healthy male volunteers were randomized 1:1:1 to receive a 3mg/kg intravenous dose of MB02, US-bevacizumab, or EU-bevacizumab, and evaluated for 100 days. [1] Methods In this randomized, double-blind, 3-way parallel group, single-dose comparative PK study, healthy male subjects were randomized to receive a single 1 mg/kg intravenous dose of HD204, EU-sourced bevacizumab or US-sourced bevacizumab. [2] Methods: In this randomized, double-blind, parallel controlled study, a total of 100 healthy Chinese male subjects were randomized (1:1) to receive a single 1 mg/kg intravenous dose of TAB008 or Avastin® over a 90-min infusion. [3]행동 양식 이 1상, 무작위, 이중 맹검, 단일 용량, 병렬 그룹 연구, 114명의 건강한 남성 지원자를 무작위로 1:1:1로 배정하여 MB02, US-베바시주맙 또는 EU-베바시주맙의 3mg/kg 정맥내 용량을 투여하고 평가했습니다. 100일 동안. [1] 방법 이 무작위, 이중 맹검, 3방향 병렬 그룹, 단일 용량 비교 PK 연구에서 건강한 남성 피험자는 HD204, EU 공급 베바시주맙 또는 미국 공급 베바시주맙의 단일 1 mg/kg 정맥내 용량을 받도록 무작위 배정되었습니다. [2] nan [3]
1 mg kg 1mg kg
We discovered that treatment with single- or repeated intravenous doses of ATN-161 (1 mg/kg) within 48 h after intranasal inoculation with SARS-CoV-2 lead to a reduction of lung viral load, viral immunofluorescence, and improved lung histology in a majority of mice 72 h post-infection. [1] We discovered that treatment with single- or repeated intravenous doses of ATN-161 (1 mg/kg) within 48 hours after intranasal inoculation with SARS-CoV-2 lead to a reduction of lung viral load, viral immunofluorescence and improved lung histology in a majority of mice 72 hours post-infection. [2] 5-2 μm, OD 30-50 nm, and NIEHS-14-2: L 10-30 μm, OD 10-20 nm) in water were administered to female Sprague-Dawley rats as a single intravenous dose of 1 mg/kg MWCNTs. [3]우리는 SARS-CoV-2 비강 접종 후 48시간 이내에 ATN-161(1mg/kg)의 단일 또는 반복 정맥내 용량으로 치료하면 폐 바이러스 부하 감소, 바이러스 면역형광 및 폐 조직학 개선으로 이어진다는 것을 발견했습니다. 대부분의 마우스는 감염 72시간 후. [1] 우리는 SARS-CoV-2 비강내 접종 후 48시간 이내에 ATN-161(1mg/kg)의 단일 또는 반복 정맥내 용량으로 치료하면 폐 바이러스 부하 감소, 바이러스 면역형광 및 개선된 폐 조직학으로 이어진다는 것을 발견했습니다. 대부분의 마우스는 감염 72시간 후. [2] nan [3]
25 μg kg 25㎍/kg
Methods Anesthetized rats underwent 6-min asphyxia-based cardiac arrest and resuscitation, after which the experimental group received a single intravenous dose of dexmedetomidine (25 μg/kg). [1] 25 μg/kg of BW single intravenous dose of Escherichia coli LPS at d 0; group 2 (IMR, n = 5) received a 25 μg/kg of BW subcutaneous dose of pegbovigrastim at d 1; group 3 (IMR + LPS, n = 5) received a 0. [2]방법 마취된 쥐에게 6분 동안 질식 기반의 심장 정지 및 소생술을 시행한 후 실험 그룹에 dexmedetomidine(25 μg/kg)을 1회 정맥 주사했습니다. [1] nan [2]
treated rats received 치료받은 쥐
Thirty-five albino rats were involved and equally divided into five groups: Group I: negative control rats received usual diet, Group II: positive control rats received BPA by oral gavage for 15 days, Group III: BPA-treated rats received single oral gavage of resveratrol daily for two weeks, Group IV: BPA-treated rats received a single intravenous dose of MSCs and Group V: BPA-treated rats received combined treatment of resveratrol and MSCs. [1]35마리의 흰둥이 쥐가 참여했고 5개의 그룹으로 동등하게 나누었습니다. 그룹 I: 음성 대조군 쥐에게 일반적인 식이 요법, 그룹 II: 양성 대조군 쥐에게 15일 동안 경구 위관 영양 공급, 그룹 III: BPA 처리 쥐에게 단일 경구 위관 영양 공급 2주 동안 매일 레스베라트롤, 그룹 IV: BPA 처리된 쥐에게 MSC의 단일 정맥내 용량을 제공하고 그룹 V: BPA 처리된 쥐에게 레스베라트롤과 MSC의 병용 치료를 받았습니다. [1]
