Dendritic Polyglycerol(수지상 폴리글리세롤)란 무엇입니까?
Dendritic Polyglycerol 수지상 폴리글리세롤 - In this work, we have developed a CSCs-specific targeted, retinoic acid (RA)-loaded gold nanostars-dendritic polyglycerol (GNSs-dPG) nanoplatform for the efficient eradication of CSCs. [1] Particularly, NGs consisted on a poly(N-isopropylacrylamide) (PNIPAM) and dendritic polyglycerol (dPG) mesh containing a semi-interpenetrating network (SIPN) of poly(hydroxymethyl 3,4-ethylenedioxythiophene) (PHMeEDOT). [2] The comparison with experimental data on complex formation between a synthetic (sulfated dendritic polyglycerol) and natural polyelectrolytes (DNA; heparin) with proteins shows full agreement with theory. [3] Here we describe a cytocompatible dendritic polyglycerol amine (dPGA) substrate-based method for prolonged culture of h-iPSC-derived MNs. [4] Dendritic polyglycerol (PG) was covalently coupled to 2-hydroxyethyl methacrylate (HEMA) by an anionically catalyzed ring-opening polymerization generating a dendritic PG-HEMA with four PG repetition units (PG4MA). [5] In this work, we synthesize a dual-responsive dendritic polyglycerol sulfate (DR-dPGS) drug delivery system by copolymerization of glycidol, ε-caprolactone and an epoxide monomer bearing a disulfide bond (SSG), followed by sulfation of terminal hydroxyl groups of the copolymer. [6] Herein, we present a drug delivery system (DDS) based on biodegradable dendritic polyglycerol sulfate-bearing poly(caprolactone) (dPGS-PCL) chains, which has been synthesized on 20 g scale using a straightforward two-step protocol. [7] Capsules were loaded with an antioxidant enzyme (catalase) and functionalized with a model drug (doxorubicin), which was conjugated to an amine-containing dendritic polyglycerol through a pH-responsive linker. [8] To address the need of efficient transmucosal drug delivery, this report presents the synthesis of novel disulfide-containing dendritic polyglycerol (dPG)-based nanogels and their preclinical testing. [9] Normal and OA-like micromasses were treated with dendritic polyglycerol sulfate-based PEG hydrogel. [10] By controlling surface polymerization of mussel-inspired dendritic polyglycerol (MI-dPG) and post-functionalization, surfaces with wetting properties ranging from superhydrophilic to superhydrophobic were fabricated. [11] This chapter summarizes the role of this class of materials in the performance of three major diagnostic devices, biodecorated membranes, polymeric nanoparticles, and labeled dendritic polyglycerol sulfate. [12] The synthetic compound dendritic polyglycerol sulfate (dPGS) is a pleiotropic acting molecule but shows a high binding affinity to immunological active molecules as L-/P-selectin or complement proteins leading to well described anti-inflammatory properties in various mouse models. [13] One component is a homobifunctional polyethylene glycol linker, carrying a strained alkyne (PEG-BCN) and the second component is the azide-functionalized dendritic polyglycerol (dPG-N3). [14] In this work, an antifouling surface coating based on the combination of mussel-inspired dendritic polyglycerol (MI-dPG), and an amine-functionalized block-copolymer of linear polyglycerol (lPG–b–OA11, OA= oligo-amine) was developed. [15] A promising alternative