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Central Role sentence examples within innate immune response



Therapeutic Impact of ODN2088 to Block TLR9 Activity in Induced Liver Fibrosis Mice.


Comparative Phenotypic and Functional Analyses of the Effects of IL-10 or TGF-β on Porcine Macrophages

Central Role sentence examples within central nervous system



The Role of Microglia in Modulating Neuroinflammation after Spinal Cord Injury


Neurotoxicity Biology and Management

Central Role sentence examples within transforming growth factor



TGF-β promote epithelial-mesenchymal transition via NF-κB/NOX4/ROS signal pathway in lung cancer cells.


Backstage players of fibrosis: NOX4, mTOR, HDAC, and S1P; companions of TGF-β.



Central Role sentence examples within transcription factors play



Constitutive Hedgehog/GLI2 signaling drives extracutaneous basaloid squamous cell carcinoma development and bone remodeling.


Effects of Grape NAC Transcription Factor DRL1 on Floral Organogenesis in Tobacco

Central Role sentence examples within coronavirus disease 2019



A Novel Point Mutation in the N Gene of SARS-CoV-2 May Affect the Detection of the Virus by Reverse Transcription-Quantitative PCR


High-Flow Nasal Cannula and COVID-19: A Clinical Review.

Central Role sentence examples within regulating gene expression



Transient ribosome slowdown at the decoding step triggers mRNA degradation independent of Znf598 in zebrafish


Identification and functional characterization of the transcription factor coding Dp1 gene in large yellow croaker Pseudosciaena crocea

Central Role sentence examples within gene expression regulation



Sir3 Heterochromatin Protein Promotes NHEJ by Direct Inhibition of Sae2


H3K4 trimethylation dynamics impact diverse developmental and environmental responses in plants

Central Role sentence examples within remains poorly understood



Irritability in Mood Disorders: Neurobiological Underpinnings and Implications for Pharmacological Intervention


Wnt1 Promotes Cementum and Alveolar Bone Growth in a Time-Dependent Manner.

Central Role sentence examples within post translational modification



Coenzyme a Biochemistry: From Neurodevelopment to Neurodegeneration


Co-Phosphorylation Networks Reveal Subtype-Specific Signaling Modules in Breast Cancer

Central Role sentence examples within human leukocyte antigen



Evidence for a shift in placental HLA-G allelic dominance and the HLA-G isoform profile during a healthy pregnancy and preeclampsia


Hypothetical COVID-19 protection mechanism: hints from centenarians

Central Role sentence examples within vascular endothelial growth



Durvalumab and pazopanib in patients with advanced soft tissue sarcoma: A single-center, single-arm, phase 2 trial.


Treatments for dry age-related macular degeneration: therapeutic avenues, clinical trials and future directions

Central Role sentence examples within health care system



Dutch shared savings program targeted at primary care: Reduced expenditures in its first year.


Essential Indicators of Quality in Primary Care Settings: An Evidence-Based, Structured, Expert Approach

Central Role sentence examples within may also play



Targeting the NLRP3 Inflammasome as a New Therapeutic Option for Overcoming Cancer


The Uncertain Link Between Gallstone Disease and Colorectal Cancer

Central Role sentence examples within advanced glycation end



AGE/RAGE in diabetic kidney disease and ageing kidney.


Gold Nanoparticle-Bioconjugated Aminoguanidine Inhibits Glycation Reaction: An In Vivo Study in a Diabetic Animal Model

Central Role sentence examples within rapamycin complex 1



mTORC1 mediates fiber type-specific regulation of protein synthesis and muscle size during denervation


Rag GTPases suppress PRL-3 degradation and predict poor clinical diagnosis of cancer patients with low PRL-3 mRNA expression.

Central Role sentence examples within phosphatidylinositol 3 kinase



Phosphatidylinositol 3-kinase (PI3K) inhibitors: a recent update on inhibitor design and clinical trials (2016–2020)


Phase I Study of Docetaxel and Temsirolimus in Refractory Solid Tumors

Central Role sentence examples within chronic low grade



The human milk oligosaccharide 3’sialyllactose promotes inflammation resolution and reduces atherosclerosis development.


Cartilage tissue engineering for obesity-induced osteoarthritis: Physiology, challenges, and future prospects

Central Role sentence examples within angiotensin converting enzyme



Diet, Probiotics and Their Impact on the Gut Microbiota during the COVID-19 Pandemic


Far di Necessità Virtù, using rare tubulopathies, Gitelman’s and Bartter’s syndromes, to inform the fight against COVID-19

Central Role sentence examples within potential therapeutic target



A genome-scale CRISPR Cas9 dropout screen identifies synthetically lethal targets in SRC-3 inhibited cancer cells


The Mechanisms of CHD8 in Neurodevelopment and Autism Spectrum Disorders

Central Role sentence examples within unfolded protein response



Probing interplays between human XBP1u translational arrest peptide and 80S ribosome


Pneumocytes are distinguished by highly elevated expression of the ER stress biomarker GRP78, a co-receptor for SARS-CoV-2, in COVID-19 autopsies

Central Role sentence examples within pattern recognition receptor



Role of Toll-like Receptors in Health and Diseases of Gastrointestinal Tract


Anti-Viral Pattern Recognition Receptors as Therapeutic Targets

Central Role sentence examples within antibiotic resistance spread



In Situ Visualization of the pKM101-Encoded Type IV Secretion System Reveals a Highly Symmetric ATPase Energy Center at the Channel Entrance


In Situ Visualization of the pKM101-Encoded Type IV Secretion System Reveals a Highly Symmetric ATPase Energy Center

Central Role sentence examples within inducible factor 1



Pharmacological inhibition of Mint3 attenuates tumour growth, metastasis, and endotoxic shock


Increasing Angiogenesis Factors in Hypoxic Diabetic Wound Conditions by siRNA Delivery: Additive Effect of LbL-Gold Nanocarriers and Desloratadine-Induced Lysosomal Escape

Central Role sentence examples within global carbon cycle



Discrete Sample Introduction Module for Quantitative and Isotopic Analysis of Methane and Other Gases by Cavity Ring-Down Spectroscopy.


Cross‐Shore Flow and Implications for Carbon Export in the California Current Ecosystem: A Lagrangian Analysis

Central Role sentence examples within long non coding



Mechanisms of Action of MiRNAs and LncRNAs in Extracellular Vesicle in Atherosclerosis


Non-Coding RNA Signatures of B-Cell Acute Lymphoblastic Leukemia

Central Role sentence examples within related factor 2



Retinal Nrf2 expression in normal and early streptozotocin-diabetic rats


Farnesoid X Receptor as Target for Therapies to Treat Cholestasis-Induced Liver Injury

Central Role sentence examples within growth factor receptor



Epidermal growth factor receptor inhibitor-induced diarrhea: clinical incidence, toxicological mechanism, and management.


Multiplexed Single-Cell Plasmonic Immunoassay of Intracellular Signaling Proteins Enables Non-Destructive Monitoring of Cell Fate.

Central Role sentence examples within genome wide association



Role of ABCA7 in Human Health and in Alzheimer’s Disease


Natural genetic variation determines microglia heterogeneity in wild-derived mouse models of Alzheimer’s disease

Central Role sentence examples within age related neurodegenerative



Amyloid beta acts synergistically as a pro-inflammatory cytokine


Alzheimer’s Disease as a Chronic Maladaptive Polyamine Stress Response

Central Role sentence examples within climate change mitigation