Endocrine Disrupting Effects(내분비 교란 효과)란 무엇입니까?
Endocrine Disrupting Effects 내분비 교란 효과 - Endocrine-disrupting effects of chemicals on human health and wildlife have been widely regarded as an important issue for their potential transgenerational effects. [1] CONTEXT Bisphenol A (BPA) is a ubiquitous contaminant with endocrine-disrupting effects in mammals. [2] These results may be rationalized in terms of size-dependent effects of BPA, which may be relevant for its endocrine-disrupting effects. [3] The endocrine-disrupting effects of insecticides on wildlife have received increasing attention in the literature in recent years. [4] Some chloro-phenols are harmful to the environment and human health, as they exert carcinogenic, mutagenic, cytotoxic, and endocrine-disrupting effects. [5] Recently, there has been great concern regarding the endocrine-disrupting effects of exposure to microplastic-derivative BUVSs in particular. [6] Initial evidence on the endocrine-disrupting effects of genetically modified (GM) food motivated us to evaluate the reproductive toxicity of GM and non-GM plant-derived edible oils in female Wistar rats. [7] Its endocrine-disrupting effects on ecological and human health lead to replacement with its structural analogs. [8] In the field of environmental toxicology, endocrine-disrupting effects have become a major concern. [9] Among these compounds, several of them are known to exert endocrine-disrupting effects causing deregulation of a variety of physiological functions affecting cell signaling pathways involved in neural cell differentiation leading to developmental neurotoxicity. [10] Assessment of systemic toxicity and endocrine-disrupting effects was based on mortality; clinical signs; body weight; food and water consumption; ophthalmological findings; urinalysis; hematology and clinical biochemistry; organ weights; necropsy and histopathological findings; regularity and length of the estrous cycle; semen quality; and toxicokinetic behavior. [11] Tetrabromobisphenol A (TBBPA) pollution in marine environmental media poses great risks to marine organisms due to its potential endocrine-disrupting effects. [12] In this study, dual-luciferase reporter gene assays were adopted to analyze their potential endocrine-disrupting effects via four receptors (ERα, GRα, MR and RXR). [13] Phenolic compounds, for example, are often not well catabolized by the microbiota within WWTPs, leaving them in effluents at levels that can exert phytotoxic and endocrine-disrupting effects. [14] Bisphenol A (BPA) contamination from food packaging material has been a major concern in recent years, due to its potential endocrine-disrupting effects on humans, especially infants and children. [15] Reports have highlighted the presence of PCBs and their metabolites, OH-PCBs, in human serum as well as their endocrine-disrupting effects on reproductive function through direct interactions with the androgen receptor (AR) and estrogen receptor (ER). [16] The results showed that, according to the tested waters, their effects on the parameters studied might be quite different indicating many different mechanisms of toxicity, including some endocrine-disrupting effects. [17] Multiple endpoints were investigated: mortality, growth inhibition, bioluminescence inhibition, genotoxicity, endocrine-disrupting effects, oxidative stress, and the induction of ethoxyresorufin-O-deethylase (EROD). [18] Exposure of human and animals to PAHs can lead to a variety of adverse effects, including carcinogenicity and teratogenicity, genotoxicity, reproductive- and endocrine-disrupting effects, immunotoxicity and neurotoxicity, the type and severity of which depend on a variety of factors. [19] Objective: Phthalates, despite their endocrine-disrupting effects, are widely used as plastifiants. [20] Therefore, these results suggested that MC-LR affected HPA, HPG and HPT axes and exerted endocrine-disrupting effects. [21] The present study was aimed to evaluate the potential endocrine-disrupting effects of chronic exposure to the low concentrations of bisphenol S (BPS) in male rats. [22] Bisphenol compounds (BPs) are a group of environmental contaminants with endocrine-disrupting effects both for humans and animals. [23] Benzophenone-3 (BP-3) is used in a wide range of personal care products and plastics to resist ultraviolet light, which has aroused considerable public concern due to its endocrine-disrupting effects. [24] Growing numbers of synthetic chemicals have potential endocrine-disrupting effects and cause potential ecological and health risks. [25] These results may be rationalized in terms of size-dependent effects of BPA, which may be relevant for its endocrine-disrupting effects. [26] These findings will provide new insights into endocrine-disrupting effects of triazole fungicides and highlight their potential ecological and health risks. [27] Human exposure to persistent and non-persistent chemicals is ubiquitous and associated with endocrine-disrupting effects. [28] This drug and its by-products are potentially toxic and have adverse effects, since these compounds have been associated with endocrine-disrupting effects, reproductive