Single Intravenous Dose 단일 정맥 투여
The primary objective is to study the effectiveness of a single intravenous dose of 2 g of cefazolin on SSIs after IR following fixation of foot, ankle and/or lower leg fractures. [1] A single intravenous dose of ADC 50 (5 or 10 nmol/kg) showed robust efficacy in an N87 gastric cancer xenograft model. [2] Thirty-five albino rats were involved and equally divided into five groups: Group I: negative control rats received usual diet, Group II: positive control rats received BPA by oral gavage for 15 days, Group III: BPA-treated rats received single oral gavage of resveratrol daily for two weeks, Group IV: BPA-treated rats received a single intravenous dose of MSCs and Group V: BPA-treated rats received combined treatment of resveratrol and MSCs. [3] Conclusions: Single intravenous dose of 2 mg/kg of XAV-19 demonstrated high serum concentrations, predictive of potent durable neutralizing activity with good tolerability. [4] As an alternative animal experimental approach, six pigs per drug received a single intravenous dose of 100 µg/kg body weight (BW) of U-47700 or 1000 µg/kg BW of tramadol to evaluate whether this species is suitable to assess the TK of NSOs. [5] METHODS In this open-label, parallel-group trial, we randomly assigned 412 patients who were undergoing total knee arthroplasty to receive one of three regimens of abelacimab (30 mg, 75 mg, or 150 mg) administered postoperatively in a single intravenous dose or to receive 40 mg of enoxaparin administered subcutaneously once daily. [6] C-CAR039 was administered as a single intravenous dose after a 3-day cyclophosphamide plus fludarabine conditioning regimen. [7] Both agents were administered as a single intravenous dose (0. [8] A single intravenous dose of 2 mg/kg of XAV-19 demonstrated high serum concentrations, predictive of potent durable neutralizing activity with good tolerability. [9] Twelve healthy female horses of 4–18 years of age and 432–600 kg of body weight received a single intravenous dose of MgSO4 (60 mg/kg) over 5 minutes, and blood and urine samples were collected at different time points over 360 minutes. [10] The elimination half-life (t1/2) values in rats after a single intravenous dose of 3, 15 and 75 mg/kg were estimated as 43. [11] Single intravenous dose of cefotaxime and multiday regimen of oral cefpodoxime showed a low incidence of infectious complications <1%. [12] Nine patients, aged 67-77 years, received a single intravenous dose of EMI-137 (0. [13] Twelve healthy female horses of 4-18 years of age and 432-600 kg of body weight received a single intravenous dose of MgSO4 (60 mg/kg) over 5 minutes, and blood and urine samples were collected at different time points over 360 minutes. [14] To do this, we administered a single intravenous dose (5 μg/kg) of cosyntropin to three captive unanaesthetised adult female grizzly bears on two occasions, during April when hair growth was arrested and during August when hair was growing. [15] The drug was administered as a single intravenous dose