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1 Mice sentence examples within collagen induced arthritis

collagen induced arthritis
콜라겐 유발 관절염

Methods: Collagen-induced arthritis was induced in DBA1 mice by immunization and booster with bovine collagen type II (CII).

방법: DBA1 마우스에서 소 콜라겐 유형 II(CII)로 면역화 및 부스터를 통해 콜라겐 유발 관절염을 유도하였다.

AB0109 SYSTEMIC OVEREXPRESSION OF INTERLEUKIN-22 INDUCES EXPRESSION OF THE NEGATIVE IMMUNE-REGULATOR SOCS3 AND POTENTLY REDUCES COLLAGEN-INDUCED ARTHRITIS IN MICE

collagen induced arthritis
콜라겐 유발 관절염

DBA/1 mice were induced with collagen-induced arthritis (CIA) and treated with purified eosinophils at different time points.

DBA/1 마우스를 콜라겐 유발 관절염(CIA)으로 유도하고 다양한 시점에서 정제된 호산구를 처리했습니다.

Eosinophils attenuate arthritis by inducing M2 macrophage polarization via inhibiting the IκB/P38 MAPK signaling pathway.

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1 Mice sentence examples within 8 week old

8 week old
8주

The goal of this study was to investigate Cannabidiol (CBD) hepatotoxicity in 8-week-old male B6C3F1 mice.

이 연구의 목표는 8주령 수컷 B6C3F1 마우스에서 칸나비디올(CBD) 간독성을 조사하는 것이었습니다.

Hepatotoxicity of a Cannabidiol-Rich Cannabis Extract in the Mouse Model

8 week old
8주

Methods: An intrapancreatic infusion of 150 µL of acetic acid or sham was performed on 8-week old CD1 mice.

방법: 8주령 CD1 마우스에 150 μL의 아세트산 또는 가짜의 췌장 내 주입을 수행했습니다.

1136-P: Chemical Pancreatectomy as a Revolutionary Therapy for Chronic Pancreatitis and Prevention of Type 3C Diabetes

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1 Mice sentence examples within high fat diet

high fat diet
고지방 다이어트

We have described that obesity induced by high-fat diet (HFD) reduces infarct size in B6D2F1 mice submitted to transient coronary occlusion.

우리는 고지방식이(HFD)에 의해 유도된 비만이 일시적인 관상동맥 폐색에 제출된 B6D2F1 마우스에서 경색 크기를 감소시킨다는 것을 설명했습니다.

High-fat diet improves tolerance to myocardial ischemia by delaying normalization of intracellular PH at reperfusion.

high fat diet
고지방 다이어트

Late-adult male and female ICR/CD1 mice (28 weeks old) were fed either a high-fat diet or a standard diet during 14 weeks.

후기 성체 수컷 및 암컷 ICR/CD1 마우스(28주령)는 14주 동안 고지방식이나 표준식이를 먹였습니다.

Impacts of the late adulthood diet-induced obesity onset on behavior, immune function, redox state and life span of male and female mice

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1 Mice sentence examples within 20 mg kg

20 mg kg
20mg kg

In the study, CD-1 mice were immune-primed with chronic corticosterone treatment (20 mg/kg IP) for two weeks and were subsequently subjected to one bout of 6 hr SD.

연구에서 CD-1 마우스는 2주 동안 만성 코르티코스테론 치료(20mg/kg IP)로 면역 프라이밍된 후 6시간 SD의 한 시합을 받았습니다.

TARGETING THE NLRP3 INFLAMMASOME IN MECHANISMS OF SLEEP DEPRIVATION-INDUCED NEUROINFLAMMATION

20 mg kg
20mg kg

OF1 mice (48 female and 48 male) were conditioned in the CPP paradigm with cocaine (20 mg/kg) and were exposed to an extinction program.

OF1 마우스(48 암컷 및 48 수컷)는 CPP 패러다임에서 코카인(20 mg/kg)으로 조절되었고 멸종 프로그램에 노출되었습니다.

The negative allosteric modulator of mGluR5, MPEP, potentiates the rewarding properties of cocaine in priming-induced reinstatement of CPP.

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1 Mice sentence examples within 100 mg kg

100 mg kg
100mg kg

Methods Female CD-1 mice received iron dextran (Fe-D) 100 mg/kg intraperitoneally for 14 days as previously shown to produce vastly supranormal iron concentrations in serum, liver, and spleen (ASM Microbe 2019 abstract HMB-373).

방법 암컷 CD-1 마우스는 이전에 혈청, 간 및 비장에서 매우 비정상적인 철 농도를 생성하는 것으로 나타난 바와 같이 14일 동안 100mg/kg의 철 덱스트란(Fe-D)을 복강내 투여했습니다(ASM Microbe 2019 abstract HMB-373).

