血管ストロークとは何ですか？
Vessel Stroke 血管ストローク - COVID-19 is associated with large and multi-vessel stroke in young people, often with non-CNS thrombotic disease and requires further study. [1] Among its various neurological presentations, cerebrovascular events often present as small-vessel strokes. [2] In conclusion, the dynamic microcirculatory stall phenomenon that is described after transient ischemia followed by reperfusion also occurs after permanent small- or large-vessel stroke and is clearly attributable to neutrophils. [3] Methods: Retrospective single-center study including patients with anterior circulation large-vessel stroke that achieved reperfusion after endovascular treatment. [4] MATERIALS AND METHODS A total of 103 patients with large-vessel stroke who were treated using thrombectomy alone at our institution between April 2019 and March 2021 were included in this study. [5] Background Following publication of trials demonstrating the efficacy of thrombectomy, societal guidelines were revised in 2015 to recommend this procedure for large-vessel stroke. [6] As a determinant of the progression rate of the ischaemic process in acute large-vessel stroke, the degree of collateralization is a strong predictor of the clinical outcome after reperfusion therapy and may influence clinical decision-making. [7] Neuroimaging revealed multifocal large-vessel strokes associated with cerebral edema; these infarcts led to herniation and death. [8] Consistent with this data, we show that polymorphisms in the ASIC1 gene locus are associated with myocardial infarction and small-vessel stroke in humans. [9] Background and Purpose— Hyperglycemia is a negative prognostic factor after acute ischemic stroke but is not known whether glucose is associated with the effects of endovascular thrombectomy (EVT) in patients with large-vessel stroke. [10] 0004), but not with small-vessel stroke or intracerebral hemorrhage. [11]COVID-19は、若者の大規模な多血管性脳卒中に関連しており、多くの場合、非CNS血栓性疾患を伴うため、さらなる研究が必要です。 [1] そのさまざまな神経学的症状の中で、脳血管イベントはしばしば小血管発作として現れます。 [2] 結論として、一過性脳虚血とそれに続く再灌流の後に説明される動的微小循環失速現象は、永続的な小血管または大血管の脳卒中の後にも発生し、明らかに好中球に起因します。 [3] 方法：血管内治療後に再灌流を達成した前循環大血管脳卒中の患者を含む遡及的単一施設研究。 [4] 材料および方法 2019年4月から2021年3月の間に当院で血栓摘出術のみを使用して治療された合計103人の大血管脳卒中患者がこの研究に含まれました。 [5] 背景血栓摘出術の有効性を実証する試験が発表された後、2015年に社会的ガイドラインが改訂され、大血管発作に対してこの手順が推奨されました。 [6] 急性大血管脳卒中における虚血過程の進行率の決定因子として、担保化の程度は再灌流療法後の臨床転帰の強力な予測因子であり、臨床的意思決定に影響を与える可能性があります。 [7] 神経画像検査により、脳浮腫に関連する多巣性大血管脳卒中が明らかになりました。これらの梗塞は、ヘルニアと死につながりました。 [8] このデータと一致して、ASIC1 遺伝子座の多型がヒトの心筋梗塞および小血管脳卒中と関連していることを示します。 [9] 背景と目的 高血糖は急性虚血性脳卒中後の予後不良因子ですが、大血管脳卒中患者の血管内血栓切除術（EVT）の影響にグルコースが関連しているかどうかは不明です。 [10] 0004)、小血管脳卒中または脳内出血を伴わない。 [11]
large artery stroke 大動脈脳卒中
All PRS for any stroke (AS), any ischemic stroke (AIS), large artery stroke (LAS), cardioembolic stroke (CES), and small vessel stroke (SVS) were constructed by PRSice-2. [1] 001) for large artery stroke; there was no association with small vessel stroke (odds ratio 0. [2] show that genetically altered levels of several coagulation factors are associated with ischaemic, cardioembolic, and large-artery stroke, but not small-vessel stroke. [3] We aimed to assess the causal association between TL, IS, and the subtypes of IS, including large artery stroke (LAS), small vessel stroke (SVS), and cardioembolic stroke (CES) by performing a series of two-sample Mendelian randomization (MR) approaches. [4] We then applied two-sample Mendelian randomization (MR) to explore associations with ischemic stroke and its major subtypes (large artery stroke, cardioembolic stroke, small vessel stroke) in the MEGASTROKE