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Dose Dependent Manner sentence examples within reduced cell viability



α-Linolenic Acid Induces Breast Cancer Cell Apoptosis by Down-Regulating Human Fatty Acid Synthase


MO018QUORUM SENSING MOLECULE INDUCES THE RECEPTOR-INTERACTING PROTEIN KINASE 1-DEPENDENT APOPTOSIS SYNERGISTICALLY WITH LIPOPOLYSACCHARIDE IN ENDOTHELIAL CELLS

Dose Dependent Manner sentence examples within cancer cell line



FCX, an arylidene derivative, induces apoptosis in androgen receptor-selective prostate cancer cells


Inactivation of the Akt/FOXM1 Signaling Pathway by Panobinostat Suppresses the Proliferation and Metastasis of Gastric Cancer Cells

Dose Dependent Manner sentence examples within decreased cell viability



High glucose induces pyroptosis of retinal microglia through NLPR3 inflammasome signaling.


Preclinical evaluation of the ETS inhibitor TK216 against relapsed and refractory childhood leukemia.


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Dose Dependent Manner sentence examples within tumor necrosis factor



Role of Militarine in PM2.5-Induced BV-2 Cell Damage.


α-Cyperone (CYP) down-regulates NF-κB and MAPKs signaling, attenuating inflammation and extracellular matrix degradation in chondrocytes, to ameliorate osteoarthritis in mice

Dose Dependent Manner sentence examples within pro inflammatory cytokine



Uncommon Bis-Amide Matrine-type Alkaloids From Sophora alopecuroides With Anti-inflammatory Effects


Anti-Inflammatory Effects of 6,7-Dihydroxy-4-Methylcoumarin on LPS-Stimulated Macrophage Phosphorylation in MAPK Signaling Pathways

Dose Dependent Manner sentence examples within inhibited cell proliferation



UPLC-orbitrap-MS-based metabolic profiling of HaCaT cells exposed to withanolides extracted from Datura metel.L: Insights from an untargeted metabolomics.


Nerolidol inhibits proliferation of leiomyoma cells via reactive oxygen species-induced DNA damage and downregulation of the ATM/Akt pathway.

Dose Dependent Manner sentence examples within breast cancer cell



In vitro cytotoxic potential of extracts from Aristolochia foetida Kunth against MCF-7 and bMECs cell lines


IP-10 (CXCL10) Can Trigger Emergence of Dormant Breast Cancer Cells in a Metastatic Liver Microenvironment

Dose Dependent Manner sentence examples within significantly inhibited cell



Effects of smokeless tobacco on cell viability, reactive oxygen species, apoptosis, and inflammatory cytokines in human umbilical vein endothelial cells


Melatonin sensitizes esophageal cancer cells to 5-fluorouracil via promotion of apoptosis by regulating EZH2 expression

Dose Dependent Manner sentence examples within 100 mg kg



Possible Involvement Of L-Arginine-Nitric Oxide Pathway In The Antidepressant Activity Of Auraptene In Mice


Echinacoside alleviates acetaminophen-induced liver injury by attenuating oxidative stress and inflammatory cytokines in mice

Dose Dependent Manner sentence examples within cell cycle arrest



Sesquiterpene lactones from Carpesium abrotanoides L. and their activity in inducing protective autophagy.


AZD3759 inhibits glioma through the blockade of the epidermal growth factor receptor and Janus kinase pathways.

Dose Dependent Manner sentence examples within arrested cell cycle



Bavachinin Induces G2/M Cell Cycle Arrest and Apoptosis via the ATM/ATR Signaling Pathway in Human Small Cell Lung Cancer and Shows an Antitumor Effect in the Xenograft Model.


Dasabuvir Suppresses Esophageal Squamous Cell Carcinoma Growth As a Novel ROCK1 Inhibitor

Dose Dependent Manner sentence examples within anti inflammatory activity



Anti-inflammatory activity of the water extract of Chloranthus serratus roots in LPS-stimulated RAW264.7 cells mediated by the Nrf2/HO-1, MAPK and NF-κB signaling pathways.


Design and synthesis of novel glycyrrhetin ureas as anti-inflammatory agents for the treatment of acute kidney injury.