1553. Human-Simulated Pharmacokinetic Profiles of Cefiderocol and Meropenem Are Conserved in Murine Models of Thigh Infection With or Without Iron Overload

100 mg kg
100mg kg

Methods Female CD-1 mice received iron dextran 100 mg/kg/d for 14 d to induce iron overload (Fe+) (ASM Microbe 2019 abstract HMB-373); an equal number of same-age mice were not dosed (NFe).

방법 암컷 CD-1 마우스는 철 과부하(Fe+)를 유도하기 위해 14일 동안 철 덱스트란 100mg/kg/d를 제공받았습니다(ASM Microbe 2019 abstract HMB-373). 동일한 수의 동년배 마우스에는 투여되지 않았습니다(NFe).

1544. Efficacy of Human-Simulated Cefiderocol Exposure Against Gram-Negative Bacteria in an Iron-Overloaded Murine Thigh Infection Model

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1 Mice sentence examples within amyloid precursor protein

amyloid precursor protein
아밀로이드 전구체 단백질

The present study investigated the beneficial effects of treadmill exercise on amyloid-β (Aβ) deposition and cognitive function in amyloid precursor protein (APP)/PS1 mice in the early stage of AD progression and microglia-mediated neuroinflammation was mainly analyzed.

본 연구에서는 알츠하이머병 진행의 초기 단계에서 아밀로이드 전구체 단백질(APP)/PS1 마우스의 아밀로이드-β(Aβ) 침착 및 인지 기능에 대한 트레드밀 운동의 유익한 효과를 조사하고 소교세포 매개 신경염증을 주로 분석했습니다.

Treadmill Exercise Decreases Aβ Deposition and Counteracts Cognitive Decline in APP/PS1 Mice, Possibly via Hippocampal Microglia Modifications

amyloid precursor protein
아밀로이드 전구체 단백질

In this study, we set out to examine the link between the inflammatory, metabolic and iron‐retentive signature of microglia in vitro and in transgenic mice that overexpress the amyloid precursor protein (APP) and presenilin 1 (PS1; APP/PS1 mice), a commonly used animal model of AD.

이 연구에서 우리는 시험관 내에서 그리고 아밀로이드 전구체 단백질(APP)과 프레세닐린 1(PS1; APP/PS1 마우스)을 과발현하는 형질전환 마우스에서 소교세포의 염증성, 대사성 및 철 보유 특성 사이의 연관성을 조사하기 시작했습니다. 일반적으로 사용되는 AD의 동물 모델.

Iron accumulation in microglia triggers a cascade of events that leads to altered metabolism and compromised function in APP/PS1 mice

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1 Mice sentence examples within short term memory

short term memory
단기 기억

In TgMAPT;TgBIN1 mice short-term memory deficits appeared earlier than in TgMAPT mice; however—unlike TgMAPT mice—TgMAPT;TgBIN1 mice did not exhibit any long-term or spatial memory deficits for at least 15 months.

TgMAPT;TgBIN1 마우스에서 단기 기억 결손이 TgMAPT 마우스보다 일찍 나타났습니다. 그러나 TgMAPT 마우스와 달리 TgMAPT;TgBIN1 마우스는 최소 15개월 동안 장기 또는 공간 기억 결핍을 나타내지 않았습니다.

BIN1 recovers tauopathy-induced long-term memory deficits in mice and interacts with Tau through Thr348 phosphorylation

short term memory
단기 기억

We found that APP/PS1 mice as old as 15-16 months had improved performance on the object replacement and Y-maze tests of short-term memory, measured at one day after anti-Ly6G treatment.

우리는 15-16개월 된 APP/PS1 마우스가 항-Ly6G 치료 후 하루에 측정된 단기 기억의 개체 교체 및 Y-미로 테스트에서 성능이 향상되었음을 발견했습니다.

Increasing cerebral blood flow improves cognition into late stages in Alzheimer’s disease mice

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1 Mice sentence examples within 3 month old

3 month old
3개월

The elevation of Rac1 activity not only accelerated 6-hour spatial memory decay in 3-month-old APP/PS1 mice, but also significantly contributed to severe memory loss in aged APP/PS1 mice.

Rac1 활성의 상승은 3개월 된 APP/PS1 마우스에서 6시간 공간 기억 감퇴를 가속화할 뿐만 아니라 노화된 APP/PS1 마우스에서 심각한 기억 상실에 크게 기여했습니다.

Inhibition of Rac1-dependent forgetting alleviates memory deficits in animal models of Alzheimer’s disease

3 month old
3개월

The APP/PS1 mice began to show cognitive decline at 3 months of age and MCT4 in the hippocampus of 2- and 3-month old APP/PS1 mice was higher than that of C57 mice.

APP/PS1 마우스는 3개월령에 인지 저하를 나타내기 시작했고 2개월 및 3개월령 APP/PS1 마우스의 해마에서 MCT4는 C57 마우스보다 높았다.

Role of monocarboxylate transporter 4 in Alzheimer disease.