using infusion rates of 200 mg/kg per hour for the first 2 hours after the start of administration and 100 mg/kg per hour during irradiation. [16] Pharmacokinetic (PK) and pharmacodynamic (PD) data after a single intravenous dose of rHuEPO (100 IU/kg) was obtained from a previous study (Yan et al. [17] Twelve hours following a single intravenous dose of mTfR-GLB1 (5. [18] Objective To evaluate and compare the functionality of mature and immature (reticulated) platelets after a single intravenous dose of vincristine in dogs. [19] Here, we tested the modulatory effects of a single intravenous dose (100 ng/ml) of the N-methyl-D-aspartate-glutamate-receptor antagonist ketamine, a compound known to induce altered states of consciousness, on metacognition and its neural correlates. [20] After acclimation to the diets, all sheep received a single intravenous dose of K15NO3 and were placed in metabolic cages for daily collection of total faeces and urine over 6 days. [21] Case Report: We report a case of Lurbi-induced TLS in a patient with metastatic SCNEC of the cecum following a single intravenous dose of Lurbi 3. [22] To investigate CBD transfer from the mother to the fetus, a single intravenous dose of CBD was administered to pregnant mice in this study, and fetal pharmacokinetics (distribution and elimination) was analyzed. [23] In the 3DD setting, dose fractionation of doxorubicin displayed a significant reduction in cardiotoxicity compared to single intravenous doses with equal exposure, implying doxorubicin peak concentrations as the PK determinant for DIC. [24] A prior Phase I proof-of-concept study showed rapid improvements in skin and pustule clearance with a single intravenous dose of spesolimab, a novel anti-interleukin-36 receptor antibody, in patients presenting with an acute GPP flare. [25] One study examined outcome six weeks after a single intravenous dose of ketamine and found benefit for SI sustained relative to 24 h post-dose. [26] Methods Anesthetized rats underwent 6-min asphyxia-based cardiac arrest and resuscitation, after which the experimental group received a single intravenous dose of dexmedetomidine (25 μg/kg). [27] METHODS AND RESULTS RITA-MI was a prospective, open-label, dose-escalation, single-arm, phase 1/2a clinical trial, which tested rituximab administered as a single intravenous dose in patients with STEMI within 48 hours of symptom onset. [28] The mean apparent terminal t1/2 after single intravenous doses of apitegromab ranged from 24 to 31 days across dose groups. [29] Nevertheless, we found uncertain evidence in favour of a single intravenous dose of ketamine (as add-on therapy to mood stabilisers) over placebo in terms of response rate up to 24 hours, however ketamine did not show any better efficacy for remission in bipolar depression. [30] Objectives Determine the pharmacokinetics of ampicillin after a single intravenous dose in healthy and azotemic dogs. [31] There were two studies in humans following a single intravenous dose of PB (1 mg) and oral dose of PB (0. [32] Seven cohorts, with 54 healthy subjects, were given a single intravenous dose of NL005 or