Discover more insights into Ligand Binding リガンド結合

Ligand Binding sentence examples within molecular docking study



Identification of APOE4 Modulators, Targeted Therapeutic Candidates in Coronary Artery Disease, Using Molecular Docking Studies


Identification of APOE4 modulators, targeted therapeutic candidates in Coronary Artery Disease, using Molecular Docking studies

Ligand Binding sentence examples within protein coupled receptor



The lipidome in nonalcoholic fatty liver disease: actionable targets


BCL7B is a potential novel diagnosis and prognosis biomarker for sarcomas using bioinformatics analysis

Ligand Binding sentence examples within isothermal titration calorimetry



Isothermal titration calorimetry (ITC): a standard operating procedure (SOP).


Two riboswitches with identical binding pockets and disparate RNA folds show different tolerances to equivalent mutations



Ligand Binding sentence examples within regulate gene expression



Influence of the Bioactive Diet Components on the Gene Expression Regulation


The P1 and P2 helices of the Guanidinium-II riboswitch interact in a ligand-dependent manner

Ligand Binding sentence examples within protein protein interaction



Solution NMR Structure of the SH3 Domain of Human Caskin1 Validates the Lack of a Typical Peptide Binding Groove and Supports a Role in Lipid Mediator Binding


Prediction and Characterization of Disorder-Order Transition Regions in Proteins by Deep Learning

Ligand Binding sentence examples within rational drug design



Robust, Efficient and Automated Methods for Accurate Prediction of Protein-Ligand Binding Affinities in AMBER Drug Discovery Boost


Covalent and non-covalent binding free energy calculations for peptidomimetic inhibitors of SARS-CoV-2 main protease.

Ligand Binding sentence examples within surface plasmon resonance



ActRIIB:ALK4-Fc alleviates muscle dysfunction and comorbidities in murine models of neuromuscular disorders.


V367F Mutation in SARS-CoV-2 Spike RBD Emerging during the Early Transmission Phase Enhances Viral Infectivity through Increased Human ACE2 Receptor Binding Affinity

Ligand Binding sentence examples within resonance energy transfer



CXCL17 is an endogenous inhibitor of CXCR4 via a novel mechanism of action


Interbase-FRET binding assay for pre-microRNAs

Ligand Binding sentence examples within conformational changes induced



Monitoring Protein-Ligand Interactions in Human Cells by Real-Time Quantitative In-Cell NMR using a High Cell Density Bioreactor.


Fenton-Chemistry-Based Oxidative Modification of Proteins Reflects Their Conformation

Ligand Binding sentence examples within co crystal structure



Tricyclic-Carbocyclic RORγt Inverse Agonists-Discovery of BMS-986313.


Biological evaluation and synthesis of calcitroic acid.

Ligand Binding sentence examples within nicotinic acetylcholine receptor



Elephants in the dark: insights and incongruities in pentameric ligand-gated ion channel models.


Modulation of Calcium Signaling by Chemogenetic Tools to Elucidate the Pathogenesis of Primary Aldosteronism

Ligand Binding sentence examples within polymerase chain reaction



Bioanalysis in the Age of New Drug Modalities


Functional and anatomical characterization of corticotropin-releasing factor receptor subtypes of the rat spinal cord involved in somatic pain relief

Ligand Binding sentence examples within consistently outperform classical



Learning from Docked Ligands: Ligand-Based Features Rescue Structure-Based Scoring Functions When Trained On Docked Poses


Learning protein-ligand binding affinity with atomic environment vectors

Ligand Binding sentence examples within enzymatic catalysis protein



An Azo Coupling-Based Chemoproteomic Approach to Systematically Profile the Tyrosine Reactivity in the Human Proteome.


An Azo Coupling-Based Chemoproteomic Approach to Systematically Profile the Tyrosine Reactivity in the Human Proteome

Ligand Binding sentence examples within amino acid sequence



The Pan social brain: An evolutionary history of neurochemical receptor genes and their potential impact on sociocognitive differences.


A bi-specific lectin from the mushroom Boletopsis grisea and its application in glycoanalytical workflows

Ligand Binding sentence examples within induced fit docking



AI3SD Video: So you predicted a protein structure – What now?


Reliable and Accurate Solution to the Induced Fit Docking Problem for Protein-Ligand Binding.

Ligand Binding sentence examples within cell surface expression



N‐glycosylation of the human neuropeptide QRFP receptor (QRFPR) is essential for ligand binding and receptor activation


Formation of Kiss1R/GPER heterocomplexes negatively regulates Kiss1R-mediated signalling through limiting receptor cell surface expression.