is the synthetic analogue dendritic polyglycerol sulfate (dPGS). [16] Dendritic polyglycerols (PGs) were synthesized and post-modified by grafting of polyethylenglycol (PEG) and polypropyleneglycol (PPG) diglycidyl ether (DGE) groups and their antifouling and fouling-release properties were tested. [17] Dendritic polyglycerol-co-polycaprolactone (PG-co-PCL)-derived block copolymers are synthesized and explored as nanoscale drug delivery platforms for a chemotherapeutic agent, gemcitabine (GEM), which is the cornerstone of therapy for pancreatic ductal adenocarcinoma (PDAC). [18] We present a comprehensive analysis of the energetics of the binding of lysozyme to dendritic polyglycerolsulfate (dPGS) in aqueous solution. [19] Here, we report the synthesis and biological evaluation of PDCs made of the highly potent antimitotic agent monomethyl auristatin E conjugated to dendritic polyglycerol and dendritic polyglycerol sulfate via a reductively cleavable, self-immolative disulfide linker. [20] The purpose of this study was to produce and characterize the dendritic polyglycerol microspheres (DPGlyM) carrier with potential for use in treatment of multiple sclerosis (MS). [21] Here, the design of actively targeting, renally excretible bimodal dendritic polyglycerols (dPGs) for diagnostic cancer imaging is described. [22] A click reaction of polyethylene glycol (PEG) and dendritic polyglycerol (dPG) has produced one of the softest (G′ = 200 Pa) but relatively robust existing hydrogels comparable to cells. [23] In the present study, we developed hydrophilic thermo-responsive nanogels with tunable volume phase transition temperatures (VPTTs) and suitable features for controlled protein delivery by the use of multifunctional, dendritic polyglycerol (dPG) as macromolecular cross-linker and temperature-sensitive polymers poly(N-isopropylacrylamide) (NIPAM) and poly(N-isopropylacrylmethacrylate) as linear counterpart. [24] Here, we introduce a novel viscosity sensor design for lipid membranes based on a reporting nanoparticle, a sulfated dendritic polyglycerol (dPGS), conjugated to a fluorescent molecular rotor, indocarbocyanine (ICC). [25]이 연구에서 우리는 CSCs의 효율적인 근절을 위한 CSCs-특정 표적화, 레티노산(RA)-로딩된 금 나노스타-수지상 폴리글리세롤(GNSs-dPG) 나노플랫폼을 개발했습니다. [1] 특히, NG는 폴리(N-이소프로필아크릴아미드)(PNIPAM) 및 폴리(하이드록시메틸 3,4-에틸렌디옥시티오펜)(PHMeEDOT)의 반-상호침투 네트워크(SIPN)를 포함하는 수지상 폴리글리세롤(dPG) 메쉬로 구성되었습니다. [2] 합성(황화 수지상 폴리글리세롤)과 천연 고분자 전해질(DNA, 헤파린)과 단백질 사이의 복합 형성에 대한 실험 데이터와의 비교는 이론과 완전히 일치함을 보여줍니다. [3] 여기에서 우리는 h-iPSC 유래 MN의 장기간 배양을 위한 세포 적합성 수지상 폴리글리세롤 아민(dPGA) 기질 기반 방법을 설명합니다. [4] 수지상 폴리글리세롤(PG)은 음이온 촉매된 개환 중합에 의해 2-하이드록시에틸 메타크릴레이트(HEMA)에 공유 결합되어 4개의 PG 반복 단위(PG4MA)가 있는 수지상 PG-HEMA를 생성합니다. [5] 이 연구에서 우리는 글리시돌, ε-카프로락톤 및 이황화 결합(SSG)을 갖는 에폭사이드 단량체의 공중합에 의해 이중 반응성 수지상 폴리글리세롤 설페이트(DR-dPGS) 약물 전달 시스템을 합성한 다음, 말단 하이드록실 그룹의 황산화를 수행합니다. 공중합체. [6] 여기에서 우리는 간단한 2단계 프로토콜을 사용하여 20g 규모에서 합성된 생분해성 수지상 폴리글리세롤 황산염 함유 폴리(카프로락톤)(dPGS-PCL) 사슬을 기반으로 하는 약물 전달 시스템(DDS)을 제시합니다. [7] 캡슐에는 항산화 효소(카탈라제)가 로딩되었고 pH 반응성 링커를 통해 아민 함유 수지상 폴리글리세롤에 접합된 모델 약물(독소루비신)으로 기능화되었습니다. [8] 효율적인 경점막 약물 전달의 필요성을 해결하기 위해 이 보고서는 새로운 이황화물 함유 수지상 폴리글리세롤(dPG) 기반 나노겔의 합성 및 전임상 테스트를 제시합니다. [9] nan [10] nan [11] nan [12] nan [13] nan [14] nan [15] nan [16] nan [17] nan [18] nan [19] nan [20] nan [21] nan [22] nan [23] nan [24] nan [25]