placebo and were observed for 28 days. [33] At steady-state anticoagulation subjects were randomized 3:1 to a single intravenous dose of ciraparantag (Study 1: 30, 60, or 120 mg; Study 2: 30, 60, 120, or 180 mg) or placebo. [34] A single intravenous dose of 55 μg/mL of [113/115 In]In-XYIMSR-01 was well-tolerated in male and female Sprague-Dawley rats. [35] For this, clinical chemistry, histopathological analysis and electrocardiographic exams were performed on female Balb/c mice that received a single intravenous dose of LCFL-PTX/DXR. [36] This double-blind, single-center, placebo-controlled dose escalation study randomized 3 cohorts of healthy volunteers to receive a single intravenous dose of NTM-1632 (0. [37] Patients were randomly assigned (1:1), according to a crossover design, to receive a single intravenous dose of autologous bone marrow-derived MSCs followed by placebo at week 24, or to receive placebo followed by autologous MSCs at week 24, with a follow-up visit at week 48. [38] In cohorts II–IV, patients received lymphodepleting chemotherapy (a single intravenous dose of cyclophosphamide 750 mg/m2), 2 days prior to the first intravenous infusion of WT1-sensitized T cells administered at escalating doses (2×107/m2 (level II), 5×107/m2 (level III), and 1×108/m2 (level IV)). [39] A strategy that includes using a fixed, single intravenous dose of 400 mg for eligible patients will help extend available supply and is likely effective in treatment of COVID-19. [40] 5-2 μm, OD 30-50 nm, and NIEHS-14-2: L 10-30 μm, OD 10-20 nm) in water were administered to female Sprague-Dawley rats as a single intravenous dose of 1 mg/kg MWCNTs. [41] A total of 40 participants were enrolled to receive a single intravenous dose of either etesevimab or placebo in one of four sequential ascending intravenous dose cohorts. [42] Following single intravenous doses of 0. [43] Each received a single intravenous dose of ICG prior to LC with the Stryker Novadaq NIR laparoscope. [44] One single intravenous dose of the assigned treatment will be administered on Day 0 of the study. [45] Paclitaxel biodisposition was evaluated for two formulations in plasma, liver, lung, brain, spinal cord, skin and muscle of rats after single intravenous dose at 6 mg/kg. [46] 25 μg/kg of BW single intravenous dose of Escherichia coli LPS at d 0; group 2 (IMR, n = 5) received a 25 μg/kg of BW subcutaneous dose of pegbovigrastim at d 1; group 3 (IMR + LPS, n = 5) received a 0. [47] In a mouse study at the Ohio State University Wexner Medical Center, a single intravenous dose of AAV-CRISPR restored dystrophin production and was still present a year later. [48] Pharmacokinetics of a single intravenous dose of naproxen (10 mg kg −1 ) was studied at days 1 and 15 post-surgery. [49] In this unique translational study article, we document that the novel curcumin‐based compound, CNB‐001, when administered as a single intravenous dose, has significant efficacy to attenuate clinically relevant behavioral deficits following ischemic events in agyrencephalic rabbits when administered 1 h post‐embolization and reduces infarct growth in gyrencephalic non‐human primates, when administered 5 min after initiation of middle cerebral artery occlusion. [50]일차 목적은 발, 발목 및/또는 하지 골절을 고정한 후 IR 후 수술 부위에 세파졸린 2g을 1회 정맥 투여했을 때의 효과를 연구하는 것입니다. [1] ADC 50의 단일 정맥내 용량(5 또는 10 nmol/kg)은 N87 위암 이종이식 모델에서 강력한 효능을 보여주었습니다. [2] 35마리의 흰둥이 쥐가 참여했고 5개의 그룹으로 동등하게 나누었습니다. 