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1 Mice sentence examples within 40 mg kg

40 mg kg
40mg kg

Methods: A total of 40 pregnant CD-1 mice were randomly and averagely assigned into four groups: control group (corn oil) and low, middle and high BPA-exposed groups (the poisonous doses were 8 mg/kg, 40 mg/kg, and 200 mg/kg, respectively) by random number table method.

방법: 임신한 CD-1 생쥐 총 40마리를 무작위로 평균적으로 대조군(옥수수 기름)과 BPA 저, 중, 고 BPA에 노출된 그룹(독성 용량은 8 mg/kg, 40 mg/kg)의 4개 그룹으로 할당했습니다. , 및 각각 200 mg/kg) 난수표 방법에 의해.

[The role of hypothalamus polycomb gene methylation in bisphenol A exposure during pregnancy and premature puberty in female offspring].

40 mg kg
40mg kg

Methods: IGT was induced in CD-1 mice by a) diet-induced insulin resistance (Western Diet, WD; 40% kcal from fat), or b) streptozotocin injection (STZ; 2x 40 mg/kg) to reduce circulating insulin.

방법: CD-1 마우스에서 IGT는 a) 식이 유도 인슐린 저항성(Western Diet, WD; 지방에서 40% kcal), 또는 b) 순환 인슐린을 줄이기 위한 스트렙토조토신 주사(STZ; 2x 40 mg/kg)에 의해 유도되었습니다.

726-P: Impaired Glucose Tolerance Blunts Exercise-Training Induced Improvements in Aerobic Exercise Capacity

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1 Mice sentence examples within 10 mg kg

10 mg kg
10mg kg

To circumvent the indirect uterine effect from ovarian toxicity of DOX and to investigate potential long-term impact of DOX on the uterus, young adult ovariectomized CD-1 mice were given an intraperitoneal injection once with PBS or DOX (10 mg/kg, a human relevant chemotherapeutic dose), and 30 days later, each set of mice was randomly assigned into three groups and subcutaneously injected with oil, 17β-estradiol (E2, for 6 h), and progesterone (P4, for 54 h), respectively.

DOX의 난소 독성으로 인한 간접적인 자궁 효과를 피하고 자궁에 대한 DOX의 잠재적인 장기적 영향을 조사하기 위해 젊은 성인 난소 절제된 CD-1 마우스에게 PBS 또는 DOX(10 mg/kg, 인간 관련 화학 요법 용량), 30일 후 각 마우스 세트를 무작위로 세 그룹으로 지정하고 각각 오일, 17β-에스트라디올(E2, 6시간) 및 프로게스테론(P4, 54시간)을 피하 주사했습니다.

Chemotherapeutic agent doxorubicin alters uterine gene expression in response to estrogen in ovariectomized CD-1 adult mice†.

10 mg kg
10mg kg

Sixty CD-1 mice were randomly divided into sham, vehicle, and JWH133-treated groups (1 mg/kg and 10 mg/kg).

60마리의 CD-1 마우스를 무작위로 가짜, 비히클 및 JWH133 처리 그룹(1 mg/kg 및 10 mg/kg)으로 나누었습니다.

JWH133, a Cannabinoid receptor-2 agonist, attenuates neurological deficits and brain oedema after experimental Intracerebral Haemorrhage in mice

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1 Mice sentence examples within 150 mg kg

150 mg kg
150mg/kg

Two days after MI, adult male CD1 mice were randomized to three groups, for four to eight weeks of oral treatment with vehicle (MI + vehicle), firibastat (150 mg/kg; MI + firibastat) or the angiotensin I converting enzyme inhibitor enalapril (1 mg/kg; MI + enalapril) as a positive control.

MI 후 2일 후, 성체 수컷 CD1 마우스를 4~8주 동안 비히클(MI+vehicle), 피리바스타트(150mg/kg; MI+피리바스타트) 또는 안지오텐신 I 전환 효소 억제제인 ​​에날라프릴로 경구 치료하는 3개 그룹으로 무작위 배정했습니다. (1mg/kg; MI+enalapril) 양성 대조군으로.

Brain renin-angiotensin system blockade with orally active aminopeptidase A inhibitor prevents cardiac dysfunction after myocardial infarction in mice.

150 mg kg
150mg/kg

Methods and Results: In a PK study in CD-1 mice, rucaparib demonstrated limited brain penetration after a single oral dose of 150 mg/kg, with a mean free brain-to-plasma AUC ratio (Kpuu, brain) of 0.

방법 및 결과: CD-1 마우스를 대상으로 한 PK 연구에서 루카파립은 150mg/kg의 단일 경구 투여 후 제한된 뇌 침투를 나타내었으며 평균 유리 뇌 대 혈장 AUC 비율(Kpuu, 뇌)은 0입니다.