dataset (34,217 cases and 404,630 controls), with coronary artery disease in the CARDIoGRAMplusC4D dataset (60,801 cases and 123,504 control), and with other cardiovascular outcomes in the UK Biobank (up to 321,406 individuals) and in phenotype-specific GWAS datasets. [5] Genetic predisposition to smoking initiation (ever smoking regularly), based on up to 372 single‐nucleotide polymorphisms, was statistically significantly positively associated with any ischemic stroke, large artery stroke, and small vessel stroke but not cardioembolic stroke or intracerebral hemorrhage. [6] While neurologists agree on the delineation of ischemic stroke (IS) into the three most common subtypes (cardioembolic stroke (CES), large artery stroke (LAS), and small vessel stroke (SVS)), several different subtyping systems exist. [7] In order to explore the function of single-nucleotide polymorphisms (SNPs) at the molecular level, in this paper, we integrated 8 GWAS datasets with brain expression quantitative trait loci (eQTL) dataset to identify SNPs and genes which are related to four types of stroke (ischemic stroke, large artery stroke, cardioembolic stroke, small vessel stroke). [8]任意の脳卒中（AS）、任意の虚血性脳卒中（AIS）、大動脈脳卒中（LAS）、心臓塞栓性脳卒中（CES）、および小血管脳卒中（SVS）のすべてのPRSは、PRSice-2によって構築されました。 [1] 001) 大動脈脳卒中の場合。小血管の脳卒中との関連はありませんでした (オッズ比 0. [2] いくつかの凝固因子の遺伝的に変化したレベルが、虚血性、心塞栓性、および大動脈の脳卒中と関連しているが、小血管の脳卒中とは関連していないことを示しています。 [3] nan [4] nan [5] nan [6] nan [7] nan [8]
stroke cardioembolic stroke
05) of RHR with all ischemic stroke, cardioembolic stroke, and large-artery stroke in the random-effects inverse-variance weighted analysis; no association was observed with CAD or small vessel stroke (Figure). [1]05) ランダム効果逆分散加重分析におけるすべての虚血性脳卒中、心臓塞栓性脳卒中、および大動脈脳卒中を伴う RHR の; CADまたは小血管の脳卒中との関連は観察されませんでした（図）。 [1]
subtypes large artery サブタイプ 大動脈
Applying 2-sample Mendelian randomization, we examined associations with ischemic stroke (60,341 cases, 454,450 controls), intracerebral hemorrhage (1,545 cases, 1,481 controls), and ischemic stroke subtypes (large artery, cardioembolic, small vessel stroke), as well as with related phenotypes (carotid atherosclerosis, imaging markers of cerebral white matter integrity, and brain atrophy). [1]2サンプルのメンデルランダム化を適用して、虚血性脳卒中（60,341症例、454,450対照）、脳内出血（1,545症例、1,481対照）、および虚血性脳卒中サブタイプ（大動脈、心臓塞栓性、小血管脳卒中）との関連を調べました。関連する表現型（頸動脈アテローム性動脈硬化症、脳白質の完全性のイメージングマーカー、および脳萎縮）。 [1]
Small Vessel Stroke 小型容器のストローク
RESULTS Genetically predicted years of education was inversely associated with ischemic, large artery, and small vessel stroke, and intracerebral hemorrhage. [1] 4%), small vessel stroke; 1 (7. [2] Applying a 2-sample mendelian randomization approach, we examined the associations of circulating cTnI concentrations with stroke (40,585 cases and 406,111 controls), ischemic stroke (34,217 cases and 406,111 controls), ischemic stroke subtypes (cardioembolic, large artery, small vessel stroke), intracerebral hemorrhage (1,545 cases and 1,481 controls) and atrial fibrillation (60,620 cases and 970,216 controls). [3] Results: Small vessel strokes were the most common accounting for 51. [4] All PRS for any stroke (AS), any ischemic stroke (AIS), large artery stroke (LAS), cardioembolic stroke (CES), and small vessel stroke (SVS) were constructed by PRSice-2. [5] 9% of stroke cases in 2019 were small vessel stroke compared to 58. [6] Individuals with small vessel strokes were older, were more likely to have a higher current CD4 cell count than those with cardioembolic strokes and had the highest mean blood pressure of the ischemic stroke subtypes. [7] In subgroup analysis, the continuous