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Activating Mutation sentence examples within epidermal growth factor



Hype or hope - Can combination therapies with third-generation EGFR-TKIs help overcome acquired resistance and improve outcomes in EGFR-mutant advanced/metastatic NSCLC?


Treatment of Brain Metastases of Non-Small Cell Lung Carcinoma

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A Reversible Shift of Driver Dependence from EGFR to Notch1 in Non-Small Cell Lung Cancer as a Cause of Resistance to Tyrosine Kinase Inhibitors


Co-occurring MET Amplification Predicts Inferior Clinical Response to First-Line Erlotinib in Advanced Stage EGFR-Mutated NSCLC Patients.

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Efficacy and Safety of Rociletinib Versus Chemotherapy in Patients With EGFR-Mutated NSCLC: The Results of TIGER-3, a Phase 3 Randomized Study


Japanese Lung Cancer Society Guidelines for Stage IV NSCLC With EGFR Mutations



Activating Mutation sentence examples within receptor tyrosine kinase



Inhibition of PI3K and MAPK pathways along with KIT inhibitors as a strategy to overcome drug resistance in gastrointestinal stromal tumors


LncRNA PVT1 promotes cells proliferation via PI3K–AKT–mTOR Pathway in gastrointestinal stromal tumor

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Pheochromocytoma/Paraganglioma, Medullary Thyroid Carcinoma, and Hereditary Endocrine Neoplasia Syndromes


Global Chromatin Changes Resulting from Single-Gene Inactivation—The Role of SMARCB1 in Malignant Rhabdoid Tumor

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Pediatric hyperparathyroidism: review and imaging update


Severe primary hyperparathyroidism in a 3-day-old neonate

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Genomic Evolution in a Patient With Lung Adenocarcinoma With a Germline EGFR T790M Mutation


Comparison of epidermal growth factor receptor mutation detection turnaround times and concordance among real-time polymerase chain reaction, high-throughput next-generation sequencing and the Biocartis Idylla™ platforms in non-small cell lung carcinomas.

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Combination Therapy of the Active KRAS-Targeting Antibody inRas37 and a PI3K Inhibitor in Pancreatic Cancer.


Epithelial memory of inflammation limits tissue damage while promoting pancreatic tumorigenesis

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Targeting Mitochondrial Metabolism in Clear Cell Carcinoma of the Ovaries


Targeting Mitochondrial Metabolism in Clear Cell Carcinoma of the Ovaries

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Simultaneous inhibition of PFKFB3 and GLS1 selectively kills KRAS-transformed pancreatic cells.


Abstract 2136: Diversity across the pancreatic ductal adenocarcinoma disease spectrum revealed by network-anchored functional genomics

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Systemic Jak1 activation causes extrarenal calcitriol production and skeletal alterations provoking stunted growth


Prevention of guanylyl cyclase–B dephosphorylation rescues achondroplastic dwarfism

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Lipid profiling of mouse intestinal organoids for studying APC mutations


Genetic mapping of novel modifiers for ApcMin induced intestinal polyps’ development using the genetic architecture power of the collaborative cross mice

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Three‐year follow up of using combination therapy with fresh‐frozen plasma and iron chelation in a patient with acaeruloplasminemia


Transient infantile hypertriglyceridemia with jaundice

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Extracellular domain shedding of the ALK receptor mediates neuroblastoma cell migration


ALK Inhibitors in Neuroblastoma: A Sprint from Bench to Bedside

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MYC hyperactivates WNT signaling in APC/CTNNB1-mutated colorectal cancer cells through miR-92a-dependent repression of DKK3.


MYC hyperactivates WNT signaling in APC/CTNNB1-mutated colorectal cancer cells through miR-92a-dependent repression of DKK3

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Evaluation of Hsp90 and mTOR inhibitors as potential drugs for the treatment of TSC1/TSC2 deficient cancer


Infections in activated PI3K delta syndrome (APDS).

