新規証拠とは何ですか？
Novel Evidence 新規証拠 - Conclusion: Our study provides a novel evidence for EcPVs infection and circulation in Chinese horses and thus lays the foundation for a systematic and detailed epidemiological study of these infections in Chinese horses. [1] This RCT builds on a successful open pilot trial conducted by our team and will provide further evaluation of a novel evidence-based treatment for pregnancy-related insomnia, which can be widely disseminated and used to treat individuals that are most in need of intervention. [2] Taken together, our results provide a novel evidence that metformin can effectively attenuate trauma-induced HO by mitigating macrophage inflammatory responses through inhibiting NF-κB signaling via SIRT1-dependent mechanisms, which favors future therapeutic investigations for trauma-related disease. [3] In the last decades, novel evidence has suggested that BPH might represent an element into the wide spectrum of disorders conforming the Metabolic Syndrome (MS). [4] Conclusions: In conclusion, several lung tissue-derived molecular signatures, highlighted in this study, might serve as novel evidence for elucidating the essential mechanisms of PAH. [5] BACKGROUND Despite prevention efforts, suicide rates continue to rise, prompting the need for novel evidence-based approaches to suicide prevention. [6] METHODS A multidisciplinary team developed a novel evidence-based process for N95 respirator re-processing and sanitation using ultraviolet (UV) light. [7] Interestingly, this study provides the novel evidence that the native and oxidized cyclic forms of the SCO-spondin-derived peptide reduce pathological factors associated with AD and restore learning and memory at both early and late disease stages. [8] Lobsters exhibit a temperature-dependent withdrawal response to immersion of tail, antennae or claws in warm water; this is novel evidence of thermal nociception for this species. [9] Conclusion These findings provide important and novel evidence that higher consumption of ultra-processed foods is associated with more rapid progression of adiposity from childhood to early adulthood. [10] Novel evidence has indicated that a competing endogenous RNA (ceRNA) mechanism may occur in AF. [11] Novel evidence is presented allowing further clarification of the mechanism of the slow-binding thymidylate synthase (TS) inhibition by N4-hydroxy-dCMP (N4-OH-dCMP). [12] Conclusions and Significance: These findings provide, in the theoretical context of consciousness, novel evidence for a reduction of regional information content as a potential systems-level mechanism of consciousness disorder in MCS and UWS. [13] Second, the authors find a novel evidence that the information from Internet forum is more superior to search frequency in volatility forecasting of stock market. [14] Our study provides essential and novel evidence for the association between hysterectomy and DM risk in women aged 30 to 49 years, which is relevant to these women and their physicians. [15] This study contributes to the growing literature of bitcoin prices with novel evidence from a large emerging economy. [16] This study provides some novel evidence of visual processing in the human brain in the free-viewing condition. [17] Thus, our present study provides a novel evidence that improved uterine endometrial receptivity and enhanced angiogenesis induced by embryo-derived chemokine CXCL12 may aid to develop a minimally-invasive therapeutic strategy for clinical treatment or supplement for the patients with repeated implantation failure with less risk. [18] Novel evidence we present argues that a loosening version of the repair mechanism must be available. [19] Conclusions This is novel evidence that suggests alcohol-induced changes in bodily states may mediate the occurrence of alcohol priming effects and highlights the potentially generative role of interoceptive mechanisms in alcohol-related behaviors. [20] Cultural attitudes that have long undermined the importance of sleep could be countered by this novel evidence. [21] Discussion This study will allow us to test and further develop a novel evidenced-based complex intervention aimed at general practice teams to expedite the diagnosis of cancer in primary care. [22] Lobsters exhibit a temperature-dependent withdrawal response to immersion of tail, antennae or claws in warm water; this is novel evidence of thermal nociception for this species. [23] Treatments have focused on symptom relief, and the increasing understanding of the pathogenesis of EB is facilitating the development of novel evidencebased therapy approaches. [24] Each study's intervention was then categorized using a novel evidence-based system of categorization, derived from the conceptual clustering framework used in machine learning. [25] Haushofer not only laid the oceanographic foundation of the “Indo-Pacific” with novel evidence in marine sciences, ethnography, and philology, but also legitimated it as a social and political space. [26] Rapid sequencing is a novel evidence‐based strategy that has the potential to dramatically improve the implementation of treatments that reduce the morbidity and mortality of patients with heart failure and a reduced ejection fraction. [27] The present study presents a novel evidence for the various biological activities of green synthesized AgNPs. [28] Therefore, we created a novel evidence-based decision tool to support EMS destination choice. [29] These results provide the novel evidence that C-MSC are a source of myofibroblasts and participate in ACM fibrotic remodeling, being highly responsive to ACM-characteristic excess TGF-β1. [30] Recently, novel evidence has supported the anti-tumourigenic potential of a mixture of trypsinogen and chymotrypsinogen. [31] Our findings are robust to the correction of potential endogeneity in the spatial weight matrix, and we provide not only novel evidence for the spatial effect of institutional differential on the domino-like spread of PTAs, but also some insights on the relationship between regionalism and multilateralism. [32] These results provide the novel evidence for understanding the function and molecular mechanism of NEAT1, and a new direction for improving the chemotherapeutic effects in PC. [33] Circ_0074491 played a suppressive role in cholesteatoma through inactivating the PI3K/Akt pathway via binding to miR-22-3p and miR-125a-5p, which provided a novel evidence for the involvement of circRNA in the development of cholesteatoma. [34] Our findings may provide a novel evidence for right-sided heart dysfunction to HA exposure. [35] These results provided the novel evidence that PTGDS may play a significant role in modulating breast cancer growth, with implications for its potential use in treating breast cancer. [36] Additionally, there is novel evidence that, for some warnings, high impulsiveness may be a factor in reduced warning efficacy, which may explain poorer cessation success in this population. [37] The implication rate of novel evidence-based treatment options was higher in the second wave. [38] This article aims to determine receptivity for advancing the Learning Healthcare System (LHS) model to a novel evidence-based health care delivery framework—Learning Health Care Community (LHCC)—in Baltimore, as a model for a national initiative. [39] These results provide a novel evidence that dioxin suppresses GH-producing cell proliferation and GH synthesis due to partly targeting DAPL1, thereby impairing offspring development. [40] The finding provides (tentative) novel evidence that training variability may benefit perceptual learning of the relatively easy tone pair and facilitate the formation of talker-independent representations of non-native tones by novice learners. [41] However, novel evidence-based approaches have opened the way for agents targeting HCM molecular substrates. [42]結論：私たちの研究は、中国の馬におけるECPV感染と循環のための新しい証拠を提供し、したがって、中国の馬におけるこれらの感染の体系的かつ詳細な疫学的研究のための基礎を築きます。 [1] このRCTは私たちのチームによって行われたオープンなパイロット試験を成功させ、妊娠関連不眠症のための新しい証拠に基づく治療をさらに評価するでしょう、そしてそれは広く普及し、そして介入を必要としている個人を治療するために使用され得る個人を扱うために使用されます。 [2] まとめると、我々の結果は、Sirt1依存性のメカニズムを介してNF-κBシグナル伝達を阻害することによってマクロファージ炎症反応を軽減することによって、メトホルミンが外傷誘発性HOを効果的に減衰させることができ、それが外傷関連疾患の将来の治療研究を促進することができるという新しい証拠を提供する。