deficiencies, embryo abnormalities and pericardial oedema. [29] Hence, binding affinity is useful for evaluating chemicals with potential endocrine-disrupting effects. [30] Phenolic environmental estrogens (PEEs) are ubiquitous in most rivers worldwide and may cause potential endocrine-disrupting effects in aquatic organisms. [31] CONCLUSIONS These investigations support a pattern of endocrine-disrupting effects by dioxin-like POPs among postmenopausal women, especially those with conditions related to peripheral estrogenicity. [32] Recent studies have reported the endocrine disrupting effects of these chemicals, especially methylparaben. [33] Although the genotoxicity, endocrine disrupting effects, reproductive toxicity of BPF has been well documented, its neurodevelopmental toxicity still remains nebulous. [34] BackgroundEnvironmental exposure to phthalates and bisphenol A (BPA) may have endocrine disrupting effects that alter length of gestation. [35] However, current toxicology testing does not thoroughly explore the endocrine disrupting effects of industrial chemicals, which may have low dose effects not predicted when determining the limit of toxicity. [36] STUDY FUNDING/COMPETING INTEREST(S) This work was supported by Danish Agency for Science, Technology and Innovation (09-067 180); Danish Ministry of the Environment, CeHoS (MST-621-00 065); Capital Region of Denmark (R129-A3966); Ministry of Higher Education and Science (DFF-1331-00 113); Innovation Fund Denmark (InnovationsFonden, 14-2013-4); The International Center for Research and Research Training in Endocrine Disrupting Effects of Male Reproduction and Child Health. [37] This phthalate is known for its reprotoxic and endocrine disrupting effects. [38] Based mainly on our recent findings, this review outlines the research progress of molecular mechanism on endocrine disrupting effects of environmental low-dose BPA, existing problems and some consideration for future studies. [39] The endocrine disrupting effects of DBP are well documented, but developmental toxicity of DBP during critical developmental time windows is understudied. [40] In this study, the endocrine disrupting effects of a BPA analog of bisphenol P (BPP) were investigated in the nonbiting midge (Chironomus tentans), a model organism in ecotoxicology. [41] A summary is provided of the natural science evidence base informing the regulation of chemicals released into the environment that may have endocrine disrupting effects on wildlife. [42] In contrast, soybeans are also known to possess unwanted side effects such as allergenic proteins and endocrine disrupting effects. [43] Some observed sublethal effects including endocrine disrupting effects, hepatotoxicity and neurotoxicity, as well as the ability to promote the development of endometrial carcinoma still raise a concern. [44] Bisphenol A (BPA), a plastic additive, is ubiquitous in the environment and has endocrine disrupting effects. [45] In addition, TCC exposure altered the expressions of the genes involved in hormonal pathways, indicating its endocrine disrupting effects. [46] They have mutagenic, teratogenic, carcinogenic, immunosuppressive and endocrine disrupting effects on both humans and animals. [47] This results revealed the endocrine disrupting effects of Pb even at an environmentally relevant level within the concentration range of ambient water quality criteria (AWQC) and the reliability of locomotion fingerprint as the indicator for detecting the risk induced by Pb pollution. [48] Background Polychlorinated biphenyls (PCBs) are persistent organic chemicals that exert neurotoxic and endocrine disrupting effects. [49] Bisphenol analogues including bisphenol A (BPA), bisphenol AF (BPAF), bisphenol F (BPF), and bisphenol S (BPS) share similar chemical structures and endocrine disrupting effects. [50]인간의 건강과 야생 동물에 대한 화학 물질의 내분비 교란 영향은 잠재적인 세대 간 영향에 대한 중요한 문제로 널리 간주되었습니다. [1] 문맥 비스페놀 A(BPA)는 포유동물에서 내분비 교란 효과가 있는 유비쿼터스 오염 물질입니다. [2] 이러한 결과는 내분비 교란 효과와 관련이 있을 수 있는 BPA의 크기 의존적 효과 측면에서 합리화될 수 있습니다. [3] 야생 동물에 대한 살충제의 내분비 교란 효과는 최근 몇 년 동안 문헌에서 점점 더 많은 관심을 받고 있습니다. [4] 일부 클로로페놀은 발암성, 돌연변이 유발성, 세포독성 및 내분비 교란 효과를 나타내기 때문에 환경과 인간의 건강에 해롭습니다. [5] 최근에는 특히 미세플라스틱 유래 BUVS 노출이 내분비 교란 효과에 대해 큰 우려를 표하고 있다. [6] 유전자 변형(GM) 식품의 내분비 교란 효과에 대한 초기 증거는 암컷 Wistar 쥐에서 GM 및 비 GM 식물 유래 식용유의 생식 독성을 평가하도록 동기를 부여했습니다. [7] 생태 및 인간 건강에 대한 내분비 교란 효과는 구조적 유사체로 대체됩니다. [8] 환경 독성학 분야에서 내분비 교란 효과가 주요 관심사가 되었습니다. [9] 이들 화합물 중 몇몇은 내분비 교란 효과를 발휘하여 발달 신경독성으로 이어지는 신경 세포 분화에 관여하는 세포 신호 전달 경로에 영향을 미치는 다양한 생리적 기능의 조절을 완화시키는 것으로 알려져 있습니다. [10] 전신 독성 및 내분비 교란 효과의 평가는 사망률을 기반으로 했습니다. 임상 징후; 체중; 음식과 물 소비; 안과 소견; 소변검사; 혈액학 및 임상 생화학; 장기 무게; 부검 및 조직병리학적 소견; 발정주기의 규칙성과 길이; 정액의 질; 및 독성 동태학적 거동. [11] 해양 환경 매체의 테트라브로모비스페놀 A(TBBPA) 오염은 잠재적인 내분비 교란 효과로 인해 해양 유기체에 큰 위험을 초래합니다. [12] 이 연구에서 이중 루시퍼라제 리포터 유전자 분석은 4가지 수용체(ERα, GRα, MR 및 RXR)를 통한 잠재적 내분비 교란 효과를 분석하기 위해 채택되었습니다. [13] 예를 들어, 페놀 화합물은 종종 WWTP 내의 미생물군에 의해 잘 이화되지 않아 식물 독성 및 내분비 교란 효과를 발휘할 수 있는 수준으로 폐수에 남습니다. [14] 식품 포장재로 인한 비스페놀 A(BPA) 오염은 인간, 특히 유아와 어린이에 대한 잠재적인 내분비 교란 효과로 인해 최근 몇 년 동안 주요 관심사였습니다. [15] 보고서는 인간 혈청에서 PCB와 그 대사 산물인 OH-PCB의 존재와 안드로겐 수용체(AR) 및 에스트로겐 수용체(ER)와의 직접적인 상호 작용을 통해 생식 기능에 대한 내분비 교란 효과를 강조했습니다. [16]