PRS remained an independent predictor for large vessel and cardioembolic stroke subtypes but not for small vessel stroke. [8] They applied inverse variance‐weighted analysis, weighted median analysis, simple median analysis, and Mendelian randomization–Egger regression to evaluate the associations of HRV with white matter hyperintensity (WMH) and small vessel stroke (SVS) in the UK Biobank neuroimaging dataset and the MEGASTROKE genome‐wide association study dataset. [9] After adjusting for tobacco use and body mass index, multivariable MR analysis suggested a causal effect of cannabis use on small vessel stroke (SVS) [odds ratio (OR) 1. [10] Objective: We investigated the causality between modifiable risk factors and the risk of two cerebral small vessel disease phenotypes: small vessel stroke (SVS) and white matter hyperintensity (WMH). [11] The GenePanda algorithm had most GWAS-confirmable genes in top 200 predictions, while RWRH had best ranks for small vessel stroke-associated genes confirmed in GWAS. [12] Applying 2-sample Mendelian randomization, we examined associations with ischemic stroke (60,341 cases, 454,450 controls), intracerebral hemorrhage (1,545 cases, 1,481 controls), and ischemic stroke subtypes (large artery, cardioembolic, small vessel stroke), as well as with related phenotypes (carotid atherosclerosis, imaging markers of cerebral white matter integrity, and brain atrophy). [13] Secondary analyses of trial data and epidemiological studies suggest that tHcy levels may be particularly associated with small vessel stroke (SVS). [14] 001) for large artery stroke; there was no association with small vessel stroke (odds ratio 0. [15] We aimed to assess the causal relationship of major depressive disorder (MDD) with ischemic stroke, especially with the small vessel stroke (SVS) subtype. [16] Clopidogrel nonresponsiveness was much higher in small vessel stroke. [17] Applying two-sample MR, we examined associations with ischemic stroke, intracerebral hemorrhage, and ischemic stroke subtypes (large artery, cardioembolic, small vessel stroke; up to 60,341 cases and 454,450 controls). [18] 05) of RHR with all ischemic stroke, cardioembolic stroke, and large-artery stroke in the random-effects inverse-variance weighted analysis; no association was observed with CAD or small vessel stroke (Figure). [19] Consequently, CRAO with inner retinal infarction is a small vessel stroke, usually with the devastating consequence of severe visual loss in the affected eye. [20] 001) and a reduce in risk of small vessel stroke (odds ratio, 0. [21] We aimed to assess the causal association between TL, IS, and the subtypes of IS, including large artery stroke (LAS), small vessel stroke (SVS), and cardioembolic stroke (CES) by performing a series of two-sample Mendelian randomization (MR) approaches. [22] We then applied two-sample Mendelian randomization (MR) to explore associations with ischemic stroke and its major subtypes (large artery stroke, cardioembolic stroke, small vessel stroke) in the MEGASTROKE dataset (34,217 cases and 404,630 controls), with coronary artery disease in the CARDIoGRAMplusC4D dataset (60,801 cases and 123,504 control), and with other cardiovascular outcomes in the UK Biobank (up to 321,406 individuals) and in phenotype-specific GWAS datasets. [23] Under causative classification of stroke, 4 loci influenced both small vessel stroke and intracerebral hemorrhage. [24] Genetic predisposition to smoking initiation (ever smoking regularly), based on up to 372 single‐nucleotide polymorphisms, was statistically significantly