Ligand Binding sentence examples within 2 receptor accessory



Regulation of Melanocortin-5 Receptor Pharmacology by Two Isoforms of MRAP2 in Ricefield Eel (Monopterus albus)


Regulation of melanocortin-5 receptor pharmacology by two isoforms of MRAP2 in ricefield eel (Monopterus albus).

Ligand Binding sentence examples within protein structure prediction



Computational analysis of missense variants in MMP2 gene linked with Winchester syndrome and Nodulosis-Arthropathy-Osteolysis reveals structural shift in protein-protein and protein-ligand complexes

Ligand Binding sentence examples within α v β



Dual inhibition of αvβ6 and αvβ1 reduces fibrogenesis in lung tissue explants from patients with IPF

Ligand Binding sentence examples within Upon Ligand Binding



AHR in the intestinal microenvironment: safeguarding barrier function


Mechanism of Vitamin D Receptor Ligand-Binding Domain Regulation Studied by gREST Simulations

Ligand Binding sentence examples within Extracellular Ligand Binding



Modulation of Calcium Signaling by Chemogenetic Tools to Elucidate the Pathogenesis of Primary Aldosteronism


Composition of receptor tyrosine kinase-mediated lipid micro-domains controlled by adaptor protein interaction

Ligand Binding sentence examples within Specific Ligand Binding



Recent Advances in the Therapeutic Development of Receptor Tyrosine Kinases (RTK) against Different Types of Cancer


Two ligand-binding sites in CO-reducing V nitrogenase reveal a general mechanistic principle

Ligand Binding sentence examples within Receptor Ligand Binding



The lipidome in nonalcoholic fatty liver disease: actionable targets


Spontaneous, synchronous zinc spikes oscillate with neural excitability and calcium spikes in primary hippocampal neuron culture

Ligand Binding sentence examples within Ar Ligand Binding



Evolution of Castration-Resistant Prostate Cancer in ctDNA during Sequential Androgen Receptor Pathway Inhibition


Discovery of novel antagonists targeting the DNA binding domain of androgen receptor by integrated docking-based virtual screening and bioassays.

Ligand Binding sentence examples within Affect Ligand Binding



Bioinformatics Analysis Unveils Certain Mutations Implicated in Spike Structure Damage and Ligand-Binding Site of Severe Acute Respiratory Syndrome Coronavirus 2


The influence of hydrogen ions on coagulation in traumatic brain injury, explored by molecular dynamics

Ligand Binding sentence examples within Orthosteric Ligand Binding



Efficient production of a functional G protein-coupled receptor in E. coli for structural studies.


Design, synthesis, and pharmacological profiling of cannabinoid 1 receptor allosteric modulators: Preclinical efficacy of C2-group GAT211 congeners for reducing intraocular pressure.

Ligand Binding sentence examples within Allosteric Ligand Binding



Orthosteric and Allosteric Dual Targeting of the Nuclear Receptor RORγt with a Bitopic Ligand


Untangling Dual-Targeting Therapeutic Mechanism of Epidermal Growth Factor Receptor (EGFR) Based on Reversed Allosteric Communication

Ligand Binding sentence examples within High Ligand Binding



Optimization and Development of Albumin–Biopolymer Bioconjugates with Solubility-Improving Properties


An insight into aptamer engineered dendrimer for cancer therapy

Ligand Binding sentence examples within Nurr1 Ligand Binding



Analogs of the Dopamine Metabolite 5,6-Dihydroxyindole Bind Directly to and Activate the Nuclear Receptor Nurr1.


Fragment-like Chloroquinolineamines Activate the Orphan Nuclear Receptor Nurr1 and Elucidate Activation Mechanisms.

Ligand Binding sentence examples within Pparγ Ligand Binding



Tetrazoles as PPARγ ligands: A Structural and Computational Investigation


Increasing endogenous PPARγ ligands improves insulin sensitivity and protects against diet-induced obesity without side effects of thiazolidinediones

Ligand Binding sentence examples within Relative Ligand Binding



Robust, Efficient and Automated Methods for Accurate Prediction of Protein-Ligand Binding Affinities in AMBER Drug Discovery Boost


Dependence of Work on the Pulling Speed in Mechanical Ligand Unbinding

Ligand Binding sentence examples within Facilitate Ligand Binding



Evidence that GPVI is expressed as a mixture of monomers and dimers, and that the D2 domain is not essential for GPVI activation.