Abstract 3888: Intracranial evaluation of the in vivo pharmacokinetics, brain distribution, and efficacy of rucaparib inBRCA-mutant, triple-negative breast cancer

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1 Mice sentence examples within blood brain barrier

blood brain barrier
혈액 뇌 장벽

Blood-brain-barrier studies in Sprague-Dawley rats and CD-1 mice indicated that the major components of PTI-00703 cat’s claw crossed the blood-brain-barrier and entered the brain parenchyma within 2 minutes of being in the blood.

Sprague-Dawley 쥐와 CD-1 쥐를 대상으로 한 혈액뇌장벽 연구에서 PTI-00703 고양이 발톱의 주요 성분이 혈액뇌장벽을 통과하여 혈액에 들어간 지 2 분 이내에 뇌실질에 들어간 것으로 나타났습니다.

The Amazon rain forest plant Uncaria tomentosa (cat’s claw) and its specific proanthocyanidin constituents are potent inhibitors and reducers of both brain plaques and tangles

blood brain barrier
혈액 뇌 장벽

Treatment with lentivirus-mediated overexpression of miR-124 or the C1q inhibitor C1INH rescued breakdown of blood-brain barrier, promoted angiogenesis and reduced Aβ deposition, and finally alleviated learning and memory deficit in APP/PS1 mice.

miR-124 또는 C1q 억제제 C1INH의 렌티바이러스 매개 과발현을 사용한 치료는 혈액-뇌 장벽의 붕괴를 구출하고, 혈관신생을 촉진하고 Aβ 침착을 감소시켰으며, 최종적으로 APP/PS1 마우스의 학습 및 기억 결핍을 완화했습니다.

miR-124 regulates cerebromicrovascular function in APP/PS1 transgenic mice via C1ql3

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1 Mice sentence examples within 20 µg kg

20 µg kg
20 µg kg

Male Wistar rats and B6CBAF1 mice treated with CT-1 (20 µg/kg per day) presented higher cardiac Gal-3 levels and myocardial fibrosis.

CT-1(하루 20μg/kg)으로 처리된 수컷 Wistar 쥐와 B6CBAF1 마우스는 더 높은 심장 Gal-3 수치와 심근 섬유증을 나타냈다.

CT-1 (Cardiotrophin-1)-Gal-3 (Galectin-3) Axis in Cardiac Fibrosis and Inflammation: Mechanistic Insights and Clinical Implications

20 µg kg
20 µg kg

Adult female CD-1 mice (39-40 days) were orally dosed with vehicle control (corn oil), DEHP (20 µg/kg/day-200 mg/kg/day), or DiNP (20 µg/kg/day-200 mg/kg/day) for 10 days.

성체 암컷 CD-1 마우스(39-40일)에 비히클 대조군(옥수수 기름), DEHP(20μg/kg/day-200mg/kg/day) 또는 DiNP(20μg/kg/day- 10일 동안 200mg/kg/일).

Subchronic Exposure to Di(2-ethylhexyl) Phthalate and Diisononyl Phthalate During Adulthood Has Immediate and Long-Term Reproductive Consequences in Female Mice

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1 Mice sentence examples within control treatment corn

control treatment corn
제어 처리 옥수수

CD-1 mice (F0) were orally exposed to control treatment (corn oil), BPA, BPE or BPS (0.

CD-1 마우스(F0)는 대조군 처리(옥수수 기름), BPA, BPE 또는 BPS(0.

Prenatal exposure to bisphenol A, E and S induces transgenerational effects on female reproductive functions in mice.

control treatment corn
제어 처리 옥수수

CD-1 mice (F0) were orally exposed to control treatment (corn oil), BPA, BPE or BPS (0.

CD-1 마우스(F0)는 대조군 처리(옥수수 기름), BPA, BPE 또는 BPS(0.

Prenatal exposure to bisphenol A, E and S induces transgenerational effects on male reproductive functions in mice.

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1 Mice sentence examples within 6 wild type

6 wild type
6 야생형

HERV-K(HML-2) RNA introduced extracellularly into the cerebrospinal fluid (CSF) of either C57BL/6 wild-type mice or APPPS1 mice, a mouse model for Alzheimer’s disease (AD), resulted in neurodegeneration.

C57BL/6 야생형 마우스 또는 알츠하이머병(AD) 마우스 모델인 APPPS1 마우스의 뇌척수액(CSF)에 HERV-K(HML-2) RNA가 세포외로 도입되어 신경변성이 발생했습니다.

Human endogenous retrovirus HERV-K(HML-2) RNA causes neurodegeneration through Toll-like receptors

6 wild type
6 야생형

METHODS Brain and lung transporter expression were quantified in C57BL/6 wild-type (WT) and Fat1 mice.

행동 양식 C57BL/6 야생형(WT) 및 Fat1 마우스에서 뇌 및 폐 수송체 발현을 정량화하였다.

Developmental Accretion of Docosahexaenoic Acid Is Independent of Fatty Acid Transporter Expression in Brain and Lung Tissues of C57BL/6 and Fat1 Mice.