그룹 I: 음성 대조군 쥐에게 일반적인 식이 요법, 그룹 II: 양성 대조군 쥐에게 15일 동안 경구 위관 영양 공급, 그룹 III: BPA 처리 쥐에게 단일 경구 위관 영양 공급 2주 동안 매일 레스베라트롤, 그룹 IV: BPA 처리된 쥐에게 MSC의 단일 정맥내 용량을 제공하고 그룹 V: BPA 처리된 쥐에게 레스베라트롤과 MSC의 병용 치료를 받았습니다. [3] nan [4] nan [5] nan [6] nan [7] nan [8] nan [9] nan [10] nan [11] nan [12] nan [13] nan [14] nan [15] nan [16] nan [17] nan [18] nan [19] nan [20] nan [21] nan [22] nan [23] nan [24] nan [25] nan [26] 방법 마취된 쥐에게 6분 동안 질식 기반의 심장 정지 및 소생술을 시행한 후 실험 그룹에 dexmedetomidine(25 μg/kg)을 1회 정맥 주사했습니다. [27] nan [28] nan [29] nan [30] nan [31] nan [32] nan [33] nan [34] nan [35] nan [36] nan [37] nan [38] nan [39] nan [40] nan [41] nan [42] nan [43] nan [44] nan [45] nan [46] nan [47] nan [48] nan [49] nan [50]
High Intravenous Dose 고용량 정맥 주사
The patient immediately received a high intravenous dose of methylprednisolone (1,000 mg per day for three days). [1] CA-HGF-treated animals, all of which looked healthy, suggesting the absence of lethal adverse effects observed in patients receiving high intravenous doses of viral vectors. [2] Recently, pharmacologic ascorbate (ascorbic acid, ascorbate, P-AscH-) given at high intravenous doses has been investigated as an adjuvant to chemotherapy and radiation therapy in the treatment of pancreatic cancer. [3] and high intravenous doses of unspecific immunoglobulins (IVIg, 1 g/kg/day i. [4] Due to its mechanism of action, by inhibiting the enzyme dihydrofolate reductase, when it is used systemically, it has multiple expected adverse effects such as mucositis, myelosuppression and it has also been observed after intrathecal administration or high intravenous doses, acute, subacute neurotoxicity where stroke like syndrome is found. [5] Ascorbic acid in high intravenous doses serves as pro-oxidant and promotes the generation of hydrogen peroxide (H2O2) and other reactive oxygen species (ROS) with oxidative stress-induced toxicity selectively to cancer cells. [6] Very high intravenous doses have already shown to be beneficial in septic patients. [7]환자는 즉시 고용량의 methylprednisolone(3일 동안 하루 1,000mg)을 정맥 주사했습니다. [1] CA-HGF로 처리된 동물은 모두 건강해 보였고, 이는 바이러스 벡터의 높은 정맥내 투여량을 투여받은 환자에서 관찰된 치명적인 부작용의 부재를 시사합니다. [2] nan [3] nan [4] nan [5] nan [6] nan [7]
Kg Intravenous Dose Kg 정맥 투여량
METHODS The data used for this analysis were obtained from 3 clinical trials and include 2229 blood samples from 322 healthy subjects who were randomized to receive a 40 mg/kg intravenous dose of raxibacumab over a period of 2. [1] Methods The 3 mg/kg intravenous dose was selected based on prior studies and physiologically based pharmacokinetic (PBPK) modeling, indicating the high likelihood of a rapid and high level of IL18 target engagement when administered prior to kidney allograft reperfusion. [2] Fasted control and TS, jugular-vein-cannulated, male Sprague-Dawley rats received either a single 5 mg/kg