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The Identity of PDGFRA D842V-Mutant Gastrointestinal Stromal Tumors (GIST)


Rare case of gastrointestinal bleeding: jejunal gastrointestinal stromal tumor

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Targeting BRAF Activation as Acquired Resistance Mechanism to EGFR Tyrosine Kinase Inhibitors in EGFR-Mutant Non-Small-Cell Lung Cancer


Survival Outcomes of Nonsmall Cell Lung Cancer Patients Treated with Afatinib Who Are Affected by Early Adverse Events

Activating Mutation sentence examples within phosphoinositide 3 kinase



Esthetic and Functional Improvement of Asymmetric Lower Limb Overgrowth in a Proteus Syndrome Patient: a Combined Surgical Technique


Alpelisib-Induced Diabetic Ketoacidosis

Activating Mutation sentence examples within human epidermal growth



A phase 2, multicenter, open-label study evaluating trastuzumab deruxtecan (T-DXd) for the treatment of solid tumors harboring specific HER2-activating mutations (DESTINY-PanTumor01).

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Colorectal Cancer-Associated Smad4 R361 Hotspot Mutations Boost Wnt/β-Catenin Signaling through Enhanced Smad4–LEF1 Binding

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Clinical and Pathologic Complete Response to Gefitinib in a Patient with SqCLC Harboring EGFR p.E746_S752delinsV Mutation

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A novel anti-c-Kit antibody-drug conjugate to treat wild-type and activating-mutant c-Kit-positive tumors.

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Inhibition of Granulocytic Myeloid-Derived Suppressor Cells Overcomes Resistance to Immune Checkpoint Inhibition in LKB1-Deficient Non–Small Cell Lung Cancer

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Expression of activated VEGFR2 by R1051Q mutation alters the energy metabolism of Sk-Mel-31 melanoma cells by increasing glutamine dependence.

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Real-world outcomes of anti-PD1 antibodies in platinum-refractory, PD-L1-positive recurrent and/or metastatic non-small cell lung cancer, and its potential practical predictors: first report from Korean Cancer Study Group LU19-05


The synthesis and bioactivity of pyrrolo[2,3-d]pyrimidine derivatives as tyrosine kinase inhibitors for NSCLC cells with EGFR mutations.

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Genetics in Endocrinology: Impact of race and sex on genetic causes of aldosterone-producing adenomas.


Genomic Evolution in a Patient With Lung Adenocarcinoma With a Germline EGFR T790M Mutation

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Discovery and characterization of novel peptide inhibitors of the NRF2/MAFG/DNA ternary complex for the treatment of cancer.


A phase 2 clinical trial on trametinib and low-dose dabrafenib in advanced pretreated BRAFV600/NRASQ61R/K/L wild-type melanoma (TraMel-WT): Interim efficacy and safety results.

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The origins and genetic interactions of KRAS mutations are allele- and tissue-specific


Suppression of Extracellular Vesicle VEGF-C–mediated Lymphangiogenesis and Pancreatic Cancer Early Dissemination By a Selective HDAC1/2 Inhibitor

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When the MET receptor kicks in to resist targeted therapies


A Reversible Shift of Driver Dependence from EGFR to Notch1 in Non-Small Cell Lung Cancer as a Cause of Resistance to Tyrosine Kinase Inhibitors

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Abstract 1077: Acquired neratinib resistance is associated with acquisition ofHER2andPIK3CAmutations and can be overcome using potent drug combinations in HER2-positive breast cancer models


Molecular Analysis of Encapsulated Papillary Carcinoma of the Breast with and without Invasion.

Activating Mutation sentence examples within Kinase Activating Mutation



Nephrotoxicity of the BRAF-kinase inhibitor Vemurafenib is driven by off-target Ferrochelatase inhibition


Impaired dopamine D3 and nicotinic acetylcholine receptor membrane localization in iPSCs-derived dopaminergic neurons from two Parkinson’s disease patients carrying the LRRK2 G2019S mutation

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Oral Juvenile Xanthogranuloma: A Clinicopathological, Immunohistochemical and BRAF V600E Study of Five New Cases, with Literature Review


The Identity of PDGFRA D842V-Mutant Gastrointestinal Stromal Tumors (GIST)

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Hyperinsulinemic Hypoglycemia in Three Generations of a Family with Glucokinase Activating Mutation, c.295T>C (p.Trp99Arg)


A Novel Variant in the CASR Gene c.368T>Cp.(Leu123Ser) in a Case of Hypocalcemia Refractory to Standard Medical Therapy

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NKX2‐1 controls lung cancer progression by inducing DUSP6 to dampen ERK activity


NKX2-1 controls lung cancer progression by inducing DUSP6 to dampen ERK activity

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Yorkie drives Ras-induced tumor progression by microRNA-mediated inhibition of cellular senescence


Extracellular domain shedding of the ALK receptor mediates neuroblastoma cell migration

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Cerebellar ataxia and exercise intolerance in Erdheim-Chester disease


BRAF V600E Mutation in Papillary Thyroid Cancer is Correlated with Adverse Clinicopathological Features but not with Iodine Exposure.