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1 Mice sentence examples within 50 mg kg

50 mg kg
50mg kg

Adult male CF-1 mice were exposed to GlyBH IN administration (equivalent to 50 mg/kg/day of Gly acid, 3 days a week, during 4 weeks).

성체 수컷 CF-1 마우스는 GlyBH IN 투여에 노출되었습니다(4주 동안 50mg/kg/day의 Gly acid, 주 3일).

Intranasal Glyphosate-Based Herbicide Administration Alters the Redox Balance and the Cholinergic System in the Mouse Brain

50 mg kg
50mg kg

CD-1 mice were treated with chronic unpredictable mild stress (CUMS) process and orally administrated with sesamin (50 mg/kg/d) for 6 weeks.

CD-1 마우스는 만성 예측할 수 없는 가벼운 스트레스(CUMS) 과정으로 처리되었고 세사민(50mg/kg/d)을 6주 동안 경구 투여했습니다.

(+)-Sesamin attenuates chronic unpredictable mild stress-induced depressive-like behaviors and memory deficits via suppression of neuroinflammation.

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1 Mice sentence examples within transgenic mouse model

transgenic mouse model
유전자 변형 마우스 모델

Here, we used a transgenic mouse model of AD that expresses a mutant amyloid-β precursor protein (T41 mice) to investigate the effects of dactolisib (alternative name: NVP-BEZ235, abbreviation BEZ), a dual PI3K/mTOR inhibitor.

여기에서 우리는 이중 PI3K/mTOR 억제제인 ​​dactolisib(대체명: NVP-BEZ235, 약어 BEZ)의 효과를 조사하기 위해 돌연변이 아밀로이드-β 전구체 단백질(T41 마우스)을 발현하는 AD의 형질전환 마우스 모델을 사용했습니다.

NVP-BEZ235 (Dactolisib) Has Protective Effects in a Transgenic Mouse Model of Alzheimer’s Disease

transgenic mouse model
유전자 변형 마우스 모델

Here we describe: (i) a novel human tau-expressing transgenic mouse model, TghTau/PS1, to study repetitive mild closed head injury (rmCHI), (ii) quantitative comparison of T-tau and P-tau from brain and plasma in TghTau/PS1 mice over a 12 month period following rmCHI (and sham), (iii) the usefulness of P-tau as an early- and late-stage blood-based biochemical biomarker for rmCHI, (iii) the influence of kinase-targeted therapeutic intervention on rmCHI-associated cognitive deficits using a combination of lithium chloride (LiCl) and R-roscovitine (ros), and (iv) correlation of behavioral and cognitive changes with concentrations of the brain and blood-based T-tau and P-tau.

여기에서 우리는 다음과 같이 설명합니다: (i) 새로운 인간 타우 발현 형질전환 마우스 모델, TghTau/PS1, 반복적인 가벼운 폐쇄 두부 손상(rmCHI) 연구, (ii) 뇌 및 혈장에서 T-타우 및 P-타우의 정량적 비교 rmCHI(및 sham) 후 12개월 동안의 TghTau/PS1 마우스, (iii) rmCHI에 대한 초기 및 후기 단계 혈액 기반 생화학적 바이오마커로서 P-tau의 유용성, (iii) 키나제 표적화의 영향 염화리튬(LiCl)과 R-로스코비틴(ros)의 조합을 사용한 rmCHI 관련 인지 장애에 대한 치료적 개입, (iv) 행동 및 인지 변화와 뇌 및 혈액 기반 T-타우 및 P-농도의 상관 관계 타우.

Novel Mouse Tauopathy Model for Repetitive Mild Traumatic Brain Injury: Evaluation of Long-Term Effects on Cognition and Biomarker Levels After Therapeutic Inhibition of Tau Phosphorylation

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1 Mice sentence examples within μg kg day

μg kg day
μg kg 일

Pregnant CD-1 mice were orally dosed daily with either tocopherol-stripped corn oil or DEHP (20 or 200 μg/kg/day; 500 or 750 mg/kg/day) from gestational day 10.

임신한 CD-1 마우스는 임신 10일부터 토코페롤이 제거된 옥수수 기름 또는 DEHP(20 또는 200μg/kg/일, 500 또는 750mg/kg/일)를 매일 경구 투여했습니다.

Exposure to di-(2-ethylhexyl) phthalate transgenerationally alters anxiety-like behavior and amygdala gene expression in adult male and female mice

μg kg day
μg kg 일

In our first study, pregnant CD-1 mice were orally exposed to BPS (2 or 200 μg/kg/day) starting on pregnancy day 9 through lactation day 20, and male mammary glands were evaluated on embryonic day 16, prior to puberty, and in early adulthood.

우리의 첫 번째 연구에서, 임신한 CD-1 마우스는 임신 9일부터 수유일 20일까지 BPS(2 또는 200 μg/kg/day)에 경구 노출되었고 수컷 유선은 사춘기 이전의 배아 16일째에 평가되었습니다. 그리고 초기 성인기에.