intravenous dose or a single 10 mg/kg oral dose of moxifloxacin alone or with a 0. [3] METHODS In this phase 1, randomized, double blind, single dose, parallel group study, 114 healthy male volunteers were randomized 1:1:1 to receive a 3mg/kg intravenous dose of MB02, US-bevacizumab, or EU-bevacizumab, and evaluated for 100 days. [4] Methods In this randomized, double-blind, 3-way parallel group, single-dose comparative PK study, healthy male subjects were randomized to receive a single 1 mg/kg intravenous dose of HD204, EU-sourced bevacizumab or US-sourced bevacizumab. [5] Methods: In this randomized, double-blind, parallel controlled study, a total of 100 healthy Chinese male subjects were randomized (1:1) to receive a single 1 mg/kg intravenous dose of TAB008 or Avastin® over a 90-min infusion. [6]행동 양식 이 분석에 사용된 데이터는 3건의 임상 시험에서 얻은 것이며 2년 동안 40mg/kg의 락시바쿠맙 정맥내 용량을 투여받은 322명의 건강한 피험자의 2229개 혈액 샘플을 포함합니다. [1] 방법 3 mg/kg 정맥내 용량은 이전 연구 및 생리학적 기반 약동학(PBPK) 모델링을 기반으로 선택되었으며, 이는 신장 동종이식 재관류 전에 투여될 때 신속하고 높은 수준의 IL18 표적 결합의 가능성이 높음을 나타냅니다. [2] 금식한 대조군 및 TS, 경정맥 캐뉼러 삽입, 수컷 Sprague-Dawley 쥐에게 단일 5mg/kg 정맥내 용량 또는 단일 10mg/kg 경구 용량의 목시플록사신을 단독으로 또는 0과 함께 투여했습니다. [3] 행동 양식 이 1상, 무작위, 이중 맹검, 단일 용량, 병렬 그룹 연구, 114명의 건강한 남성 지원자를 무작위로 1:1:1로 배정하여 MB02, US-베바시주맙 또는 EU-베바시주맙의 3mg/kg 정맥내 용량을 투여하고 평가했습니다. 100일 동안. [4] 방법 이 무작위, 이중 맹검, 3방향 병렬 그룹, 단일 용량 비교 PK 연구에서 건강한 남성 피험자는 HD204, EU 공급 베바시주맙 또는 미국 공급 베바시주맙의 단일 1 mg/kg 정맥내 용량을 받도록 무작위 배정되었습니다. [5] nan [6]
Repeated Intravenous Dose 반복 정맥 투여
Based on the results, SAMiRNA-AREG did not cause treatment-related adverse effects at dose levels of up to 300 mg/kg/day in mice after 4-week repeated intravenous doses. [1] We discovered that treatment with single- or repeated intravenous doses of ATN-161 (1 mg/kg) within 48 h after intranasal inoculation with SARS-CoV-2 lead to a reduction of lung viral load, viral immunofluorescence, and improved lung histology in a majority of mice 72 h post-infection. [2] Conclusion One repeated intravenous dose of allogeneic UC-MSCs is safe in people with recent-onset T1D and may result in better islet β cell preservation during the first year after diagnosis compared to standard treatment alone. [3] We discovered that treatment with single- or repeated intravenous doses of ATN-161 (1 mg/kg) within 48 hours after intranasal inoculation with SARS-CoV-2 lead to a reduction of lung viral load, viral immunofluorescence and improved lung histology in a majority of mice 72 hours post-infection. [4]결과에 따르면 SAMiRNA-AREG는 4주간의 반복 정맥 투여 후 마우스에서 최대 300mg/kg/day의 용량 수준에서 치료 관련 부작용을 일으키지 않았습니다. [1] 우리는 SARS-CoV-2 비강 접종 후 48시간 이내에 ATN-161(1mg/kg)의 단일 또는 반복 정맥내 용량으로 치료하면 폐 바이러스 부하 감소, 바이러스 면역형광 및 폐 조직학 개선으로 이어진다는 것을 발견했습니다. 대부분의 마우스는 감염 72시간 후. [2] nan [3] 우리는 SARS-CoV-2 비강내 접종 후 48시간 이내에 ATN-161(1mg/kg)의 단일 또는 반복 정맥내 용량으로 치료하면 폐 바이러스 부하 감소, 바이러스 면역형광 및 개선된 폐 조직학으로 이어진다는 것을 발견했습니다. 대부분의 마우스는 감염 72시간 후. [4]
Mg Intravenous Dose Mg 정맥 투여량