Dose Dependent Manner sentence examples within radical scavenging activity



Physicochemical, Antioxidant and Sensory Properties of Ready-to-drink Chrysanthemum Tea Fortified with Hydrolyzed Collagen from Salmon Scale Ossein


Antioxidant and hepatoprotective effects of Hypsizygus ulmarius polysaccharide on alcoholic liver injury in rats

Dose Dependent Manner sentence examples within 1 mg kg



Preventive and Therapeutic Efficacy of ONO-4641, a Selective Agonist for Sphingosine 1-Phosphate Receptor 1 and 5, in Preclinical Models of Type 1 Diabetes Mellitus.


Toxicity and deleterious impacts of selenium nanoparticles at supranutritional and imbalance levels on male goldfish (Carassius auratus) sperm.

Dose Dependent Manner sentence examples within inhibited cell viability



Thymoquinone anticancer activity is enhanced when combined with royal jelly in human breast cancer


Chloroform extract from Sophora Tonkinensis Gagnep. inhibit proliferation, migration, invasion and promote apoptosis of nasopharyngeal carcinoma cells by silencing the PI3K/AKT/mTOR signaling pathway.

Dose Dependent Manner sentence examples within pancreatic cancer cell



TEOA Promotes Autophagic Cell Death via ROS-Mediated Inhibition of mTOR/p70S6k Signaling Pathway in Pancreatic Cancer Cells


Anti-Allergic Drug Suppressed Pancreatic Carcinogenesis via Down-Regulation of Cellular Proliferation

Dose Dependent Manner sentence examples within body weight gain



Lily bulbs polyphenols extract ameliorates oxidative stress and lipid accumulation in vitro and in vivo.


Dose-dependent beneficial effects of citrulline supplementation in short bowel syndrome in rats.

Dose Dependent Manner sentence examples within half maximal inhibitory



Effect of manuka honey on human immunodeficiency virus type 1 reverse transcriptase activity.


Sodium metabisulfite as a cytotoxic food additive induces apoptosis in HFFF2 cells.

Dose Dependent Manner sentence examples within inducible nitric oxide



Polygonatum sibiricum polysaccharide inhibits IL-1β-induced inflammation in human chondrocytes


Citrus peel flavonoid nobiletin alleviates lipopolysaccharide-induced inflammation by activating IL-6/STAT3/FOXO3a-mediated autophagy.

Dose Dependent Manner sentence examples within mitochondrial membrane potential



Discovery of novel tubulin/HDAC dual-targeting inhibitors with strong antitumor and antiangiogenic potency.


Glycyrrhizin Mediates Downregulation of Notch Pathway Resulting in Initiation of Apoptosis and Disruption in the Cell Cycle Progression in Cervical Cancer Cells.

Dose Dependent Manner sentence examples within increased cell viability



Neuroprotective Effect of Membrane-Free Stem Cell Extract against Amyloid Beta 25–35-Induced Neurotoxicity in SH-SY5Y Cells


Effects of Ecklonia cava Extract on Neuronal Damage and Apoptosis in PC-12 Cells against Oxidative Stress.

Dose Dependent Manner sentence examples within induced cell death



Synthesis, cytotoxicity, apoptosis and cell cycle arrest of a ruthenium multi-substituted Keggin-type polyoxotungstate


Effect of Jakyakgamcho-Tang Extracts on H2O2-Induced C2C12 Myoblasts

Dose Dependent Manner sentence examples within significant cytotoxic effect



Effects of cyclophosphamide on antioxidative and immune functions of Nile tilapia (Oreochromis Niloticus) via the TLR-NF-κB signaling pathway.


Assessment of Antitumor Activity of Vinca herbacea on Human Ovarian Cancer Cell Line

Dose Dependent Manner sentence examples within cell cycle progression



Targeting of Survivin Inhibits Neuroblastoma Cell Proliferation


LncRNA UCA1 elevates the resistance of human leukemia cells to daunorubicin by the PI3K/AKT pathway via sponging miR-613

Dose Dependent Manner sentence examples within lung cancer cell



Andrographolide Induces Noxa-Dependent Apoptosis by Transactivating ATF4 in Human Lung Adenocarcinoma Cells


Shikonin inhibits the Warburg effect, cell proliferation, invasion and migration by downregulating PFKFB2 expression in lung cancer

Dose Dependent Manner sentence examples within intracellular reactive oxygen



Assessment of the Antibacterial Mechanism of Pterostilbene against Bacillus cereus through Apoptosis-like Cell Death and Evaluation of Its Beneficial Effects on the Gut Microbiota.