Inspired Dendritic Polyglycerol
By controlling surface polymerization of mussel-inspired dendritic polyglycerol (MI-dPG) and post-functionalization, surfaces with wetting properties ranging from superhydrophilic to superhydrophobic were fabricated. [1] In this work, an antifouling surface coating based on the combination of mussel-inspired dendritic polyglycerol (MI-dPG), and an amine-functionalized block-copolymer of linear polyglycerol (lPG–b–OA11, OA= oligo-amine) was developed. [2]Sulfated Dendritic Polyglycerol
The comparison with experimental data on complex formation between a synthetic (sulfated dendritic polyglycerol) and natural polyelectrolytes (DNA; heparin) with proteins shows full agreement with theory. [1] Here, we introduce a novel viscosity sensor design for lipid membranes based on a reporting nanoparticle, a sulfated dendritic polyglycerol (dPGS), conjugated to a fluorescent molecular rotor, indocarbocyanine (ICC). [2]합성(황화 수지상 폴리글리세롤)과 천연 고분자 전해질(DNA, 헤파린)과 단백질 사이의 복합 형성에 대한 실험 데이터와의 비교는 이론과 완전히 일치함을 보여줍니다. [1] nan [2]
Containing Dendritic Polyglycerol 수지상 폴리글리세롤 함유
Capsules were loaded with an antioxidant enzyme (catalase) and functionalized with a model drug (doxorubicin), which was conjugated to an amine-containing dendritic polyglycerol through a pH-responsive linker. [1] To address the need of efficient transmucosal drug delivery, this report presents the synthesis of novel disulfide-containing dendritic polyglycerol (dPG)-based nanogels and their preclinical testing. [2]캡슐에는 항산화 효소(카탈라제)가 로딩되었고 pH 반응성 링커를 통해 아민 함유 수지상 폴리글리세롤에 접합된 모델 약물(독소루비신)으로 기능화되었습니다. [1] 효율적인 경점막 약물 전달의 필요성을 해결하기 위해 이 보고서는 새로운 이황화물 함유 수지상 폴리글리세롤(dPG) 기반 나노겔의 합성 및 전임상 테스트를 제시합니다. [2]
dendritic polyglycerol sulfate 수지상 폴리글리세롤 황산염
In this work, we synthesize a dual-responsive dendritic polyglycerol sulfate (DR-dPGS) drug delivery system by copolymerization of glycidol, ε-caprolactone and an epoxide monomer bearing a disulfide bond (SSG), followed by sulfation of terminal hydroxyl groups of the copolymer. [1] Herein, we present a drug delivery system (DDS) based on biodegradable dendritic polyglycerol sulfate-bearing poly(caprolactone) (dPGS-PCL) chains, which has been synthesized on 20 g scale using a straightforward two-step protocol. [2] Normal and OA-like micromasses were treated with dendritic polyglycerol sulfate-based PEG hydrogel. [3] This chapter summarizes the role of this class of materials in the performance of three major diagnostic devices, biodecorated membranes, polymeric nanoparticles, and labeled dendritic polyglycerol sulfate. [4] The synthetic compound dendritic polyglycerol sulfate (dPGS) is a pleiotropic acting molecule but shows a high binding affinity to immunological active molecules as L-/P-selectin or complement proteins leading to well described anti-inflammatory properties in various mouse models. [5] A promising alternative is the synthetic analogue dendritic polyglycerol sulfate (dPGS). [6]이 연구에서 우리는 글리시돌, ε-카프로락톤 및 이황화 결합(SSG)을 갖는 에폭사이드 단량체의 공중합에 의해 이중 반응성 수지상 폴리글리세롤 설페이트(DR-dPGS) 약물 전달 시스템을 합성한 다음, 말단 하이드록실 그룹의 황산화를 수행합니다. 공중합체. [1] 여기에서 우리는 간단한 2단계 프로토콜을 사용하여 20g 규모에서 합성된 생분해성 수지상 폴리글리세롤 황산염 함유 폴리(카프로락톤)(dPGS-PCL) 사슬을 기반으로 하는 약물 전달 시스템(DDS)을 제시합니다. [2] nan [3] nan [4] nan [5] nan [6]