Glycolytic Reprogramming(해당과정 재프로그래밍)란 무엇입니까?
Glycolytic Reprogramming 해당과정 재프로그래밍 - Glycolytic reprogramming is an important metabolic feature in the development of pulmonary fibrosis. [1] In summary, we identified a direct role of TNF on glycolytic reprogramming of FLS and confirmed the potency of immunometabolism for RA. [2] Particularly, BPTF constituted super-enhancers that activate downstream targets like enolase 2 and SRC proto-oncogene nonreceptor tyrosine kinase, leading to glycolytic reprogramming of METTL14-/- cells. [3] Collectively, data herein point to an intriguing link between glutathionylation chemistry and glycolytic reprogramming in epithelial cells and suggest that glutathionylation chemistry may represent a therapeutic target in pulmonary pathologies with perturbations in the glycolysis pathway. [4] RNA-protein coimmunoprecipitation (RIP) and polysome analyses were performed to investigate novel mechanisms of glycolytic reprogramming in pulmonary fibrosis. [5] We found that HIF-2α suppressed anti-inflammatory macrophage mitochondrial metabolism, while HIF-1α promoted cleavage of cardioprotective MerTK through glycolytic reprogramming of macrophages. [6] It remains unclear whether glycolytic reprogramming and dysregulation of PKM2 also contribute to obese asthma. [7] We previously showed that pyruvate kinase M2 (PKM2) plays an important role in regulating the glycolytic reprogramming of fibroblasts in renal interstitial fibrosis. [8] In conclusion, PrA endows DC with a tolerogenic profile via glycolytic reprogramming, thereby inducing expansion of immunosuppressive Tregs, and preventing EAM progress. [9] Herein, we aimed to explore whether lncRNAs and miRNAs are involved in the glycolytic reprogramming under hypoxic conditions. [10] OBJECTIVEAlthough glucose metabolism reengineering is a typical feature of various tumors, including glioma, key regulators of glycolytic reprogramming are still poorly understood. [11] Conclusions The lncRNA LOC148709 plays an essential role in glycolytic reprogramming by binding to and stabilizing PFKFB3. [12] In addition, we identified the underlying mechanism, which depended on signaling through kinases Syk, PI3K, and AKT2, as well as glycolytic reprogramming. [13] The reduced corticosteroid responsiveness may be mediated by glycolytic reprogramming, specifically glycolysis-associated PI3K signaling, as PI3K inhibitor LY294002 restored the sensitivity of CXCL8 secretion to corticosteroids in A549 Rho-0 cells. [14]nan [1] nan [2] nan [3] nan [4] nan [5] nan [6] nan [7] nan [8] 결론적으로, PrA는 해당과정 재프로그래밍을 통해 DC에 관용성 프로파일을 부여하여 면역억제성 Treg의 확장을 유도하고 EAM 진행을 방지합니다. [9] 여기에서 우리는 lncRNA와 miRNA가 저산소 조건에서 해당과정 재프로그래밍에 관여하는지 여부를 조사하는 것을 목표로 했습니다. [10] 목적 포도당 대사 재설계가 신경아교종을 포함한 다양한 종양의 전형적인 특징이지만 해당과정 재프로그래밍의 주요 조절인자는 여전히 제대로 이해되지 않고 있습니다. [11] 결론 lncRNA LOC148709는 PFKFB3에 결합하고 이를 안정화함으로써 해당과정 재프로그래밍에서 필수적인 역할을 합니다. [12] 또한, 우리는 키나제 Syk, PI3K 및 AKT2를 통한 신호 전달과 해당 과정 재프로그래밍에 의존하는 기본 메커니즘을 확인했습니다. [13] 감소된 코르티코스테로이드 반응성은 PI3K 억제제 LY294002가 A549 Rho-0 세포에서 코르티코스테로이드에 대한 CXCL8 분비의 민감성을 회복함에 따라 해당과정 재프로그래밍, 특히 해당과정 관련 PI3K 신호전달에 의해 매개될 수 있습니다. [14]
Msc Glycolytic Reprogramming
Moreover, in vivo, MSC glycolytic reprogramming significantly increased their therapeutic benefit in the DTH and GVHD mouse models. [1] cP1P-induced hypoxia-inducible factor 1 alpha (HIF1α) plays a key role for MSC glycolytic reprogramming and transplantation efficacy. [2]nan [1] cP1P 유도 저산소증 유발 인자 1 알파(HIF1α)는 MSC 해당과정 재프로그래밍 및 이식 효능에 중요한 역할을 합니다. [2]
Undergo Glycolytic Reprogramming
Macrophages rapidly undergo glycolytic reprogramming in response to macroautophagy/autophagy, inflammasome activation and pyroptosis for the clearance of bacteria. [1] Here we report that MSCs exposed to such priming conditions undergo glycolytic reprogramming, which homogenizes MSCs' metabolomic profile. [2]nan [1] 여기에서 우리는 이러한 프라이밍 조건에 노출된 MSC가 해당 MSC의 대사 프로파일을 균질화하는 해당 재프로그래밍을 겪는다고 보고합니다. [2]