Chalcone Analogues 찰콘 유사체

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10.1016/j.ejmech.2018.11.034

Here, we synthesized two series of chalcone analogues (3a-s and 6a-s) based on substituting the chalcone B-ring or A-ring with a 4-oxoquinazolin-2-yl group, and then evaluated them for cytotoxic activity in human colorectal HCT-116 and breast cancer MCF-7 cell lines.

여기에서 우리는 chalcone B-ring 또는 A-ring을 4-oxoquinazolin-2-yl 기로 대체하여 2가지 시리즈의 chalcone 유사체(3a-s 및 6a-s)를 합성한 다음 인간에서 세포독성 활성을 평가했습니다. 결장직장 HCT-116 및 유방암 MCF-7 세포주.

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10.1016/j.apsb.2019.01.003

In our study, a series of chalcone analogues were designed and synthesized, and multiple potential chalcone analogues with dual antioxidant mechanisms were screened.

우리 연구에서는 일련의 칼콘 유사체를 설계하고 합성했으며 이중 항산화 메커니즘을 가진 여러 잠재적 칼콘 유사체를 스크리닝했습니다.

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10.2174/0929867326666191003154051

Tubulin inhibitors were classified to ten categories according to structural features, as colchicine derivates, CA-4 analogues, chalcone analogues, coumarin analogs, indole hybrids, quinoline and quinazoline analogs, lignan and podophyllotoxin derivatives, phenothiazine analogs, N-heterocycle hybrids and others.

튜불린 억제제는 구조적 특징에 따라 콜히신 유도체, CA-4 유사체, 칼콘 유사체, 쿠마린 유사체, 인돌 하이브리드, 퀴놀린 및 퀴나졸린 유사체, 리그난 및 포도필로톡신 유도체, 페노티아진 유사체, N-헤테로사이클 하이브리드 등의 10가지 범주로 분류되었습니다.

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Chalcone Analogues 찰콘 유사체

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Dec 13, 2024

Chalcone Analogues(찰콘 유사체)란 무엇입니까?

Chalcone Analogues 찰콘 유사체 - Here, we synthesized two series of chalcone analogues (3a-s and 6a-s) based on substituting the chalcone B-ring or A-ring with a 4-oxoquinazolin-2-yl group, and then evaluated them for cytotoxic activity in human colorectal HCT-116 and breast cancer MCF-7 cell lines. ^[1] In our study, a series of chalcone analogues were designed and synthesized, and multiple potential chalcone analogues with dual antioxidant mechanisms were screened. ^[2] Tubulin inhibitors were classified to ten categories according to structural features, as colchicine derivates, CA-4 analogues, chalcone analogues, coumarin analogs, indole hybrids, quinoline and quinazoline analogs, lignan and podophyllotoxin derivatives, phenothiazine analogs, N-heterocycle hybrids and others. ^[3]
여기에서 우리는 chalcone B-ring 또는 A-ring을 4-oxoquinazolin-2-yl 기로 대체하여 2가지 시리즈의 chalcone 유사체(3a-s 및 6a-s)를 합성한 다음 인간에서 세포독성 활성을 평가했습니다. 결장직장 HCT-116 및 유방암 MCF-7 세포주. ^[1] 우리 연구에서는 일련의 칼콘 유사체를 설계하고 합성했으며 이중 항산화 메커니즘을 가진 여러 잠재적 칼콘 유사체를 스크리닝했습니다. ^[2] 튜불린 억제제는 구조적 특징에 따라 콜히신 유도체, CA-4 유사체, 칼콘 유사체, 쿠마린 유사체, 인돌 하이브리드, 퀴놀린 및 퀴나졸린 유사체, 리그난 및 포도필로톡신 유도체, 페노티아진 유사체, N-헤테로사이클 하이브리드 등의 10가지 범주로 분류되었습니다. ^[3]