Bisphenol S alters development of the male mouse mammary gland and sensitizes it to a peripubertal estrogen challenge.

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1 Mice sentence examples within 7 month old

7 month old
7개월

Male 7-month-old SAMP8 and SAMR1 mice (senescence-accelerated mouse resistant 1) were randomly divided into 3 groups: SAMR1 control group (Rc), SAMP8 control group (Pc), and SAMP8 electroacupuncture group (Pe).

7개월 된 수컷 SAMP8 및 SAMR1 마우스(노화 가속 마우스 내성 1)를 무작위로 SAMR1 대조군(Rc), SAMP8 대조군(Pc) 및 SAMP8 전기침술군(Pe)의 3개 그룹으로 나누었습니다.

Electroacupuncture Improves Synaptic Function in SAMP8 Mice Probably via Inhibition of the AMPK/eEF2K/eEF2 Signaling Pathway

7 month old
7개월

We used 7-month-old APP/PS1 mice to determine whether albiflorin is capable of protecting against Alzheimer's disease.

우리는 7개월 된 APP/PS1 마우스를 사용하여 알비플로린이 알츠하이머병으로부터 보호할 수 있는지 여부를 확인했습니다.

Albiflorin ameliorates memory deficits in APP/PS1 transgenic mice via ameliorating mitochondrial dysfunction

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1 Mice sentence examples within week old male

week old male
일주일 된 남성

Methods: Arthritis was induced in 8-10 week old male DBA/1 mice by immunization with collagen type-II (CII) and complete Freund’s adjuvant.

방법: 8-10주령의 수컷 DBA/1 마우스에서 II형 콜라겐(CII)과 완전 프로인트 보조제로 관절염을 유도하였다.

SAT0044 HIGH THERAPEUTIC EFFICACY OF ORAL RAS INHIBITORS IN COLLAGEN INDUCED ARTHRITIS: INHIBITION OF RELEVANT MAP-KINASES AND THE CONSEQUENT INDUCTION OF AUTOREACTIVE PATHOGENIC T CELLS AND AUTOANTIBODIES

week old male
일주일 된 남성

MATERIALS AND METHODS Eight-week-old male apoE-/- mice were randomly assigned to the following 3 groups: (i) subtotally nephrectomised (SNX apoE-/-, 12 mice), (ii) uninephrectomised (UNX apoE-/-, 11 mice) or (iii) sham operated (sham-op apoE-/-, 15 mice).

재료 및 방법 8주령 수컷 apoE-/- 마우스를 다음 3개 그룹에 무작위로 할당했습니다: (i) 부분적으로 신장 절제된(SNX apoE-/-, 12마리), (ii) 신장이 절제되지 않은(UNX apoE-/-, 11마리) 또는 (iii) 가짜 조작(sham-op apoE-/-, 15마리 마우스).

Calcification of the cavernosal bodies may be responsible for development of erectile dysfunction in uremic apolipoprotein E deficient (apoE-/-) mice.

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1 Mice sentence examples within 200 mg kg

200 mg kg
200mg/kg

CD2F1 mice were injected subcutaneously with either vehicle or single dose of GT3 (200 mg/kg body weight) 24 hours before irradiation followed by oral or subcutaneous administration of various doses of simvastatin (25, 50, and 100 mg/kg body weight) before exposure to lethal doses (11.

CD2F1 마우스에 방사선 조사 24시간 전에 비히클 또는 단일 용량의 GT3(200mg/kg 체중)을 피하 주사한 후 다양한 용량의 심바스타틴(25, 50 및 100mg/kg 체중)을 경구 또는 피하 투여했습니다. 치사량에 대한 노출(11.

Enhanced Survival in Mice Exposed to Ionizing Radiation by Combination of Gamma-Tocotrienol and Simvastatin.

200 mg kg
200mg/kg

Methods In mice, we gave 200 mg/kg tea polyphenol ((-)-epigallocatechin-3-gallate (EGCG) or theaflavin) to CD-1 mice, 129/SvEv specific-pathogen-free (SPF) mice, or germ-free (GF) mice.

행동 양식 생쥐에서 우리는 CD-1 생쥐, 129/SvEv 특이적 병원균이 없는(SPF) 생쥐 또는 무균 생쥐에게 200mg/kg 차 폴리페놀((-)-에피갈로카테킨-3-갈레이트(EGCG) 또는 테아플라빈)을 투여했습니다. (GF) 마우스.

Microbiota Facilitates the Formation of the Aminated Metabolite of Tea Polyphenols Which Trap Deleterious Reactive Endogenous Metabolites (P06-022-19).

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1 Mice sentence examples within 75 mg kg

75 mg kg
75mg kg

Adult CF-1 mice were treated intraperitoneally with saline or NMDA (75 mg/kg), and some mice were treated intracerebroventricularly (i.

