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Novel multi-targeted inhibitors suppress ocular neovascularization by regulating unique gene sets.


Heterodimer formation with retinoic acid receptor RXRα modulates coactivator recruitment by peroxisome proliferator-activated receptor PPARγ



Nonsteroidal ecdysone receptor agonists use a water channel for binding to the ecdysone receptor complex EcR/USP.



Structural characterization of the microbial enzyme urocanate reductase mediating imidazole propionate production



Potent, Selective CARs as Potential T-Cell Therapeutics for HPV-positive Cancers



Diversification of mineralocorticoid receptor genes in a subterranean rodent, the naked mole-rat.



Comparative in silico Survey of Retinoic Acids as Putative Biomolecules Against VEGF Receptors: A Glycomics-based Approach



NMDA Receptors Require Multiple Pre-opening Gating Steps for Efficient Synaptic Activity



Finding novel chemoreceptors that specifically sense and trigger chemotaxis toward polycyclic aromatic hydrocarbons in Novosphingobium pentaromativorans US6-1.



Targeted Therapeutic Approach in Patients With Familial Partial Lipodystrophy Type 3



A catalogue of signal molecules that interact with sensor kinases, chemoreceptors and transcriptional regulators.



The Chemosensory Repertoire of the Eastern Diamondback Rattlesnake (Crotalus adamanteus) Reveals Complementary Genetics of Olfactory and Vomeronasal-Type Receptors.



Functional Effects In Silico Prediction for Androgen Receptor Ligand-Binding Domain Novel I836S Mutation



Diverse Native Ensembles Dictate the Differential Functional Responses of Nuclear Receptor Ligand-Binding Domains.



Characterization of putative transcriptional regulator (PH0140) and its distal homologue.



Conformational rearrangement during activation of a metabotropic glutamate receptor



Screening ligand-binding domains for rapid biosensor design and testing



In silico mutational analyses reveal different ligand-binding abilities of double pockets of medaka fish taste receptor type 1 essential for efficient taste recognition.



A New Mechanism in THRA Resistance: The First Disease-Associated Variant Leading to an Increased Inhibitory Function of THRA2



Generation, biochemical characterizations and validation of potent nanobodies derived from alpaca specific for human receptor of advanced glycation end product.



dSPRINT: predicting DNA, RNA, ion, peptide and small molecule interaction sites within protein domains



Conformational Rearrangement During Activation of a Metabotropic Glutamate Receptor



Gating mechanism and a modulatory niche of human GluN1-GluN2A NMDA receptors



Synthesis of Multi-Module Low Density Lipoprotein Receptor Class A Domains with Acid Labile Cyanopyridiniumylides (CyPY) as Aspartic Acid Masking Groups



Gating and modulation of a hetero-octameric AMPA glutamate receptor.



Structure of a double CACHE chemoreceptor ligand-binding domain from Pseudomonas syringae provides insights into the basis of proline recognition.



The Campylobacter jejuni chemoreceptor Tlp10 has a bimodal ligand-binding domain and specificity for multiple classes of chemoeffectors



Simple monitoring of endocrine-disrupting chemicals using transgenic Arabidopsis plants expressing medaka estrogen receptor.



Allosteric coupling of sub-millisecond clamshell motions in ionotropic glutamate receptor ligand-binding domains


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