Pyropia yezoensis protein protects against TNF-α-induced myotube atrophy in C2C12 myotubes via the NF-κB signaling pathway

Dose Dependent Manner sentence examples within could significantly inhibit



Noreudesmane sesquiterpenoids from Artemisia hedinii and their anti-inflammatory activities.


Effectiveness of garden burnet, Sanguisorba officinalic L., in controlling acute hepatopancreatic necrosis disease caused by infection of Vibrio parahaemolyticus in shrimp farming

Dose Dependent Manner sentence examples within time dependent manner



Naturally occurring aesculetin coumarin exerts antiproliferative effects in gastric cancer cells mediated via apoptotic cell death, cell cycle arrest and targeting PI3K/AKT/M-TOR signalling pathway.


The downstream RAF-1 signaling of fibroblast growth factor-23 participates in the osteogenetic effect caused by C-type natriuretic peptide in vitro.

Dose Dependent Manner sentence examples within significant inhibitory effect



Dammarane triterpenes and phytosterols from Dysoxylum tpongense Pierre and their anti-inflammatory activity against liver X receptors and NF-κB activation


In vitro study on the effect of cornin on the activity of cytochrome P450 enzymes

Dose Dependent Manner sentence examples within high glucose induced



Exendin-4 inhibits high glucose-induced oxidative stress in retinal pigment epithelial cells by modulating the expression and activation of p66Shc


Astragaloside IV ameliorates diabetic nephropathy in db/db mice by inhibiting NLRP3 inflammasome-mediated inflammation

Dose Dependent Manner sentence examples within caspase 3 activity



Anticancer Activity of Leonurus sibiricus L.: Possible Involvement of Intrinsic Apoptotic Pathway.


Molecular Mechanisms of Antiproliferative and Apoptosis Activity by 1,5-Bis(4-Hydroxy-3-Methoxyphenyl)1,4-Pentadiene-3-one (MS13) on Human Non-Small Cell Lung Cancer Cells

Dose Dependent Manner sentence examples within induced cell cycle



Inhibition of Cell Proliferation and Metastasis by Scutellarein Regulating PI3K/Akt/NF-κB Signaling through PTEN Activation in Hepatocellular Carcinoma


Cyclopentenone-Containing Tetrahydroquinoline and Geldanamycin Alkaloids from Streptomyces malaysiensis as Potential Anti-Androgens against Prostate Cancer Cells.

Dose Dependent Manner sentence examples within inflammatory cytokine production



Identification of chemical constituents and inhibitory effect of Ficus deltoidea fraction against lipopolysaccharide-induced nuclear factor-kappa B inflammatory pathway in murine macrophage 264.7 cells


Paeoniflorin inhibits lipopolysaccharide-induced inflammation in LO2 cells by regulating RhoA/NLRP3 pathway

Dose Dependent Manner sentence examples within human lung cancer



Selenium nanoparticle synthesis from endangered medicinal herb (Enicostema axillare)


Biogenic Synthesis of NiO Nanoparticles Using Areca catechu Leaf Extract and Their Antidiabetic and Cytotoxic Effects

Dose Dependent Manner sentence examples within negative control group



Evaluation of in vitro antioxidant activity, phytochemical screening of selected medicinal plants of Nepal and in vitro anti-inflammatory Activity of Morus alba L. and Colebrookea oppositifolia J.E. Smith


Botulinum toxin type a intralesional monotherapy for treating human hypertrophic scar in a dose-dependent manner: In an animal model.

Dose Dependent Manner sentence examples within catalase superoxide dismutase



Antiparkinsonian activity of Cucurbita pepo seeds along with possible underlying mechanism.


Black soldier fly (Hermetia illucens) larvae meal in diets of European seabass: Effects on antioxidative capacity, non-specific immunity, transcriptomic responses, and resistance to the challenge with Vibrio alginolyticus.