성체 CF-1 마우스는 생리식염수 또는 NMDA(75mg/kg)로 복강 내 치료했으며 일부 마우스는 뇌실 내 치료(i.

Adenosine and NMDA Receptors Modulate Neuroprotection-Induced NMDA Preconditioning in Mice

75 mg kg
75mg kg

Materials and methods: Immature female CD-1 mice were orally treated with vehicle (Control, n = 10) or genistein (75 mg/kg, n = 10) or 8PG with low (8PG-L, 75 mg/kg, n = 10) and high dose (8PG-H, 150 mg/kg, n = 10) for 7 consecutive days by intragastric gavage.

재료 및 방법: 미성숙 암컷 CD-1 마우스를 비히클(대조군, n = 10) 또는 제니스테인(75 mg/kg, n = 10) 또는 낮은 8PG(8PG-L, 75 mg/kg, n =)로 경구 처리했습니다. 10) 및 위내 위관영양법에 의한 연속 7일 동안 고용량(8PG-H, 150 mg/kg, n = 10).

Differential effects of genistein and 8-prenylgenistein on reproductive tissues in immature female mice

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1 Mice sentence examples within mg kg body

mg kg body
mg kg 몸

5 mg/kg body weight were administered by intraperitoneal injection to groups of 10 pregnant CD-1 mice on the 7th gestational day, and animals were sacrificed on day 18 of gestation.

임신 7일째에 임신한 CD-1 마우스 10마리에 5mg/kg 체중을 복강내 주사하고, 임신 18일째에 동물을 희생시켰다.

Effect on the offspring of pregnant females CD-1 mice treated with a single thallium(I) application.

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1 Mice sentence examples within bovine collagen type

bovine collagen type
소 콜라겐 유형

MethodsDBA/1 mice were immunized by subcutaneous injection of bovine collagen type II, in order to initiate the development of collagen-induced arthritis (CIA).

방법DBA/1 마우스는 콜라겐 유도 관절염(CIA)의 발병을 시작하기 위해 소 콜라겐 유형 II의 피하 주사로 면역화되었습니다.

Photopheresis efficacy in the treatment of rheumatoid arthritis: a pre-clinical proof of concept

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1 Mice sentence examples within 500 mg kg

500 mg kg
500mg kg

The current investigation characterizes: 1) the absorption, distribution, metabolism, and excretion (ADME) of DMAE in Wistar Han rats and B6C3F1 mice following a single gavage or intravenous (IV) administration of 10, 100 or 500 mg/kg [14C]DMAE, and 2) the ADME of [14C]choline (160 mg/kg) and the effect on its disposition following pre-treatment with DMAE (100 or 500 mg/kg).

현재 조사의 특징은 다음과 같습니다. 1) 10, 100 또는 500mg/kg의 단일 위관 영양법 또는 정맥내(IV) 투여 후 Wistar Han 쥐와 B6C3F1 쥐에서 DMAE의 흡수, 분포, 대사 및 배설(ADME) [14C] DMAE, 및 2) [14C]콜린의 ADME(160mg/kg) 및 DMAE(100 또는 500mg/kg)로 전처리 후 처리에 미치는 영향.

Comparative disposition of dimethylaminoethanol and choline in rats and mice following oral or intravenous administration.

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1 Mice sentence examples within mg kg day

mg kg day

Thus, adult female CD-1 mice were orally exposed to vehicle control or methoxychlor at 32 and 64 mg/kg/day for 30 days.

따라서, 성체 암컷 CD-1 마우스는 30일 동안 32 및 64mg/kg/day의 비히클 대조군 또는 메톡시클로르에 경구 노출되었습니다.

Ovarian follicle resilience in mice orally dosed with methoxychlor: Are reproductive impacts possible in mammals as ecological receptors?

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1 Mice sentence examples within kg body weight

kg body weight

Methods Male CF-1 mice (5 weeks of age, N = 10 per group) were per orally administered fluoxetine (20 mg per kg body weight) or diluent daily for 29 days.

방법 수컷 CF-1 마우스(5주령, 그룹당 N = 10)에게 플루옥세틴(체중 kg당 20mg) 또는 희석제를 29일 동안 매일 경구 투여했습니다.

Fluoxetine-induced alteration of murine gut microbial community structure: evidence for a microbial endocrinology-based mechanism of action responsible for fluoxetine-induced side effects

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1 Mice sentence examples within µg kg day

µg kg day

Female CD1 mice were dosed orally with DEHP (0, 20, 200 and 2000 µg/kg/day) for 30 days.

암컷 CD1 마우스에 DEHP(0, 20, 200 및 2000μg/kg/day)를 30일 동안 경구 투여했습니다.

Alterations in oocytes and early zygotes following oral exposure to di(2-ethylhexyl) phthalate in young adult female mice.