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Abstract PS11-11: Targeted safety events from a phase I/Ib study evaluating GDC-0077 alone and in combination with endocrine therapy (ET) ± palbociclib (palbo) in patients (pts) withPIK3CA-mutant (mut), hormone receptor-positive/HER2-negative metastatic breast cancer (HR+/HER2- mBC)


A single droplet digital PCR for ESR1 activating mutations detection in plasma

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Comprehensive Molecular Profiling of Desmoplastic Small Round Cell Tumor


BRAF in the cross-hairs

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Glucokinase activating mutation causing hypoglycaemia diagnosed late in adult who fasts for Ramadhan


Clinical Significance of Telomerase Reverse-Transcriptase Promoter Mutations in Hepatocellular Carcinoma

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Neuroblastoma Molecular Risk-Stratification of DNA Copy Number and ALK Genotyping via Cell-Free Circulating Tumor DNA Profiling


The role of Anti-PD-1/PD-L1 monotherapy as first-line treatment of metastatic NSCLC without targetable mutations and PD-L1 TPS 1–49%

Activating Mutation sentence examples within Constitutive Activating Mutation



Systemic Jak1 activation causes extrarenal calcitriol production and skeletal alterations provoking stunted growth


Jak1/Stat3 Activation Alters Phosphate Metabolism Independently of Sex and Extracellular Phosphate Levels.

Activating Mutation sentence examples within Novo Activating Mutation



Early-onset pulmonary and cutaneous vasculitis driven by constitutively active SRC-family kinase HCK.


STAT3 Gain-of-Function Mutations Underlie Deficiency in Human Nonclassical CD16+ Monocytes and CD141+ Dendritic Cells.

Activating Mutation sentence examples within Nra Activating Mutation



Identification of a novel CTNNA1 germline mutation predisposing to melanoma: Genotype and functional effects.


RAF1 amplification drives a subset of bladder tumors and confers sensitivity to MAPK-directed therapeutics.

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Unperturbed dormancy recording reveals stochastic awakening strategies in endocrine treated breast cancer cells


Abstract CT189: Characterization ofESR1mutations at metastatic relapse and outcome under first line aromatase inhibitor and palbociclib in the PADA-1 trial

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Abstract 1100: Gain and loss of function genome-wide CRISPR screens identify Hippo signaling as an important driver of resistance inEGFRmutant lung cancer


Drugging the Undruggable: Advances on RAS Targeting in Cancer

Activating Mutation sentence examples within Notch1 Activating Mutation



ETV6-NCOA2 fusion induces T/Myeloid mixed-phenotype leukemia by transformation of non-thymic hematopoietic progenitors.


Precursor Lymphoid Neoplasms

Activating Mutation sentence examples within Constitutively Activating Mutation



Ripretinib and MEK Inhibitors Synergize to Induce Apoptosis in Preclinical Models of GIST and Systemic Mastocytosis


Paramount Importance of Core Conformational Changes for Heparin Allosteric Activation of Antithrombin.

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ALL-043: Selective Blockade of Oncogenic NOTCH1 with the New SERCA Inhibitor CAD204520 in T-cell Acute Lymphoblastic Leukemia


A Primer on the Biology of MDS

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Клинические случаи применения иммунотерапии пембролизумабом у пациентов с немелкоклеточным раком легкого и высоким уровнем экспрессии PD-L1 в первой линии терапии


Pembrolizumab for First-Line Treatment of Advanced Non-Small-Cell Lung Cancer: Analysis of Prognostic Factors of Outcomes.

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Activating Mutation 돌연변이 활성화


Activating Mutation 돌연변이 활성화
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