Dose Dependent Manner sentence examples within mitogen activated protein



Platyphyllenone Induces Autophagy and Apoptosis by Modulating the AKT and JNK Mitogen-Activated Protein Kinase Pathways in Oral Cancer Cells


Ecklonia cava Extract Exerts Anti-Inflammatory Effect in Human Gingival Fibroblasts and Chronic Periodontitis Animal Model by Suppression of Pro-Inflammatory Cytokines and Chemokines

Dose Dependent Manner sentence examples within 200 mg kg



Attenuation of liver mitochondrial oxidative damage by the extract and desulfo glucosinolate fraction of Lepidium perfoliatum L. seeds


Safety Profile, In Vitro Anti-Inflammatory Activity, and In Vivo Antiulcerogenic Potential of Root Barks from Annona senegalensis Pers. (Annonaceae)

Dose Dependent Manner sentence examples within vascular endothelial growth



Activation of Hair Cell Growth Factors by Linoleic Acid in Malva verticillata Seed


The cancer angiogenesis co-culture assay: In vitro quantification of the angiogenic potential of tumoroids

Dose Dependent Manner sentence examples within human peripheral blood



The anti-arthritis effect of sulforaphane, an activator of Nrf2, is associated with inhibition of both B cell differentiation and the production of inflammatory cytokines


S95021, a novel selective and pan-neutralizing anti interferon alpha (IFN-α) monoclonal antibody as a candidate treatment for selected autoimmune rheumatic diseases

Dose Dependent Manner sentence examples within promoted cell proliferation



Isoegomaketone from Perilla frutescens (L.) Britt Stimulates MAPK/ERK Pathway in Human Keratinocyte to Promote Skin Wound Healing


Effect of Eriocitrin on Cell Proliferation, Apoptosis, Migration, and Scar Formation-Related Genes Expression in Tendon Stem Cells

Dose Dependent Manner sentence examples within 400 mg kg



Screening of phytocompounds, molecular docking studies, and in vivo anti-inflammatory activity of heartwood aqueous extract of Pterocarpus santalinus L.f.


Origanum vulgare L. leaf extract alleviates finasteride-induced oxidative stress in mouse liver and kidney

Dose Dependent Manner sentence examples within free radical scavenging



Antioxidant Properties and Diet-Related α-Glucosidase and Lipase Inhibitory Activities of Yogurt Supplemented with Safflower (Carthamus tinctorius L.) Petal Extract


Antimicrobial, Antioxidant, and Cytotoxic Activities of Juglans regia L. Pellicle Extract

Dose Dependent Manner sentence examples within significantly reduced cell



Gaillardin, a potent sesquiterpene lactone induces apoptosis via down-regulation of NF-κβ in gastric cancer cells, AGS and MKN45.


Protocatechuic Acid, a Simple Plant Secondary Metabolite, Induced Apoptosis by Promoting Oxidative Stress through HO-1 Downregulation and p21 Upregulation in Colon Cancer Cells

Dose Dependent Manner sentence examples within pretreatment significantly reduced



Ethanol-Induced Hepatotoxicity and Alcohol Metabolism Regulation by GABA-Enriched Fermented Smilax china Root Extract in Rats


β-caryophyllene, an FDA-Approved Food Additive, Inhibits Methamphetamine-Taking and Methamphetamine-Seeking Behaviors Possibly via CB2 and Non-CB2 Receptor Mechanisms

Dose Dependent Manner sentence examples within 231 breast cancer



Quercetin Blocks the Aggressive Phenotype of Triple Negative Breast Cancer by Inhibiting IGF1/IGF1R-Mediated EMT Program


Lycium barbarum (goji berry), human breast cancer, and antioxidant profile

Dose Dependent Manner sentence examples within smooth muscle cell



Tryptophan catabolism is dysregulated in leiomyomas.


Luteolin Ameliorates Experimental Pulmonary Arterial Hypertension via Suppressing Hippo-YAP/PI3K/AKT Signaling Pathway

Dose Dependent Manner sentence examples within mast cell degranulation



Sodium R-lipoate and enzymatically-modified isoquercitrin suppressed IgE-independent anaphylactic reactions and stress-induced gastric ulceration in mice.


Mast cell degranulation and vascular endothelial growth factor expression in mouse skin following ionizing irradiation

Dose Dependent Manner sentence examples within cancer cell growth



CopA3 peptide induces permanent cell-cycle arrest in colorectal cancer cells


Sol–Gel Synthesis of Dy-Substituted Ni0.4Cu0.2Zn0.4(Fe2-xDyx)O4 Nano Spinel Ferrites and Evaluation of Their Antibacterial, Antifungal, Antibiofilm and Anticancer Potentialities for Biomedical Application

Dose Dependent Manner sentence examples within systolic blood pressure



Evaluation of the in vivo Antihypertensive Effect and Antioxidant Activity of HL-7 and HL-10 Peptide in Mice


Evaluation of the in vivo antihypertensive effect and antioxidant activity of HL-7 and HL-10 peptide in mice.

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