In the study group, the first 500 mg intravenous dose of vitamin C diluted in normal saline was administered 2 h before colonoscopic resection of polyps and the second and third similar doses were administered on days 2 and 3 of polypectomy, respectively. [1] Intervention(s) A single 30 mg intravenous dose of ketorolac was administered after the oocyte retrieval procedure. [2] Patients were divided into two groups, one receiving the usual oral premedication and the other receiving a 20-mg intravenous dose of dexamethasone prior to chemotherapy. [3]연구 그룹에서는 생리 식염수에 희석한 비타민 C의 첫 번째 500 mg 정맥내 용량을 대장 내시경 용종 절제술 2시간 전에 투여했으며 두 번째 및 세 번째 유사한 용량은 각각 용종 절제술 2일차와 3일차에 투여했습니다. [1] 중재(들) 난자 채취 절차 후에 케토롤락의 단일 30mg 정맥내 용량이 투여되었습니다. [2] nan [3]
Preoperative Intravenous Dose
CONCLUSION(S) A single preoperative intravenous dose of 100 μg carbetocin is a simple, practical, and effective method of decreasing intraoperative blood loss and the need for blood transfusion during abdominal myomectomy, with tolerable, few, nonsignificant side-effects. [1] INTRODUCTION We hypothesised that a single preoperative intravenous dose of tranexamic acid (TXA) is effective in patients who undergo total hip arthroplasty (THA) and are at high risk of blood transfusion (preoperative haemoglobin level <13. [2]결론 수술 전 100μg 카베토신의 단일 정맥 투여는 수술 중 혈액 손실과 복부 근종 절제술 동안 수혈의 필요성을 감소시키는 간단하고 실용적이며 효과적인 방법이며, 허용 가능하고, 거의 중요하지 않은 부작용이 있습니다. [1] nan [2]
Cumulative Intravenous Dose
The primary exposures were absolute cumulative intravenous doses of 20, 40, 60 or 80 mEq potassium supplement. [1] 2–19 years, receiving a cumulative intravenous dose of 0. [2]1차 노출은 20, 40, 60 또는 80mEq 칼륨 보충제의 절대 누적 정맥내 투여량이었습니다. [1] nan [2]
G Intravenous Dose
Among 320 cases of extragenital gonorrhoea (all asymptomatic), 208 received only ceftriaxone (single 1 g intravenous dose) and 112 received additional treatment with doxycycline (100 mg two times a day for 7 days) or azithromycin (single 1 g dose) for concomitant STIs (predominantly, Chlamydia trachomatis (CT)). [1] Methods Using transcranial Doppler, we measured the mean flow velocity in the middle cerebral artery (cm/sec) and calculated the pulsatility index and resistive index on admission and 30 m after the administration of a 6 g intravenous dose of magnesium sulfate in septic patients with a positive Confusion Assessment Method for the ICU (CAM-ICU) score and Glasgow Coma Scale (GCS) less than 15 during the first 24 h from the onset of sepsis. [2]320건의 외음부 임질(모두 무증상) 중 208건은 세프트리악손(단일 1g 정맥내 투여)만 투여받았고 112건은 독시사이클린(100mg 1일 2회 7일간) 또는 아지스로마이신(단회 1g 투여)으로 추가 치료를 받았다. 성병(주로, 클라미디아 트라코마티스(CT)). [1] nan [2]
Initial Intravenous Dose
Most initial intravenous doses (93%) were lower than the guideline recommendations. [1] Furosemide was by far the most common diuretic given and the initial intravenous dose was only 20 mg in more than half of ICU admissions. [2]대부분의 초기 정맥 투여량(93%)은 가이드라인 권장 사항보다 낮았습니다. [1] nan [2]
Multiple Intravenous Dose 다중 정맥 투여
Also, we assessed the preliminary efficacy and pharmacodynamics of multiple intravenous doses in Japanese patients with moderate to severe ulcerative colitis (UC). [1] To assess effects of donanemab on brain amyloid plaque load after single and multiple intravenous doses, as well as pharmacokinetics, safety/tolerability, and immunogenicity. [2]또한 중등도에서 중증의 궤양성 대장염(UC)이 있는 일본 환자에서 다중 정맥 투여의 예비 효능 및 약력학을 평가했습니다. [1] 단일 및 다중 정맥내 투여 후 뇌 아밀로이드 플라크 부하에 대한 도나네맙의 효과 및 약동학, 안전성/내약성 및 면역원성을 평가하기 위해. [2]