positively associated with any ischemic stroke, large artery stroke, and small vessel stroke but not cardioembolic stroke or intracerebral hemorrhage. [25] Results: The miR-126 gene rs4636297 polymorphism was associated with decreased small vessel stroke risk (GA vs. [26] While neurologists agree on the delineation of ischemic stroke (IS) into the three most common subtypes (cardioembolic stroke (CES), large artery stroke (LAS), and small vessel stroke (SVS)), several different subtyping systems exist. [27] In order to explore the function of single-nucleotide polymorphisms (SNPs) at the molecular level, in this paper, we integrated 8 GWAS datasets with brain expression quantitative trait loci (eQTL) dataset to identify SNPs and genes which are related to four types of stroke (ischemic stroke, large artery stroke, cardioembolic stroke, small vessel stroke). [28]結果 遺伝的に予測された教育年数は、虚血性、大動脈、小血管の脳卒中、および脳内出血と逆相関していました。 [1] 4％）、小血管発作; 1（7。 [2] nan [3] nan [4] 任意の脳卒中（AS）、任意の虚血性脳卒中（AIS）、大動脈脳卒中（LAS）、心臓塞栓性脳卒中（CES）、および小血管脳卒中（SVS）のすべてのPRSは、PRSice-2によって構築されました。 [5] nan [6] nan [7] nan [8] nan [9] nan [10] nan [11] nan [12] 2サンプルのメンデルランダム化を適用して、虚血性脳卒中（60,341症例、454,450対照）、脳内出血（1,545症例、1,481対照）、および虚血性脳卒中サブタイプ（大動脈、心臓塞栓性、小血管脳卒中）との関連を調べました。関連する表現型（頸動脈アテローム性動脈硬化症、脳白質の完全性のイメージングマーカー、および脳萎縮）。 [13] 試験データと疫学的研究の二次分析は、tHcy レベルが特に小血管発作 (SVS) と関連している可能性があることを示唆しています。 [14] 001) 大動脈脳卒中の場合。小血管の脳卒中との関連はありませんでした (オッズ比 0. [15] nan [16] nan [17] nan [18] 05) ランダム効果逆分散加重分析におけるすべての虚血性脳卒中、心臓塞栓性脳卒中、および大動脈脳卒中を伴う RHR の; CADまたは小血管の脳卒中との関連は観察されませんでした（図）。 [19] nan [20] nan [21] nan [22] nan [23] nan [24] nan [25] nan [26] nan [27] nan [28]
Large Vessel Stroke 大型容器ストローク
Do genetic thrombophilic states, strongly associated with venous thrombosis, independently cause arterial events in adults? Should cases of patent foramen ovale be closed with mechanical devices in patients with cryptogenic stroke? What are the optimal treatments for cerebral vein thrombosis, carotid artery dissection, and antiphospholipid syndrome and are DOACs acceptable treatment for these indications? What is the mechanism underlying large vessel stroke in patients with COVID-19? This is a narrative review. [1] Conclusions Tandem cervical carotid occlusion in patients with acute large vessel stroke did not lower the odds of good functional outcome in our study. [2] We report the case of a 28-year-old female patient with COVID-19-associated large vessel stroke and the results of the tissue analyses of the extracted clot. [3] In our cohort, half of young patients with cryptogenic stroke fit the risk factor phenotype of small and large vessel strokes. [4] To the Editor: We read with great interest the article by Khandelwal et al1 titled “Incidence, Characteristics, and Outcomes of Large Vessel Stroke in COVID-19 Cohort: An International Multicenter Study. [5] Of the single large vessel strokes, 62. [6] We identified six carriers, who had higher percentages of large vessel stroke subtype (66. [7] Conclusion: We could formulate an ES prediction tool using the following components: (a) cortical location, (b) large vessel stroke, (c) mRS at admission, (d) anticoagulant use, and (e) presence of hypertension. [8] There are several ongoing studies exploring whether select protein and RNA biomarkers of plaque progression or vulnerability could facilitate the reclassification of some ESUS as large vessel strokes or help to optimize secondary prevention strategies. [9] COVID19 was associated with severe stroke symptoms due to large vessel strokes [3]. [10] There have been reports of large vessel stroke occurring in coronavirus disease 