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1 Mice sentence examples within Group 1 Mice

Group 1 Mice
그룹 1 마우스

The control group was immunized with rOmp22 alone, while group 1 mice were injected subcutaneously with rOmp22 along with conventional adjuvants (FCA, FIA), and group 2 mice with rOmp22 mixed with rDnaJ.

대조군은 rOmp22 단독으로 면역화시킨 반면, 그룹 1 마우스에는 통상적인 보조제(FCA, FIA)와 함께 rOmp22를 피하 주사하였고, 그룹 2 마우스에는 rDnaJ와 혼합된 rOmp22를 주입하였다.

Evaluation of immuno-modulating effect of recombinant heat shock protein 40 of Brucella abortus in mice

Group 1 Mice
그룹 1 마우스

Group 1 mice consumed plain drinking water throughout the trial.

그룹 1 마우스는 실험 내내 일반 식수를 섭취했습니다.

Emu Oil reduces disease severity in a mouse model of chronic ulcerative colitis

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1 Mice sentence examples within 1 mice received

1 mice received
1 마우스 수신

In strategy 1 mice received ADR once weekly for 4 weeks and were then administered CSF1R inhibitor (PLX5622) starting 72 h post-ADR treatment.

전략 1에서 마우스는 4 주 동안 매주 1회 ADR을 받은 다음 ADR 처리 후 72시간 동안 CSF1R 억제제(PLX5622)를 투여했습니다.

Attenuation of neuroinflammation reverses Adriamycin-induced cognitive impairments

1 mice received
1 마우스 수신

64 CD-1 mice received the AuNPs by intraperitoneal injection.

64마리의 CD-1 마우스는 복강내 주사에 의해 AuNPs를 받았다.

Biodistribution and Physiologically-Based Pharmacokinetic Modeling of Gold Nanoparticles in Mice with Interspecies Extrapolation

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1 Mice sentence examples within 1 mice displayed

1 mice displayed
1 마우스 표시

Ifih1-m1 mice displayed virus-accelerated T1D, but NOD.

Ifih1-m1 마우스는 바이러스 가속 T1D를 나타내었지만 NOD.

1726-P: MDA5, a Janus-Faced dsRNA Sensor in Coxsackievirus-Accelerated Autoimmune Diabetes

1 mice displayed
1 마우스 표시

In contrast, isolated islets from Tg-Mt1 mice displayed impaired glucose-stimulated insulin secretion (GSIS).

대조적으로, Tg-Mt1 마우스에서 분리된 섬은 손상된 포도당 자극 인슐린 분비(GSIS)를 나타냈다.

Metallothionein 1 negatively regulates glucose-stimulated insulin secretion and is differentially expressed in conditions of beta cell compensation and failure in mice and humans

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1 Mice sentence examples within 1 mice compared

1 mice compared
1 마우스 비교

Additionally, clone-derived viruses produced identical infection rates and phenotypes in CD-1 mice compared to the parental strains.

또한, 클론 유래 바이러스는 부모 균주와 비교하여 CD-1 마우스에서 동일한 감염률 및 표현형을 생성했습니다.

Infectious cDNA clones of two strains of Mayaro virus for studies on viral pathogenesis and vaccine development.

1 mice compared
1 마우스 비교

In vivo fluorescence imaging successfully showed tumour tissues clearly both in TLR5+ and TLR5− 4T1 mice compared with lentivirus untreated 4T1 tumour.

생체내 형광 이미징은 렌티바이러스 미처리 4T1 종양과 비교하여 TLR5+ 및 TLR5- 4T1 마우스 모두에서 종양 조직을 성공적으로 명확하게 보여주었습니다.

TLR5 is a new reporter for triple‐negative breast cancer indicated by radioimmunoimaging and fluorescent staining

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1 Mice sentence examples within 1 mice showed

1 mice showed
1 마우스 표시

Previous toxicokinetic studies of arsenite ingestion in neonatal CD-1 mice showed consistent evidence for metabolic and physiologic immaturity that led to elevated internal exposures to trivalent arsenic species in the youngest mice, relative to adults.

신생아 CD-1 마우스에서 비소 섭취에 대한 이전의 독성 동태학적 연구는 성인에 비해 가장 어린 마우스에서 3가 비소 종에 대한 내부 노출을 증가시키는 대사 및 생리학적 미성숙에 대한 일관된 증거를 보여주었습니다.

Metabolism and disposition of arsenic species from controlled dosing with sodium arsenite in adult and neonatal rhesus monkeys. VI. Toxicokinetic studies following oral administration.

1 mice showed
1 마우스 표시

Tg-S1PR1 mice showed enhanced ligation-induced neointimal hyperplasia with increased neointimal cell proliferation, compared with control nTg mice.

Tg-S1PR1 마우스는 대조군 nTg 마우스와 비교하여 증가된 신생내막 세포 증식과 함께 결찰 유도된 신생내막 증식증을 나타내었다.