The Oxoglutarate Binding Site and Regulatory Mechanism Are Conserved in Ammonium Transporter Inhibitors GlnKs from Methanococcales

Ligand Binding sentence examples within Predicted Ligand Binding



Nematode nuclear receptors as integrators of sensory information


Investigate Inhibitory Effects of Ginger polyphenols compare to Simvastatin towards HMG-CoA reductase: An Integrated Molecular Docking and Molecular dynamic simulation

Ligand Binding sentence examples within Potential Ligand Binding



Mining for Ligandable Cavities in RNA.


Structural insights into understudied human cytochrome P450 enzymes.

Ligand Binding sentence examples within Following Ligand Binding



“100 Years of progress in understanding insulin, its mechanism of action, and its roles in disease and diabetes therapy”


Glucocorticoid receptor dimerization in the cytoplasm might be essential for nuclear localization.

Ligand Binding sentence examples within Major Ligand Binding



Lysine reactivity profiling reveals molecular insights into human serum albumin–small-molecule drug interactions


Allosteric regulation of 3CL protease of SARS-CoV-2 and SARS-CoV observed in the crystal structure ensemble

Ligand Binding sentence examples within Without Ligand Binding



Subcellular dynamics of estrogen-related receptors involved in transrepression through interactions with scaffold attachment factor B1.


Design and study of in silico binding dynamics of certain isoxazole bearing leads against Aβ-42 and BACE-1 loop in protein fibrillation

Ligand Binding sentence examples within Direct Ligand Binding



Mechanical Activation of the Angiotensin II Type I Receptor (AT1R) Contributes to Abdominal Aortic Aneurysm Formation


McpT, a Broad-Range Carboxylate Chemoreceptor in Sinorhizobium meliloti

Ligand Binding sentence examples within Whereby Ligand Binding



Neural relational inference to learn allosteric long-range interactions in proteins from molecular dynamics simulations


Unconventional Antibacterials and Adjuvants.

Ligand Binding sentence examples within Competitive Ligand Binding



Megestrol acetate is a specific inducer of CYP3A4 mediated by human pregnane X receptor


A quinazoline-based bromodomain inhibitor, CN210, ameliorates indomethacin-induced ileitis in mice by inhibiting inflammatory cytokine expression.

Ligand Binding sentence examples within Novel Ligand Binding



Apo and ligand-bound high resolution Cryo-EM structures of the human Kv3.1 reveal a novel binding site for positive modulators


Structures of the TRPM5 channel elucidate mechanisms of activation and inhibition

Ligand Binding sentence examples within Affinity Ligand Binding



Dysregulation of Hepatitis B Virus Nucleocapsid Assembly with RNA-directed Small Ligands


Click chemistry in silico, docking, quantum chemical calculations, and molecular dynamics simulations to identify novel 1,2,4-triazole-based compounds as potential aromatase inhibitors

Ligand Binding sentence examples within Gpcr Ligand Binding



Bioinformatics analyses of significant genes, related pathways and candidate prognostic biomarkers in Alzheimer’s disease


A Metadynamics-Based Protocol for the Determination of GPCR-Ligand Binding Modes

Ligand Binding sentence examples within Organic Ligand Binding



Expansion of the Family of Molecular Nanoparticles of Cerium Dioxide and Their Catalytic Scavenging of Hydroxyl Radicals.


Vanadium isotope composition of seawater

Ligand Binding sentence examples within While Ligand Binding



Helix 12 stabilization contributes to basal transcriptional activity of PXR


Molecular Architecture of a Network of Potential Intracellular EGFR Modulators Involving the Juxtamembrane Segment, ARNO, Phospholipids and CaM

Ligand Binding sentence examples within Canonical Ligand Binding



Solution NMR Structure of the SH3 Domain of Human Caskin1 Validates the Lack of a Typical Peptide Binding Groove and Supports a Role in Lipid Mediator Binding


Structural Investigation of Orf Virus Bcl-2 Homolog ORFV125 Interactions with BH3-Motifs from BH3-Only Proteins Puma and Hrk

Ligand Binding sentence examples within Three Ligand Binding



Mapping Co-regulatory Interactions among Ligand Binding sites in RyR1.


Mapping Co-regulatory Interactions among Ligand Binding sites in RyR1

Ligand Binding sentence examples within Natural Ligand Binding



Allergens and their associated small molecule ligands—their dual role in sensitization


Quorum Sensing Inhibiting Activity of Cefoperazone and Its Metallic Derivatives on Pseudomonas aeruginosa

Ligand Binding sentence examples within Rapid Ligand Binding



Defining the Energetic Basis for a Conformational Switch Mediating Ligand-Independent Activation of Mutant Estrogen Receptors in Breast Cancer


The Problems of Applying Classical Pharmacology Analysis to Modern In Vitro Drug Discovery Assays: Slow Binding Kinetics and High Target Concentration