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Trans‐Anastomotic Tubes in Oesophageal Atresia Repair



Keyboard: An R Package Suite for Early Phase Dose-finding Designs



cLRT-Mod: An efficient methodology for pharmacometric model-based analysis of longitudinal phase II dose finding studies under model uncertainty.



Bayesian dose-regimen assessment in early phase oncology incorporating pharmacokinetics and pharmacodynamics.



Would the Recommended Dose Have Been Different Using Novel Dose-Finding Designs? Comparing Dose-Finding Designs in Published Trials.



A Review of the Dose Justification of Phase 3 Trials to Regulatory Authorities for Drugs Intended for the Treatment of Type 2 Diabetes in Europe



Sustained efficacy and safety of burosumab, a monoclonal antibody to FGF23, in children with X-linked hypophosphatemia.



Adaptive Design For Identifying Maximum Tolerated Dose Early To Accelerate Dose-Finding Trial



TRAFIC: statistical design and analysis plan for a pragmatic early phase 1/2 Bayesian adaptive dose escalation trial in rheumatoid arthritis



Is more better? An analysis of toxicity and response outcomes from dose-finding clinical trials in cancer



BOIN Suite: A Software Platform to Design and Implement Novel Early-Phase Clinical Trials.



Phase 2 Study of Danicopan in Paroxysmal Nocturnal Hemoglobinuria Patients with an Inadequate Response to Eculizumab.



Abstract 925: Introduction to the preclinical profile of SYD1875, a novel site-specifically conjugated duocarmycin-based 5T4-targeting antibody-drug conjugate



Consistency of the CRM when the dose-toxicity curve is not monotone and its application to the POCRM.



Determination of the 90% Effective Dose of Phenylephrine Boluses to Treat Spinal Anesthesia-Induced Hypotension in Patients with Severe Preeclampsia during Cesarean Delivery: A Pilot Study



TRAFIC: Statistical Plan for a Pragmatic Early Phase 1/2 Bayesian Adaptive Dose Escalation Trial in Rheumatoid Arthritis



Identifying treatment effect heterogeneity in dose-finding trials using Bayesian hierarchical models.



A randomized, double-blind, placebo-controlled trial of ondansetron for the treatment of cocaine use disorder with post hoc pharmacogenetic analysis.



Hi3 + 3: A model-assisted dose-finding design borrowing historical data.



Targeting synovial fibroblast proliferation in rheumatoid arthritis (TRAFIC): an open-label, dose-finding, phase 1b trial



Safety and efficacy of tolebrutinib, an oral brain-penetrant BTK inhibitor, in relapsing multiple sclerosis: a phase 2b, randomised, double-blind, placebo-controlled trial



Triple Chemotherapy (DOX) in Patients with Advanced Gastro-Esophageal Adenocarcinoma - A Phase II Study



A Dose-Finding Trial for Hyperthermic Intraperitoneal Cisplatin in Gynecological Cancer Patients Receiving Hyperthermic Intraperitoneal Chemotherapy



Early Completion of Model-Assisted Designs for Dose-Finding Trials



Intravenous oxytocin dosing regimens for postpartum hemorrhage prevention at cesarean section: a systematic review and meta-analysis.



Joint modelling of a binary and a continuous outcome measured at two cycles to determine the optimal dose



Results of phase I clinical trial of high doses of seleno-l-methionine (SLM) in sequential combination with axitinib in previously treated and relapsed clear cell renal carcinoma (ccRCC) patients


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