Two Intravenous Dose 2회 정맥내 투여
When treated with two intravenous doses of remestemcel-L separated by 48 hours, rapid normalization of left ventricular ejection fraction, notable reductions in biomarkers of systemic and cardiac inflammation, and improved clinical status occurred. [1] The aim of this study was to develop a population PK model of TXA administered as a single intra-articular dose and as two intravenous doses, and to study the sources of interindividual variability (IIV) in the PK processes of TXA. [2]48시간 간격으로 2회의 정맥내 레메스템셀-L을 투여했을 때, 좌심실 박출률의 급속한 정상화, 전신 및 심장 염증의 바이오마커의 현저한 감소 및 개선된 임상 상태가 발생했습니다. [1] 이 연구의 목적은 단일 관절내 투여량과 2회의 정맥내 투여량으로 투여되는 TXA의 집단 약동학 모델을 개발하고 TXA의 약동학 과정에서 개인간 변동성(IIV)의 원인을 연구하는 것이었습니다. [2]
Weekly Intravenous Dose 주간 정맥 투여량
The treatment comprised hu3S193 antibody administration at weekly intravenous doses of 20 mg/m2 for 8-week cycles. [1] Dosing included five weekly intravenous doses of ALXN1830 (10 mg/kg), and follow-up through day 112 (study termination). [2]치료는 8주 주기 동안 20 mg/m2의 매주 정맥내 투여량으로 hu3S193 항체 투여를 포함하였다. [1] 투여에는 ALXN1830(10mg/kg)의 5주간 정맥내 투여 및 112일째(연구 종료)까지의 추적 관찰이 포함되었습니다. [2]
Three Intravenous Dose 3회 정맥내 투여
In three separate experiments, we delivered three intravenous doses of CN-105 (up to 0. [1] S(+)‐ibuprofen (S‐IBU) and R(−)‐ibuprofen (R‐IBU) concentrations were measured in 16 neonates with patent ductus arteriosus during a cycle of therapy (three intravenous doses of 10–5–5 mg kg−1 at 24‐h intervals), at the end of the first infusion and 6, 24, 48, and 72 h later. [2]3개의 개별 실험에서 우리는 CN-105를 3회 정맥내 투여했습니다(최대 0. [1] S(+)-ibuprofen(S-IBU) 및 R(-)-ibuprofen(R-IBU) 농도는 치료 주기 동안 동맥관 개존증이 있는 16명의 신생아에서 측정되었습니다(10-5-5 mg kg의 3회 정맥 투여 24시간 간격으로 -1), 첫 번째 주입 종료 시 및 6, 24, 48 및 72 h 후. [2]
One Intravenous Dose 1회 정맥내 투여
Methods Patients included in the prospectively maintained ENEIDA registry who received at least one intravenous dose of ustekinumab due to active UC [Partial Mayo Score (PMS) >2] were included. [1] Methods Patients included in the prospectively maintained ENEIDA registry who received at least one intravenous dose of ustekinumab due to active UC [Partial Mayo Score (PMS) >2] were included. [2]방법 활성 UC[부분 메이요 점수(PMS) >2]로 인해 우스테키누맙을 1회 이상 정맥내 투여한 전향적으로 유지되는 ENEIDA 등록부에 포함된 환자가 포함되었습니다. [1] 방법 활성 UC[부분 메이요 점수(PMS) >2]로 인해 우스테키누맙을 1회 이상 정맥내 투여한 전향적으로 유지되는 ENEIDA 등록부에 포함된 환자가 포함되었습니다. [2]
Ml Intravenous Dose Ml 정맥 투여량
The animal was placed in the left lateral decubitus position, then was performed trichotomy and epidural administration of 2% lidocaine (4 mg/kg) and maintenance with propofol 10 mg/mL intravenous dose-effect and oxygen mask 3 liters/min, antibiotic prophylaxis was performed with 10% enrofloxacin (2. [1] The dexamethasone group received a 2-mL intravenous dose of 8 mg of dexamethasone 60 minutes before the induction of anesthesia. [2]동물을 왼쪽 옆 욕창 위치에 놓은 후 삼분절제술 및 2% 리도카인(4mg/kg)의 경막외 투여 및 프로포폴 10mg/mL 정맥 투여 효과 및 산소 마스크 3리터/분으로 유지 관리, 항생제 예방을 수행했습니다. 10% 엔로플록사신(2. [1] 덱사메타손 그룹은 마취 유도 60분 전에 덱사메타손 8mg을 2mL 정맥 주사했습니다. [2]