2019 (COVID-19) positive patients, with very few reported in the age group less than 50 years. [11] Large vessel strokes have been reported in young patients with COVID-19 disease. [12] We report on the use of systemic heparinization following thrombolysis with intravenous tissue plasminogen activator (t-PA) for acute ischemic large vessel stroke, in the setting of COVID-19-induced hypercoagulability, with partial recanalization of the internal carotid artery. [13] Three patients presented cerebrovascular complications including two spontaneous intraparenchymal hemorrhages and 1 ischemic large vessel stroke. [14] There have been reports of large vessel stroke occurring in coronavirus disease 2019 (COVID-19) positive patients, with very few reported in the age group less than 50 years. [15] MATERIALS AND METHODS Patients who underwent mechanical thrombectomy (MT) for anterior circulation large vessel stroke in a single center were retrospectively reviewed. [16] Background: This study was to evaluate the correlation of the hypoperfusion intensity ratio (HIR) with the collateral score from multiphase computed tomography angiography (mCTA) among patients with large vessel stroke. [17] However the consensus is that for large vessel strokes, IT should be considered if patients present within 4. [18] Background and purpose A direct aspiration first pass technique involves first-line aspiration to remove the thrombus through a large-bore aspiration catheter in large vessel strokes. [19] INTRODUCTION Serum S100β levels are mostly used for predicting outcomes of large vessel stroke (LVS). [20] Conclusion Compared with BMT, the use of MT in the early time window in large vessel stroke results in a more substantial limitation of infarct growth in patients with poor collaterals. [21] In contrast to adult patients, our experience suggests that this pattern is relatively more common in pediatric patients with large vessel stroke, including both perinatal and pediatric arterial ischemic stroke (AIS). [22] Mechanical thrombectomy (MT) is more common in the acute care of large vessel strokes. [23]静脈血栓症と強く関連している遺伝的血栓性状態は、成人に独立して動脈イベントを引き起こしますか？卵円孔開存の症例は、潜在性脳卒中の患者の機械的装置で閉じる必要がありますか？脳静脈血栓症、頸動脈解離、および抗リン脂質抗体症候群の最適な治療法は何ですか？DOACはこれらの適応症に対して許容できる治療法ですか？ COVID-19患者の大血管発作の根底にあるメカニズムは何ですか？これは物語のレビューです。 [1] 結論急性大血管発作の患者におけるタンデム頸動脈閉塞は、我々の研究において良好な機能的転帰のオッズを低下させなかった。 [2] nan [3] nan [4] nan [5] nan [6] 大血管発作サブタイプの割合が高い6人の保因者を特定しました（66。 [7] nan [8] nan [9] nan [10] 2019年のコロナウイルス病（COVID-19）陽性の患者で大血管発作が発生したという報告があり、50歳未満の年齢層ではほとんど報告されていません。 [11] nan [12] nan [13] nan [14] 2019年のコロナウイルス病（COVID-19）陽性の患者で大血管発作が発生したという報告があり、50歳未満の年齢層ではほとんど報告されていません。 [15] nan [16] nan [17] しかし、コンセンサスは、大血管の脳卒中の場合、患者が 4 以内に存在する場合は IT を考慮する必要があるということです。 [18] 背景と目的 直接吸引初回通過法では、大血管ストロークで大口径吸引カテーテルを介して血栓を除去するための第一選択吸引が行われます。 [19] nan [20] nan [21] nan [22] nan [23]
vessel stroke subtype
We identified six carriers, who had higher percentages of large vessel stroke subtype (66. [1] 001) and small-vessel stroke subtype (0. [2]大血管発作サブタイプの割合が高い6人の保因者を特定しました（66。 [1] nan [2]
vessel stroke occurring 血管ストロークの発生
There have been reports of large vessel stroke occurring in coronavirus disease 2019 (COVID-19) positive patients, with very few reported in the age group less than 50 years. [1] There have been reports of large vessel stroke occurring in coronavirus disease 2019 (COVID-19) positive patients, with very few reported in the age group less than 50 years. [2]2019年のコロナウイルス病（COVID-19）陽性の患者で大血管発作が発生したという報告があり、50歳未満の年齢層ではほとんど報告されていません。 [1] 2019年のコロナウイルス病（COVID-19）陽性の患者で大血管発作が発生したという報告があり、50歳未満の年齢層ではほとんど報告されていません。 [2]